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This gene encodes a zinc finger protein of unknown function. It bears similarity to a zinc finger protein which acts as a transcriptional activator. This gene lies in a region of the X chromosome which has been associated with cognitive disability. [provided by RefSeq, Jul 2008] See more...
Aliases for ZNF711 Gene
Aliases for ZNF711 Gene
External Ids for ZNF711 Gene
- HGNC: 13128
- Entrez Gene: 7552
- Ensembl: ENSG00000147180
- OMIM: 314990
- UniProtKB: Q9Y462
Previous HGNC Symbols for ZNF711 Gene
- ZNF6
- MRX65
Previous GeneCards Identifiers for ZNF711 Gene
- GC0XP084385
- GC0XP084498
- GC0XP078072
Summaries for ZNF711 Gene
-
This gene encodes a zinc finger protein of unknown function. It bears similarity to a zinc finger protein which acts as a transcriptional activator. This gene lies in a region of the X chromosome which has been associated with cognitive disability. [provided by RefSeq, Jul 2008]
GeneCards Summary for ZNF711 Gene
ZNF711 (Zinc Finger Protein 711) is a Protein Coding gene. Diseases associated with ZNF711 include Mental Retardation, X-Linked 97 and Non-Syndromic X-Linked Intellectual Disability. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is ZFX.
UniProtKB/Swiss-Prot Summary for ZNF711 Gene
-
Transcription regulator required for brain development. Probably acts as a transcription factor that binds to the promoter of target genes and recruits PHF8 histone demethylase, leading to activate expression of genes involved in neuron development, such as KDM5C.
Additional gene information for ZNF711 Gene
- HGNC(13128)
- Entrez Gene(7552)
- Ensembl(ENSG00000147180)
- OMIM(314990)
- UniProtKB(Q9Y462)
- Open Targets Platform(ENSG00000147180)
- Monarch Initiative
- Search for ZNF711 at DataMed
- Search for ZNF711 at HumanCyc
No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF711 Gene
Genomics for ZNF711 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for ZNF711 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH0XJ085243 | Promoter/Enhancer | 1.8 | EPDnew Ensembl ENCODE CraniofacialAtlas | 607 | +1.2 | 1181 | 4.4 | ZNF629 LARP7 PRDM1 ZIC2 RBFOX2 PKNOX1 POLR2A PATZ1 YY1 ZNF341 | ZNF711 SATL1 lnc-POF1B-3 RF00001-358 POF1B | |
| GH0XJ085188 | Enhancer | 0.2 | FANTOM5 | 1.8 | -55.3 | -55252 | 0.2 | SATL1 ZNF711 ENSG00000276391 piR-47086-353 lnc-POF1B-3 APOOL | ||
| GH0XJ085002 | Promoter/Enhancer | 1.9 | EPDnew Ensembl ENCODE CraniofacialAtlas | 0.1 | -239.9 | -239919 | 2.6 | SP1 GATAD2A PRDM10 RFX1 PKNOX1 POLR2A REST IKZF2 BRD9 HDAC1 | APOOL SATL1 RF00017-8557 ZNF711 | |
| GH0XJ085220 | Enhancer | 0.2 | FANTOM5 | 0.4 | -23.1 | -23139 | 0.1 | SATL1 LOC101928128 ZNF711 lnc-POF1B-3 APOOL | ||
| GH0XJ085051 | Enhancer | 0.8 | Ensembl ENCODE | 0.1 | -190.9 | -190919 | 2.6 | CTCF RAD21 JUND CEBPB JUN FOS SCRT1 EP300 FOSL2 SMC3 | SATL1 APOOL RF00017-8558 HSALNG0138890 ZNF711 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ZNF711 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF711
- Top Transcription factor binding sites by QIAGEN in the ZNF711 gene promoter:
-
- E2F
- E2F-1
- E2F-2
- E2F-3a
- E2F-4
- E2F-5
- GATA-1
- GATA-2
- GATA-3
- RFX1
Genomic Locations for ZNF711 Gene
Genomic Locations for ZNF711 Gene
- chrX:85,243,820-85,273,362
- (GRCh38/hg38)
- Size:
- 29,543 bases
- Orientation:
- Plus strand
- chrX:84,498,997-84,528,368
- (GRCh37/hg19)
- Size:
- 29,372 bases
- Orientation:
- Plus strand
Genomic View for ZNF711 Gene
Genes around ZNF711 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- Xq21.1 by HGNC
- Xq21.1 by Entrez Gene
- Xq21.1 by Ensembl
ZNF711 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ZNF711 Gene
Proteins for ZNF711 Gene
-
Protein details for ZNF711 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y462-ZN711_HUMAN
- Recommended name:
- Zinc finger protein 711
- Protein Accession:
- Q9Y462
- B4DSV4
- Q6NX42
- Q9Y4J6
Protein attributes for ZNF711 Gene
- Size:
- 761 amino acids
- Molecular mass:
- 86245 Da
- Quaternary structure:
-
- Interacts with PHF8.
