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Aliases for ZNF697 Gene

Aliases for ZNF697 Gene

  • Zinc Finger Protein 697 2 3 5

External Ids for ZNF697 Gene

Previous GeneCards Identifiers for ZNF697 Gene

  • GC01M119877
  • GC01M119963
  • GC01M120162
  • GC01M118020

Summaries for ZNF697 Gene

GeneCards Summary for ZNF697 Gene

ZNF697 (Zinc Finger Protein 697) is a Protein Coding gene. Among its related pathways are Gene Expression.

UniProtKB/Swiss-Prot for ZNF697 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF697 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF697 Gene

Genomics for ZNF697 Gene

GeneHancer (GH) Regulatory Elements for ZNF697 Gene

Promoters and enhancers for ZNF697 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I119645 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 562.3 +0.8 834 3.9 HDGF ARNT ARID4B SIN3A DMAP1 YY1 POLR2B ZNF766 ZNF143 FOS ZNF697 PHGDH GC01M119620
GH01I119711 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.7 -64.9 -64939 3.6 PKNOX1 SMAD1 SIN3A FEZF1 DMAP1 ZNF2 POLR2B ZNF766 ZNF213 KLF13 PHGDH LOC105378937 ADAM30 ZNF697 LOC105378936
GH01I119672 Enhancer 1.1 Ensembl ENCODE 21.3 -26.3 -26272 3.6 FOXA2 ARID4B RAD21 RFX5 YY1 ZNF335 ZNF766 ZNF366 ZNF143 FOS ZNF697 PHGDH HSD3BP5 LOC105378937
GH01I119723 Enhancer 0.9 ENCODE 21 -76.9 -76882 2.3 FOXA2 MLX ARID4B ETS1 ATF7 SP5 MIER2 KAT8 NFIL3 SSRP1 PHGDH ZNF697 HMGCS2 LINC00622 LOC105378936 LOC105378937
GH01I119765 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 8.9 -119.6 -119637 4.5 ELF3 FOXA2 NFIB ARID4B ZNF195 THRB RAD21 RARA YY1 SCRT2 HMGCS2 HSD3BP5 LOC101929147 ADAM30 REG4 ZNF697 PIR35373 GC01P119741
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF697 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF697 gene promoter:

Genomic Locations for ZNF697 Gene

Genomic Locations for ZNF697 Gene
28,794 bases
Minus strand

Genomic View for ZNF697 Gene

Genes around ZNF697 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF697 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF697 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF697 Gene

Proteins for ZNF697 Gene

  • Protein details for ZNF697 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 697
    Protein Accession:
    Secondary Accessions:
    • Q96IT2

    Protein attributes for ZNF697 Gene

    545 amino acids
    Molecular mass:
    60461 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAI21950.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for ZNF697 Gene

Post-translational modifications for ZNF697 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF697 Gene

No data available for DME Specific Peptides for ZNF697 Gene

Domains & Families for ZNF697 Gene

Gene Families for ZNF697 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF697 Gene


Suggested Antigen Peptide Sequences for ZNF697 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF697: view

Function for ZNF697 Gene

Molecular function for ZNF697 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF697 Gene

Gene Ontology (GO) - Molecular Function for ZNF697 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF697: view

Phenotypes for ZNF697 Gene

GenomeRNAi human phenotypes for ZNF697:
genes like me logo Genes that share phenotypes with ZNF697: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF697 Gene

Localization for ZNF697 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF697 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF697 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF697 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF697: view

Pathways & Interactions for ZNF697 Gene

SuperPathways for ZNF697 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF697: view

Pathways by source for ZNF697 Gene

2 Reactome pathways for ZNF697 Gene

Gene Ontology (GO) - Biological Process for ZNF697 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with ZNF697: view

No data available for SIGNOR curated interactions for ZNF697 Gene

Drugs & Compounds for ZNF697 Gene

(2) Drugs for ZNF697 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Interferon beta-1a Approved, Investigational Pharma 206
Interferon beta-1b Approved Pharma 87
genes like me logo Genes that share compounds with ZNF697: view

Transcripts for ZNF697 Gene

mRNA/cDNA for ZNF697 Gene

(4) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF697 Gene

Zinc finger protein 697:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF697 Gene

No ASD Table

Relevant External Links for ZNF697 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF697 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF697 Gene

Protein differential expression in normal tissues from HIPED for ZNF697 Gene

This gene is overexpressed in Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF697 Gene

Protein tissue co-expression partners for ZNF697 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF697 Gene:


SOURCE GeneReport for Unigene cluster for ZNF697 Gene:


Evidence on tissue expression from TISSUES for ZNF697 Gene

  • Skin(4.2)
genes like me logo Genes that share expression patterns with ZNF697: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF697 Gene

Orthologs for ZNF697 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF697 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF697 33 34
  • 99.63 (n)
(Bos Taurus)
Mammalia ZNF697 33 34
  • 91.16 (n)
(Canis familiaris)
Mammalia ZNF697 33 34
  • 89.73 (n)
(Mus musculus)
Mammalia Zfp697 33 16 34
  • 87.87 (n)
(Rattus norvegicus)
Mammalia Zfp697 33
  • 87.38 (n)
(Ornithorhynchus anatinus)
Mammalia ZNF697 34
  • 83 (a)
(Monodelphis domestica)
Mammalia ZNF697 34
  • 63 (a)
(Danio rerio)
Actinopterygii ZNF697 34
  • 38 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 29 (a)
Species where no ortholog for ZNF697 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF697 Gene

Gene Tree for ZNF697 (if available)
Gene Tree for ZNF697 (if available)

Paralogs for ZNF697 Gene

(652) SIMAP similar genes for ZNF697 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF697: view

No data available for Paralogs for ZNF697 Gene

Variants for ZNF697 Gene

Sequence variations from dbSNP and Humsavar for ZNF697 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000017137 -- 119,628,067(-) G/A 5_prime_UTR_variant, intron_variant
rs1000071970 -- 119,628,266(-) T/C 5_prime_UTR_variant, intron_variant
rs1000209155 -- 119,630,376(-) C/T 5_prime_UTR_variant, intron_variant
rs1000234723 -- 119,642,312(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000252699 -- 119,622,602(-) G/T 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF697 Gene

Variant ID Type Subtype PubMed ID
dgv524n54 CNV gain 21841781
dgv525n54 CNV loss 21841781
esv2671484 CNV deletion 23128226
esv2758964 CNV gain+loss 17122850
nsv463317 CNV gain 19166990
nsv508034 OTHER sequence alteration 20534489
nsv524681 CNV gain 19592680
nsv547621 CNV loss 21841781

Variation tolerance for ZNF697 Gene

Gene Damage Index Score: 2.32; 41.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF697 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF697 Gene

Disorders for ZNF697 Gene

Additional Disease Information for ZNF697

No disorders were found for ZNF697 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF697 Gene

Publications for ZNF697 Gene

  1. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58
  2. Mutations of the aminoacyl-tRNA-synthetases SARS and WARS2 are implicated in the etiology of autosomal recessive intellectual disability. (PMID: 28236339) Musante L … Kuss AW (Human mutation 2017) 4 58
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  4. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H … Vidal M (Nature methods 2011) 3 58
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 4 58

Products for ZNF697 Gene

Sources for ZNF697 Gene

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