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This gene encodes a zinc finger protein of unknown function. It bears similarity to a zinc finger protein which acts as a transcriptional activator. This gene lies in a region of the X chromosome which has been associated with cognitive disability. [provided by RefSeq, Jul 2008]
ZNF711 (Zinc Finger Protein 711) is a Protein Coding gene. Diseases associated with ZNF711 include Mental Retardation, X-Linked 97 and Non-Syndromic X-Linked Intellectual Disability. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is ZFX.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH0XJ085243 | Promoter/Enhancer | 1.8 | EPDnew Ensembl ENCODE CraniofacialAtlas | 607 | +1.2 | 1181 | 4.4 | ZNF629 LARP7 PRDM1 ZIC2 RBFOX2 PKNOX1 POLR2A PATZ1 YY1 ZNF341 | ZNF711 SATL1 lnc-POF1B-3 RF00001-358 POF1B | |
GH0XJ085188 | Enhancer | 0.2 | FANTOM5 | 1.8 | -55.3 | -55252 | 0.2 | SATL1 ZNF711 ENSG00000276391 piR-47086-353 lnc-POF1B-3 APOOL | ||
GH0XJ085002 | Promoter/Enhancer | 1.9 | EPDnew Ensembl ENCODE CraniofacialAtlas | 0.1 | -239.9 | -239919 | 2.6 | SP1 GATAD2A PRDM10 RFX1 PKNOX1 POLR2A REST IKZF2 BRD9 HDAC1 | APOOL SATL1 RF00017-8557 ZNF711 | |
GH0XJ085220 | Enhancer | 0.2 | FANTOM5 | 0.4 | -23.1 | -23139 | 0.1 | SATL1 LOC101928128 ZNF711 lnc-POF1B-3 APOOL | ||
GH0XJ085051 | Enhancer | 0.8 | Ensembl ENCODE | 0.1 | -190.9 | -190919 | 2.6 | CTCF RAD21 JUND CEBPB JUN FOS SCRT1 EP300 FOSL2 SMC3 | SATL1 APOOL RF00017-8558 HSALNG0138890 ZNF711 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IBA | -- |
GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISM | 19274049 |
GO:0003676 | nucleic acid binding | IEA | -- |
GO:0003677 | DNA binding | IEA | -- |
GO:0003700 | DNA-binding transcription factor activity | IBA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IBA,IDA | 20346720 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Gene Expression |
.48
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
GO:0006357 | regulation of transcription by RNA polymerase II | IEA | -- |
GO:0010468 | regulation of gene expression | IBA | 21873635 |
GO:0010845 | positive regulation of reciprocal meiotic recombination | IBA | 21873635 |
GO:0045893 | positive regulation of transcription, DNA-templated | IBA,IMP | 20346720 |
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | · | 12c | ^ | 13 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||||||||||||||||||||||||||||
SP2: | |||||||||||||||||||||||||||||||||||||||||||
SP3: | |||||||||||||||||||||||||||||||||||||||||||
SP4: | - | ||||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | ||||||||||||||||||||||||||||||||||||||||
SP6: | |||||||||||||||||||||||||||||||||||||||||||
SP7: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
SP8: | |||||||||||||||||||||||||||||||||||||||||||
SP9: |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ZNF711 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | ZNF711 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | ZNF711 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Zfp711 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Zfp711 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | ZNF711 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | ZNF711 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | ZNF6 31 |
|
OneToOne | |
ZNF711 30 |
|
||||
Lizard (Anolis carolinensis) |
Reptilia | ZNF711 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | znf711 30 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 0X pos | Variation | AA Info | Type |
---|---|---|---|---|---|
723229 | Likely Benign: not provided | 85,271,735(+) | T/C | SYNONYMOUS_VARIANT | |
754047 | Likely Benign: not provided | 85,268,328(+) | T/C | SYNONYMOUS_VARIANT | |
807785 | Uncertain Significance: not provided | 85,255,735(+) | A/G | MISSENSE_VARIANT | |
807786 | Uncertain Significance: not provided | 85,271,514(+) | G/A | MISSENSE_VARIANT | |
871854 | Uncertain Significance: not provided | 85,255,624(+) | G/T | MISSENSE_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2466752 | CNV | deletion | 19546169 |
esv2740275 | CNV | deletion | 23290073 |
esv3559049 | CNV | deletion | 23714750 |
Disorder | Aliases | PubMed IDs |
---|---|---|
mental retardation, x-linked 97 |
|
|
non-syndromic x-linked intellectual disability |
|
|
premature ovarian failure 2b |
|
|
syndromic x-linked intellectual disability |
|
|
syndromic x-linked intellectual disability siderius type |
|
|