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Aliases for ZNF7 Gene

Aliases for ZNF7 Gene

  • Zinc Finger Protein 7 2 3 5
  • Zinc Finger Protein 7 (KOX 4, Clone HF.16) 2 3
  • Zinc Finger Protein HF.16 3 4
  • Zinc Finger Protein KOX4 3 4
  • KOX4 3 4
  • C2-H2 Type Zinc Finger Protein 3
  • Zinc Finger Protein-7 (KOX4) 3
  • Zinc Finger Protein Zfp30 3
  • HF.16 3
  • Zf30 3

External Ids for ZNF7 Gene

Previous GeneCards Identifiers for ZNF7 Gene

  • GC08P143660
  • GC08P146090
  • GC08P145633
  • GC08P146057
  • GC08P146023
  • GC08P146052
  • GC08P141168

Summaries for ZNF7 Gene

GeneCards Summary for ZNF7 Gene

ZNF7 (Zinc Finger Protein 7) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA binding transcription factor activity. An important paralog of this gene is ZNF251.

UniProtKB/Swiss-Prot for ZNF7 Gene

  • May be involved in transcriptional regulation.

Gene Wiki entry for ZNF7 Gene

Additional gene information for ZNF7 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF7 Gene

Genomics for ZNF7 Gene

GeneHancer (GH) Regulatory Elements for ZNF7 Gene

Promoters and enhancers for ZNF7 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I144825 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 567.3 +1.1 1114 6.5 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 ZBTB7B YY1 ZNF7 RPL8 CPSF1 ZNF517 VPS28 ZNF16 COMMD5 ADCK5 SLC52A2 PARP10
GH08I144455 Enhancer 1.3 Ensembl ENCODE 169.8 -371.0 -371018 1.6 HDGF HNRNPUL1 PKNOX1 FOXA2 ARNT ZFP64 SIN3A ZNF2 POLR2B ZNF766 ZNF251 ZNF623 ZNF7 LRRC14 ZNF250 ZNF16 CPSF1 VPS28 ZNF517 ZNF34
GH08I144899 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 77.4 +74.1 74127 3.6 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B IRF4 ZNF250 ZNF7 CPSF1 VPS28 RPL8 ZNF16 ZNF251 SHARPIN GPAA1 PARP10
GH08I144101 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 79.3 -723.6 -723553 4 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF416 ZNF143 ZNF548 SP3 NFYC SHARPIN MAF1 ZNF623 ZNF7 ZNF16 ZNF696 ZNF517 ZNF251 ZNF250 CPSF1
GH08I144506 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 48 -318.5 -318495 4 HDGF PKNOX1 CLOCK ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B IRF4 MFSD3 ZNF7 CPSF1 VPS28 ZNF250 ZNF623 ZNF251 ENSG00000254533 LRRC14 ZNF707
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF7 gene promoter:

Genomic Locations for ZNF7 Gene

Genomic Locations for ZNF7 Gene
20,046 bases
Plus strand

Genomic View for ZNF7 Gene

Genes around ZNF7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF7 Gene

Proteins for ZNF7 Gene

  • Protein details for ZNF7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 7
    Protein Accession:
    Secondary Accessions:
    • B4DT08
    • D3DWN6
    • P17015
    • Q8N8Y4

    Protein attributes for ZNF7 Gene

    686 amino acids
    Molecular mass:
    77887 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF7 Gene


neXtProt entry for ZNF7 Gene

Post-translational modifications for ZNF7 Gene

No Post-translational modifications

No data available for DME Specific Peptides for ZNF7 Gene

Domains & Families for ZNF7 Gene

Gene Families for ZNF7 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF7 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF7: view

Function for ZNF7 Gene

Molecular function for ZNF7 Gene

GENATLAS Biochemistry:
zinc finger protein 7 (clone ZFP.16,KOX4),Kruppel-like
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF7 Gene

Gene Ontology (GO) - Molecular Function for ZNF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding TAS,IEA --
GO:0003700 DNA binding transcription factor activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF7: view
genes like me logo Genes that share phenotypes with ZNF7: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF7 Gene

Localization for ZNF7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF7 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF7 gene
Compartment Confidence
nucleus 5
mitochondrion 3
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ZNF7: view

