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ZNF692 Gene(Protein Coding)

Zinc Finger Protein 692

GCID:
GC01M248850
GIFtS:
40
Genes Participants
UDN Logo

Aliases for ZNF692 Gene

Aliases for ZNF692 Gene

  • Zinc Finger Protein 692 2 3 5
  • AICAR Responsive Element Binding Protein 2 3
  • Zfp692 3
  • AREBP 3

External Ids for ZNF692 Gene

Previous GeneCards Identifiers for ZNF692 Gene

  • GC01M245354
  • GC01M247110
  • GC01M249144
  • GC01M219385

Summaries for ZNF692 Gene

GeneCards Summary for ZNF692 Gene

ZNF692 (Zinc Finger Protein 692) is a Protein Coding gene. Among its related pathways are Gene Expression. An important paralog of this gene is ZNF653.

UniProtKB/Swiss-Prot for ZNF692 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF692 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF692 Gene

Genomics for ZNF692 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for ZNF692 Gene

Promoters and enhancers for ZNF692 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH01I248857 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 558.1 +1.9 1920 3.6 HDGF PKNOX1 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 POLR2B ZNF766 ZNF692 ENSG00000227237 PGBD2 PIR53527
GH01I248820 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.6 +35.9 35858 9.8 HDGF PKNOX1 FOXA2 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 SH3BP5L MIR3124 PGBD2 ENSG00000227237 ZNF692 RNU6-1205P RPL23AP25 GC01P248810
GH01I248871 Enhancer 1.5 Ensembl ENCODE dbSUPER 15.1 -12.5 -12496 3.2 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B IRF4 PGBD2 PIR45492 TRE-CTC2-1 TRL-CAA4-1 SH3BP5L ZNF692 RNU6-1205P
GH01I248924 Enhancer 1.1 Ensembl ENCODE 11.3 -65.1 -65147 2.5 HDAC1 HDGF PKNOX1 ATF1 TAF9B ARNT BATF RAD21 RFX5 TCF12 ZNF672 ENSG00000227237 ZNF692 PGBD2 SH3BP5L PIR45582 PIR40629 GC01P248921
GH01I248886 Enhancer 0.7 Ensembl dbSUPER 11.5 -25.9 -25903 0.2 MEIS2 NFIC IKZF1 ZNF592 RNU6-1205P ZNF672 ENSG00000227237 ZNF692 SH3BP5L PIR34959 PGBD2 TRE-CTC2-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF692 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF692 gene promoter:

Genomic Locations for ZNF692 Gene

Genomic Locations for ZNF692 Gene
chr1:248,850,004-248,860,798
(GRCh38/hg38)
Size:
10,795 bases
Orientation:
Minus strand
chr1:249,144,203-249,153,343
(GRCh37/hg19)

Genomic View for ZNF692 Gene

Genes around ZNF692 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF692 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF692 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ZNF692 Gene

Proteins for ZNF692 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for ZNF692 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BU19-ZN692_HUMAN
    Recommended name:
    Zinc finger protein 692
    Protein Accession:
    Q9BU19
    Secondary Accessions:
    • B4DXZ0
    • Q5SRA5
    • Q5SRA6
    • Q9HBC9
    • Q9NW93
    • Q9NWY6
    • Q9UF97

    Protein attributes for ZNF692 Gene

    Size:
    519 amino acids
    Molecular mass:
    56968 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ZNF692 Gene

    Alternative splice isoforms for ZNF692 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF692 Gene

Protein Expression for ZNF692 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for ZNF692 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF692 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF692 Gene

Domains & Families for ZNF692 Gene

Gene Families for ZNF692 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF692 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF692 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BU19

UniProtKB/Swiss-Prot:

ZN692_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF692: view

Function for ZNF692 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for ZNF692 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF692 Gene

Gene Ontology (GO) - Molecular Function for ZNF692 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA 17097062
GO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA 17097062
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF692: view
genes like me logo Genes that share phenotypes with ZNF692: view

Animal Model Products

Targeted motifs for ZNF692 Gene
HOMER Transcription Factor Regulatory Elements motif ZNF692
  • Consensus sequence: GTGGGCCCCA Submotif: canonical Cell Type: HEK293 GEO ID: GSE58341

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA and Transcription Factor Targets for ZNF692 Gene

Localization for ZNF692 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF692 Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF692 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (4)
  • Nucleus (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF692 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with ZNF692: view

Pathways & Interactions for ZNF692 Gene

SuperPathways for ZNF692 Gene

PathCards logo More details on SuperPathways for ZNF692
SuperPathway Contained pathways
1 Gene Expression
Gene Expression
.48
Generic Transcription Pathway
.48
genes like me logo Genes that share pathways with ZNF692: view

Pathways by source for ZNF692 Gene

2 Reactome pathways for ZNF692 Gene

Interacting Proteins for ZNF692 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000391200%0d%0a9606.ENSP00000369131%0d%0a9606.ENSP00000353622%0d%0a9606.ENSP00000367705%0d%0a9606.ENSP00000264705%0d%0a9606.ENSP00000276072%0d%0a
Selected Interacting proteins: ENSP00000391200 for ZNF692 Gene via STRING

SIGNOR curated interactions for ZNF692 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for ZNF692 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 17097062
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF692: view

Drugs & Compounds for ZNF692 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for ZNF692 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for ZNF692 Gene

