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Aliases for ZNF720 Gene

Aliases for ZNF720 Gene

  • Zinc Finger Protein 720 2 3 5

External Ids for ZNF720 Gene

Previous GeneCards Identifiers for ZNF720 Gene

  • GC16P031635
  • GC16P029284

Summaries for ZNF720 Gene

GeneCards Summary for ZNF720 Gene

ZNF720 (Zinc Finger Protein 720) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF670-ZNF695.

Additional gene information for ZNF720 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF720 Gene

Genomics for ZNF720 Gene

GeneHancer (GH) Regulatory Elements for ZNF720 Gene

Promoters and enhancers for ZNF720 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I031712 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +1.0 1010 3.3 PKNOX1 SMAD1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF213 ZNF720 CLUHP3 STX4 RNF40 ENSG00000260267 YBX3P1 GC16M031728
GH16I031713 Enhancer 0.5 ENCODE 550.8 -1.1 -1054 0.2 PAF1 RFX1 POLR2A ZFP64 ZBTB20 ENSG00000261731 ZNF720
GH16I031093 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 56.9 -618.6 -618638 4 HDGF PKNOX1 CLOCK FOXA2 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 VKORC1 ENSG00000255439 ENSG00000280160 SETD1A ZNF785 ZNF720 FUS ZNF689 SRCAP ZNF747
GH16I030785 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 36.6 -926.5 -926491 3.4 MLX ZFP64 ARID4B SIN3A ZNF2 ZBTB7B YY1 SLC30A9 ZNF213 E2F8 ZNF629 SRCAP SETD1A ENSG00000260267 INO80E SMG1P5 ENSG00000260304 ZNF764 NPIPB13 RNF40
GH16I031071 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 29 -639.6 -639589 5 CLOCK MLX ZFP64 DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF646 ZNF668 PIR38332 PIR37153 ZNF785 FUS ZNF720 KAT8 SETD1A ZNF688
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF720 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF720 gene promoter:

Genomic Locations for ZNF720 Gene

Genomic Locations for ZNF720 Gene
chr16:31,713,229-31,794,869
(GRCh38/hg38)
Size:
81,641 bases
Orientation:
Plus strand
chr16:31,724,550-31,806,190
(GRCh37/hg19)

Genomic View for ZNF720 Gene

Genes around ZNF720 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF720 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF720 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF720 Gene

Proteins for ZNF720 Gene

  • Protein details for ZNF720 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z2F6-ZN720_HUMAN
    Recommended name:
    Putative protein ZNF720
    Protein Accession:
    Q7Z2F6
    Secondary Accessions:
    • Q6ZQX1

    Protein attributes for ZNF720 Gene

    Size:
    126 amino acids
    Molecular mass:
    14454 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF720 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF720 Gene

Post-translational modifications for ZNF720 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF720 Gene

Domains & Families for ZNF720 Gene

Gene Families for ZNF720 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZNF720 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF720 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZNF720: view

No data available for UniProtKB/Swiss-Prot for ZNF720 Gene

Function for ZNF720 Gene

Phenotypes From GWAS Catalog for ZNF720 Gene

Gene Ontology (GO) - Molecular Function for ZNF720 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with ZNF720: view

Phenotypes for ZNF720 Gene

GenomeRNAi human phenotypes for ZNF720:
genes like me logo Genes that share phenotypes with ZNF720: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF720 Gene

Localization for ZNF720 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF720 gene
Compartment Confidence
nucleus 3
cytosol 3
cytoskeleton 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF720 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with ZNF720: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ZNF720 Gene

Pathways & Interactions for ZNF720 Gene

SuperPathways for ZNF720 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF720: view

Pathways by source for ZNF720 Gene

2 Reactome pathways for ZNF720 Gene

Interacting Proteins for ZNF720 Gene

Gene Ontology (GO) - Biological Process for ZNF720 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF720: view

No data available for SIGNOR curated interactions for ZNF720 Gene

Drugs & Compounds for ZNF720 Gene

No Compound Related Data Available

Transcripts for ZNF720 Gene

Unigene Clusters for ZNF720 Gene

Zinc finger protein 720:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF720 Gene

No ASD Table

Relevant External Links for ZNF720 Gene

GeneLoc Exon Structure for
ZNF720
ECgene alternative splicing isoforms for
ZNF720

Expression for ZNF720 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF720 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF720 Gene:

ZNF720

SOURCE GeneReport for Unigene cluster for ZNF720 Gene:

Hs.528826
genes like me logo Genes that share expression patterns with ZNF720: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF720 Gene

Orthologs for ZNF720 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF720 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF720 34
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LOC100336208 33
  • 76.71 (n)
mouse
(Mus musculus)
Mammalia Gm19965 34
  • 14 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 7 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 6 (a)
ManyToMany
-- 34
  • 6 (a)
ManyToMany
Species where no ortholog for ZNF720 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF720 Gene

ENSEMBL:
Gene Tree for ZNF720 (if available)
TreeFam:
Gene Tree for ZNF720 (if available)

Paralogs for ZNF720 Gene

Paralogs for ZNF720 Gene

(561) SIMAP similar genes for ZNF720 Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for ZNF720 Gene

genes like me logo Genes that share paralogs with ZNF720: view

Variants for ZNF720 Gene

Sequence variations from dbSNP and Humsavar for ZNF720 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000156792 -- 31,721,426(+) T/C intron_variant
rs1000253186 -- 31,723,220(+) T/G intron_variant
rs1000339605 -- 31,717,099(+) C/T intron_variant
rs1000441882 -- 31,756,158(+) G/A intron_variant
rs1000550304 -- 31,750,113(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF720 Gene

Variant ID Type Subtype PubMed ID
dgv50e203 CNV gain+loss 21179565
esv2658959 CNV deletion 23128226
esv2714195 CNV deletion 23290073
esv3570465 CNV gain 25503493
esv3638408 CNV loss 21293372
esv3892829 CNV loss 25118596
nsv1057598 CNV gain 25217958
nsv1078216 CNV insertion 25765185
nsv833195 CNV loss 17160897

Variation tolerance for ZNF720 Gene

Residual Variation Intolerance Score: 68.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.67; 14.32% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF720 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF720

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF720 Gene

Disorders for ZNF720 Gene

Additional Disease Information for ZNF720

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ZNF720 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF720 Gene

Publications for ZNF720 Gene

  1. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  2. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) Oláh J … Ovádi J (The Journal of biological chemistry 2011) 3 58
  3. Genetic associations of variants in genes encoding HIV-dependency factors required for HIV-1 infection. (PMID: 21083371) Chinn LW … O'Brien SJ (The Journal of infectious diseases 2010) 44 58
  4. Identification of host proteins required for HIV infection through a functional genomic screen. (PMID: 18187620) Brass AL … Elledge SJ (Science (New York, N.Y.) 2008) 3 58
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58

Products for ZNF720 Gene

Sources for ZNF720 Gene

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