Aliases for ZNF697 Gene

Aliases for ZNF697 Gene

  • Zinc Finger Protein 697 2 3 4 5
  • MGC45731 2
  • ZNF697 5

External Ids for ZNF697 Gene

Previous GeneCards Identifiers for ZNF697 Gene

  • GC01M119877
  • GC01M119963
  • GC01M120162
  • GC01M118020

Summaries for ZNF697 Gene

GeneCards Summary for ZNF697 Gene

ZNF697 (Zinc Finger Protein 697) is a Protein Coding gene. Diseases associated with ZNF697 include Cholestasis-Lymphedema Syndrome. Among its related pathways are Gene Expression. An important paralog of this gene is ZNF774.

UniProtKB/Swiss-Prot Summary for ZNF697 Gene

Additional gene information for ZNF697 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF697 Gene

Genomics for ZNF697 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF697 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J119645 Promoter/Enhancer 2 Ensembl ENCODE CraniofacialAtlas dbSUPER 612.2 +1.0 966 4.2 RNF2 CTCF HNRNPL PRDM10 ZNF629 TFE3 SIX5 LEF1 SOX13 IKZF1 ZNF697 PHGDH lnc-ZNF697-2 HSD3B1
GH01J119672 Promoter/Enhancer 1.3 ENCODE CraniofacialAtlas 21.4 -26.2 -26176 3.6 CREB1 CTCF ZNF692 JUND REST RAD21 TRIM22 ZNF600 ZNF341 SP2 ZNF697 PHGDH HSD3BP5 piR-55194-023 HMGCS2
GH01J119711 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.7 -65.1 -65084 4.1 HNRNPL GATAD2A PRDM10 ZNF629 REST TFE3 ZNF692 JUND ZSCAN4 RBFOX2 PHGDH LOC105378937 ADAM30 ZNF697 LOC105378936 HMGCS2
GH01J119723 Enhancer 1.1 Ensembl ENCODE 21 -76.9 -76881 2.5 GATAD2A ATF7 SOX13 NFKBIZ RCOR2 PRDM1 PHF21A ZSCAN4 RXRB IRF2 PHGDH ZNF697 HMGCS2 LINC00622 LOC105378936 LOC105378937
GH01J119613 Enhancer 0.9 Ensembl ENCODE 20.8 +33.7 33665 2 CTCF ZNF143 ZNF24 REST RAD21 IRF2 TRIM22 ZNF600 KLF9 HMBOX1 ZNF697 PHGDH ADAM30 lnc-ZNF697-2 lnc-ZNF697-3 HSD3B1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF697 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF697

Top Transcription factor binding sites by QIAGEN in the ZNF697 gene promoter:
  • GR
  • GR-alpha
  • GR-beta
  • MRF-2
  • Pax-4a
  • PPAR-gamma1
  • PPAR-gamma2
  • SRY
  • STAT3
  • STAT5A

Genomic Locations for ZNF697 Gene

Genomic Locations for ZNF697 Gene
28,890 bases
Minus strand
28,397 bases
Minus strand

Genomic View for ZNF697 Gene

Genes around ZNF697 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF697 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF697 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF697 Gene

Proteins for ZNF697 Gene

  • Protein details for ZNF697 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 697
    Protein Accession:
    Secondary Accessions:
    • Q96IT2

    Protein attributes for ZNF697 Gene

    545 amino acids
    Molecular mass:
    60461 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF697 Gene

Post-translational modifications for ZNF697 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF697 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF697 Gene

Domains & Families for ZNF697 Gene

Gene Families for ZNF697 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF697 Gene


Suggested Antigen Peptide Sequences for ZNF697 Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ92048 (Q8N508_HUMAN)
  • Zinc finger protein 697 (ZN697_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF697: view

Function for ZNF697 Gene

Molecular function for ZNF697 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF697 Gene

Gene Ontology (GO) - Molecular Function for ZNF697 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF697: view

Phenotypes for ZNF697 Gene

genes like me logo Genes that share phenotypes with ZNF697: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF697

