Aliases for ZNF714 Gene

Aliases for ZNF714 Gene

  • Zinc Finger Protein 714 2 3 4 5
  • ZNF714 5

External Ids for ZNF714 Gene

Previous GeneCards Identifiers for ZNF714 Gene

  • GC19P021052
  • GC19P021264
  • GC19P020755

Summaries for ZNF714 Gene

GeneCards Summary for ZNF714 Gene

ZNF714 (Zinc Finger Protein 714) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF85.

UniProtKB/Swiss-Prot Summary for ZNF714 Gene

Additional gene information for ZNF714 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF714 Gene

Genomics for ZNF714 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF714 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J021019 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 622 -59.9 -59871 4.6 SP1 CREB1 PRDM10 LEF1 IKZF1 POLR2A ZNF692 FOS JUND LARP7 ZNF714 ZNF430 ZNF90 BNIP3P26 RPL7AP10 ZNF66 ZNF431 ZNF486 CCNYL6 BNIP3P16
GH19J021081 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 611.9 +1.1 1134 3.5 SP1 CREB1 GATAD2A TFE3 ZNF512 NFKBIZ ZNF692 POLR2A NFRKB FOS ZNF714 NONHSAG025249.2 lnc-ZNF430-2 ZNF431
GH19J021087 Promoter 0.3 EPDnew 600.4 +5.0 5046 0.1 ZNF714 lnc-ZNF430-2 NONHSAG025249.2 RNA5SP469 RF00001-157 ZNF431
GH19J021141 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 11.8 +60.8 60816 3.7 SP1 CREB1 PRDM10 ZNF512 ZNF692 POLR2A FOS LARP7 DDX20 RBFOX2 ZNF431 ZNF708 ZNF714 ENSG00000268555 ENSG00000268119 ZNF738 ZNF429 piR-39972-013
GH19J021126 Enhancer 1 Ensembl ENCODE 22.1 +46.6 46561 4.2 GATAD2A ZNF512 LEF1 IKZF1 PKNOX1 NR2C1 ZNF24 DPF2 HDAC1 ZNF600 piR-50517-007 ZNF714 ZNF431 ENSG00000268119 BNIP3P17 ZNF493 VN1R81P lnc-ZNF431-2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF714 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF714

Top Transcription factor binding sites by QIAGEN in the ZNF714 gene promoter:
  • Ik-1
  • Ik-2
  • IRF-7A

Genomic Locations for ZNF714 Gene

Genomic Locations for ZNF714 Gene
43,124 bases
Plus strand
43,121 bases
Plus strand

Genomic View for ZNF714 Gene

Genes around ZNF714 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF714 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF714 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF714 Gene

Proteins for ZNF714 Gene

  • Protein details for ZNF714 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 714
    Protein Accession:
    Secondary Accessions:
    • Q49AI1
    • Q86W65
    • Q8ND40

    Protein attributes for ZNF714 Gene

    554 amino acids
    Molecular mass:
    63883 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH50468.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=CAD39077.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF714 Gene


neXtProt entry for ZNF714 Gene

Post-translational modifications for ZNF714 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF714 Gene

Domains & Families for ZNF714 Gene

Gene Families for ZNF714 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZNF714 Gene

  • KRAB box

Suggested Antigen Peptide Sequences for ZNF714 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 714 (ZN714_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF714: view

Function for ZNF714 Gene

Molecular function for ZNF714 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF714 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA 21873635
GO:0003676 nucleic acid binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF714: view
genes like me logo Genes that share phenotypes with ZNF714: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF714

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF714 Gene

Localization for ZNF714 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF714 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF714 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF714 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with ZNF714: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF714 Gene

Pathways & Interactions for ZNF714 Gene

genes like me logo Genes that share pathways with ZNF714: view

Pathways by source for ZNF714 Gene

2 Reactome pathways for ZNF714 Gene
1 KEGG pathway for ZNF714 Gene

Gene Ontology (GO) - Biological Process for ZNF714 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA,IBA 21873635
genes like me logo Genes that share ontologies with ZNF714: view

