This gene encodes a Kruppel-associated box (KRAB) zinc-finger protein, which belongs to a large group of transcriptional regulators in mammals. These proteins bind nucleic acids and play important roles in various cellular functions, including cell proliferation, differentiation and apoptosis, and in regulating viral replication and transcription. A pseudogene of this gene was ... See more...

Aliases for ZNF717 Gene

Aliases for ZNF717 Gene

  • Zinc Finger Protein 717 2 3 4 5
  • Krueppel-Like Factor X17 3 4
  • Zinc Finger Protein 838 2 3
  • X17 2 3
  • Kruppel-Like Zinc Finger Factor X17 3
  • ZNF838 3
  • ZNF717 5
  • OB1 3

External Ids for ZNF717 Gene

Previous HGNC Symbols for ZNF717 Gene

  • ZNF838

Previous GeneCards Identifiers for ZNF717 Gene

  • GC03M075870
  • GC03U900858
  • GC03M075758

Summaries for ZNF717 Gene

Entrez Gene Summary for ZNF717 Gene

  • This gene encodes a Kruppel-associated box (KRAB) zinc-finger protein, which belongs to a large group of transcriptional regulators in mammals. These proteins bind nucleic acids and play important roles in various cellular functions, including cell proliferation, differentiation and apoptosis, and in regulating viral replication and transcription. A pseudogene of this gene was identified on chromosome 1. [provided by RefSeq, May 2016]

GeneCards Summary for ZNF717 Gene

ZNF717 (Zinc Finger Protein 717) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZNF658.

UniProtKB/Swiss-Prot Summary for ZNF717 Gene

Additional gene information for ZNF717 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF717 Gene

Genomics for ZNF717 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF717 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J075784 Promoter/Enhancer 1.5 Ensembl ENCODE CraniofacialAtlas 600.7 +0.5 473 2.2 SP1 SIX5 BACH1 LARP7 ZNF143 POLR2A ELF4 YY1 NRF1 MGA ZNF717 LINC00960 RPL23AP49 piR-31952-016 FRG2C
GH03J075906 Promoter/Enhancer 1.2 Ensembl ENCODE CraniofacialAtlas 18.5 -121.4 -121402 1.6 CTCF POLR2A RAD21 TAF1 TBP L3MBTL2 EZH2 NONHSAG035458.2 ROBO2 ZNF717 ENSG00000222883
GH03J075668 Promoter/Enhancer 1.4 Ensembl ENCODE CraniofacialAtlas 13.7 +114.6 114607 5.6 POLR2A CTCF ZNF37A MGA ZFX ZBTB20 SP2 EGR1 ZNF444 GABPA LINC00960 RPL23AP49 lnc-ZNF717-1 HNRNPA3P6 ZNF717 DUX4L26 lnc-FRG2C-8 FRG2C
GH03J075658 Promoter/Enhancer 1.1 Ensembl ENCODE 13.7 +127.0 126982 1.6 GATAD2A CTCF ZNF692 ZIC2 RBFOX2 PATZ1 ZNF501 KLF9 ZFX ZBTB20 RARRES2P1 lnc-FRG2C-9 HNRNPA3P6 ZNF717 DUX4L26 FRG2C RPL23AP49 lnc-FRG2C-8 lnc-ZNF717-1
GH03J075640 Promoter/Enhancer 1.5 EPDnew ENCODE CraniofacialAtlas 5.2 +143.4 143398 3 CREB1 CTCF PRDM10 ZNF629 SIX5 PRDM1 ZNF143 POLR2A NR2C1 RAD21 FRG2C ZNF717 lnc-FRG2C-10 lnc-ZNF717-2 RPL23AP49 lnc-ZNF717-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF717 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF717

Genomic Locations for ZNF717 Gene

Genomic Locations for ZNF717 Gene
106,924 bases
Minus strand
75,941 bases
Minus strand

Genomic View for ZNF717 Gene

Genes around ZNF717 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF717 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF717 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF717 Gene

Proteins for ZNF717 Gene

  • Protein details for ZNF717 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 717
    Protein Accession:

    Protein attributes for ZNF717 Gene

    904 amino acids
    Molecular mass:
    105251 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAK28319.1; Type=Frameshift; Evidence={ECO:0000305};

neXtProt entry for ZNF717 Gene

Post-translational modifications for ZNF717 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF717 Gene

