Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZNF716 Gene

Aliases for ZNF716 Gene

  • Zinc Finger Protein 716 2 3 5

External Ids for ZNF716 Gene

Previous GeneCards Identifiers for ZNF716 Gene

  • GC07P057321
  • GC07P057501
  • GC07P057110
  • GC07P057513
  • GC07P057506
  • GC07P057524
  • GC07P057533
  • GC07P057545
  • GC07P057556
  • GC07P057568
  • GC07P057581

Summaries for ZNF716 Gene

GeneCards Summary for ZNF716 Gene

ZNF716 (Zinc Finger Protein 716) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF479.

UniProtKB/Swiss-Prot for ZNF716 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF716 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF716 Gene

Genomics for ZNF716 Gene

GeneHancer (GH) Regulatory Elements for ZNF716 Gene

Promoters and enhancers for ZNF716 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I057450 Promoter 0.5 EPDnew 550.8 0.0 -12 0.1 ZNF716 GC07P057602
GH07I057646 Enhancer 0.5 FANTOM5 2.8 +196.7 196727 0.4 ZNF639 NRF1 ENSG00000243981 GC07M057647 GC07M057648 PIR48046 PIR45164 LOC100420545 ZNF716
GH07I057579 Enhancer 0.5 FANTOM5 1.4 +129.6 129630 0.4 SMAD5 ZNF479 ZNF716 NCOR1P3 GC07M057495 LOC105375301
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF716 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF716 gene promoter:

Genomic Locations for ZNF716 Gene

Genomic Locations for ZNF716 Gene
23,383 bases
Plus strand

Genomic View for ZNF716 Gene

Genes around ZNF716 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF716 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF716 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF716 Gene

Proteins for ZNF716 Gene

  • Protein details for ZNF716 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 716
    Protein Accession:

    Protein attributes for ZNF716 Gene

    495 amino acids
    Molecular mass:
    57006 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF716 Gene

Post-translational modifications for ZNF716 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF716 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF716 Gene

Domains & Families for ZNF716 Gene

Gene Families for ZNF716 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF716 Gene

Suggested Antigen Peptide Sequences for ZNF716 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF716: view

Function for ZNF716 Gene

Molecular function for ZNF716 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF716 Gene

Gene Ontology (GO) - Molecular Function for ZNF716 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF716: view

Phenotypes for ZNF716 Gene

genes like me logo Genes that share phenotypes with ZNF716: view

Animal Model Products

CRISPR Products

miRNA for ZNF716 Gene

miRTarBase miRNAs that target ZNF716

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF716 Gene

Localization for ZNF716 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF716 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF716 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF716 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF716: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF716 Gene

Pathways & Interactions for ZNF716 Gene

SuperPathways for ZNF716 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF716: view

Pathways by source for ZNF716 Gene

2 Reactome pathways for ZNF716 Gene

Gene Ontology (GO) - Biological Process for ZNF716 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF716: view

No data available for SIGNOR curated interactions for ZNF716 Gene

Drugs & Compounds for ZNF716 Gene

No Compound Related Data Available

Transcripts for ZNF716 Gene

mRNA/cDNA for ZNF716 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF716 Gene

Zinc finger protein 716:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF716 Gene

No ASD Table

Relevant External Links for ZNF716 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF716 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF716 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF716 Gene

This gene is overexpressed in Testis (x47.4).

NURSA nuclear receptor signaling pathways regulating expression of ZNF716 Gene:


SOURCE GeneReport for Unigene cluster for ZNF716 Gene:

genes like me logo Genes that share expression patterns with ZNF716: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF716 Gene

Orthologs for ZNF716 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF716 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF716 33 34
  • 99.06 (n)
(Mus musculus)
Mammalia Zfp493 34
  • 55 (a)
(Bos Taurus)
Mammalia -- 34
  • 47 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 47 (a)
-- 34
  • 34 (a)
(Canis familiaris)
Mammalia -- 34
  • 35 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 47 (a)
-- 34
  • 36 (a)
-- 34
  • 35 (a)
-- 34
  • 30 (a)
-- 34
  • 29 (a)
-- 34
  • 28 (a)
-- 34
  • 28 (a)
-- 34
  • 26 (a)
Species where no ortholog for ZNF716 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF716 Gene

Gene Tree for ZNF716 (if available)
Gene Tree for ZNF716 (if available)

Paralogs for ZNF716 Gene

(502) SIMAP similar genes for ZNF716 Gene using alignment to 1 proteins: Pseudogenes for ZNF716 Gene

genes like me logo Genes that share paralogs with ZNF716: view

Variants for ZNF716 Gene

Sequence variations from dbSNP and Humsavar for ZNF716 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000136526 -- 57,448,866(+) C/A upstream_transcript_variant
rs1000167556 -- 57,448,586(+) T/C upstream_transcript_variant
rs1000352838 -- 57,456,575(+) A/G intron_variant
rs1000722392 -- 57,456,850(+) C/A intron_variant
rs1001992388 -- 57,453,418(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF716 Gene

Variant ID Type Subtype PubMed ID
dgv11354n54 CNV gain 21841781
dgv11355n54 CNV gain 21841781
dgv6367n100 CNV gain 25217958
dgv6368n100 CNV loss 25217958
dgv6369n100 CNV gain 25217958
dgv6370n100 CNV loss 25217958
dgv6371n100 CNV gain 25217958
dgv6372n100 CNV gain 25217958
dgv816n27 CNV gain 19166990
esv2752161 CNV gain 17911159
esv2752162 CNV gain 17911159
esv2752163 CNV gain 17911159
esv2759531 CNV gain 17122850
esv2761119 CNV gain+loss 21179565
esv3576359 CNV gain 25503493
esv3613300 CNV loss 21293372
esv3613301 CNV gain 21293372
nsv1016541 CNV gain 25217958
nsv1021062 CNV gain 25217958
nsv1027062 CNV gain 25217958
nsv1032246 CNV loss 25217958
nsv464484 CNV gain 19166990
nsv464486 CNV gain 19166990
nsv520659 CNV gain 19592680
nsv607048 CNV gain 21841781
nsv607055 CNV gain 21841781
nsv607057 CNV gain 21841781
nsv970847 CNV duplication 23825009
nsv970848 CNV duplication 23825009

Variation tolerance for ZNF716 Gene

Residual Variation Intolerance Score: 47.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.99; 74.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF716 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF716 Gene

Disorders for ZNF716 Gene

Additional Disease Information for ZNF716

No disorders were found for ZNF716 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF716 Gene

Publications for ZNF716 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4 58
  3. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? (PMID: 23314748) Nathan JA … Goldberg AL (The EMBO journal 2013) 3 58
  4. Gene-alcohol interactions identify several novel blood pressure loci including a promising locus near SLC16A9. (PMID: 24376456) Simino J … Rao DC (Frontiers in genetics 2013) 3 58
  5. Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project. (PMID: 17903300) Fox CS … Atwood LD (BMC medical genetics 2007) 44 58

Products for ZNF716 Gene

Sources for ZNF716 Gene

Loading form....