Aliases for ZNF709 Gene

Aliases for ZNF709 Gene

  • Zinc Finger Protein 709 2 3 4 5
  • FLJ38281 2
  • ZNF709 5

External Ids for ZNF709 Gene

Previous GeneCards Identifiers for ZNF709 Gene

  • GC19M012434
  • GC19M012571
  • GC19M012145

Summaries for ZNF709 Gene

GeneCards Summary for ZNF709 Gene

ZNF709 (Zinc Finger Protein 709) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ENSG00000196826.

UniProtKB/Swiss-Prot Summary for ZNF709 Gene

Additional gene information for ZNF709 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF709 Gene

Genomics for ZNF709 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF709 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF709 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF709

Top Transcription factor binding sites by QIAGEN in the ZNF709 gene promoter:
  • AML1a
  • C/EBPalpha
  • NF-1
  • NF-1/L
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)
  • PPAR-alpha
  • SRF
  • SRF (504 AA)

Genomic Locations for ZNF709 Gene

Genomic Locations for ZNF709 Gene
chr19:12,461,184-12,513,854
(GRCh38/hg38)
Size:
52,671 bases
Orientation:
Minus strand
chr19:12,571,998-12,624,668
(GRCh37/hg19)
Size:
52,671 bases
Orientation:
Minus strand

Genomic View for ZNF709 Gene

Genes around ZNF709 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF709 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF709 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF709 Gene

Proteins for ZNF709 Gene

  • Protein details for ZNF709 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N972-ZN709_HUMAN
    Recommended name:
    Zinc finger protein 709
    Protein Accession:
    Q8N972
    Secondary Accessions:
    • A8K4E6

    Protein attributes for ZNF709 Gene

    Size:
    641 amino acids
    Molecular mass:
    74652 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF709 Gene

Post-translational modifications for ZNF709 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF709 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF709 Gene

Domains & Families for ZNF709 Gene

Gene Families for ZNF709 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF709 Gene

InterPro:
Blocks:
  • KRAB box
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF709 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ78267, highly similar to Homo sapiens zinc finger protein 709 (ZNF709), mRNA (A8K4E6_HUMAN)
  • Zinc finger protein 709 (ZN709_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8N972

UniProtKB/Swiss-Prot:

ZN709_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF709: view

Function for ZNF709 Gene

Molecular function for ZNF709 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF709 Gene

Gene Ontology (GO) - Molecular Function for ZNF709 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000976 transcription regulatory region sequence-specific DNA binding IEA --
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA 21873635
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF709: view
genes like me logo Genes that share phenotypes with ZNF709: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF709

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF709 Gene

Localization for ZNF709 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF709 Gene

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF709 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with ZNF709: view

No data available for Subcellular locations from COMPARTMENTS for ZNF709 Gene

Pathways & Interactions for ZNF709 Gene

genes like me logo Genes that share pathways with ZNF709: view

Pathways by source for ZNF709 Gene

2 Reactome pathways for ZNF709 Gene
1 KEGG pathway for ZNF709 Gene

Interacting Proteins for ZNF709 Gene

Gene Ontology (GO) - Biological Process for ZNF709 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IBA 21873635
genes like me logo Genes that share ontologies with ZNF709: view

No data available for SIGNOR curated interactions for ZNF709 Gene

Drugs & Compounds for ZNF709 Gene

No Compound Related Data Available

Transcripts for ZNF709 Gene

mRNA/cDNA for ZNF709 Gene

2 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF709

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF709 Gene

No ASD Table

Relevant External Links for ZNF709 Gene

GeneLoc Exon Structure for
ZNF709

Expression for ZNF709 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF709 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF709 Gene

This gene is overexpressed in Testis (x9.6).

Protein differential expression in normal tissues from HIPED for ZNF709 Gene

This gene is overexpressed in Cerebrospinal fluid (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF709 Gene



Protein tissue co-expression partners for ZNF709 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF709

SOURCE GeneReport for Unigene cluster for ZNF709 Gene:

Hs.631623
genes like me logo Genes that share expression patterns with ZNF709: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF709 Gene

Orthologs for ZNF709 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF709 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF709 30
  • 99.84 (n)
Rat
(Rattus norvegicus)
Mammalia LOC100911320 30
  • 81.24 (n)
Mouse
(Mus musculus)
Mammalia Zfp872 31
  • 78 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia ZNF709 30
  • 74.64 (n)
Cow
(Bos Taurus)
Mammalia -- 31
  • 61 (a)
ManyToMany
Species where no ortholog for ZNF709 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF709 Gene

ENSEMBL:
Gene Tree for ZNF709 (if available)
TreeFam:
Gene Tree for ZNF709 (if available)

Paralogs for ZNF709 Gene

(451) SIMAP similar genes for ZNF709 Gene using alignment to 2 proteins:

  • ZN709_HUMAN
  • H7C129_HUMAN
genes like me logo Genes that share paralogs with ZNF709: view

Variants for ZNF709 Gene

Additional dbSNP identifiers (rs#s) for ZNF709 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF709 Gene

Variant ID Type Subtype PubMed ID
dgv3436n100 CNV gain 25217958
dgv3437n100 CNV gain 25217958
nsv1059260 CNV loss 25217958
nsv1063081 CNV gain 25217958
nsv1066523 CNV gain 25217958
nsv1113975 CNV deletion 24896259
nsv963008 CNV duplication 23825009

Variation tolerance for ZNF709 Gene

Residual Variation Intolerance Score: 16.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.79; 16.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF709 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF709

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF709 Gene

Disorders for ZNF709 Gene

Additional Disease Information for ZNF709

No disorders were found for ZNF709 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF709 Gene

Publications for ZNF709 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  3. Proteomic identification and functional characterization of a novel ARF6 GTPase-activating protein, ACAP4. (PMID: 16737952) Fang Z … Yao X (Molecular & cellular proteomics : MCP 2006) 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4

Products for ZNF709 Gene

Sources for ZNF709 Gene