- SequenceCaution:
-
- Sequence=BAG61766.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=CAA39837.2; Type=Frameshift; Evidence={ECO:0000305}; Sequence=CAA39837.2; Type=Miscellaneous discrepancy; Note=Chimera.; Evidence={ECO:0000305};
Protein Expression for ZNF711 Gene
Post-translational modifications for ZNF711 Gene
Other Protein References for ZNF711 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for ZNF711
- Novus Biologicals Antibodies for ZNF711
-
Abcam antibodies for ZNF711
- Invitrogen Antibodies for ZNF711 (AFLGC-ZNF711)
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for ZNF711
- Origene Custom Protein Services for ZNF711
- Novus Biologicals proteins for ZNF711
No data available for DME Specific Peptides for ZNF711 Gene
Domains & Families for ZNF711 Gene
Gene Families for ZNF711 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Disease related genes
- Predicted intracellular proteins
- Transcription factors
Protein Domains for ZNF711 Gene
- InterPro:
- Blocks:
-
- Zfx / Zfy transcription activation region
- ProtoNet:
Suggested Antigen Peptide Sequences for ZNF711 Gene
- GenScript: Design optimal peptide antigens:
-
- ZNF711 protein (Q6PK66_HUMAN)
- Zinc finger protein 6 (ZN711_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9Y462- Family:
-
- Belongs to the krueppel C2H2-type zinc-finger protein family.
Function for ZNF711 Gene
Molecular function for ZNF711 Gene
- UniProtKB/Swiss-Prot Function:
- Transcription regulator required for brain development. Probably acts as a transcription factor that binds to the promoter of target genes and recruits PHF8 histone demethylase, leading to activate expression of genes involved in neuron development, such as KDM5C.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IBA | -- |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISM | 19274049 |
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003700 | DNA-binding transcription factor activity | IBA | -- |
Phenotypes for ZNF711 Gene
- MGI mutant phenotypes for ZNF711:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for ZNF711:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Decreased epidermal growth factor (EGF) endocytosis, decreased transferrin (TF) endocytosis
- Decreased viability ratio
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
- Cell division defect
- Decreased POU5F1-GFP protein expression
- Increased number of mitotic cells
- Increased G2M DNA content
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ZNF711 - Select products 50% OFF >
- * ZNF711 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for ZNF711
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ZNF711
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZNF711
miRNA for ZNF711 Gene
- miRTarBase miRNAs that target ZNF711
-
- hsa-miR-335-5p (MIRT017955)
- hsa-miR-19b-3p (MIRT031177)
- hsa-miR-18a-5p (MIRT031317)
- hsa-miR-615-3p (MIRT040430)
- hsa-miR-151a-3p (MIRT043601)
- hsa-miR-218-5p (MIRT046981)
- hsa-miR-548c-3p (MIRT110174)
- hsa-miR-34a-3p (MIRT328117)
- hsa-miR-142-5p (MIRT328118)
- hsa-miR-559 (MIRT328119)
- hsa-miR-548b-5p (MIRT328120)
- hsa-miR-548a-5p (MIRT328121)
- hsa-miR-548c-5p (MIRT328122)
- hsa-miR-548d-5p (MIRT328123)
- hsa-miR-548j-5p (MIRT328124)
- hsa-miR-548k (MIRT328125)
- hsa-miR-548l (MIRT328126)
- hsa-miR-548h-5p (MIRT328127)
- hsa-miR-548i (MIRT328128)
- hsa-miR-3157-5p (MIRT328129)
- hsa-miR-548w (MIRT328130)
- hsa-miR-548y (MIRT328131)
- hsa-miR-548o-5p (MIRT328132)
- hsa-miR-548ab (MIRT328133)
- hsa-miR-548ad-5p (MIRT328134)
- hsa-miR-548ae-5p (MIRT328135)
- hsa-miR-548ak (MIRT328136)
- hsa-miR-548am-5p (MIRT328137)
- hsa-miR-548ap-5p (MIRT328138)
- hsa-miR-548aq-5p (MIRT328139)
- hsa-miR-548ar-5p (MIRT328140)
- hsa-miR-548as-5p (MIRT328141)
- hsa-miR-548au-5p (MIRT328142)
- hsa-miR-5590-3p (MIRT328143)
- hsa-miR-548av-5p (MIRT328144)
- hsa-miR-548ay-5p (MIRT328145)
- hsa-miR-8054 (MIRT328146)
