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Aliases for ZNF704 Gene

Aliases for ZNF704 Gene

  • Zinc Finger Protein 704 2 3 4 5
  • Gig1 3

External Ids for ZNF704 Gene

Previous GeneCards Identifiers for ZNF704 Gene

  • GC08U900620
  • GC08M081714
  • GC08M081550
  • GC08M077030

Summaries for ZNF704 Gene

GeneCards Summary for ZNF704 Gene

ZNF704 (Zinc Finger Protein 704) is a Protein Coding gene. Among its related pathways are Gene Expression. An important paralog of this gene is ZNF395.

UniProtKB/Swiss-Prot for ZNF704 Gene

  • Transcription factor which binds to RE2 sequence elements in the MYOD1 enhancer.

Additional gene information for ZNF704 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF704 Gene

Genomics for ZNF704 Gene

GeneHancer (GH) Regulatory Elements for ZNF704 Gene

Promoters and enhancers for ZNF704 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J080871 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 607.9 +1.2 1243 3.4 ZNF652 SP1 ELF3 CEBPG ZSCAN21 ZBTB7A YY1 SP7 ZNF384 MZF1 ZNF704 HMGB1P41
GH08J080899 Enhancer 0.8 Ensembl ENCODE 17.6 -25.1 -25086 2.3 CEBPG NFIB MAFK CEBPA GATAD2A ZNF24 CEBPB NFIC NR2F2 GATA3 ZNF704 FTH1P11 ENSG00000254060
GH08J080820 Enhancer 1 Ensembl ENCODE 8.1 +54.0 53994 2.1 CEBPG HNF1A ZNF384 KAT8 SOX13 CEBPA GATAD2A RXRB IRF2 MNT ZNF704 HMGB1P41
GH08J080809 Enhancer 0.9 Ensembl ENCODE 7.9 +64.5 64488 1.8 TARDBP CTBP1 HES1 PKNOX1 MLLT1 ZNF217 DPF2 CUX1 GATAD2B NFIB CHMP4C ENSG00000272518 RNU11-6P ZNF704 HMGB1P41 GC08M080788
GH08J080807 Enhancer 0.8 Ensembl ENCODE 8.1 +66.3 66327 1.5 CTBP1 SMARCA5 ZNF217 DPF2 GATA3 ELF1 JUND RCOR1 FOS ZBTB40 RNU11-6P ZNF704 HMGB1P41 GC08M080788
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF704 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF704 gene promoter:
  • aMEF-2
  • AP-2gamma
  • c-Myb
  • E2F
  • E2F-1
  • FAC1
  • MEF-2
  • MEF-2A
  • MyoD
  • p53

Genomic Locations for ZNF704 Gene

Genomic Locations for ZNF704 Gene
chr8:80,628,451-80,874,781
(GRCh38/hg38)
Size:
246,331 bases
Orientation:
Minus strand
chr8:81,540,686-81,787,016
(GRCh37/hg19)
Size:
246,331 bases
Orientation:
Minus strand

Genomic View for ZNF704 Gene

Genes around ZNF704 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF704 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF704 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF704 Gene

Proteins for ZNF704 Gene

  • Protein details for ZNF704 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZNC4-ZN704_HUMAN
    Recommended name:
    Zinc finger protein 704
    Protein Accession:
    Q6ZNC4
    Secondary Accessions:
    • B2RNE6
    • B9EGW6

    Protein attributes for ZNF704 Gene

    Size:
    412 amino acids
    Molecular mass:
    45276 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF704 Gene

Post-translational modifications for ZNF704 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF704 Gene

No data available for DME Specific Peptides for ZNF704 Gene

Domains & Families for ZNF704 Gene

Gene Families for ZNF704 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZNF704 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF704 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 704 (ZN704_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6ZNC4

UniProtKB/Swiss-Prot:

ZN704_HUMAN :
  • The CR1 and CR2 motifs mediate sequence-specific DNA binding, and are important for binding to the MYOD1 enhancer.
Domain:
  • The CR1 and CR2 motifs mediate sequence-specific DNA binding, and are important for binding to the MYOD1 enhancer.
genes like me logo Genes that share domains with ZNF704: view

Function for ZNF704 Gene

Molecular function for ZNF704 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor which binds to RE2 sequence elements in the MYOD1 enhancer.

