This gene encodes a zinc finger protein of unknown function. It bears similarity to a zinc finger protein which acts as a transcriptional activator. This gene lies in a region of the X chromosome which has been associated with cognitive disability. [provided by RefSeq, Jul 2008] See more...

Aliases for ZNF711 Gene

Aliases for ZNF711 Gene

  • Zinc Finger Protein 711 2 3 4 5
  • CMPX1 2 3 4
  • Mental Retardation, X-Linked 65 2 3
  • Zinc Finger Protein 6 (CMPX1) 2 3
  • Zinc Finger Protein 6 2 4
  • DJ75N13.1 2 3
  • Zfp711 2 3
  • MRX97 2 3
  • ZNF4 2 3
  • ZNF5 2 3
  • ZNF6 3 4
  • DJ75N13.1 (Znf6-Like) 3
  • ZNF711 5
  • MRX65 3

External Ids for ZNF711 Gene

Previous HGNC Symbols for ZNF711 Gene

  • ZNF6
  • MRX65

Previous GeneCards Identifiers for ZNF711 Gene

  • GC0XP084385
  • GC0XP084498
  • GC0XP078072

Summaries for ZNF711 Gene

Entrez Gene Summary for ZNF711 Gene

  • This gene encodes a zinc finger protein of unknown function. It bears similarity to a zinc finger protein which acts as a transcriptional activator. This gene lies in a region of the X chromosome which has been associated with cognitive disability. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZNF711 Gene

ZNF711 (Zinc Finger Protein 711) is a Protein Coding gene. Diseases associated with ZNF711 include Mental Retardation, X-Linked 97 and Non-Syndromic X-Linked Intellectual Disability. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is ZFX.

UniProtKB/Swiss-Prot Summary for ZNF711 Gene

  • Transcription regulator required for brain development. Probably acts as a transcription factor that binds to the promoter of target genes and recruits PHF8 histone demethylase, leading to activate expression of genes involved in neuron development, such as KDM5C.

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF711 Gene

Genomics for ZNF711 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF711 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ085243 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE CraniofacialAtlas 607 +1.2 1181 4.4 ZNF629 LARP7 PRDM1 ZIC2 RBFOX2 PKNOX1 POLR2A PATZ1 YY1 ZNF341 ZNF711 SATL1 lnc-POF1B-3 RF00001-358 POF1B
GH0XJ085188 Enhancer 0.2 FANTOM5 1.8 -55.3 -55252 0.2 SATL1 ZNF711 ENSG00000276391 piR-47086-353 lnc-POF1B-3 APOOL
GH0XJ085002 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 0.1 -239.9 -239919 2.6 SP1 GATAD2A PRDM10 RFX1 PKNOX1 POLR2A REST IKZF2 BRD9 HDAC1 APOOL SATL1 RF00017-8557 ZNF711
GH0XJ085220 Enhancer 0.2 FANTOM5 0.4 -23.1 -23139 0.1 SATL1 LOC101928128 ZNF711 lnc-POF1B-3 APOOL
GH0XJ085051 Enhancer 0.8 Ensembl ENCODE 0.1 -190.9 -190919 2.6 CTCF RAD21 JUND CEBPB JUN FOS SCRT1 EP300 FOSL2 SMC3 SATL1 APOOL RF00017-8558 HSALNG0138890 ZNF711
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF711 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF711

Top Transcription factor binding sites by QIAGEN in the ZNF711 gene promoter:
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • GATA-1
  • GATA-2
  • GATA-3
  • RFX1

Genomic Locations for ZNF711 Gene

Genomic Locations for ZNF711 Gene
chrX:85,243,820-85,273,362
(GRCh38/hg38)
Size:
29,543 bases
Orientation:
Plus strand
chrX:84,498,997-84,528,368
(GRCh37/hg19)
Size:
29,372 bases
Orientation:
Plus strand

Genomic View for ZNF711 Gene

Genes around ZNF711 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF711 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF711 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF711 Gene

