Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZNF705A Gene

Aliases for ZNF705A Gene

  • Zinc Finger Protein 705A 2 3 3 5

External Ids for ZNF705A Gene

Previous GeneCards Identifiers for ZNF705A Gene

  • GC12P008217
  • GC12P008140
  • GC12P008218
  • GC12P008276
  • GC12P008137
  • GC12P008290

Summaries for ZNF705A Gene

GeneCards Summary for ZNF705A Gene

ZNF705A (Zinc Finger Protein 705A) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF705D.

UniProtKB/Swiss-Prot for ZNF705A Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF705A Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF705A Gene

Genomics for ZNF705A Gene

GeneHancer (GH) Regulatory Elements for ZNF705A Gene

Promoters and enhancers for ZNF705A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J008156 Enhancer 0.9 Ensembl ENCODE 650.7 +0.2 189 2 PKNOX1 JUN ZNF766 ZNF316 POLR2A ZSCAN5C NFE2 MAFK ZNF639 ZNF197 ZNF705A CLEC4A NECAP1 ENSG00000284393 FAM66C
GH12J008155 Enhancer 0.2 FANTOM5 650.7 -1.8 -1774 0.2 ZNF705A CLEC4A CLEC4E C3AR1 CLEC6A NECAP1 CLEC4D GCSHP4 ENSG00000284393
GH12J008179 Promoter/Enhancer 1.4 Ensembl ENCODE 0.3 +23.3 23301 1.4 HDGF SIN3A GLI4 ZNF2 YY1 GLIS2 ZNF213 ZNF143 KLF7 SP3 FAM66C CLEC4A LINC00612 ZNF705A ENSG00000276417
GH12J008145 Enhancer 0.4 Ensembl ENCODE 0.4 -10.8 -10828 1.7 GCSHP4 ENSG00000284393 ZNF705A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF705A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF705A gene promoter:
  • AREB6

Genomic Locations for ZNF705A Gene

Genomic Locations for ZNF705A Gene
31,526 bases
Plus strand
50,401 bases
Plus strand

Genomic View for ZNF705A Gene

Genes around ZNF705A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF705A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF705A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF705A Gene

Proteins for ZNF705A Gene

  • Protein details for ZNF705A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 705A
    Protein Accession:

    Protein attributes for ZNF705A Gene

    300 amino acids
    Molecular mass:
    34734 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF705A Gene

Post-translational modifications for ZNF705A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF705A Gene

No data available for DME Specific Peptides for ZNF705A Gene

Domains & Families for ZNF705A Gene

Gene Families for ZNF705A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF705A Gene

Suggested Antigen Peptide Sequences for ZNF705A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF705A: view

Function for ZNF705A Gene

Molecular function for ZNF705A Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF705A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IBA --
GO:0043565 sequence-specific DNA binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF705A: view
genes like me logo Genes that share phenotypes with ZNF705A: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF705A Gene

Localization for ZNF705A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF705A Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF705A gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF705A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF705A: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF705A Gene

Pathways & Interactions for ZNF705A Gene

SuperPathways for ZNF705A Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF705A: view

Pathways by source for ZNF705A Gene

2 Reactome pathways for ZNF705A Gene

Interacting Proteins for ZNF705A Gene

Gene Ontology (GO) - Biological Process for ZNF705A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF705A: view

No data available for SIGNOR curated interactions for ZNF705A Gene

Drugs & Compounds for ZNF705A Gene

No Compound Related Data Available

Transcripts for ZNF705A Gene

mRNA/cDNA for ZNF705A Gene

(3) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF705A Gene

Zinc finger protein 705A:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF705A Gene

No ASD Table

Relevant External Links for ZNF705A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF705A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF705A Gene

mRNA differential expression in normal tissues according to GTEx for ZNF705A Gene

This gene is overexpressed in Testis (x13.1).

NURSA nuclear receptor signaling pathways regulating expression of ZNF705A Gene:


SOURCE GeneReport for Unigene cluster for ZNF705A Gene:

genes like me logo Genes that share expression patterns with ZNF705A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF705A Gene

Orthologs for ZNF705A Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF705A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF705A 34 33
  • 99.33 (n)
(Canis familiaris)
Mammalia -- 34
  • 57 (a)
(Bos Taurus)
Mammalia ZNF705A 34
  • 56 (a)
-- 34
  • 28 (a)
(Mus musculus)
Mammalia Clec4a1 16 33
(Rattus norvegicus)
Mammalia Clec4a1 33
Species where no ortholog for ZNF705A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF705A Gene

Gene Tree for ZNF705A (if available)
Gene Tree for ZNF705A (if available)
Evolutionary constrained regions (ECRs) for ZNF705A: view image

Paralogs for ZNF705A Gene

Paralogs for ZNF705A Gene

(451) SIMAP similar genes for ZNF705A Gene using alignment to 4 proteins:

  • Z705A_HUMAN
  • U3KQ42_HUMAN Pseudogenes for ZNF705A Gene

genes like me logo Genes that share paralogs with ZNF705A: view

Variants for ZNF705A Gene

Sequence variations from dbSNP and Humsavar for ZNF705A Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1001458392 -- 8,172,901(+) C/T intron_variant
rs1001885594 -- 8,173,216(+) A/T intron_variant
rs1001911872 -- 8,173,520(+) C/A intron_variant
rs1002152633 -- 8,179,836(+) T/C 3_prime_UTR_variant
rs1002521567 -- 8,179,517(+) G/A 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF705A Gene

Variant ID Type Subtype PubMed ID
dgv1358n100 CNV gain 25217958
dgv1359n100 CNV gain 25217958
dgv2339n54 CNV gain 21841781
esv2759877 CNV gain+loss 17122850
esv29886 CNV gain+loss 19812545
nsv428270 CNV gain 18775914
nsv471365 CNV gain 19718026
nsv826226 CNV gain 20364138
nsv8899 CNV gain+loss 18304495
nsv976564 CNV duplication 23825009

Variation tolerance for ZNF705A Gene

Residual Variation Intolerance Score: 81.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.18; 84.81% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF705A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF705A Gene

Disorders for ZNF705A Gene

Additional Disease Information for ZNF705A

No disorders were found for ZNF705A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF705A Gene

Publications for ZNF705A Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for ZNF705A Gene

Sources for ZNF705A Gene

Loading form....