Aliases for ZNF695 Gene

Aliases for ZNF695 Gene

  • Zinc Finger Protein 695 2 3 4 5
  • Zinc Finger Protein SBZF3 3 4
  • SBZF3 2 3
  • ZNF695 5

External Ids for ZNF695 Gene

Previous GeneCards Identifiers for ZNF695 Gene

  • GC01M243435
  • GC01M245175
  • GC01M247109
  • GC01M217542
  • GC01M247113

Summaries for ZNF695 Gene

GeneCards Summary for ZNF695 Gene

ZNF695 (Zinc Finger Protein 695) is a Protein Coding gene. Diseases associated with ZNF695 include Hypertrophy Of Breast and Cornelia De Lange Syndrome. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF724.

UniProtKB/Swiss-Prot Summary for ZNF695 Gene

Additional gene information for ZNF695 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF695 Gene

Genomics for ZNF695 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF695 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J247006 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 616.5 +0.7 692 3.2 SP1 CREB1 TEAD4 FOS FOXA1 DDX20 RBFOX2 PKNOX1 POLR2A REST ZNF695 ZNF669 ZNF670-ZNF695 AHCTF1 piR-30821-004
GH01J247077 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 8.2 -70.4 -70423 3.4 RNF2 SP1 GATAD2A SOX13 IKZF1 POLR2A LARP7 GABPA DDX20 ZNF143 ZNF670-ZNF695 ZNF670 ZNF669 AHCTF1 ZNF124 ZNF496 ZNF695 ENSG00000215796 MG828730-009
GH01J247110 Promoter/Enhancer 1.7 Ensembl ENCODE CraniofacialAtlas 8 -103.9 -103853 3.1 HNRNPL GATAD2A TFE3 LEF1 IKZF1 NFKBIZ JUND MTA2 RBFOX2 PKNOX1 C1orf229 lnc-ZNF669-1 ZNF124 ZNF669 ZNF695 ENSG00000227671 MG828730-009
GH01J246106 Enhancer 1 Ensembl ENCODE 4.7 +901.4 901392 4.6 LEF1 JUND MTA2 PHF21A PKNOX1 NR2C1 ZNF24 ZNF740 DPF2 HDAC1 SMYD3-AS1 SCCPDH ZNF695 lnc-TFB2M-7 SMYD3 KIF26B
GH01J246111 Enhancer 0.8 Ensembl 5 +896.1 896092 1.6 ZNF512 PKNOX1 ZNF24 DPF2 FOXJ2 MGA GTF2E2 CBX3 HMBOX1 NFE2 SMYD3-AS1 ENSG00000235096 ZNF695 lnc-CNST-4 CHCHD4P5 SMYD3 KIF26B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF695 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF695

Top Transcription factor binding sites by QIAGEN in the ZNF695 gene promoter:
  • AREB6
  • GATA-1
  • Meis-1
  • Meis-1a
  • Meis-1b

Genomic Locations for ZNF695 Gene

Genomic Locations for ZNF695 Gene
62,548 bases
Minus strand
62,547 bases
Minus strand

Genomic View for ZNF695 Gene

Genes around ZNF695 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF695 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF695 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF695 Gene

Proteins for ZNF695 Gene

  • Protein details for ZNF695 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 695
    Protein Accession:
    Secondary Accessions:
    • Q5T0N9
    • Q5T0P1
    • Q5T0P3
    • Q7Z2W8
    • Q7Z648

    Protein attributes for ZNF695 Gene

    515 amino acids
    Molecular mass:
    60149 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF695 Gene


neXtProt entry for ZNF695 Gene

Post-translational modifications for ZNF695 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF695 Gene

No data available for DME Specific Peptides for ZNF695 Gene

Domains & Families for ZNF695 Gene

Gene Families for ZNF695 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF695 Gene

  • KRAB box

Suggested Antigen Peptide Sequences for ZNF695 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein SBZF3 (ZN695_HUMAN)
genes like me logo Genes that share domains with ZNF695: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ZNF695 Gene

Function for ZNF695 Gene

Molecular function for ZNF695 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF695 Gene

