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Aliases for ZNF709 Gene

Aliases for ZNF709 Gene

  • Zinc Finger Protein 709 2 3 5

External Ids for ZNF709 Gene

Previous GeneCards Identifiers for ZNF709 Gene

  • GC19M012434
  • GC19M012571
  • GC19M012145

Summaries for ZNF709 Gene

GeneCards Summary for ZNF709 Gene

ZNF709 (Zinc Finger Protein 709) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ENSG00000196826.

UniProtKB/Swiss-Prot for ZNF709 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF709 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF709 Gene

Genomics for ZNF709 Gene

GeneHancer (GH) Regulatory Elements for ZNF709 Gene

Promoters and enhancers for ZNF709 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I012483 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 563.9 +29.2 29153 1.8 PKNOX1 ATF1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 YY1 GLIS2 ZNF143 ZNF709 ENSG00000269755 ZNF20 ZNF878 ZNF44 ZNF433 ZNF563 ZNF763 SYCE2 ZNF443
GH19I013148 Promoter/Enhancer 2.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 62.3 -639.8 -639841 10.2 MLX DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 STX10 ENSG00000267598 IER2 CCDC130 ZNF136 ZNF44 TRMT1 ZNF709 ZNF564 ZNF791
GH19I013011 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 47.1 -506.3 -506341 17.2 HDGF FOXA2 MLX ARNT ARID4B FEZF1 DMAP1 ZNF2 YY1 ZNF213 NFIX ZNF136 ZNF709 ZNF791 TRMT1 CCDC130 MRI1 ZNF44 ZNF564 ZNF625
GH19I012983 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 61.8 -470.9 -470948 3.2 HDGF PKNOX1 CLOCK FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 ZNF766 ZNF136 ZNF625 ZNF442 ZNF844 CCDC130 ZNF564 ZNF799 WDR83OS ZNF788 ZNF709
GH19I011531 Enhancer 1.4 FANTOM5 Ensembl ENCODE 65.5 +981.4 981416 1.6 PKNOX1 ATF1 ZNF493 ZFP64 ZNF213 FOS ZNF202 ZC3H11A REST ZNF623 ZNF627 ILF3 ZNF136 ZNF442 ZNF844 ZNF625 KRI1 ZNF44 ZNF441 ZNF709
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF709 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF709 gene promoter:

Genomic Locations for ZNF709 Gene

Genomic Locations for ZNF709 Gene
52,671 bases
Minus strand

Genomic View for ZNF709 Gene

Genes around ZNF709 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF709 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF709 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF709 Gene

Proteins for ZNF709 Gene

  • Protein details for ZNF709 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 709
    Protein Accession:
    Secondary Accessions:
    • A8K4E6

    Protein attributes for ZNF709 Gene

    641 amino acids
    Molecular mass:
    74652 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF709 Gene

Post-translational modifications for ZNF709 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF709 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF709 Gene

Domains & Families for ZNF709 Gene

Gene Families for ZNF709 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF709 Gene

Suggested Antigen Peptide Sequences for ZNF709 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF709: view

Function for ZNF709 Gene

Molecular function for ZNF709 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF709 Gene

Gene Ontology (GO) - Molecular Function for ZNF709 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000976 transcription regulatory region sequence-specific DNA binding IEA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF709: view
genes like me logo Genes that share phenotypes with ZNF709: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF709 Gene

Localization for ZNF709 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF709 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF709 gene
Compartment Confidence
nucleus 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF709 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF709: view

Pathways & Interactions for ZNF709 Gene

SuperPathways for ZNF709 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF709: view

Pathways by source for ZNF709 Gene

2 Reactome pathways for ZNF709 Gene

Gene Ontology (GO) - Biological Process for ZNF709 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF709: view

No data available for SIGNOR curated interactions for ZNF709 Gene

Drugs & Compounds for ZNF709 Gene

No Compound Related Data Available

Transcripts for ZNF709 Gene

mRNA/cDNA for ZNF709 Gene

Unigene Clusters for ZNF709 Gene

Zinc finger protein 709:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF709 Gene

No ASD Table

Relevant External Links for ZNF709 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF709 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF709 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF709 Gene

This gene is overexpressed in Testis (x9.6).

Protein differential expression in normal tissues from HIPED for ZNF709 Gene

This gene is overexpressed in Cerebrospinal fluid (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF709 Gene

Protein tissue co-expression partners for ZNF709 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF709 Gene:


SOURCE GeneReport for Unigene cluster for ZNF709 Gene:


Evidence on tissue expression from TISSUES for ZNF709 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ZNF709: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF709 Gene

Orthologs for ZNF709 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF709 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF709 33
  • 99.84 (n)
(Rattus norvegicus)
Mammalia LOC100911320 33
  • 81.24 (n)
(Mus musculus)
Mammalia Zfp872 34
  • 78 (a)
(Canis familiaris)
Mammalia ZNF709 33
  • 74.64 (n)
(Bos Taurus)
Mammalia -- 34
  • 61 (a)
Species where no ortholog for ZNF709 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF709 Gene

Gene Tree for ZNF709 (if available)
Gene Tree for ZNF709 (if available)

Paralogs for ZNF709 Gene

Paralogs for ZNF709 Gene

(451) SIMAP similar genes for ZNF709 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF709: view

Variants for ZNF709 Gene

Sequence variations from dbSNP and Humsavar for ZNF709 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000089549 -- 12,468,166(-) C/G intron_variant
rs1000125533 -- 12,461,619(-) G/T 3_prime_UTR_variant
rs1000145934 -- 12,472,928(-) C/T intron_variant
rs1000279050 -- 12,466,196(-) C/T intron_variant
rs1000339841 -- 12,480,540(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF709 Gene

Variant ID Type Subtype PubMed ID
dgv3436n100 CNV gain 25217958
dgv3437n100 CNV gain 25217958
nsv1059260 CNV loss 25217958
nsv1063081 CNV gain 25217958
nsv1066523 CNV gain 25217958
nsv1113975 CNV deletion 24896259
nsv963008 CNV duplication 23825009

Variation tolerance for ZNF709 Gene

Residual Variation Intolerance Score: 16.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.79; 16.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF709 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF709 Gene

Disorders for ZNF709 Gene

Additional Disease Information for ZNF709

No disorders were found for ZNF709 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF709 Gene

Publications for ZNF709 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58
  3. Proteomic identification and functional characterization of a novel ARF6 GTPase-activating protein, ACAP4. (PMID: 16737952) Fang Z … Yao X (Molecular & cellular proteomics : MCP 2006) 3 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for ZNF709 Gene

Sources for ZNF709 Gene

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