Aliases for ZNF688 Gene
External Ids for ZNF688 Gene
- HGNC: 30489
- Entrez Gene: 146542
- Ensembl: ENSG00000229809
- UniProtKB: P0C7X2
Previous GeneCards Identifiers for ZNF688 Gene
- GC16M030489
- GC16M030009
- GC16M028144
Summaries for ZNF688 Gene
GeneCards Summary for ZNF688 Gene
ZNF688 (Zinc Finger Protein 688) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF785.
UniProtKB/Swiss-Prot for ZNF688 Gene
-
May be involved in transcriptional regulation.
Additional gene information for ZNF688 Gene
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF688 Gene
Genomics for ZNF688 Gene
GeneHancer (GH) Regulatory Elements for ZNF688 Gene
Promoters and enhancers for ZNF688 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around ZNF688 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for ZNF688 Gene
Genomic Locations for ZNF688 Gene
- chr16:30,569,346-30,572,734
- (GRCh38/hg38)
- Size:
- 3,389 bases
- Orientation:
- Minus strand
- chr16:30,580,667-30,584,055
- (GRCh37/hg19)
Genomic View for ZNF688 Gene
Genes around ZNF688 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16p11.2 by Entrez Gene
- 16p11.2 by HGNC
- 16p11.2 by Ensembl
ZNF688 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ZNF688 Gene
Proteins for ZNF688 Gene
-
Protein details for ZNF688 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P0C7X2-ZN688_HUMAN
- Recommended name:
- Zinc finger protein 688
- Protein Accession:
- P0C7X2
- A8MV39
- B3KV51
- O75701
- Q8IW91
- Q8WV14
- Q96MN0
Protein attributes for ZNF688 Gene
- Size:
- 276 amino acids
- Molecular mass:
- 30575 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAC31673.1; Type=Erroneous gene model prediction; Note=The predicted gene has been split into 2 genes: ZNF688 and ZNF785.; Evidence={ECO:0000305};
Protein Expression for ZNF688 Gene
Post-translational modifications for ZNF688 Gene
Other Protein References for ZNF688 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for ZNF688
- Invitrogen Antibodies for ZNF688
- GeneTex ZNF688 Antibody for ZNF688
-
Boster Bio Antibodies for ZNF688
-
Santa Cruz Biotechnology (SCBT) Antibodies for ZNF688
Protein Products
-
OriGene Purified Proteins for ZNF688
- Search Origene for MassSpec and Protein Over-expression Lysates for ZNF688
- Origene Custom Protein Services for ZNF688
- antibodies-online: Search results for 2 available ZNF688 Proteins ranked by validation data
- Compare Top ZNF688 Proteins
-
Quality Products:
- Search GeneTex for Proteins for ZNF688
Assay Products
No data available for DME Specific Peptides for ZNF688 Gene
Domains & Families for ZNF688 Gene
Gene Families for ZNF688 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for ZNF688 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for ZNF688 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P0C7X2- Family:
-
- Belongs to the krueppel C2H2-type zinc-finger protein family.
Function for ZNF688 Gene
Molecular function for ZNF688 Gene
- UniProtKB/Swiss-Prot Function:
- May be involved in transcriptional regulation.
Phenotypes From GWAS Catalog for ZNF688 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003674 | molecular_function | ND | -- |
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for ZNF688 Gene
- GenomeRNAi human phenotypes for ZNF688:
-
- Decreased viability ratio
- Increased shRNA abundance (Z-score > 2)
- Effect on mitosis
- Dynamic nuclei (hole, folded or small irregular)
- Decreased HIV-LTR-beta-galactosidase protein expression
- Decreased shRNA abundance (Z-score < -2)
- Negative genetic interaction between MUS81-/- and MUS81+/+
- Decreased Aire reporter expression
- Decreased viability after Maraba virus infection
- Increased viability
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for ZNF688
-
CRISPR Products
-
OriGene CRISPR knockouts for ZNF688
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- genomics-online: gRNA clones - Search results for 44 available ZNF688 gene related products
- Overview of 44 available ZNF688 gene related products
- Applied Biological Materials CRISPR for ZNF688
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZNF688
- GenScript: Design CRISPR guide RNA sequences for ZNF688
miRNA for ZNF688 Gene
- miRTarBase miRNAs that target ZNF688
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ZNF688
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- Overview of 44 available ZNF688 gene related products
Clone Products
- VectorBuilder custom plasmid, inducible vectors for ZNF688
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ZNF688
- Applied Biological Materials Clones for ZNF688
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for ZNF688
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF688 Gene
Localization for ZNF688 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ZNF688 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| plasma membrane | 2 |
- Cell Junctions (2)
- Nucleoplasm (2)
- Plasma membrane (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005575 | cellular_component | ND | -- |
| GO:0005622 | intracellular | IEA | -- |
| GO:0005634 | nucleus | IEA | -- |
Pathways & Interactions for ZNF688 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Gene Expression |
.48
|
|
Pathways by source for ZNF688 Gene
2 Reactome pathways for ZNF688 Gene
Interacting Proteins for ZNF688 Gene
GPS-Prot Interaction Network for ZNF688
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0008150 | biological_process | ND | -- |
No data available for SIGNOR curated interactions for ZNF688 Gene
Transcripts for ZNF688 Gene
mRNA/cDNA for ZNF688 Gene
- (90) Selected AceView cDNA sequences:
- (3) Additional mRNA sequences :
- (6) REFSEQ mRNAs :
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000223459 2506 bps (uc002dyt.4)
- ENST00000562455 562 bps (uc059tfo.1)
- ENST00000563276 1492 bps (uc002dys.4)
- ENST00000563665 1414 bps (uc059tfn.1)
- ENST00000563707 244 bps (uc059tfr.1)
Unigene Clusters for ZNF688 Gene
- Zinc finger protein 688:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for ZNF688
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ZNF688
- genomics-online: gRNA clones - Search results for 44 available ZNF688 gene related products
- Overview of 44 available ZNF688 gene related products
- Applied Biological Materials CRISPR for ZNF688
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZNF688
- GenScript: Design CRISPR guide RNA sequences for ZNF688
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ZNF688
- Browse OriGene Inhibitory RNA Products For ZNF688
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF688
- genomics-online: shRNA clones - Search results for 44 available ZNF688 gene related products
- Overview of 44 available ZNF688 gene related products
Clone Products
- VectorBuilder custom plasmid, inducible vectors for ZNF688
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ZNF688
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ZNF688
- Applied Biological Materials Clones for ZNF688
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for ZNF688 Gene
This gene is overexpressed in Blymphocyte (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF688 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of ZNF688 Gene:
ZNF688SOURCE GeneReport for Unigene cluster for ZNF688 Gene:
Hs.301463Evidence on tissue expression from TISSUES for ZNF688 Gene
- Nervous system(4.1)
Primer Products
-
OriGene qPCR primer pairs and template standards for ZNF688
-
OriGene qPCR primer pairs for ZNF688
- genomics-online: primer clones - Search results for 44 available ZNF688 gene related products
- Overview of 44 available ZNF688 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF688 Gene
Orthologs for ZNF688 Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ZNF688 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | ZNF688 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | ZNF688 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Zfp688 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | LOC102554302 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
OneToMany |
- Species where no ortholog for ZNF688 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Evolution for ZNF688 Gene
- ENSEMBL:
- Gene Tree for ZNF688 (if available)
- TreeFam:
- Gene Tree for ZNF688 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ZNF688: view image
Paralogs for ZNF688 Gene
(224) SIMAP similar genes for ZNF688 Gene using alignment to 6 proteins:
- ZN688_HUMAN
- H3BPA7_HUMAN
- H3BR26_HUMAN
- H3BR45_HUMAN
- H3BTK8_HUMAN
- L0R5I2_HUMAN
- ZNF619
- ZNF627
- ZNF707
- ZNF823
- ZNF75A
- ZNF616
- ZNF433
- ZNF785
- ZNF571
- ZNF3
- ZNF383
- ZNF320
- ZNF780A
- ZNF761
- ZNF519
- ZNF649
- ZNF347
- ZNF780B
- ZNF565
- ZNF124
- ZNF525
- ZNF331
- ZNF625
- ZNF721
- ZNF670
- ZNF669
- ZNF595
- ZNF562
- ZNF554
- ZFP14
- ZNF630
- ZNF101
- ZIK1
- ZNF83
- ZNF561
- ZNF607
- ZNF28
- ZNF747
- ZNF577
- ZNF766
- ZNF205
- ZNF549
- ZNF283
- ZNF17
- ZNF540
- ZNF230
- ZNF569
- ZNF140
- ZNF718
- ZNF556
- ZNF23
- ZNF141
- ZNF789
- ZNF133
- ZNF19
- ZNF841
- ZNF791
- ZNF529
- ZFP1
- ZNF613
- ZNF551
- ZNF547
- ZFS-6
- ZNF420
- ZNF695
- ZNF267
- ZNF470
- ZNF300
- ZNF250
- kr-znf3
- ZNF778
- ZNF234
- ZKSCAN5
- ZNF415
- LOC101928664
- ZNF350
- ZNF793
- ZNF426
- ZNF33B
- ZNF78L1
- ZNF788
- ZNF709
- ZNF700
- ZNF229
- ZNF682
- ZNF610
- ZNF559
- ZNF429
- ZNF208
- KRBOX1
- ZNF548
- ZNF717
- ZNF302
- ZNF
- ZNF880
- ZNF677
- ZNF274
- ZNF814
- ZNF624
- ZNF836
- ZNF705A
- ZNF850
- ZNF582
- HKR1
- ZNF621
- ZNF614
- ZNF517
- ZFS-5
- ZNF195
- ZNF226
- ZNF615
- ZNF790
- ZNF514
- ZNF528
- ZNF596
- ZNF776
- ZNF846
- ZNF317
- ZNF286A
- ZNF486
- ZNF300P1
- ZNF7
- ZNF675
- ZNF461
- ZNF181
- ZNF527
- ZNF227
- ZNF418
- ZNF138
- ZNF85
- ZNF324B
- ZNF84
- ZNF720
- ZNF91
- ZNF844
- ZNF816
- ZNF737
- ZNF471
- ZNF221
- ZNF155
- ZNF546
- ZNF510
- ZNF485
- ZNF443
- ZNF177
- ZNF169
- ZFP90
- ZNF724P
- ZFP30
- ZNF66
- ZNF273
- ZNF257
- POM121C
- MGC12518
- ZNF224
- ZNF773
- ZNF763
- ZNF599
- ZNF233
- ZNF112
- ZNF620
- ZNF585B
- ZNF354A
- ZNF33A
- ZNF93
- ZNF684
- ZNF432
- ZNF570
- ZNF223
- ZNF506
- ZNF135
- ZNF12
- ZNF667
- ZNF419
- ZNF268
- ZNF726
- ZNF611
- ZNF879
- ZNF584
- ZNF583
- ZNF431
- FIK
- ZNF264
- ZNF81
- ZFP28
- ZNF10
- ZNF430
- ZNF225
- ZNF222
- ZNF251
- HZF16
- ZNF738
- ZNF98
- ZNF43
- ZNF586
- ZNF248
- ZNF235
- ZNF516
- ZNF354B
- ZNF219
- DKFZp434J0650
- ZNF674
- ZNF552
- KRBOX4
- ZNF90
- ZNF573
- ZNF672
- ZNF254
- FLJ00301
- ZNF175
- ZNF585A
- ZFS-2
- ZNF808
- ZNF114
- ZNF550
- ZNF544
- ZNF410
- ZNF655
- ZNF493
- TIPUH1
- ZNF575
- ZNF480
- ZNF345
- A-328A3.4
Variants for ZNF688 Gene
| SNP ID | Clin | Chr 16 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1001038511 | -- | 30,573,195(-) | C/T | upstream_transcript_variant | |
| rs1001123878 | -- | 30,574,327(-) | C/T | upstream_transcript_variant | |
| rs1002154695 | -- | 30,573,590(-) | A/T | upstream_transcript_variant | |
| rs1002248114 | -- | 30,574,117(-) | C/G | upstream_transcript_variant | |
| rs1003006183 | -- | 30,570,127(-) | C/T | coding_sequence_variant, missense_variant |
Residual Variation Intolerance Score:
35.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.94;
19.42% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ZNF688 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ZNF688
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZNF688 Gene
Disorders for ZNF688 Gene
Additional Disease Information for ZNF688
No disorders were found for ZNF688 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF688 Gene
Publications for ZNF688 Gene
- Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PMID: 10493829) Loftus BJ … Adams MD (Genomics 1999) 2 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. (PMID: 26871637) Yang X … Vidal M (Cell 2016) 3 58
- Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation. (PMID: 20562864) Nozawa RS … Obuse C (Nature cell biology 2010) 3 58
Products for ZNF688 Gene
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 33 available ZNF688 Antibodies ranked by validation data
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Sources for ZNF688 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
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