Aliases for ZNF718 Gene

Aliases for ZNF718 Gene

  • Zinc Finger Protein 718 2 3 4 5
  • FLJ90036 2
  • ZNF718 5

External Ids for ZNF718 Gene

Previous GeneCards Identifiers for ZNF718 Gene

  • GC04P000115
  • GC04P000047
  • GC04P000117
  • GC04P000050

Summaries for ZNF718 Gene

GeneCards Summary for ZNF718 Gene

ZNF718 (Zinc Finger Protein 718) is a Protein Coding gene. Diseases associated with ZNF718 include Warburg Micro Syndrome 1 and Warburg Micro Syndrome 3. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF595.

UniProtKB/Swiss-Prot Summary for ZNF718 Gene

Additional gene information for ZNF718 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF718 Gene

Genomics for ZNF718 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF718 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF718 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF718

Top Transcription factor binding sites by QIAGEN in the ZNF718 gene promoter:
  • AML1a
  • AP-1
  • FOXJ2
  • FOXJ2 (long isoform)
  • GR
  • GR-alpha
  • HFH-1
  • Meis-1
  • Pbx1a
  • Sox5

Genomic Locations for ZNF718 Gene

Genomic Locations for ZNF718 Gene
78,061 bases
Plus strand
33,394 bases
Plus strand

Genomic View for ZNF718 Gene

Genes around ZNF718 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF718 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF718 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF718 Gene

Proteins for ZNF718 Gene

  • Protein details for ZNF718 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 718
    Protein Accession:
    Secondary Accessions:
    • A0A075B7G5
    • A8WFQ3
    • Q3SXZ4
    • Q3SXZ5

    Protein attributes for ZNF718 Gene

    478 amino acids
    Molecular mass:
    55359 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF718 Gene


neXtProt entry for ZNF718 Gene

Post-translational modifications for ZNF718 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF718 Gene

No data available for DME Specific Peptides for ZNF718 Gene

Domains & Families for ZNF718 Gene

Gene Families for ZNF718 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZNF718 Gene

  • KRAB box

Suggested Antigen Peptide Sequences for ZNF718 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 718 (A8WFQ3_HUMAN)
  • ZNF718 protein (Q7Z7K8_HUMAN)
  • Zinc finger protein 718 (ZN718_HUMAN)
genes like me logo Genes that share domains with ZNF718: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ZNF718 Gene

Function for ZNF718 Gene

Molecular function for ZNF718 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF718 Gene

Gene Ontology (GO) - Molecular Function for ZNF718 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA 21873635
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF718: view

Phenotypes for ZNF718 Gene

GenomeRNAi human phenotypes for ZNF718:
genes like me logo Genes that share phenotypes with ZNF718: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF718

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF718 Gene

Localization for ZNF718 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF718 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF718 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for ZNF718 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IBA 21873635
genes like me logo Genes that share ontologies with ZNF718: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF718 Gene

Pathways & Interactions for ZNF718 Gene

genes like me logo Genes that share pathways with ZNF718: view

Pathways by source for ZNF718 Gene

2 Reactome pathways for ZNF718 Gene
1 KEGG pathway for ZNF718 Gene

Interacting Proteins for ZNF718 Gene

Gene Ontology (GO) - Biological Process for ZNF718 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA,IBA 21873635
genes like me logo Genes that share ontologies with ZNF718: view

No data available for SIGNOR curated interactions for ZNF718 Gene

Drugs & Compounds for ZNF718 Gene

No Compound Related Data Available

Transcripts for ZNF718 Gene

mRNA/cDNA for ZNF718 Gene

18 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF718

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF718 Gene

No ASD Table

Relevant External Links for ZNF718 Gene

GeneLoc Exon Structure for

Expression for ZNF718 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF718 Gene

Protein differential expression in normal tissues from HIPED for ZNF718 Gene

This gene is overexpressed in Monocytes (54.3) and Adipocyte (14.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF718 Gene

Protein tissue co-expression partners for ZNF718 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF718

SOURCE GeneReport for Unigene cluster for ZNF718 Gene:

genes like me logo Genes that share expression patterns with ZNF718: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF718 Gene

