Aliases for ZNF692 Gene

Aliases for ZNF692 Gene

  • Zinc Finger Protein 692 2 3 4 5
  • AICAR Responsive Element Binding Protein 2 3
  • Zfp692 3
  • AREBP 3

External Ids for ZNF692 Gene

Previous GeneCards Identifiers for ZNF692 Gene

  • GC01M245354
  • GC01M247110
  • GC01M249144
  • GC01M219385

Summaries for ZNF692 Gene

GeneCards Summary for ZNF692 Gene

ZNF692 (Zinc Finger Protein 692) is a Protein Coding gene. Among its related pathways are Gene Expression. An important paralog of this gene is ZFP91-CNTF.

UniProtKB/Swiss-Prot Summary for ZNF692 Gene

Additional gene information for ZNF692 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF692 Gene

Genomics for ZNF692 Gene

GeneHancer (GH) Regulatory Elements for ZNF692 Gene

Promoters and enhancers for ZNF692 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J248857 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 508 +2.0 1967 3.7 ZNF217 EP300 CTCF NRF1 MYC POLR2G GTF2E2 PHF8 ZFX ZBTB5 ZNF692 ENSG00000227237 lnc-SH3BP5L-3 lnc-SH3BP5L-2
GH01J248861 Promoter 0.4 Ensembl 500.7 -0.7 -703 1 EGR2 ZNF692 ENSG00000227237 PGBD2
GH01J248820 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.6 +35.9 35858 9.8 EP300 FOXK2 ZBTB40 ZNF217 CTCF SIN3A POLR2G NCOR1 PHF8 SIX5 SH3BP5L MIR3124 PGBD2 ENSG00000227237 ZNF692 RNU6-1205P RPL23AP25 lnc-SH3BP5L-1 lnc-ZNF692-1
GH01J248904 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 13.4 -45.8 -45833 3.9 HNRNPK ZNF217 CTCF NRF1 POLR2G PHF8 ZFX POLR2A ZBTB10 CLOCK PGBD2 ZNF692 RNU6-1205P RF00026-118 piR-30876-015
GH01J248871 Promoter/Enhancer 1.6 ENCODE CraniofacialAtlas dbSUPER 15.1 -12.5 -12496 3.2 RXRA ZBTB40 ZNF217 EP300 TCF12 POLR2G SP1 GTF2E2 PHF8 TEAD4 AB330770-006 PGBD2 TRE-CTC2-1 TRL-CAA4-1 piR-33123-007 piR-51493 SH3BP5L ZNF692 RNU6-1205P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF692 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF692

Top Transcription factor binding sites by QIAGEN in the ZNF692 gene promoter:
  • AREB6
  • CUTL1
  • Ik-1
  • NF-1
  • Nkx2-5

Genomic Locations for ZNF692 Gene

Genomic Locations for ZNF692 Gene
chr1:248,850,004-248,860,798
(GRCh38/hg38)
Size:
10,795 bases
Orientation:
Minus strand
chr1:249,144,203-249,153,343
(GRCh37/hg19)
Size:
9,141 bases
Orientation:
Minus strand

Genomic View for ZNF692 Gene

Genes around ZNF692 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF692 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF692 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF692 Gene

Proteins for ZNF692 Gene

  • Protein details for ZNF692 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BU19-ZN692_HUMAN
    Recommended name:
    Zinc finger protein 692
    Protein Accession:
    Q9BU19
    Secondary Accessions:
    • B4DXZ0
    • Q5SRA5
    • Q5SRA6
    • Q9HBC9
    • Q9NW93
    • Q9NWY6
    • Q9UF97

    Protein attributes for ZNF692 Gene

    Size:
    519 amino acids
    Molecular mass:
    56968 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ZNF692 Gene

    Alternative splice isoforms for ZNF692 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF692 Gene

Post-translational modifications for ZNF692 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF692 Gene

Domains & Families for ZNF692 Gene

Gene Families for ZNF692 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF692 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF692 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 692 (ZN692_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BU19

UniProtKB/Swiss-Prot:

ZN692_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF692: view

Function for ZNF692 Gene

Molecular function for ZNF692 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF692 Gene

Gene Ontology (GO) - Molecular Function for ZNF692 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA 17097062
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific IDA 17097062
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF692: view
genes like me logo Genes that share phenotypes with ZNF692: view

Animal Model Products

CRISPR Products

Targeted motifs for ZNF692 Gene
HOMER Transcription Factor Regulatory Elements motif ZNF692
  • Consensus sequence: GTGGGCCCCA Submotif: canonical Cell Type: HEK293 GEO ID: GSE58341

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA and Transcription Factor Targets for ZNF692 Gene

Localization for ZNF692 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF692 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF692 gene
Compartment Confidence
nucleus 5
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (4)
  • Nucleoplasm (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF692 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with ZNF692: view