(18) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(169) Selected AceView cDNA sequences:
(30) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF692 Gene

Zinc finger protein 692:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF692 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d · 5e · 5f · 5g · 5h · 5i ^ 6a · 6b · 6c ·
SP1: - - - - - - - - - - - - - - -
SP2: - - - - - - - - - - - - - - - -
SP3: - - - - - - - - - - - - - - -
SP4:
SP5: - - - - - - - - - - - - - - -
SP6: - - - - - - - - -
SP7:
SP8:
SP9:
SP10: - - - - - - - - -
SP11: - - - -
SP12:
SP13: - - - - - - - - - - - - - - -
SP14: - - - - - - -
SP15: - - - - - - - -
SP16: - - - - - - - - - - - - - - - -
SP17: - - - - - - - - - - - - - - - -
SP18: - - - - - - - - -
SP19: - - - - - - - - - - - - -
SP20: - - - - - - - - - - - -
SP21: - - - -
SP22:
SP23:
SP24:
SP25:
SP26: - - - - - -
SP27: - - - - -
SP28: - - -
SP29: - - - -
SP30: - -
SP31:

ExUns: 6d · 6e · 6f · 6g ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c · 12d · 12e ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18a ·
SP1: - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - - - - - - - - - - -
SP4: - -
SP5: - - - - - - - - -
SP6: - - - - -
SP7: - -
SP8: - - - - - - - -
SP9: - - -
SP10: - - - - -
SP11: - - - - -
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21: - - - - - - - -
SP22: - - - -
SP23: - -
SP24: -
SP25: -
SP26:
SP27:
SP28:
SP29:
SP30:
SP31: - - - - -

Relevant External Links for ZNF692 Gene

GeneLoc Exon Structure for
ZNF692
ECgene alternative splicing isoforms for
ZNF692

Expression for ZNF692 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF692 Gene

mRNA expression in normal human tissues for ZNF692 Gene
mRNA expression by BioGPS for ZNF692 GenemRNA expression by GTEx for ZNF692 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF692 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF692 Gene



Protein tissue co-expression partners for ZNF692 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF692 Gene:

ZNF692

SOURCE GeneReport for Unigene cluster for ZNF692 Gene:

Hs.377705

Evidence on tissue expression from TISSUES for ZNF692 Gene

  • Nervous system(4.5)
  • Lung(4.3)
genes like me logo Genes that share expression patterns with ZNF692: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF692 Gene

Orthologs for ZNF692 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF692 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia ZNF692 33 34
  • 99.74 (n)
dog
(Canis familiaris)
 Mammalia ZNF692 33 34
  • 86.42 (n)
cow
(Bos Taurus)
 Mammalia ZNF692 33 34
  • 85.42 (n)
rat
(Rattus norvegicus)
 Mammalia Zfp692 33
  • 84.93 (n)
mouse
(Mus musculus)
 Mammalia Zfp692 33 16 34
  • 80.04 (n)
oppossum
(Monodelphis domestica)
 Mammalia ZNF692 34
  • 66 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves ZNF692 34
  • 49 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia ZNF692 34
  • 43 (a)
 OneToOne
zebrafish
(Danio rerio)
 Actinopterygii znf692 33 34
  • 59.39 (n)
sea squirt
(Ciona savignyi)
 Ascidiacea -- 34
  • 17 (a)
 OneToMany
Species where no ortholog for ZNF692 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF692 Gene

ENSEMBL:
Gene Tree for ZNF692 (if available)
TreeFam:
Gene Tree for ZNF692 (if available)

Paralogs for ZNF692 Gene

Paralogs for ZNF692 Gene

(104) SIMAP similar genes for ZNF692 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with ZNF692: view

Variants for ZNF692 Gene

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  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for ZNF692 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000226515 -- 248,852,938(-) G/A intron_variant
rs1000342818 -- 248,858,991(-) A/T 5_prime_UTR_variant, coding_sequence_variant, genic_upstream_transcript_variant, intron_variant, non_coding_transcript_variant, synonymous_variant, upstream_transcript_variant
rs1000451652 -- 248,851,928(-) C/A intron_variant
rs1000855712 -- 248,858,883(-) G/A 5_prime_UTR_variant, intron_variant
rs1001869251 -- 248,862,595(-) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF692 Gene

Variant ID Type Subtype PubMed ID
dgv631n100 CNV gain 25217958
dgv644n100 CNV gain 25217958
esv21433 CNV loss 19812545
esv2750832 CNV gain 17911159
esv2750835 CNV gain 17911159
esv3575994 CNV gain 25503493
esv3589576 CNV gain 21293372
esv3589577 CNV gain 21293372
nsv5398 CNV insertion 18451855
nsv549745 CNV loss 21841781
nsv999043 CNV gain 25217958

Variation tolerance for ZNF692 Gene

Residual Variation Intolerance Score: 37.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.57; 72.27% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF692 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF692

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF692 Gene

Disorders for ZNF692 Gene

Additional Disease Information for ZNF692

ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ZNF692 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF692 Gene

Publications for ZNF692 Gene

  1. AMP-activated protein kinase regulates PEPCK gene expression by direct phosphorylation of a novel zinc finger transcription factor. (PMID: 17097062) Inoue E … Yamauchi J (Biochemical and biophysical research communications 2006) 2 3 58
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

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