Gene Ontology (GO) - Molecular Function for ZNF695 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA 21873635
GO:0003676 nucleic acid binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF695: view
genes like me logo Genes that share phenotypes with ZNF695: view

Animal Model Products

CRISPR Products

miRNA for ZNF695 Gene

miRTarBase miRNAs that target ZNF695

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF695

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF695 Gene

Localization for ZNF695 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF695 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF695 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF695 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IBA 21873635
genes like me logo Genes that share ontologies with ZNF695: view

Pathways & Interactions for ZNF695 Gene

PathCards logo

SuperPathways for ZNF695 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF695 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA,IBA 21873635
genes like me logo Genes that share ontologies with ZNF695: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF695 Gene

Drugs & Compounds for ZNF695 Gene

No Compound Related Data Available

Transcripts for ZNF695 Gene

mRNA/cDNA for ZNF695 Gene

7 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF695

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF695 Gene

No ASD Table

Relevant External Links for ZNF695 Gene

GeneLoc Exon Structure for

Expression for ZNF695 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF695 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF695 Gene

This gene is overexpressed in Testis (x10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF695 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF695

SOURCE GeneReport for Unigene cluster for ZNF695 Gene:

genes like me logo Genes that share expression patterns with ZNF695: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF695 Gene

Orthologs for ZNF695 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF695 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF695 30 31
  • 99.22 (n)
(Mus musculus)
Mammalia ZFP953 31
  • 54 (a)
(Monodelphis domestica)
Mammalia -- 31
  • 51 (a)
-- 31
  • 33 (a)
(Bos Taurus)
Mammalia -- 31
  • 47 (a)
(Canis familiaris)
Mammalia -- 31
  • 34 (a)
(Anolis carolinensis)
Reptilia -- 31
  • 47 (a)
-- 31
  • 36 (a)
-- 31
  • 36 (a)
-- 31
  • 30 (a)
-- 31
  • 28 (a)
-- 31
  • 28 (a)
-- 31
  • 27 (a)
-- 31
  • 25 (a)
Species where no ortholog for ZNF695 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF695 Gene

Gene Tree for ZNF695 (if available)
Gene Tree for ZNF695 (if available)
Evolutionary constrained regions (ECRs) for ZNF695: view image

Paralogs for ZNF695 Gene

Paralogs for ZNF695 Gene

(506) SIMAP similar genes for ZNF695 Gene using alignment to 3 proteins:

  • ZN695_HUMAN
  • F2Z3A3_HUMAN
  • F6W2C3_HUMAN Pseudogenes for ZNF695 Gene

genes like me logo Genes that share paralogs with ZNF695: view

Variants for ZNF695 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF695 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs2642973 - p.Arg84Lys
rs2642992 - p.Val87Ala
rs55762230 - p.Met110Ile

Additional dbSNP identifiers (rs#s) for ZNF695 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF695 Gene

Variant ID Type Subtype PubMed ID
esv2668869 CNV deletion 23128226
esv33129 CNV gain+loss 17666407
esv3589499 CNV loss 21293372
esv3589500 CNV loss 21293372
esv3891381 CNV loss 25118596
nsv1141906 OTHER inversion 24896259
nsv524007 CNV gain 19592680
nsv549546 CNV loss 21841781
nsv945436 CNV duplication 23825009
nsv999879 CNV gain 25217958

Variation tolerance for ZNF695 Gene

Residual Variation Intolerance Score: 85.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.18; 61.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF695 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF695 Gene

Disorders for ZNF695 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ZNF695 Gene - From: DISEASES

Disorder Aliases PubMed IDs
hypertrophy of breast
  • breasts enlarged
cornelia de lange syndrome
  • cdls
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with ZNF695: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF695 Gene

Publications for ZNF695 Gene

  1. Splice variants of zinc finger protein 695 mRNA associated to ovarian cancer. (PMID: 24007497) Juárez-Méndez S … Moreno J (Journal of ovarian research 2013) 2 3
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3

Products for ZNF695 Gene

Sources for ZNF695 Gene