Domains & Families for ZNF717 Gene

Gene Families for ZNF717 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZNF717 Gene

  • C2H2-type zinc finger signature

Suggested Antigen Peptide Sequences for ZNF717 Gene

GenScript: Design optimal peptide antigens:
  • Krueppel-like factor X17 (ZN717_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF717: view

Function for ZNF717 Gene

Molecular function for ZNF717 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF717 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF717: view

Phenotypes for ZNF717 Gene

genes like me logo Genes that share phenotypes with ZNF717: view

Animal Model Products

CRISPR Products

miRNA for ZNF717 Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF717

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF717 Gene

Localization for ZNF717 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF717 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF717 gene
Compartment Confidence
nucleus 5
plasma membrane 2
extracellular 1
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF717 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF717: view

Pathways & Interactions for ZNF717 Gene

genes like me logo Genes that share pathways with ZNF717: view

Pathways by source for ZNF717 Gene

2 Reactome pathways for ZNF717 Gene
1 KEGG pathway for ZNF717 Gene

Interacting Proteins for ZNF717 Gene

Gene Ontology (GO) - Biological Process for ZNF717 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF717: view

No data available for SIGNOR curated interactions for ZNF717 Gene

Drugs & Compounds for ZNF717 Gene

No Compound Related Data Available

Transcripts for ZNF717 Gene

mRNA/cDNA for ZNF717 Gene

10 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF717

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF717 Gene

No ASD Table

Relevant External Links for ZNF717 Gene

GeneLoc Exon Structure for

Expression for ZNF717 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF717 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF717 Gene

This gene is overexpressed in Brain (43.3) and Platelet (25.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF717 Gene

Protein tissue co-expression partners for ZNF717 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF717

SOURCE GeneReport for Unigene cluster for ZNF717 Gene:


Evidence on tissue expression from TISSUES for ZNF717 Gene

  • Muscle(4.2)
genes like me logo Genes that share expression patterns with ZNF717: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF717 Gene

Orthologs for ZNF717 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF717 Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Zfp39 30 17
  • 67.69 (n)
Gm13212 31
  • 40 (a)
(Rattus norvegicus)
Mammalia Zfp39 30
  • 67.44 (n)
(Monodelphis domestica)
Mammalia -- 31
  • 43 (a)
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 38 (a)
(Bos Taurus)
Mammalia -- 31
  • 37 (a)
(Gallus gallus)
Aves -- 31
  • 36 (a)
(Anolis carolinensis)
Reptilia -- 31
  • 54 (a)
(Danio rerio)
Actinopterygii si:ch211-209n20.58 31
  • 39 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 44 (a)
-- 31
  • 42 (a)
-- 31
  • 38 (a)
-- 31
  • 33 (a)
Species where no ortholog for ZNF717 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ZNF717 Gene

Gene Tree for ZNF717 (if available)
Gene Tree for ZNF717 (if available)
Evolutionary constrained regions (ECRs) for ZNF717: view image

Paralogs for ZNF717 Gene

Paralogs for ZNF717 Gene

(530) SIMAP similar genes for ZNF717 Gene using alignment to 6 proteins:

  • ZN717_HUMAN
  • C9J5W8_HUMAN
  • C9J8I7_HUMAN
genes like me logo Genes that share paralogs with ZNF717: view

Variants for ZNF717 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF717 Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
769608 Benign: not provided 75,741,362(-) T/C MISSENSE_VARIANT
770535 Likely Benign: not provided 75,741,269(-) G/A INTRON_VARIANT
rs193921040 Uncertain Significance: Malignant tumor of prostate 75,738,395(-) G/C MISSENSE_VARIANT,INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for ZNF717 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF717 Gene

