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Aliases for ZNF704 Gene

Aliases for ZNF704 Gene

  • Zinc Finger Protein 704 2 3 5
  • GIG1 3

External Ids for ZNF704 Gene

Previous GeneCards Identifiers for ZNF704 Gene

  • GC08U900620
  • GC08M081714
  • GC08M081550
  • GC08M077030

Summaries for ZNF704 Gene

GeneCards Summary for ZNF704 Gene

ZNF704 (Zinc Finger Protein 704) is a Protein Coding gene. Among its related pathways are Gene Expression. An important paralog of this gene is ZNF395.

Additional gene information for ZNF704 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF704 Gene

Genomics for ZNF704 Gene

GeneHancer (GH) Regulatory Elements for ZNF704 Gene

Promoters and enhancers for ZNF704 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I080871 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 558.1 +1.2 1243 3.4 FOXA2 ARID4B SIN3A ZNF2 YY1 GLIS2 NFYC MXD4 REST KAT8 ZNF704 HMGB1P41
GH08I080900 Enhancer 0.8 Ensembl ENCODE 17.6 -25.1 -25134 1.2 GATAD2A NFIA TEAD1 CEBPB ZNF384 CEBPG GATA3 CEBPA MAFK ZNF704 FTH1P11 ENSG00000254060
GH08I079934 Enhancer 0.7 ENCODE dbSUPER 12.4 +939.7 939682 1.3 FOXA2 ZNF302 FOSL2 FOXA1 ENSG00000251867 ZNF704 ZBTB10 RNU7-85P GC08P079918 ENSG00000272518 MRPS28 ENSG00000276418
GH08I080724 Enhancer 1.3 FANTOM5 Ensembl ENCODE 5 +147.9 147923 4.3 INSM2 RAD21 ZNF335 ZNF366 RCOR1 KLF7 ATF7 REST ZEB2 NFIL3 ZNF704 PIR36752 GC08M080664
GH08I080820 Enhancer 0.8 ENCODE 8.1 +54.0 53994 2.1 ELF3 FOXA2 MLX ARID4B RAD21 ZNF48 RARA RCOR1 CREM THAP11 ZNF704 HMGB1P41
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF704 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF704 gene promoter:

Genomic Locations for ZNF704 Gene

Genomic Locations for ZNF704 Gene
246,331 bases
Minus strand

Genomic View for ZNF704 Gene

Genes around ZNF704 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF704 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF704 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF704 Gene

Proteins for ZNF704 Gene

  • Protein details for ZNF704 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 704
    Protein Accession:
    Secondary Accessions:
    • B2RNE6
    • B9EGW6

    Protein attributes for ZNF704 Gene

    412 amino acids
    Molecular mass:
    45276 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF704 Gene

Post-translational modifications for ZNF704 Gene

No Post-translational modifications

Other Protein References for ZNF704 Gene

No data available for DME Specific Peptides for ZNF704 Gene

Domains & Families for ZNF704 Gene

Gene Families for ZNF704 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZNF704 Gene


Suggested Antigen Peptide Sequences for ZNF704 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZNF704: view

No data available for UniProtKB/Swiss-Prot for ZNF704 Gene

Function for ZNF704 Gene

Phenotypes From GWAS Catalog for ZNF704 Gene

Gene Ontology (GO) - Molecular Function for ZNF704 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001158 enhancer sequence-specific DNA binding IBA --
GO:0003676 nucleic acid binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF704: view

Phenotypes for ZNF704 Gene

genes like me logo Genes that share phenotypes with ZNF704: view

Animal Models for ZNF704 Gene

MGI Knock Outs for ZNF704:

miRNA for ZNF704 Gene

miRTarBase miRNAs that target ZNF704

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZNF704 Gene

Localization for ZNF704 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF704 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF704 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,IEA --
genes like me logo Genes that share ontologies with ZNF704: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ZNF704 Gene

Pathways & Interactions for ZNF704 Gene

SuperPathways for ZNF704 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF704: view

Pathways by source for ZNF704 Gene

2 Reactome pathways for ZNF704 Gene

Interacting Proteins for ZNF704 Gene

Gene Ontology (GO) - Biological Process for ZNF704 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription by RNA polymerase II IEA,IBA --
genes like me logo Genes that share ontologies with ZNF704: view