Pathways & Interactions for ZNF692 Gene

PathCards logo

SuperPathways for ZNF692 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF692: view

Pathways by source for ZNF692 Gene

2 Reactome pathways for ZNF692 Gene

SIGNOR curated interactions for ZNF692 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for ZNF692 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 17097062
genes like me logo Genes that share ontologies with ZNF692: view

Drugs & Compounds for ZNF692 Gene

No Compound Related Data Available

Transcripts for ZNF692 Gene

mRNA/cDNA for ZNF692 Gene

5 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
30 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF692 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d · 5e · 5f · 5g · 5h · 5i ^ 6a · 6b · 6c ·
SP1: - - - - - - - - - - - - - - -
SP2: - - - - - - - - - - - - - - - -
SP3: - - - - - - - - - - - - - - -
SP4:
SP5: - - - - - - - - - - - - - - -
SP6: - - - - - - - - -
SP7:
SP8:
SP9:
SP10: - - - - - - - - -
SP11: - - - -
SP12:
SP13: - - - - - - - - - - - - - - -
SP14: - - - - - - -
SP15: - - - - - - - -
SP16: - - - - - - - - - - - - - - - -
SP17: - - - - - - - - - - - - - - - -
SP18: - - - - - - - - -
SP19: - - - - - - - - - - - - -
SP20: - - - - - - - - - - - -
SP21: - - - -
SP22:
SP23:
SP24:
SP25:
SP26: - - - - - -
SP27: - - - - -
SP28: - - -
SP29: - - - -
SP30: - -
SP31:

ExUns: 6d · 6e · 6f · 6g ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c · 12d · 12e ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18a ·
SP1: - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - - - - - - - - - - -
SP4: - -
SP5: - - - - - - - - -
SP6: - - - - -
SP7: - -
SP8: - - - - - - - -
SP9: - - -
SP10: - - - - -
SP11: - - - - -
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21: - - - - - - - -
SP22: - - - -
SP23: - -
SP24: -
SP25: -
SP26:
SP27:
SP28:
SP29:
SP30:
SP31: - - - - -

Relevant External Links for ZNF692 Gene

GeneLoc Exon Structure for
ZNF692

Expression for ZNF692 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF692 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF692 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF692 Gene



Protein tissue co-expression partners for ZNF692 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF692

SOURCE GeneReport for Unigene cluster for ZNF692 Gene:

Hs.377705

Evidence on tissue expression from TISSUES for ZNF692 Gene

  • Nervous system(4.5)
  • Lung(4.3)
genes like me logo Genes that share expression patterns with ZNF692: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF692 Gene

Orthologs for ZNF692 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF692 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF692 31 30
  • 99.74 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF692 31 30
  • 86.42 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF692 31 30
  • 85.42 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp692 30
  • 84.93 (n)
mouse
(Mus musculus)
Mammalia Zfp692 17 31 30
  • 80.04 (n)
oppossum
(Monodelphis domestica)
Mammalia ZNF692 31
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZNF692 31
  • 49 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZNF692 31
  • 43 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii znf692 31 30
  • 59.39 (n)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 17 (a)
OneToMany
Species where no ortholog for ZNF692 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF692 Gene

ENSEMBL:
Gene Tree for ZNF692 (if available)
TreeFam:
Gene Tree for ZNF692 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF692: view image

Paralogs for ZNF692 Gene

genes like me logo Genes that share paralogs with ZNF692: view

Variants for ZNF692 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF692 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
788693 Benign: not provided 248,850,411(-) G/A SYNONYMOUS_VARIANT
rs144108516 Uncertain Significance: Severe Myopia 248,858,213(-) C/G MISSENSE_VARIANT,FIVE_PRIME_UTR_VARIANT
rs13313088 - p.Pro230Arg

Additional dbSNP identifiers (rs#s) for ZNF692 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF692 Gene

Variant ID Type Subtype PubMed ID
dgv631n100 CNV gain 25217958
dgv644n100 CNV gain 25217958
esv21433 CNV loss 19812545
esv2750832 CNV gain 17911159
esv2750835 CNV gain 17911159
esv3575994 CNV gain 25503493
esv3589576 CNV gain 21293372
esv3589577 CNV gain 21293372
nsv5398 CNV insertion 18451855
nsv549745 CNV loss 21841781
nsv999043 CNV gain 25217958

Variation tolerance for ZNF692 Gene

Residual Variation Intolerance Score: 37.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.57; 72.27% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF692 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF692

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF692 Gene

Disorders for ZNF692 Gene

Additional Disease Information for ZNF692

No disorders were found for ZNF692 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF692 Gene

Publications for ZNF692 Gene

No publications were found for ZNF692 Gene.

Products for ZNF692 Gene

Sources for ZNF692 Gene