Aliases for ZNF708 Gene

Aliases for ZNF708 Gene

  • Zinc Finger Protein 708 2 3 4 5
  • KOX8 2 3 4
  • ZNF15, ZNF15L1 2 3
  • ZNF15L1 3 4
  • ZNF15 3 4
  • Zinc Finger Protein 15-Like 1 (KOX 8) 3
  • Zinc Finger Protein 15-Like 1 4
  • Zinc Finger Protein KOX8 4
  • Zinc Finger Protein 15 4
  • ZNF708 5

External Ids for ZNF708 Gene

Previous HGNC Symbols for ZNF708 Gene

  • ZNF15
  • ZNF15L1

Previous GeneCards Identifiers for ZNF708 Gene

  • GC07U901540
  • GC19M021266
  • GC19M021473
  • GC19M020964
  • GC19M021222
  • GC19M022580
  • GC19M022788
  • GC19M022838
  • GC19M023707
  • GC19M021346
  • GC19M021462
  • GC19M021530
  • GC19M021715
  • GC19M021914
  • GC19M022102
  • GC19M022291
  • GC19M022460

Summaries for ZNF708 Gene

GeneCards Summary for ZNF708 Gene

ZNF708 (Zinc Finger Protein 708) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF724.

UniProtKB/Swiss-Prot Summary for ZNF708 Gene

Additional gene information for ZNF708 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF708 Gene

Genomics for ZNF708 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF708 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF708 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF708

Top Transcription factor binding sites by QIAGEN in the ZNF708 gene promoter:
  • GATA-1

Genomic Locations for ZNF708 Gene

Genomic Locations for ZNF708 Gene
chr19:21,290,385-21,329,439
(GRCh38/hg38)
Size:
39,055 bases
Orientation:
Minus strand
chr19:21,473,962-21,512,227
(GRCh37/hg19)
Size:
38,266 bases
Orientation:
Minus strand

Genomic View for ZNF708 Gene

Genes around ZNF708 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF708 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF708 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF708 Gene

Proteins for ZNF708 Gene

  • Protein details for ZNF708 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17019-ZN708_HUMAN
    Recommended name:
    Zinc finger protein 708
    Protein Accession:
    P17019
    Secondary Accessions:
    • Q6ZMR0

    Protein attributes for ZNF708 Gene

    Size:
    499 amino acids
    Molecular mass:
    57357 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAD18665.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

neXtProt entry for ZNF708 Gene

Post-translational modifications for ZNF708 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF708 Gene

Domains & Families for ZNF708 Gene

Gene Families for ZNF708 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF708 Gene

InterPro:
Blocks:
  • C2H2-type zinc finger signature
  • KRAB box
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF708 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein KOX8 (ZN708_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P17019

UniProtKB/Swiss-Prot:

ZN708_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF708: view

Function for ZNF708 Gene

Molecular function for ZNF708 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF708 Gene

Gene Ontology (GO) - Molecular Function for ZNF708 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA 21873635
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF708: view
genes like me logo Genes that share phenotypes with ZNF708: view

Animal Model Products

CRISPR Products

miRNA for ZNF708 Gene

miRTarBase miRNAs that target ZNF708

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF708

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF708 Gene

Localization for ZNF708 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF708 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF708 gene
Compartment Confidence
nucleus 4
peroxisome 0

Gene Ontology (GO) - Cellular Components for ZNF708 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ZNF708: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF708 Gene

Pathways & Interactions for ZNF708 Gene

genes like me logo Genes that share pathways with ZNF708: view

Pathways by source for ZNF708 Gene

2 Reactome pathways for ZNF708 Gene
1 KEGG pathway for ZNF708 Gene

Gene Ontology (GO) - Biological Process for ZNF708 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA,IBA 21873635
genes like me logo Genes that share ontologies with ZNF708: view

