Aliases for ZNF704 Gene

Aliases for ZNF704 Gene

  • Zinc Finger Protein 704 2 3 4 5
  • Gig1 2 3
  • FLJ16218 2
  • ZNF704 5

External Ids for ZNF704 Gene

Previous GeneCards Identifiers for ZNF704 Gene

  • GC08U900620
  • GC08M081714
  • GC08M081550
  • GC08M077030

Summaries for ZNF704 Gene

GeneCards Summary for ZNF704 Gene

ZNF704 (Zinc Finger Protein 704) is a Protein Coding gene. Diseases associated with ZNF704 include Progesterone-Receptor Positive Breast Cancer. Among its related pathways are Gene Expression. An important paralog of this gene is ZNF395.

UniProtKB/Swiss-Prot Summary for ZNF704 Gene

  • Transcription factor which binds to RE2 sequence elements in the MYOD1 enhancer.

Additional gene information for ZNF704 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF704 Gene

Genomics for ZNF704 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF704 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J080871 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 607.7 +10.9 10895 3.4 CEBPG GATAD2A PRDM10 ZNF629 RFX5 ZNF692 FOXA1 RBFOX2 POLR2A PATZ1 ZNF704 piR-36756-085 ZBTB10
GH08J080864 Enhancer 1.3 FANTOM5 Ensembl ENCODE 9 +19.4 19415 2.4 CREB1 GATAD2A ATF7 ZNF629 SOX13 RCOR2 JUND PRDM1 DPF2 HDAC1 RNU11-6P ZNF704 PAG1 ZBTB10 piR-36756-085
GH08J080837 Enhancer 1 FANTOM5 Ensembl ENCODE 8.4 +43.7 43666 6.3 ATF7 ZBTB17 NFIC ZFHX2 SPI1 RCOR1 NFIB ZNF366 ZNF660 ZNF398 RNU11-6P ZNF704 piR-38562-080 piR-39341-398 ZBTB10
GH08J080807 Enhancer 0.9 Ensembl ENCODE 8.1 +75.0 74952 3.5 TARDBP FOXA1 HES1 SMARCA5 CTBP1 ZNF444 MLLT1 PKNOX1 ZNF217 GATAD2B RNU11-6P ZNF704 HMGB1P41 lnc-PAG1-4 lnc-PAG1-7 lnc-PAG1-5 ZBTB10
GH08J080724 Enhancer 1.3 FANTOM5 Ensembl ENCODE CraniofacialAtlas 5 +157.6 157558 4.3 CREB1 ATF7 ZNF629 ZNF692 JUND POLR2A PATZ1 SP1 ZNF600 ZNF341 ZNF704 piR-57133-588 lnc-ZBTB10-5 lnc-PAG1-7 ZBTB10
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF704 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF704

Top Transcription factor binding sites by QIAGEN in the ZNF704 gene promoter:
  • aMEF-2
  • AP-2gamma
  • c-Myb
  • E2F
  • E2F-1
  • FAC1
  • MEF-2
  • MEF-2A
  • MyoD
  • p53

Genomic Locations for ZNF704 Gene

Genomic Locations for ZNF704 Gene
chr8:80,628,451-80,884,416
(GRCh38/hg38)
Size:
255,966 bases
Orientation:
Minus strand
chr8:81,540,686-81,787,016
(GRCh37/hg19)
Size:
246,331 bases
Orientation:
Minus strand

Genomic View for ZNF704 Gene

Genes around ZNF704 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF704 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF704 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF704 Gene

Proteins for ZNF704 Gene

  • Protein details for ZNF704 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZNC4-ZN704_HUMAN
    Recommended name:
    Zinc finger protein 704
    Protein Accession:
    Q6ZNC4
    Secondary Accessions:
    • B2RNE6
    • B9EGW6

    Protein attributes for ZNF704 Gene

    Size:
    412 amino acids
    Molecular mass:
    45276 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF704 Gene

Post-translational modifications for ZNF704 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF704 Gene

No data available for DME Specific Peptides for ZNF704 Gene

Domains & Families for ZNF704 Gene

Gene Families for ZNF704 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZNF704 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF704 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 704 (ZN704_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6ZNC4

UniProtKB/Swiss-Prot:

ZN704_HUMAN :
  • The CR1 and CR2 motifs mediate sequence-specific DNA binding, and are important for binding to the MYOD1 enhancer.
Domain:
  • The CR1 and CR2 motifs mediate sequence-specific DNA binding, and are important for binding to the MYOD1 enhancer.
genes like me logo Genes that share domains with ZNF704: view

Function for ZNF704 Gene

Molecular function for ZNF704 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor which binds to RE2 sequence elements in the MYOD1 enhancer.