Variant ID Type Subtype PubMed ID
dgv2543n106 CNV deletion 24896259
dgv2544n106 CNV deletion 24896259
dgv2721e59 CNV duplication 20981092
dgv2722e59 CNV duplication 20981092
dgv2724e59 CNV duplication 20981092
dgv4773n100 CNV gain 25217958
dgv4790n100 CNV gain 25217958
dgv4794n100 CNV gain 25217958
dgv4795n100 CNV gain 25217958
dgv773e201 CNV deletion 23290073
dgv774e201 CNV deletion 23290073
dgv775e201 CNV deletion 23290073
dgv812n67 CNV gain 20364138
dgv8385n54 CNV gain 21841781
esv1200496 CNV insertion 17803354
esv1727154 CNV insertion 17803354
esv2004829 CNV deletion 18987734
esv2241639 CNV deletion 18987734
esv2422315 CNV deletion 17116639
esv2436311 CNV gain 19546169
esv26581 CNV gain+loss 19812545
esv2661069 CNV deletion 23128226
esv2671489 CNV deletion 23128226
esv2725476 CNV deletion 23290073
esv2725477 CNV deletion 23290073
esv2725478 CNV deletion 23290073
esv2725479 CNV deletion 23290073
esv2725480 CNV deletion 23290073
esv2725481 CNV deletion 23290073
esv2725482 CNV deletion 23290073
esv2725483 CNV deletion 23290073
esv2725484 CNV deletion 23290073
esv2725486 CNV deletion 23290073
esv2725487 CNV deletion 23290073
esv2725488 CNV deletion 23290073
esv2725494 CNV deletion 23290073
esv2725498 CNV deletion 23290073
esv2725500 CNV deletion 23290073
esv2725501 CNV deletion 23290073
esv2725502 CNV deletion 23290073
esv2725503 CNV deletion 23290073
esv2725504 CNV deletion 23290073
esv2759157 CNV gain+loss 17122850
esv2763755 CNV gain+loss 21179565
esv2836125 CNV deletion 24192839
esv3310543 CNV novel sequence insertion 20981092
esv33470 CNV loss 17666407
esv3366855 CNV insertion 20981092
esv3379967 CNV duplication 20981092
esv3398233 CNV insertion 20981092
esv3432420 CNV insertion 20981092
esv3434335 CNV duplication 20981092
esv3450847 CNV duplication 20981092
esv3562089 CNV deletion 23714750
esv3893724 CNV loss 25118596
esv3893725 CNV gain 25118596
esv5731 CNV gain 19470904
esv9630 CNV loss 19470904
nsv1008600 CNV gain 25217958
nsv1008795 CNV loss 25217958
nsv1012185 CNV loss 25217958
nsv1015074 CNV gain 25217958
nsv10283 CNV gain+loss 18304495
nsv1073231 CNV deletion 25765185
nsv1073654 CNV deletion 25765185
nsv1074602 CNV deletion 25765185
nsv1077423 CNV duplication 25765185
nsv1110413 CNV duplication 24896259
nsv1114394 CNV deletion 24896259
nsv1120457 CNV tandem duplication 24896259
nsv1131707 CNV deletion 24896259
nsv1139130 CNV deletion 24896259
nsv1139794 CNV duplication 24896259
nsv1141437 CNV duplication 24896259
nsv428418 CNV loss 18775914
nsv471427 CNV gain 19718026
nsv509831 OTHER sequence alteration 20534489
nsv513053 CNV loss 21212237
nsv529016 CNV gain 19592680
nsv590724 CNV loss 21841781
nsv590725 CNV loss 21841781
nsv821408 CNV duplication 20802225
nsv822138 CNV gain 20364138
nsv822140 CNV loss 20364138
nsv954891 CNV duplication 24416366
nsv954892 CNV duplication 24416366
nsv956263 CNV deletion 24416366
nsv956278 CNV deletion 24416366
nsv956291 CNV deletion 24416366
nsv956299 CNV deletion 24416366
nsv956301 CNV deletion 24416366
nsv967112 CNV duplication 23825009
nsv967113 CNV duplication 23825009

Variation tolerance for ZNF717 Gene

Gene Damage Index Score: 2.86; 48.26% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF717 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF717 Gene

Disorders for ZNF717 Gene

Additional Disease Information for ZNF717

No disorders were found for ZNF717 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF717 Gene

Publications for ZNF717 Gene

  1. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny DM … Gibbs RA (Nature 2006) 3 4
  2. Diverse modes of clonal evolution in HBV-related hepatocellular carcinoma revealed by single-cell genome sequencing. (PMID: 29327728) Duan M … Gao Q (Cell research 2018) 3
  3. Interaction proteomics analysis of polycomb proteins defines distinct PRC1 complexes in mammalian cells. (PMID: 21282530) Vandamme J … Angrand PO (Molecular & cellular proteomics : MCP 2011) 3
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  5. Genome-wide association with diabetes-related traits in the Framingham Heart Study. (PMID: 17903298) Meigs JB … Dupuis J (BMC medical genetics 2007) 41

Products for ZNF717 Gene

Sources for ZNF717 Gene