Proteins for ZNF711 Gene

  • Protein details for ZNF711 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y462-ZN711_HUMAN
    Recommended name:
    Zinc finger protein 711
    Protein Accession:
    Q9Y462
    Secondary Accessions:
    • B4DSV4
    • Q6NX42
    • Q9Y4J6

    Protein attributes for ZNF711 Gene

    Size:
    761 amino acids
    Molecular mass:
    86245 Da
    Quaternary structure:
    • Interacts with PHF8.
    SequenceCaution:
    • Sequence=BAG61766.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=CAA39837.2; Type=Frameshift; Evidence={ECO:0000305}; Sequence=CAA39837.2; Type=Miscellaneous discrepancy; Note=Chimera.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF711 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF711 Gene

Post-translational modifications for ZNF711 Gene

  • Ubiquitination at Lys224 and Lys289
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZNF711 Gene

Domains & Families for ZNF711 Gene

Gene Families for ZNF711 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF711 Gene

InterPro:
Blocks:
  • Zfx / Zfy transcription activation region
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF711 Gene

GenScript: Design optimal peptide antigens:
  • ZNF711 protein (Q6PK66_HUMAN)
  • Zinc finger protein 6 (ZN711_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y462

UniProtKB/Swiss-Prot:

ZN711_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF711: view

Function for ZNF711 Gene

Molecular function for ZNF711 Gene

UniProtKB/Swiss-Prot Function:
Transcription regulator required for brain development. Probably acts as a transcription factor that binds to the promoter of target genes and recruits PHF8 histone demethylase, leading to activate expression of genes involved in neuron development, such as KDM5C.

Gene Ontology (GO) - Molecular Function for ZNF711 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA --
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISM 19274049
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IBA --
genes like me logo Genes that share ontologies with ZNF711: view
genes like me logo Genes that share phenotypes with ZNF711: view

Human Phenotype Ontology for ZNF711 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

miRNA for ZNF711 Gene

miRTarBase miRNAs that target ZNF711
Targeted motifs for ZNF711 Gene
HOMER Transcription Factor Regulatory Elements motif ZNF711
  • Consensus sequence: AGGCCTAG Submotif: canonical Cell Type: SHSY5Y GEO ID: GSE20673

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF711

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Animal Models and Transcription Factor Targets for ZNF711 Gene

Localization for ZNF711 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF711 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF711 gene
Compartment Confidence
nucleus 5
plasma membrane 1
extracellular 1
cytoskeleton 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF711 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,IDA 20346720
genes like me logo Genes that share ontologies with ZNF711: view

Pathways & Interactions for ZNF711 Gene

PathCards logo

SuperPathways for ZNF711 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF711: view

Pathways by source for ZNF711 Gene

2 Reactome pathways for ZNF711 Gene

Gene Ontology (GO) - Biological Process for ZNF711 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0010468 regulation of gene expression IBA 21873635
GO:0010845 positive regulation of reciprocal meiotic recombination IBA 21873635
GO:0045893 positive regulation of transcription, DNA-templated IBA,IMP 20346720
genes like me logo Genes that share ontologies with ZNF711: view

No data available for SIGNOR curated interactions for ZNF711 Gene

Drugs & Compounds for ZNF711 Gene

No Compound Related Data Available

Transcripts for ZNF711 Gene

mRNA/cDNA for ZNF711 Gene

9 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF711

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF711 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13
SP1: -
SP2:
SP3:
SP4: -
SP5: - - -
SP6:
SP7: - - - -
SP8:
SP9:

Relevant External Links for ZNF711 Gene

GeneLoc Exon Structure for
ZNF711

Expression for ZNF711 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF711 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZNF711 Gene

This gene is overexpressed in Testis (x5.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF711 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF711

SOURCE GeneReport for Unigene cluster for ZNF711 Gene:

Hs.326801

mRNA Expression by UniProt/SwissProt for ZNF711 Gene:

Q9Y462-ZN711_HUMAN
Tissue specificity: Expressed in neural tissues.

