Aliases for ZNF705D Gene

Aliases for ZNF705D Gene

  • Zinc Finger Protein 705D 2 3 4 5
  • Putative Zinc Finger Protein 705C 3
  • Zinc Finger Protein 705C 3
  • ZNF705C 3
  • ZNF705D 5

External Ids for ZNF705D Gene

Previous GeneCards Identifiers for ZNF705D Gene

  • GC08U900805
  • GC08P011985
  • GC08P011946

Summaries for ZNF705D Gene

GeneCards Summary for ZNF705D Gene

ZNF705D (Zinc Finger Protein 705D) is a Protein Coding gene. Diseases associated with ZNF705D include Retinitis Pigmentosa 13 and Retinitis Pigmentosa 11. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF705B.

UniProtKB/Swiss-Prot Summary for ZNF705D Gene

Additional gene information for ZNF705D Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF705D Gene

Genomics for ZNF705D Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF705D Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J012089 Enhancer 0.2 Ensembl 600.7 +0.6 563 0.2 ZNF705D piR-32214-629 piR-53029-122 FAM66A USP17L7
GH08J012115 Promoter 1.2 EPDnew Ensembl CraniofacialAtlas 0.3 +26.8 26763 1.4 CTCF ZFX NRF1 FAM66D FAM66A piR-31534-633 USP17L7 ZNF705D
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF705D on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF705D

Top Transcription factor binding sites by QIAGEN in the ZNF705D gene promoter:
  • E47
  • ITF-2
  • Pax-4a
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)
  • Tal-1
  • Tal-1beta

Genomic Locations for ZNF705D Gene

Genomic Locations for ZNF705D Gene
26,179 bases
Plus strand
26,179 bases
Plus strand

Genomic View for ZNF705D Gene

Genes around ZNF705D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF705D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF705D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF705D Gene

Proteins for ZNF705D Gene

  • Protein details for ZNF705D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 705D
    Protein Accession:
    Secondary Accessions:
    • A8K971
    • A8MY01
    • Q2TAN0

    Protein attributes for ZNF705D Gene

    300 amino acids
    Molecular mass:
    34712 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF705D Gene

Post-translational modifications for ZNF705D Gene

No Post-translational modifications

Other Protein References for ZNF705D Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF705D Gene

Domains & Families for ZNF705D Gene

Gene Families for ZNF705D Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF705D Gene

Suggested Antigen Peptide Sequences for ZNF705D Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 705D (Z705D_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF705D: view

Function for ZNF705D Gene

Molecular function for ZNF705D Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF705D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IBA 21873635
GO:0043565 sequence-specific DNA binding IBA 21873635
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF705D: view

Phenotypes for ZNF705D Gene

genes like me logo Genes that share phenotypes with ZNF705D: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF705D Gene

Localization for ZNF705D Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF705D Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF705D gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF705D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF705D: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF705D Gene

Pathways & Interactions for ZNF705D Gene

genes like me logo Genes that share pathways with ZNF705D: view

Pathways by source for ZNF705D Gene

2 Reactome pathways for ZNF705D Gene
1 KEGG pathway for ZNF705D Gene

Interacting Proteins for ZNF705D Gene

Gene Ontology (GO) - Biological Process for ZNF705D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF705D: view

No data available for SIGNOR curated interactions for ZNF705D Gene

Drugs & Compounds for ZNF705D Gene

No Compound Related Data Available

Transcripts for ZNF705D Gene

mRNA/cDNA for ZNF705D Gene

1 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF705D Gene

No ASD Table

Relevant External Links for ZNF705D Gene

GeneLoc Exon Structure for

Expression for ZNF705D Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF705D Gene

mRNA differential expression in normal tissues according to GTEx for ZNF705D Gene

This gene is overexpressed in Testis (x42.5) and Brain - Caudate (basal ganglia) (x5.6).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF705D

SOURCE GeneReport for Unigene cluster for ZNF705D Gene:


Evidence on tissue expression from TISSUES for ZNF705D Gene

  • Skin(4.1)
genes like me logo Genes that share expression patterns with ZNF705D: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF705D Gene

Orthologs for ZNF705D Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF705D Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 31
  • 95 (a)
(Canis familiaris)
Mammalia LOC482938 30
  • 74.22 (n)
-- 31
  • 56 (a)
(Bos Taurus)
Mammalia ZNF705A 30 31
  • 73.83 (n)
-- 31
  • 28 (a)
Species where no ortholog for ZNF705D was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF705D Gene

Gene Tree for ZNF705D (if available)
Gene Tree for ZNF705D (if available)

Paralogs for ZNF705D Gene

(335) SIMAP similar genes for ZNF705D Gene using alignment to 1 proteins:

  • Z705D_HUMAN
genes like me logo Genes that share paralogs with ZNF705D: view

Variants for ZNF705D Gene

Additional dbSNP identifiers (rs#s) for ZNF705D Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF705D Gene

Variant ID Type Subtype PubMed ID
dgv1270e199 CNV deletion 23128226
dgv154e203 CNV gain+loss 21179565
dgv244e55 CNV gain 17911159
dgv27n31 CNV gain 19718026
dgv3773n106 CNV deletion 24896259
dgv7015n100 CNV gain 25217958
dgv7016n100 CNV gain 25217958
dgv7017n100 CNV gain 25217958
dgv7018n100 CNV gain+loss 25217958
dgv7019n100 CNV gain 25217958
dgv7020n100 CNV loss 25217958
dgv7021n100 CNV loss 25217958
esv22986 CNV gain+loss 19812545
esv2660145 CNV deletion 23128226
esv2736614 CNV deletion 23290073
esv2759593 CNV gain+loss 17122850
nsv1034132 CNV gain 25217958
nsv1075529 CNV deletion 25765185
nsv1075530 CNV deletion 25765185
nsv1122187 CNV deletion 24896259
nsv1161718 OTHER complex 26073780
nsv428195 CNV gain 18775914
nsv471461 CNV gain 19718026
nsv516685 CNV gain+loss 19592680
nsv8288 CNV gain+loss 18304495
nsv951104 CNV deletion 24416366
nsv967564 CNV duplication 23825009

Variation tolerance for ZNF705D Gene

Gene Damage Index Score: 0.08; 1.90% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF705D Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF705D Gene

Disorders for ZNF705D Gene

MalaCards: The human disease database

(3) MalaCards diseases for ZNF705D Gene - From: DISEASES

Disorder Aliases PubMed IDs
retinitis pigmentosa 13
  • rp13
retinitis pigmentosa 11
  • rp11
retinitis pigmentosa
  • retinitis pigmentosa 1
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with ZNF705D: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF705D Gene

Publications for ZNF705D Gene

  1. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  3. DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C … Lander ES (Nature 2006) 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4

Products for ZNF705D Gene

Sources for ZNF705D Gene