Pathways & Interactions for ZNF7 Gene

No Data Available

Interacting Proteins for ZNF7 Gene

Selected Interacting proteins: P17097-ZNF7_HUMAN for ZNF7 Gene via IID

Gene Ontology (GO) - Biological Process for ZNF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA,IEA --
GO:0007275 multicellular organism development TAS 2106481
genes like me logo Genes that share ontologies with ZNF7: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF7 Gene

Drugs & Compounds for ZNF7 Gene

No Compound Related Data Available

Transcripts for ZNF7 Gene

Unigene Clusters for ZNF7 Gene

Zinc finger protein 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF7 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b
SP1: - - -
SP2: - - - -
SP3: - - -
SP4: - -

Relevant External Links for ZNF7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF7 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF7 Gene:


SOURCE GeneReport for Unigene cluster for ZNF7 Gene:


mRNA Expression by UniProt/SwissProt for ZNF7 Gene:

Tissue specificity: Ubiquitously present in many human cell lines of different embryological derivation.

Evidence on tissue expression from TISSUES for ZNF7 Gene

  • Nervous system(2.9)
genes like me logo Genes that share expression patterns with ZNF7: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF7 Gene

Orthologs for ZNF7 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF7 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF7 33 34
  • 99.09 (n)
(Canis familiaris)
Mammalia ZNF7 33 34
  • 83.5 (n)
(Rattus norvegicus)
Mammalia LOC100910444 33
  • 81.41 (n)
(Bos Taurus)
Mammalia ZNF7 33 34
  • 81 (n)
(Mus musculus)
Mammalia Zfp7 33 16 34
  • 76.73 (n)
(Monodelphis domestica)
Mammalia ZNF7 34
  • 55 (a)
Species where no ortholog for ZNF7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF7 Gene

Gene Tree for ZNF7 (if available)
Gene Tree for ZNF7 (if available)

Paralogs for ZNF7 Gene

(548) SIMAP similar genes for ZNF7 Gene using alignment to 10 proteins:

genes like me logo Genes that share paralogs with ZNF7: view

Variants for ZNF7 Gene

Sequence variations from dbSNP and Humsavar for ZNF7 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000025187 -- 144,839,454(+) G/A intron_variant
rs1000078481 -- 144,839,663(+) G/A intron_variant
rs1000119752 -- 144,838,619(+) G/C intron_variant
rs1000231786 -- 144,834,837(+) T/C intron_variant
rs1000338509 -- 144,844,275(+) C/A genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF7 Gene

Variant ID Type Subtype PubMed ID
nsv612969 CNV loss 21841781
nsv522459 CNV loss 19592680
nsv469809 CNV loss 16826518
nsv1031737 CNV gain 25217958
nsv1023752 CNV gain 25217958
esv3619142 CNV loss 21293372
esv3544406 CNV deletion 23714750
esv3269274 CNV deletion 24192839
esv2674326 CNV deletion 23128226
esv2506190 CNV deletion 19546169
dgv3937n106 CNV deletion 24896259

Variation tolerance for ZNF7 Gene

Residual Variation Intolerance Score: 5.52% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.31; 26.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF7 Gene

Disorders for ZNF7 Gene

Additional Disease Information for ZNF7

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ZNF7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF7 Gene

Publications for ZNF7 Gene

  1. cDNA isolation, expression analysis, and chromosomal localization of two human zinc finger genes. (PMID: 2106481) Lania L … Pelicci PG (Genomics 1990) 2 3 4 58
  2. Genome-wide linkage scans for type 2 diabetes mellitus in four ethnically diverse populations-significant evidence for linkage on chromosome 4q in African Americans: the Family Investigation of Nephropathy and Diabetes Research Group. (PMID: 19795399) Malhotra A … Family Investigation of Nephropathy and Diabetes Research Group (Diabetes/metabolism research and reviews 2009) 3 44 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Characterization and mapping of human genes encoding zinc finger proteins. (PMID: 1946370) Bray P … Dawid IB (Proceedings of the National Academy of Sciences of the United States of America 1991) 2 3 58

Products for ZNF7 Gene

Sources for ZNF7 Gene

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