Phenotypes From GWAS Catalog for ZNF704 Gene

Gene Ontology (GO) - Molecular Function for ZNF704 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000987 proximal promoter sequence-specific DNA binding IEA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF704: view
genes like me logo Genes that share phenotypes with ZNF704: view

Animal Models for ZNF704 Gene

MGI Knock Outs for ZNF704:

Animal Model Products

CRISPR Products

miRNA for ZNF704 Gene

miRTarBase miRNAs that target ZNF704

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF704

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZNF704 Gene

Localization for ZNF704 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF704 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF704 gene
Compartment Confidence
nucleus 4

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF704 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF704: view

Pathways & Interactions for ZNF704 Gene

PathCards logo

SuperPathways for ZNF704 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF704: view

Pathways by source for ZNF704 Gene

2 Reactome pathways for ZNF704 Gene

Gene Ontology (GO) - Biological Process for ZNF704 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF704: view

No data available for SIGNOR curated interactions for ZNF704 Gene

Drugs & Compounds for ZNF704 Gene

No Compound Related Data Available

Transcripts for ZNF704 Gene

mRNA/cDNA for ZNF704 Gene

3 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF704

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF704 Gene

No ASD Table

Relevant External Links for ZNF704 Gene

GeneLoc Exon Structure for
ZNF704

Expression for ZNF704 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF704 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF704 Gene

This gene is overexpressed in Heart (61.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF704 Gene



Protein tissue co-expression partners for ZNF704 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF704

SOURCE GeneReport for Unigene cluster for ZNF704 Gene:

Hs.434957

Evidence on tissue expression from TISSUES for ZNF704 Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with ZNF704: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF704 Gene

Orthologs for ZNF704 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF704 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF704 30 31
  • 99.51 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZNF704 30 31
  • 92.23 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ZNF704 30 31
  • 90.21 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Zfp704 30
  • 86.27 (n)
Mouse
(Mus musculus)
Mammalia Zfp704 30 17 31
  • 85.54 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia ZNF704 31
  • 75 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ZNF704 31
  • 58 (a)
OneToOne
Chicken
(Gallus gallus)
Aves ZNF704 30 31
  • 78.73 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ZNF704 31
  • 69 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii znf704 30 31
  • 68.49 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta Glut4EF 31
  • 13 (a)
OneToMany
Species where no ortholog for ZNF704 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ZNF704 Gene

ENSEMBL:
Gene Tree for ZNF704 (if available)
TreeFam:
Gene Tree for ZNF704 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF704: view image

Paralogs for ZNF704 Gene

Paralogs for ZNF704 Gene

(3) SIMAP similar genes for ZNF704 Gene using alignment to 2 proteins:

  • ZN704_HUMAN
  • E5RGL7_HUMAN
genes like me logo Genes that share paralogs with ZNF704: view

Variants for ZNF704 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF704 Gene

SNP ID Clinical significance and condition Chr 08 pos Variation AA Info Type
rs3907424 - p.Ala35Ser

Additional dbSNP identifiers (rs#s) for ZNF704 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF704 Gene

Variant ID Type Subtype PubMed ID
esv2678182 CNV deletion 23128226
esv2737218 CNV deletion 23290073
esv3617784 CNV loss 21293372
esv5734 CNV gain 19470904
nsv1075152 CNV deletion 25765185
nsv1076092 CNV deletion 25765185
nsv1119182 CNV deletion 24896259
nsv1136048 CNV deletion 24896259
nsv1152674 CNV deletion 26484159
nsv476087 CNV novel sequence insertion 20440878
nsv476661 CNV novel sequence insertion 20440878
nsv831366 CNV loss 17160897
nsv951448 CNV deletion 24416366
nsv971672 CNV duplication 23825009
nsv981956 CNV duplication 23825009

Variation tolerance for ZNF704 Gene

Residual Variation Intolerance Score: 33.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.69; 82.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF704 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF704

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF704 Gene

Disorders for ZNF704 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF704 Gene - From: DISEASES

Disorder Aliases PubMed IDs
progesterone-receptor positive breast cancer
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with ZNF704: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF704 Gene

Publications for ZNF704 Gene

  1. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  2. A four-gene transcript score to predict metastatic-lethal progression in men treated for localized prostate cancer: Development and validation studies. (PMID: 31376183) Cheng A … Stanford JL (The Prostate 2019) 3
  3. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  5. Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. (PMID: 28611215) Fei T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2017) 3

Products for ZNF704 Gene

Sources for ZNF704 Gene