Aliases for ZNF696 Gene

Aliases for ZNF696 Gene

  • Zinc Finger Protein 696 2 3 4 5
  • FLJ14129 2
  • ZNF696 5

External Ids for ZNF696 Gene

Previous GeneCards Identifiers for ZNF696 Gene

  • GC08P144445
  • GC08P144446
  • GC08P144373
  • GC08P139627

Summaries for ZNF696 Gene

GeneCards Summary for ZNF696 Gene

ZNF696 (Zinc Finger Protein 696) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZNF135.

UniProtKB/Swiss-Prot Summary for ZNF696 Gene

Additional gene information for ZNF696 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF696 Gene

Genomics for ZNF696 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF696 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J143289 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 250.7 +1.3 1325 4 CHD2 TBP MXD4 NR2C1 MNT DEK IKZF1 SMAD5 ETS1 IRF2 ENSG00000272172 HSALNG0069269 HSALNG0069271 ZNF696 MINCR ZNF623 LINC02878 SHARPIN MAF1 JRK
GH08J144101 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 35.3 +814.4 814391 4.3 CHD2 TBP ZBTB10 SP1 MXD4 SIX5 NR2C1 DEK IKZF1 SMAD5 MAF1 SHARPIN ZNF623 ZNF7 ZNF250 ZNF251 ZNF16 LRRC14 VPS28 ZNF696
GH08J143595 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 31.6 +308.3 308256 5.1 TBP ZBTB10 SP1 MXD4 SIX5 NR2C1 MNT SMAD5 HES1 ZFP64 TIGD5 EEF1D lnc-NAPRT-3 piR-51576 ZC3H3 CPSF1 VPS28 NAPRT JRK ZNF623
GH08J143669 Enhancer 0.9 Ensembl 42.3 +379.8 379755 0.7 ARID3A ZNF217 IKZF1 SIX4 ZBTB7B ZNF521 NBN TRIM25 KLF7 NONO CPSF1 ZNF623 VPS28 JRK ZNF696 ENSG00000255182 ZNF707 ADCK5 ZFP41 MINCR
GH08J144073 Promoter/Enhancer 1.5 FANTOM5 Ensembl ENCODE 21 +784.7 784714 1.2 TBP MNT IKZF1 SMAD5 ELF1 ARNT ZNF395 VEZF1 GABPA TAF9B WDR97 ZNF251 ZNF696 ZNF252P ENSG00000254533 TSSK5P SPATC1 ENSG00000255085 CYC1 MAF1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF696 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF696

Top Transcription factor binding sites by QIAGEN in the ZNF696 gene promoter:
  • AP-4
  • Bach2
  • NF-E2
  • NF-E2 p45

Genomic Locations for ZNF696 Gene

Latest Assembly
10,277 bases
Plus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
8,536 bases
Plus strand

(GRCh37/hg19 by Ensembl)
8,386 bases
Plus strand

Genomic View for ZNF696 Gene

Genes around ZNF696 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF696 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF696 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF696 Gene

Proteins for ZNF696 Gene

  • Protein details for ZNF696 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 696
    Protein Accession:
    Secondary Accessions:
    • A0AVE2

    Protein attributes for ZNF696 Gene

    374 amino acids
    Molecular mass:
    40575 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF696 Gene

Post-translational modifications for ZNF696 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF696 Gene

No data available for DME Specific Peptides for ZNF696 Gene

Domains & Families for ZNF696 Gene

Gene Families for ZNF696 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF696 Gene

  • C2H2-type zinc finger signature

Suggested Antigen Peptide Sequences for ZNF696 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 696 (ZN696_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF696: view

Function for ZNF696 Gene

Molecular function for ZNF696 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF696 Gene

Gene Ontology (GO) - Molecular Function for ZNF696 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA 21873635
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific IBA 21873635
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 32296183
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF696: view
genes like me logo Genes that share phenotypes with ZNF696: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF696

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF696 Gene

Localization for ZNF696 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF696 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF696 gene
Compartment Confidence
nucleus 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF696 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with ZNF696: view

Pathways & Interactions for ZNF696 Gene

PathCards logo

SuperPathways for ZNF696 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF696: view

Pathways by source for ZNF696 Gene

2 Reactome pathways for ZNF696 Gene

Gene Ontology (GO) - Biological Process for ZNF696 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription by RNA polymerase II IBA 21873635
genes like me logo Genes that share ontologies with ZNF696: view

No data available for SIGNOR curated interactions for ZNF696 Gene

Drugs & Compounds for ZNF696 Gene

No Compound Related Data Available

Transcripts for ZNF696 Gene

mRNA/cDNA for ZNF696 Gene

2 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF696

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF696 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d · 3e ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d
SP1: - - - - - - - -
SP2: - -
SP3: - - -
SP4: - - - -
SP6: -

Relevant External Links for ZNF696 Gene

GeneLoc Exon Structure for

Expression for ZNF696 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF696 Gene

Protein differential expression in normal tissues from HIPED for ZNF696 Gene

This gene is overexpressed in Cerebrospinal fluid (58.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF696 Gene

Protein tissue co-expression partners for ZNF696 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF696

SOURCE GeneReport for Unigene cluster for ZNF696 Gene:


Evidence on tissue expression from TISSUES for ZNF696 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with ZNF696: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF696 Gene

Orthologs for ZNF696 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF696 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF696 30 31
  • 99.11 (n)
(Canis familiaris)
Mammalia ZNF696 30 31
  • 75.05 (n)
(Bos Taurus)
Mammalia LOC511669 30
  • 72.34 (n)
(Monodelphis domestica)
Mammalia ZNF696 31
  • 47 (a)
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 44 (a)
-- 31
  • 41 (a)
-- 31
  • 36 (a)
-- 31
  • 25 (a)
(Mus musculus)
Mammalia 9130023H24Rik 31
  • 38 (a)
(Anolis carolinensis)
Reptilia -- 31
  • 52 (a)
-- 31
  • 44 (a)
-- 31
  • 44 (a)
Species where no ortholog for ZNF696 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF696 Gene

Gene Tree for ZNF696 (if available)
Gene Tree for ZNF696 (if available)
Evolutionary constrained regions (ECRs) for ZNF696: view image

Paralogs for ZNF696 Gene

Paralogs for ZNF696 Gene

(542) SIMAP similar genes for ZNF696 Gene using alignment to 6 proteins:

  • ZN696_HUMAN
  • E5RG39_HUMAN
  • E5RH76_HUMAN
  • E5RH99_HUMAN
genes like me logo Genes that share paralogs with ZNF696: view

Variants for ZNF696 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for ZNF696 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for ZNF696 Gene

Variant ID Type Subtype PubMed ID
esv33151 CNV gain 17666407
esv3573029 CNV loss 25503493
esv3573030 CNV loss 25503493
nsv1016726 CNV loss 25217958
nsv470247 CNV loss 18288195
nsv473318 CNV novel sequence insertion 20440878
nsv950010 CNV deletion 24416366

Variation tolerance for ZNF696 Gene

Residual Variation Intolerance Score: 71.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.97; 19.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF696 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF696 Gene

Disorders for ZNF696 Gene

Additional Disease Information for ZNF696

No disorders were found for ZNF696 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF696 Gene

Publications for ZNF696 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains. (PMID: 32814053) Haenig C … Wanker EE (Cell reports 2020) 3
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  5. The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery. (PMID: 29180619) Kumar R … Vertegaal ACO (Nature communications 2017) 3

Products for ZNF696 Gene

Sources for ZNF696 Gene