- hsa-miR-548bb-5p (MIRT328147)
- hsa-miR-188-3p (MIRT328167)
- hsa-miR-5692a (MIRT328168)
- hsa-miR-5007-3p (MIRT367067)
- hsa-miR-5579-5p (MIRT367069)
- hsa-miR-4666b (MIRT367070)
- hsa-miR-5700 (MIRT367071)
- hsa-miR-802 (MIRT367101)
- hsa-miR-543 (MIRT367102)
- hsa-miR-3143 (MIRT367103)
- hsa-miR-95-5p (MIRT367106)
- hsa-miR-130a-3p (MIRT367107)
- hsa-miR-301a-3p (MIRT367108)
- hsa-miR-130b-3p (MIRT367109)
- hsa-miR-454-3p (MIRT367113)
- hsa-miR-301b-3p (MIRT367114)
- hsa-miR-3140-3p (MIRT367115)
- hsa-miR-3149 (MIRT367116)
- hsa-miR-4295 (MIRT367117)
- hsa-miR-3666 (MIRT367118)
- hsa-miR-297 (MIRT504969)
- hsa-miR-675-3p (MIRT504970)
- hsa-miR-5701 (MIRT504971)
- hsa-miR-6847-3p (MIRT504972)
- hsa-miR-6512-5p (MIRT504973)
- hsa-miR-511-5p (MIRT504974)
- hsa-miR-6830-3p (MIRT504975)
- hsa-miR-4691-3p (MIRT504976)
- hsa-miR-4803 (MIRT504977)
- hsa-miR-569 (MIRT564607)
- hsa-miR-551b-5p (MIRT564608)
- hsa-miR-5680 (MIRT571510)
- hsa-miR-212-3p (MIRT571511)
- hsa-miR-132-3p (MIRT571512)
Targeted motifs for ZNF711 Gene
HOMER Transcription Factor Regulatory Elements motif ZNF711
- Consensus sequence: AGGCCTAG Submotif: canonical Cell Type: SHSY5Y GEO ID: GSE20673
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ZNF711
- Browse OriGene Inhibitory RNA Products For ZNF711
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF711
Clone Products
- Applied Biological Materials (abm): Clones for ZNF711 - Select products 50% OFF >
- * ZNF711 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for ZNF711
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ZNF711
Cell Line Products
-
Horizon Cell Lines for ZNF711
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Animal Models and Transcription Factor Targets for ZNF711 Gene
Localization for ZNF711 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ZNF711 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| cytosol | 1 |
| lysosome | 1 |
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IBA,IDA | 20346720 |
Pathways & Interactions for ZNF711 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Gene Expression |
.48
|
|
Pathways by source for ZNF711 Gene
2 Reactome pathways for ZNF711 Gene
Interacting Proteins for ZNF711 Gene
GPS-Prot Interaction Network for ZNF711
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006357 | regulation of transcription by RNA polymerase II | IEA | -- |
| GO:0010468 | regulation of gene expression | IBA | 21873635 |
| GO:0010845 | positive regulation of reciprocal meiotic recombination | IBA | 21873635 |
| GO:0045893 | positive regulation of transcription, DNA-templated | IBA,IMP | 20346720 |
No data available for SIGNOR curated interactions for ZNF711 Gene
Transcripts for ZNF711 Gene
mRNA/cDNA for ZNF711 Gene
- 9 REFSEQ mRNAs :
- 9 NCBI additional mRNA sequence :
- 3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000276123 2887 nts (view in UCSC)
- ENST00000360700 4844 nts (view in UCSC)
- ENST00000373165 4124 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ZNF711 - Select products 50% OFF >
- * ZNF711 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for ZNF711
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ZNF711
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZNF711
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ZNF711
- Browse OriGene Inhibitory RNA Products For ZNF711
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF711
Clone Products
- Applied Biological Materials (abm): Clones for ZNF711 - Select products 50% OFF >
- * ZNF711 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for ZNF711
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ZNF711
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | · | 12c | ^ | 13 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||||||||||||||||||||
| SP9: |
Relevant External Links for ZNF711 Gene
- GeneLoc Exon Structure for
- ZNF711
Expression for ZNF711 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Cardiovascular System)