Orthologs for ZNF718 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for ZNF718 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF718 30
  • 99.37 (n)
Species where no ortholog for ZNF718 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF718 Gene

Gene Tree for ZNF718 (if available)
Gene Tree for ZNF718 (if available)
Evolutionary constrained regions (ECRs) for ZNF718: view image

Paralogs for ZNF718 Gene

Paralogs for ZNF718 Gene

(541) SIMAP similar genes for ZNF718 Gene using alignment to 3 proteins:

  • ZN718_HUMAN
  • Q7Z7K8_HUMAN
genes like me logo Genes that share paralogs with ZNF718: view

Variants for ZNF718 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF718 Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
rs7440274 - p.His413Arg
rs7677201 - p.Ser297Tyr
rs9684214 - p.Lys140Arg
rs9684215 - p.Lys140Asn

Additional dbSNP identifiers (rs#s) for ZNF718 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF718 Gene

Variant ID Type Subtype PubMed ID
dgv1447e212 CNV gain 25503493
dgv1448e212 CNV loss 25503493
dgv1449e212 CNV gain 25503493
dgv2697n106 CNV deletion 24896259
dgv5059n100 CNV gain 25217958
dgv5060n100 CNV gain 25217958
dgv5065n100 CNV loss 25217958
dgv5070n100 CNV gain 25217958
dgv5071n100 CNV gain 25217958
dgv5072n100 CNV loss 25217958
dgv5073n100 CNV loss 25217958
dgv5074n100 CNV loss 25217958
dgv5075n100 CNV loss 25217958
dgv8874n54 CNV loss 21841781
esv2456521 CNV deletion 19546169
esv2762401 CNV loss 21179565
esv2762402 CNV loss 21179565
esv2763816 CNV gain+loss 21179565
esv3304624 CNV mobile element insertion 20981092
esv33512 CNV gain 17666407
esv3355 OTHER sequence alteration 18987735
esv3360440 CNV insertion 20981092
esv3599345 CNV loss 21293372
esv3599346 CNV gain 21293372
esv3599347 CNV loss 21293372
esv3599353 CNV loss 21293372
esv3599354 CNV gain 21293372
esv3599355 CNV loss 21293372
esv3599357 CNV loss 21293372
esv3599358 CNV gain 21293372
esv3599359 CNV gain 21293372
esv3893860 CNV loss 25118596
esv3893861 CNV gain 25118596
esv3893862 CNV gain 25118596
esv5403 OTHER complex 18987735
esv7180 CNV loss 19470904
nsv1001192 CNV loss 25217958
nsv1001533 CNV gain 25217958
nsv1001899 CNV loss 25217958
nsv1011039 CNV loss 25217958
nsv1013934 CNV gain 25217958
nsv1074123 CNV deletion 25765185
nsv1150471 CNV deletion 26484159
nsv4193 CNV insertion 18451855
nsv461141 CNV gain 19166990
nsv461142 CNV loss 19166990
nsv508985 CNV insertion 20534489
nsv515005 CNV loss 21397061
nsv516451 CNV gain+loss 19592680
nsv593189 CNV gain 21841781
nsv593190 CNV gain 21841781
nsv593192 CNV loss 21841781
nsv593193 CNV gain 21841781
nsv593194 CNV loss 21841781
nsv593197 CNV gain 21841781
nsv829833 CNV gain 17160897
nsv967716 CNV duplication 23825009

Additional Variant Information for ZNF718 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for ZNF718 Gene

Disorders for ZNF718 Gene

MalaCards: The human disease database

(5) MalaCards diseases for ZNF718 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF718

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with ZNF718: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF718 Gene

Publications for ZNF718 Gene

  1. Inherited genetic variant predisposes to aggressive but not indolent prostate cancer. (PMID: 20080650) Xu J … Isaacs WB (Proceedings of the National Academy of Sciences of the United States of America 2010) 3 41
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. (PMID: 28611215) Fei T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2017) 3
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3

Products for ZNF718 Gene

Sources for ZNF718 Gene