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Aliases for ZNF710 Gene

Aliases for ZNF710 Gene

  • Zinc Finger Protein 710 2 3 5

External Ids for ZNF710 Gene

Previous GeneCards Identifiers for ZNF710 Gene

  • GC15P088346
  • GC15P090544
  • GC15P066721

Summaries for ZNF710 Gene

GeneCards Summary for ZNF710 Gene

ZNF710 (Zinc Finger Protein 710) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and transcription cofactor activity. An important paralog of this gene is ZNF366.

UniProtKB/Swiss-Prot for ZNF710 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF710 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF710 Gene

Genomics for ZNF710 Gene

GeneHancer (GH) Regulatory Elements for ZNF710 Gene

Promoters and enhancers for ZNF710 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I089997 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 557.9 +3.1 3058 8.4 HDGF PKNOX1 CLOCK FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 ZNF710 FANCI NIFKP5 ENSG00000259212 ENSG00000259314 UNC45A POLG ENSG00000228998 PRC1 TICRR
GH15I090056 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 26.6 +62.2 62174 9.6 HDGF PKNOX1 ARNT IRF4 ZNF766 E2F8 ZNF207 ZNF143 SP3 SP5 ZNF710 IQGAP1 POLG UNC45A LOC100631255 ENSG00000259314 IDH2 MESP1 ENSG00000228998 AP3S2
GH15I090018 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 23.9 +20.9 20855 3.4 CTCF BCOR MAX ZMYM3 RAD21 RARA ZNF7 YY1 ADNP VEZF1 IQGAP1 ZNF710 MESP1 ANPEP CIB1 AP3S2 ENSG00000273691 MIR3174
GH15I090028 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 19.9 +35.9 35921 13.7 PKNOX1 FOXA2 SMAD1 MLX ARNT ARID4B IRF4 YY1 SLC30A9 ZNF766 ZNF710 IQGAP1 VPS33B AP3S2 SEMA4B ANPEP ENSG00000273691 PIR55871
GH15I089780 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 14.3 -215.6 -215606 5.9 PKNOX1 CLOCK FOXA2 ARID4B NEUROD1 SIN3A ZBTB7B YY1 ZNF766 ZNF207 MESP1 ZNF710 ENSG00000259314 POLG WDR93 MESP2 PEX11A CIB1 ANPEP
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF710 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF710 gene promoter:

Genomic Locations for ZNF710 Gene

Genomic Locations for ZNF710 Gene
chr15:89,999,046-90,082,206
(GRCh38/hg38)
Size:
83,161 bases
Orientation:
Plus strand
chr15:90,544,624-90,625,438
(GRCh37/hg19)

Genomic View for ZNF710 Gene

Genes around ZNF710 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF710 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF710 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF710 Gene

Proteins for ZNF710 Gene

  • Protein details for ZNF710 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N1W2-ZN710_HUMAN
    Recommended name:
    Zinc finger protein 710
    Protein Accession:
    Q8N1W2
    Secondary Accessions:
    • A0AVS3
    • Q6ZMK9
    • Q8NDU0

    Protein attributes for ZNF710 Gene

    Size:
    664 amino acids
    Molecular mass:
    74461 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF710 Gene

Post-translational modifications for ZNF710 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF710 Gene

Domains & Families for ZNF710 Gene

Gene Families for ZNF710 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF710 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF710 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N1W2

UniProtKB/Swiss-Prot:

ZN710_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF710: view

Function for ZNF710 Gene

Molecular function for ZNF710 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF710 Gene

Gene Ontology (GO) - Molecular Function for ZNF710 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF710: view

Phenotypes for ZNF710 Gene

genes like me logo Genes that share phenotypes with ZNF710: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF710 Gene

Localization for ZNF710 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF710 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF710 gene
Compartment Confidence
nucleus 5
cytosol 3
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF710 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF710: view

Pathways & Interactions for ZNF710 Gene

SuperPathways for ZNF710 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF710: view

