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Aliases for ZNF69 Gene

Aliases for ZNF69 Gene

  • Zinc Finger Protein 69 2 3 4 5
  • HZNF3 3 4
  • Zinc Finger Protein 69 (Cos5) 2
  • Cos5 3
  • ZNF3 3

External Ids for ZNF69 Gene

Previous GeneCards Identifiers for ZNF69 Gene

  • GC22U990054
  • GC19P011802
  • GC19P011654
  • GC19P011998
  • GC19P011573

Summaries for ZNF69 Gene

GeneCards Summary for ZNF69 Gene

ZNF69 (Zinc Finger Protein 69) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ENSG00000267179.

UniProtKB/Swiss-Prot for ZNF69 Gene

Additional gene information for ZNF69 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF69 Gene

Genomics for ZNF69 Gene

GeneHancer (GH) Regulatory Elements for ZNF69 Gene

Promoters and enhancers for ZNF69 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J011887 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 612 +1.2 1152 3.5 ELF3 ZNF148 POLR2A RERE GTF2F1 AHR TFE3 SP1 PPARG HNF1A ZNF69 VN2R15P GC19P011845
GH19J011848 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 600.3 -38.7 -38740 1.9 SP1 ELF3 KAT8 POLR2A LARP7 PKNOX1 GABPA IRF2 KMT2B TGIF2 ZNF439 ZNF69 ZNF433 ZNF440 ZNF491 GC19P011845 ENSG00000278897
GH19J011987 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 12 +100.3 100317 2.6 SP1 CC2D1A CTCF CBFA2T2 ZNF148 NKRF ZNF687 ZSCAN21 TFE3 TRIM24 ZNF433-AS1 ZNF844 ENSG00000286098 ZNF136 ZNF791 ZNF763 ZNF564 ZNF799 ZNF442 ZNF69
GH19J011923 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.2 +37.8 37817 4.4 HDGF ZNF652 ZFX SP1 CTCF ZNF148 NKRF POLR2A ZNF121 CEBPG ZNF700 ENSG00000267179 ZNF627 ZNF136 ZNF44 ZNF763 ZNF20 ZNF564 ZNF442 ZNF791
GH19J011797 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 8.5 -89.1 -89083 2.6 SP1 ELF3 CTCF CBFA2T2 NKRF CEBPG AHR PPARG SP5 RAD21 ZNF491 ENSG00000267646 GC19P011801 PIR49375 ZNF440 ZNF441 ZNF625-ZNF20 ZNF439 ZNF433-AS1 RNA5SP464
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF69 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF69 gene promoter:
  • NF-kappaB1

Genomic Locations for ZNF69 Gene

Genomic Locations for ZNF69 Gene
26,768 bases
Plus strand
26,768 bases
Plus strand

Genomic View for ZNF69 Gene

Genes around ZNF69 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF69 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF69 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF69 Gene

Proteins for ZNF69 Gene

  • Protein details for ZNF69 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 69
    Protein Accession:
    Secondary Accessions:
    • Q86VA7

    Protein attributes for ZNF69 Gene

    566 amino acids
    Molecular mass:
    65761 Da
    Quaternary structure:
    No Data Available
    • Sequence=AK001669; Type=Frameshift; Positions=415; Evidence={ECO:0000305}; Sequence=CAC16147.1; Type=Frameshift; Positions=367, 369; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF69 Gene


neXtProt entry for ZNF69 Gene

Post-translational modifications for ZNF69 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF69 Gene

Domains & Families for ZNF69 Gene

Gene Families for ZNF69 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF69 Gene

Suggested Antigen Peptide Sequences for ZNF69 Gene

GenScript: Design optimal peptide antigens:
  • hZNF3 (ZNF69_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF69: view

Function for ZNF69 Gene

Molecular function for ZNF69 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
GENATLAS Biochemistry:
zinc finger protein 69 (C2H2 type,Kruppel-like)