Evidence on tissue expression from TISSUES for ZNF711 Gene

  • Nervous system(4.7)

Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF711 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • digestive
  • integumentary
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
  • urinary
Regions:
Head and neck:
  • brain
  • cerebellum
  • cheek
  • chin
  • cranial nerve
  • ear
  • eye
  • eyelid
  • face
  • forehead
  • head
  • jaw
  • lip
  • mandible
  • maxilla
  • mouth
  • nose
  • outer ear
  • salivary gland
  • skull
  • tooth
Thorax:
  • lung
  • rib
  • rib cage
Pelvis:
  • pelvis
  • testicle
  • urinary bladder
Limb:
  • ankle
  • digit
  • elbow
  • finger
  • foot
  • hand
  • hip
  • knee
  • lower limb
  • shoulder
  • toe
  • upper limb
  • wrist
General:
  • hair
  • peripheral nerve
  • peripheral nervous system
  • skin
  • spinal column
  • vertebrae
genes like me logo Genes that share expression patterns with ZNF711: view

No data available for Protein differential expression in normal tissues and Protein tissue co-expression partners for ZNF711 Gene

Orthologs for ZNF711 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF711 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF711 30 31
  • 99.73 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZNF711 30 31
  • 95.53 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ZNF711 30 31
  • 95.23 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Zfp711 30
  • 92.86 (n)
Mouse
(Mus musculus)
Mammalia Zfp711 30 17 31
  • 92.29 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ZNF711 31
  • 80 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia ZNF711 31
  • 73 (a)
OneToOne
Chicken
(Gallus gallus)
Aves ZNF6 31
  • 82 (a)
OneToOne
ZNF711 30
  • 81.37 (n)
Lizard
(Anolis carolinensis)
Reptilia ZNF711 31
  • 81 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii znf711 30 31
  • 67.94 (n)
OneToOne
Species where no ortholog for ZNF711 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ZNF711 Gene

ENSEMBL:
Gene Tree for ZNF711 (if available)
TreeFam:
Gene Tree for ZNF711 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF711: view image

Paralogs for ZNF711 Gene

genes like me logo Genes that share paralogs with ZNF711: view

Variants for ZNF711 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF711 Gene

SNP ID Clinical significance and condition Chr 0X pos Variation AA Info Type
723229 Likely Benign: not provided 85,271,735(+) T/C SYNONYMOUS_VARIANT
754047 Likely Benign: not provided 85,268,328(+) T/C SYNONYMOUS_VARIANT
807785 Uncertain Significance: not provided 85,255,735(+) A/G MISSENSE_VARIANT
807786 Uncertain Significance: not provided 85,271,514(+) G/A MISSENSE_VARIANT
871854 Uncertain Significance: not provided 85,255,624(+) G/T MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for ZNF711 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF711 Gene

Variant ID Type Subtype PubMed ID
esv2466752 CNV deletion 19546169
esv2740275 CNV deletion 23290073
esv3559049 CNV deletion 23714750

Variation tolerance for ZNF711 Gene

Residual Variation Intolerance Score: 18.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.72; 15.32% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF711 Gene

Human Gene Mutation Database (HGMD)
ZNF711
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF711

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF711 Gene

Disorders for ZNF711 Gene

MalaCards: The human disease database

(8) MalaCards diseases for ZNF711 Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, Orphanet, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

ZN711_HUMAN
  • Mental retardation, X-linked 97 (MRX97) [MIM:300803]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. {ECO:0000269 PubMed:19377476, ECO:0000269 PubMed:27993705}. Note=The disease is caused by mutations affecting the gene represented in this entry.
genes like me logo Genes that share disorders with ZNF711: view

No data available for Genatlas for ZNF711 Gene

Publications for ZNF711 Gene

  1. Mutations in two large pedigrees highlight the role of ZNF711 in X-linked intellectual disability. (PMID: 27993705) van der Werf IM … Kooy RF (Gene 2017) 2 3 4
  2. A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation. (PMID: 19377476) Tarpey PS … Stratton MR (Nature genetics 2009) 2 3 4
  3. A functional link between the histone demethylase PHF8 and the transcription factor ZNF711 in X-linked mental retardation. (PMID: 20346720) Kleine-Kohlbrecher D … Helin K (Molecular cell 2010) 3 4
  4. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for ZNF711 Gene

Sources for ZNF711 Gene