Aliases for ZNF7 Gene

Aliases for ZNF7 Gene

  • Zinc Finger Protein 7 2 3 4 5
  • KOX4 2 3 4
  • Zinc Finger Protein 7 (KOX 4, Clone HF.16) 2 3
  • Zinc Finger Protein HF.16 3 4
  • Zinc Finger Protein KOX4 3 4
  • HF.16 2 3
  • C2-H2 Type Zinc Finger Protein 3
  • Zinc Finger Protein-7 (KOX4) 3
  • Zinc Finger Protein Zfp30 3
  • Zf30 3
  • ZNF7 5

External Ids for ZNF7 Gene

Previous GeneCards Identifiers for ZNF7 Gene

  • GC08P143660
  • GC08P146090
  • GC08P145633
  • GC08P146057
  • GC08P146023
  • GC08P146052
  • GC08P141168
  • GC08P144842

Summaries for ZNF7 Gene

GeneCards Summary for ZNF7 Gene

ZNF7 (Zinc Finger Protein 7) is a Protein Coding gene. Diseases associated with ZNF7 include Mixed Sleep Apnea. Among its related pathways are Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZNF585B.

UniProtKB/Swiss-Prot Summary for ZNF7 Gene

Gene Wiki entry for ZNF7 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF7 Gene

Genomics for ZNF7 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF7 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF7 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF7

Top Transcription factor binding sites by QIAGEN in the ZNF7 gene promoter:
  • AREB6
  • C/EBPalpha
  • Elk-1
  • GATA-1
  • Ik-2
  • NRSF form 1
  • NRSF form 2
  • p300
  • Pax-6
  • STAT5A

Genomic Locations for ZNF7 Gene

Genomic Locations for ZNF7 Gene
chr8:144,827,464-144,848,070
(GRCh38/hg38)
Size:
20,607 bases
Orientation:
Plus strand
chr8:146,052,849-146,072,894
(GRCh37/hg19)
Size:
20,046 bases
Orientation:
Plus strand

Genomic View for ZNF7 Gene

Genes around ZNF7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF7 Gene

Proteins for ZNF7 Gene

  • Protein details for ZNF7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17097-ZNF7_HUMAN
    Recommended name:
    Zinc finger protein 7
    Protein Accession:
    P17097
    Secondary Accessions:
    • B4DT08
    • D3DWN6
    • P17015
    • Q8N8Y4

    Protein attributes for ZNF7 Gene

    Size:
    686 amino acids
    Molecular mass:
    77887 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF7 Gene

Post-translational modifications for ZNF7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF7 Gene

Domains & Families for ZNF7 Gene

Gene Families for ZNF7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF7 Gene

InterPro:
Blocks:
  • C2H2-type zinc finger signature
  • KRAB box
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF7 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ54719, highly similar to Zinc finger protein 7 (B4DT08_HUMAN)
  • cDNA FLJ38706 fis, clone KIDNE2002795, moderately similar to ZINC FINGER PROTEIN 7 (Q8N8Y4_HUMAN)
  • Zinc finger protein zfp30 (Q92970_HUMAN)
  • Zinc finger protein KOX4 (ZNF7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P17097

UniProtKB/Swiss-Prot:

ZNF7_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF7: view

Function for ZNF7 Gene

Molecular function for ZNF7 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
GENATLAS Biochemistry:
zinc finger protein 7 (clone ZFP.16,KOX4),Kruppel-like

Phenotypes From GWAS Catalog for ZNF7 Gene

Gene Ontology (GO) - Molecular Function for ZNF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding TAS,IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF7: view
genes like me logo Genes that share phenotypes with ZNF7: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF7

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF7 Gene

Localization for ZNF7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF7 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF7 gene
Compartment Confidence
nucleus 4
mitochondrion 2
cytosol 2
cytoskeleton 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ZNF7: view

Pathways & Interactions for ZNF7 Gene

PathCards logo

SuperPathways for ZNF7 Gene

genes like me logo Genes that share pathways with ZNF7: view

Pathways by source for ZNF7 Gene

1 KEGG pathway for ZNF7 Gene

Gene Ontology (GO) - Biological Process for ZNF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007275 multicellular organism development TAS 2106481
genes like me logo Genes that share ontologies with ZNF7: view