Phenotypes From GWAS Catalog for ZNF69 Gene

Gene Ontology (GO) - Molecular Function for ZNF69 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF69: view
genes like me logo Genes that share phenotypes with ZNF69: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF69

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF69 Gene

Localization for ZNF69 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF69 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF69 gene
Compartment Confidence
nucleus 4
extracellular 2
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF69 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with ZNF69: view

Pathways & Interactions for ZNF69 Gene

PathCards logo

SuperPathways for ZNF69 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF69 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF69: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF69 Gene

Drugs & Compounds for ZNF69 Gene

No Compound Related Data Available

Transcripts for ZNF69 Gene

mRNA/cDNA for ZNF69 Gene

(4) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for ZNF69 Gene

Zinc finger protein 69:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF69

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF69 Gene

No ASD Table

Relevant External Links for ZNF69 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF69 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF69 Gene

Protein differential expression in normal tissues from HIPED for ZNF69 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF69 Gene

Protein tissue co-expression partners for ZNF69 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF69 Gene:


SOURCE GeneReport for Unigene cluster for ZNF69 Gene:


Evidence on tissue expression from TISSUES for ZNF69 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ZNF69: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF69 Gene

Orthologs for ZNF69 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF69 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF69 35
  • 82 (a)
(Bos Taurus)
Mammalia -- 35
  • 15 (a)
(Canis familiaris)
Mammalia -- 35
  • 9 (a)
(Mus musculus)
Mammalia Zfp867 35
  • 8 (a)
Species where no ortholog for ZNF69 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF69 Gene

Gene Tree for ZNF69 (if available)
Gene Tree for ZNF69 (if available)
Evolutionary constrained regions (ECRs) for ZNF69: view image

Paralogs for ZNF69 Gene

(471) SIMAP similar genes for ZNF69 Gene using alignment to 2 proteins:

  • C9JR48_HUMAN
genes like me logo Genes that share paralogs with ZNF69: view

Variants for ZNF69 Gene

Sequence variations from dbSNP and Humsavar for ZNF69 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000031080 -- 11,974,612(+) C/G/T genic_downstream_transcript_variant, intron_variant
rs1000057418 -- 11,945,987(+) G/C genic_downstream_transcript_variant, intron_variant
rs1000102796 -- 11,954,652(+) G/A/T genic_downstream_transcript_variant, intron_variant
rs1000118339 -- 11,941,121(+) G/A genic_downstream_transcript_variant, intron_variant
rs1000307814 -- 11,963,343(+) C/G/T genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF69 Gene

Variant ID Type Subtype PubMed ID
dgv3428n100 CNV gain 25217958
dgv3429n100 CNV loss 25217958
dgv653e214 CNV loss 21293372
esv2718185 CNV deletion 23290073
esv2718186 CNV deletion 23290073
esv3643677 CNV gain 21293372
esv3643682 CNV gain 21293372
esv3643683 CNV loss 21293372
nsv458356 CNV gain 19166990
nsv525966 CNV gain 19592680
nsv578618 CNV gain 21841781
nsv578619 CNV loss 21841781
nsv960791 CNV duplication 23825009

Variation tolerance for ZNF69 Gene

Residual Variation Intolerance Score: 62.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.88; 18.29% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF69 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF69 Gene

Disorders for ZNF69 Gene

Additional Disease Information for ZNF69

No disorders were found for ZNF69 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF69 Gene

Publications for ZNF69 Gene

  1. Cloning of six new genes with zinc finger motifs mapping to short and long arms of human acrocentric chromosome 22 (p and q11.2). (PMID: 1639391) Aubry M … Rouleau GA (Genomics 1992) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Systematic identification of pathological lamin A interactors. (PMID: 24623722) Dittmer TA … Misteli T (Molecular biology of the cell 2014) 3 58
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 58

Products for ZNF69 Gene

Sources for ZNF69 Gene

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