- Definitive Hematopoietic Stem Cells Definitive Yolk Sac
- Hematopoietic Stem Cells Hematopoietic Bone Marrow
-
Yolk Sac (Extraembryonic Tissues)
- Definitive Hematopoietic Stem Cells Definitive Yolk Sac
-
Eye (Sensory Organs)
- Mature Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
-
Epithelial Cells
- Mature Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
-
Mesoderm (Gastrulation Derivatives)
- Mesothelial Cells Hepatic Mesenchyme
-
Liver (Hepatobiliary System)
- Mesothelial Cells Hepatic Mesenchyme
-
Heart (Cardiovascular System)
- Cardiac Fibroblasts Myocardium
-
Fibroblasts
- Cardiac Fibroblasts Myocardium
-
Ovary (Reproductive System)
- XX Germ Cells Ovigerous Cord
-
Gonad
- XX Germ Cells Ovigerous Cord
mRNA differential expression in normal tissues according to GTEx for ZNF711 Gene
This gene is overexpressed in Testis (x5.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF711 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF711
SOURCE GeneReport for Unigene cluster for ZNF711 Gene:
Hs.326801mRNA Expression by UniProt/SwissProt for ZNF711 Gene:
Q9Y462-ZN711_HUMAN
Tissue specificity:
Expressed in neural tissues.
Evidence on tissue expression from TISSUES for ZNF711 Gene
- Nervous system(4.7)
Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF711 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- digestive
- integumentary
- nervous
- reproductive
- respiratory
- skeletal muscle
- skeleton
- urinary
Regions:
Head and neck:
- brain
- cerebellum
- cheek
- chin
- cranial nerve
- ear
- eye
- eyelid
- face
- forehead
- head
- jaw
- lip
- mandible
- maxilla
- mouth
- nose
- outer ear
- salivary gland
- skull
- tooth
Thorax:
- lung
- rib
- rib cage
Pelvis:
- pelvis
- testicle
- urinary bladder
Limb:
- ankle
- digit
- elbow
- finger
- foot
- hand
- hip
- knee
- lower limb
- shoulder
- toe
- upper limb
- wrist
General:
- hair
- peripheral nerve
- peripheral nervous system
- skin
- spinal column
- vertebrae
Primer Products
-
OriGene qPCR primer pairs for ZNF711
-
OriGene qPCR primer pairs and template standards for ZNF711
Gene Expression Assay Products
No data available for Protein differential expression in normal tissues and Protein tissue co-expression partners for ZNF711 Gene
Orthologs for ZNF711 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | ZNF711 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | ZNF711 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | ZNF711 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Zfp711 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Zfp711 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | ZNF711 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | ZNF711 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | ZNF6 31 |
|
OneToOne | |
| ZNF711 30 |
|
||||
| Lizard (Anolis carolinensis) |
Reptilia | ZNF711 31 |
|
OneToOne | |
| Zebrafish (Danio rerio) |
Actinopterygii | znf711 30 31 |
|
OneToOne |
- Species where no ortholog for ZNF711 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for ZNF711 Gene
- ENSEMBL:
- Gene Tree for ZNF711 (if available)
- TreeFam:
- Gene Tree for ZNF711 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ZNF711: view image
Paralogs for ZNF711 Gene
Paralogs for ZNF711 Gene
- ZFX 5
- ZFY 5
- ZFAT 5
- PRDM15 5
- ZNF792 5
- ZNF304 5
- ZNF548 5
- ZNF549 5
- ZSCAN20 5
- ZBTB11 5
- ZNF79 5
- ZNF418 5
- ZNF256 5
- ZSCAN2 5
- ZNF570 5
- ZNF561 5
- ZNF480 5
- E4F1 5
- ZNF583 5
- ZNF772 5
- ZNF551 5
- ZNF154 5
- ZNF586 5
- ZNF773 5
- ZNF419 5
- ZNF660 5
- ZNF610 5
- ZNF134 5
- ZNF8 5
- ZNF837 5
- ZNF584 5
- ZNF562 5
- ZNF793 5
- ZIK1 5
- ZNF552 5
- IKZF5 5
- ZNF587B 5
- ZNF691 5
- ENSG00000268163 5
- ENSG00000268133 5
- ENSG00000268107 5
(86) SIMAP similar genes for ZNF711 Gene using alignment to 4 proteins:
- ZN711_HUMAN
- F5H896_HUMAN
- J3KPS6_HUMAN
- Q6PK66_HUMAN
- ZFY
- ZFX
- ZNF55
- kr-znf3
- KLF4