No data available for SIGNOR curated interactions for ZNF7 Gene

Drugs & Compounds for ZNF7 Gene

No Compound Related Data Available

Transcripts for ZNF7 Gene

mRNA/cDNA for ZNF7 Gene

10 REFSEQ mRNAs :
23 NCBI additional mRNA sequence :
18 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF7

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF7 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b
SP1: - - -
SP2: - - - -
SP3: - - -
SP4: - -

Relevant External Links for ZNF7 Gene

GeneLoc Exon Structure for
ZNF7

Expression for ZNF7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF7 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF7

SOURCE GeneReport for Unigene cluster for ZNF7 Gene:

Hs.493218

mRNA Expression by UniProt/SwissProt for ZNF7 Gene:

P17097-ZNF7_HUMAN
Tissue specificity: Ubiquitously present in many human cell lines of different embryological derivation.

Evidence on tissue expression from TISSUES for ZNF7 Gene

  • Nervous system(3.3)
  • Heart(2)
genes like me logo Genes that share expression patterns with ZNF7: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF7 Gene

Orthologs for ZNF7 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF7 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF7 30 31
  • 99.09 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZNF7 30 31
  • 83.5 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia LOC100910444 30
  • 81.41 (n)
Cow
(Bos Taurus)
Mammalia ZNF7 30 31
  • 81 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Zfp7 30 17 31
  • 76.73 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ZNF7 31
  • 55 (a)
OneToOne
Species where no ortholog for ZNF7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF7 Gene

ENSEMBL:
Gene Tree for ZNF7 (if available)
TreeFam:
Gene Tree for ZNF7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF7: view image

Paralogs for ZNF7 Gene

Paralogs for ZNF7 Gene

(548) SIMAP similar genes for ZNF7 Gene using alignment to 10 proteins:

  • ZNF7_HUMAN
  • B4DT08_HUMAN
  • E9PIH3_HUMAN
  • E9PJX9_HUMAN
  • E9PJZ3_HUMAN
  • E9PM16_HUMAN
  • E9PPK0_HUMAN
  • E9PQI2_HUMAN
  • F5H290_HUMAN
  • Q8N8Y4_HUMAN
genes like me logo Genes that share paralogs with ZNF7: view

Variants for ZNF7 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF7 Gene

SNP ID Clinical significance and condition Chr 08 pos Variation AA Info Type
rs1735169 - p.Gly188Arg
rs1735170 - p.Leu596Phe
rs2228180 - p.Ser347Leu

Additional dbSNP identifiers (rs#s) for ZNF7 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF7 Gene

Variant ID Type Subtype PubMed ID
dgv3937n106 CNV deletion 24896259
esv2506190 CNV deletion 19546169
esv2674326 CNV deletion 23128226
esv3269274 CNV deletion 24192839
esv3544406 CNV deletion 23714750
esv3619142 CNV loss 21293372
nsv1023752 CNV gain 25217958
nsv1031737 CNV gain 25217958
nsv469809 CNV loss 16826518
nsv522459 CNV loss 19592680
nsv612969 CNV loss 21841781

Variation tolerance for ZNF7 Gene

Residual Variation Intolerance Score: 5.52% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.31; 26.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF7

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF7 Gene

Disorders for ZNF7 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF7 Gene - From: DISEASES

Disorder Aliases PubMed IDs
mixed sleep apnea
  • complex sleep apnea
- elite association - COSMIC cancer census association via MalaCards
Search ZNF7 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ZNF7

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with ZNF7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF7 Gene

Publications for ZNF7 Gene

  1. cDNA isolation, expression analysis, and chromosomal localization of two human zinc finger genes. (PMID: 2106481) Lania L … Pelicci PG (Genomics 1990) 2 3 4
  2. Genome-wide linkage scans for type 2 diabetes mellitus in four ethnically diverse populations-significant evidence for linkage on chromosome 4q in African Americans: the Family Investigation of Nephropathy and Diabetes Research Group. (PMID: 19795399) Malhotra A … Family Investigation of Nephropathy and Diabetes Research Group (Diabetes/metabolism research and reviews 2009) 3 41
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. Characterization and mapping of human genes encoding zinc finger proteins. (PMID: 1946370) Bray P … Dawid IB (Proceedings of the National Academy of Sciences of the United States of America 1991) 2 3

Products for ZNF7 Gene

Sources for ZNF7 Gene