Pathways by source for ZNF710 Gene

2 Reactome pathways for ZNF710 Gene

Interacting Proteins for ZNF710 Gene

Gene Ontology (GO) - Biological Process for ZNF710 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF710: view

No data available for SIGNOR curated interactions for ZNF710 Gene

Drugs & Compounds for ZNF710 Gene

No Compound Related Data Available

Transcripts for ZNF710 Gene

Unigene Clusters for ZNF710 Gene

Zinc finger protein 710:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF710 Gene

No ASD Table

Relevant External Links for ZNF710 Gene

GeneLoc Exon Structure for
ZNF710
ECgene alternative splicing isoforms for
ZNF710

Expression for ZNF710 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF710 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF710 Gene

This gene is overexpressed in Pancreas (x4.2).

Protein differential expression in normal tissues from HIPED for ZNF710 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF710 Gene



Protein tissue co-expression partners for ZNF710 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF710 Gene:

ZNF710

SOURCE GeneReport for Unigene cluster for ZNF710 Gene:

Hs.459311

Evidence on tissue expression from TISSUES for ZNF710 Gene

  • Spleen(4.2)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ZNF710: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF710 Gene

Orthologs for ZNF710 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZNF710 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF710 33 34
  • 99.4 (n)
dog
(Canis familiaris)
Mammalia ZNF710 33 34
  • 92.01 (n)
cow
(Bos Taurus)
Mammalia ZNF710 33 34
  • 90.91 (n)
rat
(Rattus norvegicus)
Mammalia Zfp710 33
  • 89.04 (n)
mouse
(Mus musculus)
Mammalia Zfp710 33 16 34
  • 88.91 (n)
oppossum
(Monodelphis domestica)
Mammalia ZNF710 34
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZNF710 33 34
  • 80.3 (n)
lizard
(Anolis carolinensis)
Reptilia ZNF710 34
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia znf710 33
  • 68.54 (n)
zebrafish
(Danio rerio)
Actinopterygii znf710a 33 34
  • 71.03 (n)
ZNF710 (1 of 2) 34
  • 48 (a)
OneToMany
wufi04b07 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9921 33
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PZF1 34 36
  • 22 (a)
OneToMany
Species where no ortholog for ZNF710 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF710 Gene

ENSEMBL:
Gene Tree for ZNF710 (if available)
TreeFam:
Gene Tree for ZNF710 (if available)

Paralogs for ZNF710 Gene

Paralogs for ZNF710 Gene

(303) SIMAP similar genes for ZNF710 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ZNF710: view

Variants for ZNF710 Gene

Sequence variations from dbSNP and Humsavar for ZNF710 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000013312 -- 90,001,393(+) C/T upstream_transcript_variant
rs1000083223 -- 90,003,337(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000124990 -- 90,047,686(+) ATGAT/AT genic_upstream_transcript_variant, intron_variant
rs1000138131 -- 90,061,461(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000145046 -- 90,011,888(+) G/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF710 Gene

Variant ID Type Subtype PubMed ID
dgv112e55 CNV gain 17911159
esv2760054 CNV gain 17122850
esv3569864 CNV gain 25503493
esv3581814 CNV loss 25503493
esv3637210 CNV loss 21293372
esv3637211 CNV gain 21293372
esv3637212 CNV loss 21293372
esv997696 CNV deletion 20482838
nsv1071235 CNV deletion 25765185
nsv1121901 CNV deletion 24896259
nsv827430 CNV loss 20364138
nsv94745 CNV deletion 16902084

Variation tolerance for ZNF710 Gene

Residual Variation Intolerance Score: 48.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.45; 43.15% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF710 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF710

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF710 Gene

Disorders for ZNF710 Gene

Additional Disease Information for ZNF710

No disorders were found for ZNF710 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF710 Gene

Publications for ZNF710 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58
  4. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for ZNF710 Gene

Sources for ZNF710 Gene

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