No data available for SIGNOR curated interactions for ZNF704 Gene

Drugs & Compounds for ZNF704 Gene

No Compound Related Data Available

Transcripts for ZNF704 Gene

mRNA/cDNA for ZNF704 Gene

(4) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF704 Gene

Zinc finger protein 704:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF704 Gene

No ASD Table

Relevant External Links for ZNF704 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF704 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF704 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF704 Gene

This gene is overexpressed in Heart (61.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF704 Gene

Protein tissue co-expression partners for ZNF704 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF704 Gene:


SOURCE GeneReport for Unigene cluster for ZNF704 Gene:


Evidence on tissue expression from TISSUES for ZNF704 Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with ZNF704: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF704 Gene

Orthologs for ZNF704 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF704 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF704 33 34
  • 99.51 (n)
(Canis familiaris)
Mammalia ZNF704 33 34
  • 92.23 (n)
(Bos Taurus)
Mammalia ZNF704 33 34
  • 90.21 (n)
(Rattus norvegicus)
Mammalia Zfp704 33
  • 86.27 (n)
(Mus musculus)
Mammalia Zfp704 33 16 34
  • 85.54 (n)
(Ornithorhynchus anatinus)
Mammalia ZNF704 34
  • 75 (a)
(Monodelphis domestica)
Mammalia ZNF704 34
  • 58 (a)
(Gallus gallus)
Aves ZNF704 33 34
  • 78.73 (n)
(Anolis carolinensis)
Reptilia ZNF704 34
  • 69 (a)
(Danio rerio)
Actinopterygii znf704 33 34
  • 68.49 (n)
fruit fly
(Drosophila melanogaster)
Insecta Glut4EF 34
  • 13 (a)
Species where no ortholog for ZNF704 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF704 Gene

Gene Tree for ZNF704 (if available)
Gene Tree for ZNF704 (if available)

Paralogs for ZNF704 Gene

Paralogs for ZNF704 Gene

(3) SIMAP similar genes for ZNF704 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF704: view

Variants for ZNF704 Gene

Sequence variations from dbSNP and Humsavar for ZNF704 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000007419 -- 80,870,472(-) G/T intron_variant
rs1000018860 -- 80,817,180(-) T/C intron_variant
rs1000022630 -- 80,856,623(-) G/T intron_variant
rs1000024029 -- 80,741,645(-) G/A intron_variant
rs1000043167 -- 80,785,984(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF704 Gene

Variant ID Type Subtype PubMed ID
nsv981956 CNV duplication 23825009
nsv971672 CNV duplication 23825009
nsv951448 CNV deletion 24416366
nsv831366 CNV loss 17160897
nsv476661 CNV novel sequence insertion 20440878
nsv476087 CNV novel sequence insertion 20440878
nsv1152674 CNV deletion 26484159
nsv1136048 CNV deletion 24896259
nsv1119182 CNV deletion 24896259
nsv1076092 CNV deletion 25765185
nsv1075152 CNV deletion 25765185
esv5734 CNV gain 19470904
esv3617784 CNV loss 21293372
esv2737218 CNV deletion 23290073
esv2678182 CNV deletion 23128226

Variation tolerance for ZNF704 Gene

Residual Variation Intolerance Score: 33.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.69; 82.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF704 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF704 Gene

Disorders for ZNF704 Gene

Additional Disease Information for ZNF704

No disorders were found for ZNF704 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF704 Gene

Publications for ZNF704 Gene

  1. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  2. Substrate trapping proteomics reveals targets of the βTrCP2/FBXW11 ubiquitin ligase. (PMID: 25332235) Kim TY … Major MB (Molecular and cellular biology 2015) 3 58
  3. DNA Damage Regulates Translation through β-TRCP Targeting of CReP. (PMID: 26091241) Loveless TB … Toczyski DP (PLoS genetics 2015) 3 58
  4. A quantitative atlas of mitotic phosphorylation. (PMID: 18669648) Dephoure N … Gygi SP (Proceedings of the National Academy of Sciences of the United States of America 2008) 4 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 58

Products for ZNF704 Gene

Sources for ZNF704 Gene

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