Phenotypes From GWAS Catalog for ZNF704 Gene

Gene Ontology (GO) - Molecular Function for ZNF704 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001158 enhancer sequence-specific DNA binding IEA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF704: view
genes like me logo Genes that share phenotypes with ZNF704: view

Animal Models for ZNF704 Gene

MGI Knock Outs for ZNF704:

Animal Model Products

CRISPR Products

miRNA for ZNF704 Gene

miRTarBase miRNAs that target ZNF704

Clone Products

  • Applied Biological Materials (abm): Clones for ZNF704 - Now 50% OFF >
  • * ZNF704 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * ZNF704 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZNF704 Gene

Localization for ZNF704 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF704 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF704 gene
Compartment Confidence
nucleus 4

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF704 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF704: view

Pathways & Interactions for ZNF704 Gene

PathCards logo

SuperPathways for ZNF704 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF704: view

Pathways by source for ZNF704 Gene

2 Reactome pathways for ZNF704 Gene

Interacting Proteins for ZNF704 Gene

Gene Ontology (GO) - Biological Process for ZNF704 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF704: view

No data available for SIGNOR curated interactions for ZNF704 Gene

Drugs & Compounds for ZNF704 Gene

No Compound Related Data Available

Transcripts for ZNF704 Gene

mRNA/cDNA for ZNF704 Gene

(3) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(6) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for ZNF704 Gene

Zinc finger protein 704:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for ZNF704 - Now 50% OFF >
  • * ZNF704 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * ZNF704 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF704 Gene

No ASD Table

Relevant External Links for ZNF704 Gene

GeneLoc Exon Structure for
ZNF704
ECgene alternative splicing isoforms for
ZNF704

Expression for ZNF704 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF704 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF704 Gene

This gene is overexpressed in Heart (61.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF704 Gene



Protein tissue co-expression partners for ZNF704 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF704 Gene:

ZNF704

SOURCE GeneReport for Unigene cluster for ZNF704 Gene:

Hs.434957

Evidence on tissue expression from TISSUES for ZNF704 Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with ZNF704: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF704 Gene

Orthologs for ZNF704 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF704 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF704 35 34
  • 99.51 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF704 35 34
  • 92.23 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF704 35 34
  • 90.21 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp704 34
  • 86.27 (n)
mouse
(Mus musculus)
Mammalia Zfp704 17 35 34
  • 85.54 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF704 35
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZNF704 35
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZNF704 35 34
  • 78.73 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZNF704 35
  • 69 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii znf704 35 34
  • 68.49 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Glut4EF 35
  • 13 (a)
OneToMany
Species where no ortholog for ZNF704 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF704 Gene

ENSEMBL:
Gene Tree for ZNF704 (if available)
TreeFam:
Gene Tree for ZNF704 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF704: view image

Paralogs for ZNF704 Gene

Paralogs for ZNF704 Gene

(3) SIMAP similar genes for ZNF704 Gene using alignment to 2 proteins:

  • ZN704_HUMAN
  • E5RGL7_HUMAN
genes like me logo Genes that share paralogs with ZNF704: view

Variants for ZNF704 Gene

Sequence variations from dbSNP and Humsavar for ZNF704 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000007419 -- 80,870,472(-) G/T intron_variant
rs1000018860 -- 80,817,180(-) T/C intron_variant
rs1000022630 -- 80,856,623(-) G/T intron_variant
rs1000024029 -- 80,741,645(-) G/A intron_variant
rs1000043167 -- 80,785,984(-) G/A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF704 Gene

Variant ID Type Subtype PubMed ID
esv2678182 CNV deletion 23128226
esv2737218 CNV deletion 23290073
esv3617784 CNV loss 21293372
esv5734 CNV gain 19470904
nsv1075152 CNV deletion 25765185
nsv1076092 CNV deletion 25765185
nsv1119182 CNV deletion 24896259
nsv1136048 CNV deletion 24896259
nsv1152674 CNV deletion 26484159
nsv476087 CNV novel sequence insertion 20440878
nsv476661 CNV novel sequence insertion 20440878
nsv831366 CNV loss 17160897
nsv951448 CNV deletion 24416366
nsv971672 CNV duplication 23825009
nsv981956 CNV duplication 23825009

Variation tolerance for ZNF704 Gene

Residual Variation Intolerance Score: 33.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.69; 82.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF704 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF704

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF704 Gene

Disorders for ZNF704 Gene

Additional Disease Information for ZNF704

No disorders were found for ZNF704 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF704 Gene

Publications for ZNF704 Gene

  1. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  2. Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. (PMID: 28611215) Fei T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2017) 3 58
  3. Substrate trapping proteomics reveals targets of the βTrCP2/FBXW11 ubiquitin ligase. (PMID: 25332235) Kim TY … Major MB (Molecular and cellular biology 2015) 3 58
  4. DNA Damage Regulates Translation through β-TRCP Targeting of CReP. (PMID: 26091241) Loveless TB … Toczyski DP (PLoS genetics 2015) 3 58
  5. A quantitative atlas of mitotic phosphorylation. (PMID: 18669648) Dephoure N … Gygi SP (Proceedings of the National Academy of Sciences of the United States of America 2008) 4 58

Products for ZNF704 Gene

Sources for ZNF704 Gene

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