- HZF16
- ZBTB17
- ZNF
- ZNF672
- ZNF500
- ZFS-5
- ZFS-2
- A-328A3.4
- ZSCAN21
- ZNF410
- HZF36
- smap-7
- ZNF56
- ZNF525
- ZNF234
- KLF1
- DKFZp686N0199
- ZFP64
- ZNF566
- ZNF22
- ZNF121
- REST
- PLZF
- DKFZp547H249
- zf30
- ZNF778
- ZNF72
- ZNF70
- ZNF570
- ZNF219
- ZFS-6
- KLF13
- HZF17
- DKFZp762K012
- DKFZp666C237
- ZNF78L1
- ZNF770
- ZNF697
- ZNF600
- ZNF436
- HZF30
- DKFZp686M04222
- DKFZp434J0650
- DKFZp434G1930
- ZNF664
- ZNF833P
- ZNF827
- ZNF808
- ZNF763
- ZNF720
- ZNF710
- ZNF660
- ZNF586
- ZNF492
- ZNF485
- ZNF32
- ZNF146
- ZNF117
- ZIC1
- ZFP1
- Nbla00121
- DKFZp570I0164
- CTCFL
- ZNF558
- ZNF883
- ZNF876P
- ZNF805
- ZNF791
- ZNF736
- ZNF718
- ZNF564
- ZNF501
- ZNF480
- ZNF345
- ZNF28
- ZNF263
- ZFS-3
- ZFS-1
- ZBTB47
- MST154
- DKFZp686B16128
Variants for ZNF711 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF711 Gene
| SNP ID | Clinical significance and condition | Chr 0X pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 723229 | Likely Benign: not provided | 85,271,735(+) | T/C | SYNONYMOUS_VARIANT | |
| 754047 | Likely Benign: not provided | 85,268,328(+) | T/C | SYNONYMOUS_VARIANT | |
| 807785 | Uncertain Significance: not provided | 85,255,735(+) | A/G | MISSENSE_VARIANT | |
| 807786 | Uncertain Significance: not provided | 85,271,514(+) | G/A | MISSENSE_VARIANT | |
| 871854 | Uncertain Significance: not provided | 85,255,624(+) | G/T | MISSENSE_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2466752 | CNV | deletion | 19546169 |
| esv2740275 | CNV | deletion | 23290073 |
| esv3559049 | CNV | deletion | 23714750 |
Residual Variation Intolerance Score:
18.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.72;
15.32% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ZNF711 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF711 Gene
Disorders for ZNF711 Gene
(8) MalaCards diseases for ZNF711 Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, Orphanet, DISEASES, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| mental retardation, x-linked 97 |
|
|
| non-syndromic x-linked intellectual disability |
|
|
| premature ovarian failure 2b |
|
|
| syndromic x-linked intellectual disability |
|
|
| syndromic x-linked intellectual disability siderius type |
|
|
Search ZNF711 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
ZN711_HUMAN- Mental retardation, X-linked 97 (MRX97) [MIM:300803]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. {ECO:0000269 PubMed:19377476, ECO:0000269 PubMed:27993705}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for ZNF711
No data available for Genatlas for ZNF711 Gene
Publications for ZNF711 Gene
- Mutations in two large pedigrees highlight the role of ZNF711 in X-linked intellectual disability. (PMID: 27993705) van der Werf IM … Kooy RF (Gene 2017) 2 3 4
- A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation. (PMID: 19377476) Tarpey PS … Stratton MR (Nature genetics 2009) 2 3 4
- A functional link between the histone demethylase PHF8 and the transcription factor ZNF711 in X-linked mental retardation. (PMID: 20346720) Kleine-Kohlbrecher D … Helin K (Molecular cell 2010) 3 4
- The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
Products for ZNF711 Gene
- Custom Antibody ServicesOriGene Antibodies for ZNF711
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- antibodies-online: Show 10 available Zinc Finger Protein 711 Antibodies ranked by validation data
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- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF711
Sources for ZNF711 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
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- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
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- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
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- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB