Aliases for ZNF689 Gene

Aliases for ZNF689 Gene

  • Zinc Finger Protein 689 2 3 4 5
  • Transcription-Involved Protein Upregulated In HCC 1 3
  • TIPUH1 3

External Ids for ZNF689 Gene

Previous GeneCards Identifiers for ZNF689 Gene

  • GC16M030523
  • GC16M030613
  • GC16M028178

Summaries for ZNF689 Gene

GeneCards Summary for ZNF689 Gene

ZNF689 (Zinc Finger Protein 689) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF160.

UniProtKB/Swiss-Prot Summary for ZNF689 Gene

Additional gene information for ZNF689 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF689 Gene

Genomics for ZNF689 Gene

GeneHancer (GH) Regulatory Elements for ZNF689 Gene

Promoters and enhancers for ZNF689 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF689 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF689

Top Transcription factor binding sites by QIAGEN in the ZNF689 gene promoter:
  • ATF6
  • E2F
  • E2F-1
  • GATA-2
  • HSF1 (long)
  • HSF1short
  • Ik-2
  • NF-kappaB
  • NF-kappaB1
  • ZIC2

Genomic Locations for ZNF689 Gene

Genomic Locations for ZNF689 Gene
chr16:30,602,558-30,624,012
(GRCh38/hg38)
Size:
21,455 bases
Orientation:
Minus strand
chr16:30,613,879-30,635,333
(GRCh37/hg19)
Size:
21,455 bases
Orientation:
Minus strand

Genomic View for ZNF689 Gene

Genes around ZNF689 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF689 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF689 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF689 Gene

Proteins for ZNF689 Gene

  • Protein details for ZNF689 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96CS4-ZN689_HUMAN
    Recommended name:
    Zinc finger protein 689
    Protein Accession:
    Q96CS4
    Secondary Accessions:
    • Q658J5

    Protein attributes for ZNF689 Gene

    Size:
    500 amino acids
    Molecular mass:
    56907 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF689 Gene

Post-translational modifications for ZNF689 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF689 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF689 Gene

Domains & Families for ZNF689 Gene

Gene Families for ZNF689 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF689 Gene

Blocks:
  • KRAB box
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF689 Gene

GenScript: Design optimal peptide antigens:
  • Transcription-involved protein upregulated in HCC 1 (Q25QX8_HUMAN)
  • Zinc finger protein 689 (ZN689_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96CS4

UniProtKB/Swiss-Prot:

ZN689_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF689: view

Function for ZNF689 Gene

Molecular function for ZNF689 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF689 Gene

Gene Ontology (GO) - Molecular Function for ZNF689 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF689: view
genes like me logo Genes that share phenotypes with ZNF689: view

Animal Models for ZNF689 Gene

MGI Knock Outs for ZNF689:
  • Zfp689 Zfp689<tm1.1(KOMP)Vlcg>

Animal Model Products

CRISPR Products

miRNA for ZNF689 Gene

miRTarBase miRNAs that target ZNF689

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF689

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZNF689 Gene

Localization for ZNF689 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF689 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF689 gene
Compartment Confidence
nucleus 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli fibrillar center (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF689 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF689: view

Pathways & Interactions for ZNF689 Gene

genes like me logo Genes that share pathways with ZNF689: view

Pathways by source for ZNF689 Gene

2 Reactome pathways for ZNF689 Gene
1 KEGG pathway for ZNF689 Gene

Gene Ontology (GO) - Biological Process for ZNF689 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0035914 skeletal muscle cell differentiation IEA --
genes like me logo Genes that share ontologies with ZNF689: view

No data available for SIGNOR curated interactions for ZNF689 Gene

Drugs & Compounds for ZNF689 Gene

No Compound Related Data Available

Transcripts for ZNF689 Gene

mRNA/cDNA for ZNF689 Gene

1 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF689

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF689 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d
SP1: - - - -
SP2: - -
SP3: -
SP4:

Relevant External Links for ZNF689 Gene

GeneLoc Exon Structure for
ZNF689

Expression for ZNF689 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF689 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF689 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF689 Gene



Protein tissue co-expression partners for ZNF689 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF689

SOURCE GeneReport for Unigene cluster for ZNF689 Gene:

Hs.454685

Evidence on tissue expression from TISSUES for ZNF689 Gene

  • Lung(4.2)
genes like me logo Genes that share expression patterns with ZNF689: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF689 Gene

Orthologs for ZNF689 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF689 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF689 31 30
  • 99.6 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF689 31 30
  • 90.98 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF689 31 30
  • 89.67 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp689 17 31 30
  • 88.11 (n)
rat
(Rattus norvegicus)
Mammalia Zfp689 30
  • 87.37 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 36 (a)
OneToMany
Species where no ortholog for ZNF689 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF689 Gene

ENSEMBL:
Gene Tree for ZNF689 (if available)
TreeFam:
Gene Tree for ZNF689 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF689: view image

Paralogs for ZNF689 Gene

(350) SIMAP similar genes for ZNF689 Gene using alignment to 1 proteins:

  • ZN689_HUMAN
genes like me logo Genes that share paralogs with ZNF689: view

Variants for ZNF689 Gene

Additional dbSNP identifiers (rs#s) for ZNF689 Gene

Variation tolerance for ZNF689 Gene

Residual Variation Intolerance Score: 8.39% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.54; 11.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF689 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF689

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Structural Variations from Database of Genomic Variants (DGV) for ZNF689 Gene

Disorders for ZNF689 Gene

Additional Disease Information for ZNF689

No disorders were found for ZNF689 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF689 Gene

Publications for ZNF689 Gene

No publications were found for ZNF689 Gene.

Products for ZNF689 Gene

Sources for ZNF689 Gene