No data available for SIGNOR curated interactions for ZNF708 Gene

Drugs & Compounds for ZNF708 Gene

No Compound Related Data Available

Transcripts for ZNF708 Gene

mRNA/cDNA for ZNF708 Gene

3 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF708

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF708 Gene

No ASD Table

Relevant External Links for ZNF708 Gene

GeneLoc Exon Structure for
ZNF708

Expression for ZNF708 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF708 Gene

Protein differential expression in normal tissues from HIPED for ZNF708 Gene

This gene is overexpressed in Placenta (62.2) and Peripheral blood mononuclear cells (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF708 Gene



Protein tissue co-expression partners for ZNF708 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF708

SOURCE GeneReport for Unigene cluster for ZNF708 Gene:

Hs.466296

Evidence on tissue expression from TISSUES for ZNF708 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with ZNF708: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF708 Gene

Orthologs for ZNF708 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF708 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF708 30 31
  • 98.64 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Zfp493 31
  • 61 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia -- 31
  • 57 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 50 (a)
ManyToMany
-- 31
  • 41 (a)
ManyToMany
Dog
(Canis familiaris)
Mammalia -- 31
  • 40 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 56 (a)
ManyToMany
-- 31
  • 47 (a)
ManyToMany
-- 31
  • 41 (a)
ManyToMany
-- 31
  • 38 (a)
ManyToMany
-- 31
  • 36 (a)
ManyToMany
-- 31
  • 36 (a)
ManyToMany
-- 31
  • 35 (a)
ManyToMany
-- 31
  • 31 (a)
ManyToMany
Species where no ortholog for ZNF708 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF708 Gene

ENSEMBL:
Gene Tree for ZNF708 (if available)
TreeFam:
Gene Tree for ZNF708 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF708: view image

Paralogs for ZNF708 Gene

Paralogs for ZNF708 Gene

(545) SIMAP similar genes for ZNF708 Gene using alignment to 4 proteins:

  • ZN708_HUMAN
  • M0QYN4_HUMAN
  • M0R1G3_HUMAN
  • M0R2V2_HUMAN
genes like me logo Genes that share paralogs with ZNF708: view

Variants for ZNF708 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF708 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs1781872 - p.Lys58Thr
rs1781873 - p.Lys49Glu
rs504280 - p.Arg66Gln
rs547516 - p.Ala7Val

Additional dbSNP identifiers (rs#s) for ZNF708 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF708 Gene

Variant ID Type Subtype PubMed ID
esv2665276 CNV deletion 23128226
esv2718325 CNV deletion 23290073
esv2718327 CNV deletion 23290073
esv2751783 CNV loss 17911159
esv2762027 CNV loss 21179565
esv3643921 CNV loss 21293372
esv3893179 CNV loss 25118596
esv4924 OTHER complex 18987735
nsv1061327 CNV gain 25217958
nsv1116311 CNV deletion 24896259
nsv1140249 OTHER inversion 24896259
nsv1151573 OTHER inversion 26484159
nsv458377 CNV gain 19166990
nsv578809 CNV gain 21841781
nsv578950 CNV loss 21841781
nsv963023 CNV duplication 23825009

Variation tolerance for ZNF708 Gene

Residual Variation Intolerance Score: 94.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.99; 60.07% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF708 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF708

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF708 Gene

Disorders for ZNF708 Gene

No disorders were found for ZNF708 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF708 Gene

Publications for ZNF708 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. Twenty-seven nonoverlapping zinc finger cDNAs from human T cells map to nine different chromosomes with apparent clustering. (PMID: 2014798) Huebner K … Thiesen HJ (American journal of human genetics 1991) 2 3
  3. Multiple genes encoding zinc finger domains are expressed in human T cells. (PMID: 2288909) Thiesen HJ (The New biologist 1990) 3 4
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  5. Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. (PMID: 28611215) Fei T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2017) 3

Products for ZNF708 Gene

Sources for ZNF708 Gene