Aliases for ZNF699 Gene

Aliases for ZNF699 Gene

  • Zinc Finger Protein 699 2 3 4 5
  • Hangover Homolog 3 4
  • Hang 2 3
  • Hangover, Drosophila, Homolog Of 3
  • FLJ38144 2
  • ZNF699 5

External Ids for ZNF699 Gene

Previous GeneCards Identifiers for ZNF699 Gene

  • GC19M009269
  • GC19M009404
  • GC19M008987

Summaries for ZNF699 Gene

GeneCards Summary for ZNF699 Gene

ZNF699 (Zinc Finger Protein 699) is a Protein Coding gene. Diseases associated with ZNF699 include Alcohol Dependence. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZNF546.

UniProtKB/Swiss-Prot Summary for ZNF699 Gene

Additional gene information for ZNF699 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF699 Gene

Genomics for ZNF699 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF699 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J009305 Promoter/Enhancer 1.6 Ensembl ENCODE CraniofacialAtlas 600.7 +1.8 1828 5.6 TEAD4 PRDM10 IKZF1 KDM1A POLR2A JUND PRDM1 PHF21A RBFOX2 PKNOX1 ZNF699 hsa-miR-5095-262 lnc-ZNF699-1 ZNF266 ZNF426 ZNF561 ENSG00000267510 OR7E24
GH19J010100 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 93.7 -794.5 -794549 8.3 SP1 CREB1 GATAD2A HNRNPL ZNF629 TFE3 ZNF512 RFX1 SIX5 NFKBIZ PPAN ANGPTL6 PPAN-P2RY11 ILF3 ZNF699 LOC100419831 ZNF317 KRI1 FBXL12 ZNF559
GH19J009314 Promoter 0.3 EPDnew 600.7 -4.4 -4448 0.1 ZNF699 piR-39891-034 lnc-ZNF699-1 ZNF559
GH19J010110 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 75.9 -803.2 -803190 5.2 SP1 HNRNPL CTCF ZBTB33 PRDM10 ZNF692 POLR2A BACH1 STAT3 ZNF143 P2RY11 piR-54092 ILF3 ZNF699 ZNF266 ZNF559 ZNF317 DNMT1 LOC100419831 PPAN
GH19J008524 Promoter/Enhancer 2 Ensembl ENCODE CraniofacialAtlas dbSUPER 54.8 +783.5 783479 2.9 CREB1 GATAD2A CTCF PRDM10 ZNF629 NFKBIZ ZNF692 DDX20 PRDM1 RBFOX2 lnc-ZNF414-2 HNRNPM ELAVL1 ZNF558 ZNF699 ZNF317 ZNF266 ZNF559 XAB2 ZNF414
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF699 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF699

Top Transcription factor binding sites by QIAGEN in the ZNF699 gene promoter:
  • C/EBPalpha
  • Ik-1
  • Ik-2

Genomic Locations for ZNF699 Gene

Genomic Locations for ZNF699 Gene
18,699 bases
Minus strand
15,564 bases
Minus strand

Genomic View for ZNF699 Gene

Genes around ZNF699 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF699 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF699 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF699 Gene

Proteins for ZNF699 Gene

  • Protein details for ZNF699 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 699
    Protein Accession:
    Secondary Accessions:
    • Q8N9A1

    Protein attributes for ZNF699 Gene

    642 amino acids
    Molecular mass:
    73956 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC04552.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF699 Gene

Post-translational modifications for ZNF699 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF699 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF699 Gene

Domains & Families for ZNF699 Gene

Gene Families for ZNF699 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF699 Gene

  • C2H2-type zinc finger signature
  • KRAB box

Suggested Antigen Peptide Sequences for ZNF699 Gene

GenScript: Design optimal peptide antigens:
  • Hangover homolog (ZN699_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF699: view

Function for ZNF699 Gene

Molecular function for ZNF699 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF699 Gene

Gene Ontology (GO) - Molecular Function for ZNF699 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF699: view
genes like me logo Genes that share phenotypes with ZNF699: view

Animal Model Products

CRISPR Products

miRNA for ZNF699 Gene

miRTarBase miRNAs that target ZNF699

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF699

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF699 Gene

Localization for ZNF699 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF699 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF699 gene
Compartment Confidence
nucleus 4
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endosome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for ZNF699 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF699: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF699 Gene

Pathways & Interactions for ZNF699 Gene

genes like me logo Genes that share pathways with ZNF699: view

Pathways by source for ZNF699 Gene

2 Reactome pathways for ZNF699 Gene
1 KEGG pathway for ZNF699 Gene

Gene Ontology (GO) - Biological Process for ZNF699 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF699: view

No data available for SIGNOR curated interactions for ZNF699 Gene

Drugs & Compounds for ZNF699 Gene

No Compound Related Data Available

Transcripts for ZNF699 Gene

mRNA/cDNA for ZNF699 Gene

4 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF699

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF699 Gene

No ASD Table

Relevant External Links for ZNF699 Gene

GeneLoc Exon Structure for

Expression for ZNF699 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF699 Gene

Protein differential expression in normal tissues from HIPED for ZNF699 Gene

This gene is overexpressed in Islet of Langerhans (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF699 Gene

Protein tissue co-expression partners for ZNF699 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF699

SOURCE GeneReport for Unigene cluster for ZNF699 Gene:


Evidence on tissue expression from TISSUES for ZNF699 Gene

  • Nervous system(2.1)
genes like me logo Genes that share expression patterns with ZNF699: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF699 Gene

Orthologs for ZNF699 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF699 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia ZNF699 30
  • 89.97 (n)
(Bos Taurus)
Mammalia ZNF699 30 31
  • 84.15 (n)
(Mus musculus)
Mammalia Gm2004 31
  • 53 (a)
Gm14419 31
  • 53 (a)
Gm10324 31
  • 51 (a)
Zfp433 31
  • 49 (a)
5430403G16Rik 31
  • 43 (a)
(Monodelphis domestica)
Mammalia -- 31
  • 44 (a)
Species where no ortholog for ZNF699 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF699 Gene

Gene Tree for ZNF699 (if available)
Gene Tree for ZNF699 (if available)
Evolutionary constrained regions (ECRs) for ZNF699: view image

Paralogs for ZNF699 Gene

Paralogs for ZNF699 Gene

(439) SIMAP similar genes for ZNF699 Gene using alignment to 1 proteins:

  • ZN699_HUMAN
genes like me logo Genes that share paralogs with ZNF699: view

Variants for ZNF699 Gene

Additional dbSNP identifiers (rs#s) for ZNF699 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF699 Gene

Variant ID Type Subtype PubMed ID
esv3643632 CNV gain 21293372
nsv521091 CNV loss 19592680
nsv523472 CNV loss 19592680

Variation tolerance for ZNF699 Gene

Residual Variation Intolerance Score: 13.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.01; 20.67% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF699 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF699 Gene

Disorders for ZNF699 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF699 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
alcohol dependence
  • alcoholism
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF699

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with ZNF699: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF699 Gene

Publications for ZNF699 Gene

  1. Alcohol dependence is associated with the ZNF699 gene, a human locus related to Drosophila hangover, in the Irish Affected Sib Pair Study of Alcohol Dependence (IASPSAD) sample. (PMID: 16940975) Riley BP … Prescott CA (Molecular psychiatry 2006) 2 3 41
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3

Products for ZNF699 Gene

Sources for ZNF699 Gene