No data available for SIGNOR curated interactions for ZNF714 Gene

Drugs & Compounds for ZNF714 Gene

No Compound Related Data Available

Transcripts for ZNF714 Gene

mRNA/cDNA for ZNF714 Gene

11 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF714

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF714 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d · 5e · 5f · 5g · 5h
SP3: -
SP4: -
SP5: - -
SP6: -
SP7: - - -
SP8: - - - -

Relevant External Links for ZNF714 Gene

GeneLoc Exon Structure for

Expression for ZNF714 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF714 Gene

Protein differential expression in normal tissues from HIPED for ZNF714 Gene

This gene is overexpressed in CD8 Tcells (55.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF714 Gene

Protein tissue co-expression partners for ZNF714 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF714

SOURCE GeneReport for Unigene cluster for ZNF714 Gene:


Evidence on tissue expression from TISSUES for ZNF714 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with ZNF714: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF714 Gene

Orthologs for ZNF714 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF714 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF714 30 31
  • 99.58 (n)
(Mus musculus)
Mammalia Zfp493 31
  • 55 (a)
(Bos Taurus)
Mammalia -- 31
  • 51 (a)
(Monodelphis domestica)
Mammalia -- 31
  • 48 (a)
-- 31
  • 38 (a)
(Canis familiaris)
Mammalia -- 31
  • 36 (a)
(Anolis carolinensis)
Reptilia -- 31
  • 53 (a)
-- 31
  • 39 (a)
-- 31
  • 37 (a)
-- 31
  • 33 (a)
-- 31
  • 31 (a)
-- 31
  • 30 (a)
-- 31
  • 30 (a)
-- 31
  • 27 (a)
Species where no ortholog for ZNF714 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF714 Gene

Gene Tree for ZNF714 (if available)
Gene Tree for ZNF714 (if available)
Evolutionary constrained regions (ECRs) for ZNF714: view image

Paralogs for ZNF714 Gene

Paralogs for ZNF714 Gene

(533) SIMAP similar genes for ZNF714 Gene using alignment to 6 proteins:

  • ZN714_HUMAN
  • M0QY60_HUMAN
  • M0QZ91_HUMAN
  • M0R0T4_HUMAN
  • M0R2G4_HUMAN Pseudogenes for ZNF714 Gene

genes like me logo Genes that share paralogs with ZNF714: view

Variants for ZNF714 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF714 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs10427116 -. - p.Ile473Valp.Ile472Val
rs2884554 - p.Lys331Arg

Additional dbSNP identifiers (rs#s) for ZNF714 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF714 Gene

Variant ID Type Subtype PubMed ID
dgv1734n106 CNV deletion 24896259
dgv510e201 CNV deletion 23290073
dgv82e19 CNV loss 19470904
esv2660807 CNV deletion 23128226
esv2665276 CNV deletion 23128226
esv2718324 CNV deletion 23290073
esv2718325 CNV deletion 23290073
esv2763043 CNV gain 21179565
esv3556170 CNV deletion 23714750
esv3643914 CNV loss 21293372
esv4924 OTHER complex 18987735
esv5243 CNV loss 18987735
nsv1061327 CNV gain 25217958
nsv1065384 CNV loss 25217958
nsv1072871 CNV deletion 25765185
nsv1146999 CNV deletion 26484159
nsv458377 CNV gain 19166990
nsv578809 CNV gain 21841781
nsv960811 CNV duplication 23825009

Variation tolerance for ZNF714 Gene

Residual Variation Intolerance Score: 89.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.43; 28.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF714 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF714 Gene

Disorders for ZNF714 Gene

No disorders were found for ZNF714 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF714 Gene

Publications for ZNF714 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3
  3. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for ZNF714 Gene

Sources for ZNF714 Gene