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF697 Gene

Localization for ZNF697 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF697 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF697 gene
Compartment Confidence
nucleus 4
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF697 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF697: view

Pathways & Interactions for ZNF697 Gene

PathCards logo

SuperPathways for ZNF697 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF697: view

Pathways by source for ZNF697 Gene

2 Reactome pathways for ZNF697 Gene

Interacting Proteins for ZNF697 Gene

Gene Ontology (GO) - Biological Process for ZNF697 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with ZNF697: view

No data available for SIGNOR curated interactions for ZNF697 Gene

Drugs & Compounds for ZNF697 Gene

(2) Drugs for ZNF697 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Interferon beta-1a Approved, Investigational Pharma 221
Interferon beta-1b Approved Pharma 95
genes like me logo Genes that share compounds with ZNF697: view

Transcripts for ZNF697 Gene

mRNA/cDNA for ZNF697 Gene

5 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF697

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF697 Gene

No ASD Table

Relevant External Links for ZNF697 Gene

GeneLoc Exon Structure for

Expression for ZNF697 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF697 Gene

Protein differential expression in normal tissues from HIPED for ZNF697 Gene

This gene is overexpressed in Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF697 Gene

Protein tissue co-expression partners for ZNF697 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF697

SOURCE GeneReport for Unigene cluster for ZNF697 Gene:


Evidence on tissue expression from TISSUES for ZNF697 Gene

  • Skin(4.2)
genes like me logo Genes that share expression patterns with ZNF697: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF697 Gene

Orthologs for ZNF697 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF697 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF697 30 31
  • 99.63 (n)
(Bos Taurus)
Mammalia ZNF697 30 31
  • 91.16 (n)
(Canis familiaris)
Mammalia ZNF697 30 31
  • 89.73 (n)
(Mus musculus)
Mammalia Zfp697 30 17 31
  • 87.87 (n)
(Rattus norvegicus)
Mammalia Zfp697 30
  • 87.38 (n)
(Ornithorhynchus anatinus)
Mammalia ZNF697 31
  • 83 (a)
(Monodelphis domestica)
Mammalia ZNF697 31
  • 63 (a)
(Danio rerio)
Actinopterygii ZNF697 31
  • 38 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 29 (a)
Species where no ortholog for ZNF697 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ZNF697 Gene

Gene Tree for ZNF697 (if available)
Gene Tree for ZNF697 (if available)
Evolutionary constrained regions (ECRs) for ZNF697: view image

Paralogs for ZNF697 Gene

(652) SIMAP similar genes for ZNF697 Gene using alignment to 2 proteins:

  • ZN697_HUMAN
  • Q8N508_HUMAN
genes like me logo Genes that share paralogs with ZNF697: view

Variants for ZNF697 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF697 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
VAR_078436 - p.Pro158Thr

Additional dbSNP identifiers (rs#s) for ZNF697 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF697 Gene

Variant ID Type Subtype PubMed ID
dgv524n54 CNV gain 21841781
dgv525n54 CNV loss 21841781
esv2671484 CNV deletion 23128226
esv2758964 CNV gain+loss 17122850
nsv463317 CNV gain 19166990
nsv508034 OTHER sequence alteration 20534489
nsv524681 CNV gain 19592680
nsv547621 CNV loss 21841781

Variation tolerance for ZNF697 Gene

Gene Damage Index Score: 2.32; 41.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF697 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF697 Gene

Disorders for ZNF697 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF697 Gene - From: DISEASES

Disorder Aliases PubMed IDs
cholestasis-lymphedema syndrome
  • chls
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with ZNF697: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF697 Gene

Publications for ZNF697 Gene

  1. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3
  2. The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery. (PMID: 29180619) Kumar R … Vertegaal ACO (Nature communications 2017) 3
  3. Mutations of the aminoacyl-tRNA-synthetases SARS and WARS2 are implicated in the etiology of autosomal recessive intellectual disability. (PMID: 28236339) Musante L … Kuss AW (Human mutation 2017) 4
  4. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3

Products for ZNF697 Gene

Sources for ZNF697 Gene