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Aliases for ZNF688 Gene
External Ids for ZNF688 Gene
- HGNC: 30489
- Entrez Gene: 146542
- Ensembl: ENSG00000229809
- UniProtKB: P0C7X2
Previous GeneCards Identifiers for ZNF688 Gene
- GC16M030489
- GC16M030009
- GC16M030581
- GC16M028144
Summaries for ZNF688 Gene
GeneCards Summary for ZNF688 Gene
ZNF688 (Zinc Finger Protein 688) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF785.
UniProtKB/Swiss-Prot Summary for ZNF688 Gene
-
May be involved in transcriptional regulation.
Additional gene information for ZNF688 Gene
- HGNC(30489)
- Entrez Gene(146542)
- Ensembl(ENSG00000229809)
- UniProtKB(P0C7X2)
- Open Targets Platform(ENSG00000229809)
- Search for ZNF688 at DataMed
- Search for ZNF688 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF688 Gene
Genomics for ZNF688 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for ZNF688 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ZNF688 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF688
- Top Transcription factor binding sites by QIAGEN in the ZNF688 gene promoter:
-
- deltaCREB
- E2F
- E2F-1
- E2F-2
- E2F-3a
- E2F-4
- E2F-5
- STAT1
- STAT1alpha
- STAT1beta
Genomic Locations for ZNF688 Gene
Genomic Locations for ZNF688 Gene
- chr16:30,569,346-30,572,734
- (GRCh38/hg38)
- Size:
- 3,389 bases
- Orientation:
- Minus strand
- chr16:30,580,667-30,584,055
- (GRCh37/hg19)
- Size:
- 3,389 bases
- Orientation:
- Minus strand
Genomic View for ZNF688 Gene
Genes around ZNF688 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16p11.2 by HGNC
- 16p11.2 by Entrez Gene
- 16p11.2 by Ensembl
ZNF688 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ZNF688 Gene
Proteins for ZNF688 Gene
-
Protein details for ZNF688 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P0C7X2-ZN688_HUMAN
- Recommended name:
- Zinc finger protein 688
- Protein Accession:
- P0C7X2
- A8MV39
- B3KV51
- O75701
- Q8IW91
- Q8WV14
- Q96MN0
Protein attributes for ZNF688 Gene
- Size:
- 276 amino acids
- Molecular mass:
- 30575 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAC31673.1; Type=Erroneous gene model prediction; Note=The predicted gene has been split into 2 genes: ZNF688 and ZNF785.; Evidence={ECO:0000305};
Protein Expression for ZNF688 Gene
Post-translational modifications for ZNF688 Gene
Other Protein References for ZNF688 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for ZNF688
- Invitrogen Antibodies for ZNF688 (AFLGC-ZNF688)
-
Boster Bio Antibodies for ZNF688
-
Santa Cruz Biotechnology (SCBT) Antibodies for ZNF688
Protein Products
-
OriGene Purified Proteins for ZNF688
- Search Origene for MassSpec and Protein Over-expression Lysates for ZNF688
- Origene Custom Protein Services for ZNF688
- antibodies-online: Show 2 available ZNF688 Proteins ranked by validation data
- Compare Top ZNF688 Proteins
-
Quality Products:
-
Abcam proteins for ZNF688
No data available for DME Specific Peptides for ZNF688 Gene
Domains & Families for ZNF688 Gene
Gene Families for ZNF688 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for ZNF688 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for ZNF688 Gene
- GenScript: Design optimal peptide antigens:
-
- Zinc finger protein 688, isoform CRA_a (A8MV39_HUMAN)
- Zinc finger protein 688 (ZN688_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P0C7X2- Family:
-
- Belongs to the krueppel C2H2-type zinc-finger protein family.
Function for ZNF688 Gene
Molecular function for ZNF688 Gene
- UniProtKB/Swiss-Prot Function:
- May be involved in transcriptional regulation.
Phenotypes From GWAS Catalog for ZNF688 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003674 | molecular_function | ND | -- |
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003700 | DNA-binding transcription factor activity | IBA | 21873635 |
| GO:0043565 | sequence-specific DNA binding | IBA | 21873635 |
Phenotypes for ZNF688 Gene
- GenomeRNAi human phenotypes for ZNF688:
-
- Decreased viability
- Decreased viability ratio
- Increased shRNA abundance (Z-score > 2)
- Decreased viability after Maraba virus infection
- Negative genetic interaction between MUS81-/- and MUS81+/+
- Decreased shRNA abundance (Z-score < -2)
- Decreased HIV-LTR-beta-galactosidase protein expression
- Two nuclei (binuclear)
- Decreased Aire reporter expression
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ZNF688 - Select products 50% OFF >
- * ZNF688 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for ZNF688
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ZNF688
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZNF688
miRNA for ZNF688 Gene
- miRTarBase miRNAs that target ZNF688
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ZNF688
- Browse OriGene Inhibitory RNA Products For ZNF688
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Clone Products
- Applied Biological Materials (abm): Clones for ZNF688 - Select products 50% OFF >
- * ZNF688 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for ZNF688
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ZNF688
Cell Line Products
-
Horizon Cell Lines for ZNF688
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF688 Gene
Localization for ZNF688 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ZNF688 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 4 |
| plasma membrane | 1 |
- Cell Junctions (2)
- Nucleoplasm (2)
- Plasma membrane (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005575 | cellular_component | ND | -- |
| GO:0005634 | nucleus | IBA | 21873635 |
Pathways & Interactions for ZNF688 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Gene Expression |
.48
|
|
| 2 | Herpes simplex virus 1 infection | ||
Pathways by source for ZNF688 Gene
2 Reactome pathways for ZNF688 Gene
1 KEGG pathway for ZNF688 Gene
Interacting Proteins for ZNF688 Gene
Selected Interacting proteins:
P0C7X2-ZN688_HUMAN
ENSP00000223459
for ZNF688 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for ZNF688
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0008150 | biological_process | ND | -- |
No data available for SIGNOR curated interactions for ZNF688 Gene
Transcripts for ZNF688 Gene
mRNA/cDNA for ZNF688 Gene
- 2 REFSEQ mRNAs :
- 8 NCBI additional mRNA sequence :
- 7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000223459 2506 nts (view in UCSC)
- ENST00000562455 562 nts (view in UCSC)
- ENST00000563276 1492 nts (view in UCSC)
- ENST00000563665 1414 nts (view in UCSC)
- ENST00000563707 244 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ZNF688 - Select products 50% OFF >
- * ZNF688 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for ZNF688
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ZNF688
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZNF688
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ZNF688
- Browse OriGene Inhibitory RNA Products For ZNF688
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF688
Clone Products
- Applied Biological Materials (abm): Clones for ZNF688 - Select products 50% OFF >
- * ZNF688 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for ZNF688
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ZNF688
Relevant External Links for ZNF688 Gene
- GeneLoc Exon Structure for
- ZNF688
Expression for ZNF688 Gene
This gene is overexpressed in Blymphocyte (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF688 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF688
SOURCE GeneReport for Unigene cluster for ZNF688 Gene:
Hs.301463Evidence on tissue expression from TISSUES for ZNF688 Gene
- Nervous system(4.2)
Primer Products
-
OriGene qPCR primer pairs for ZNF688
-
OriGene qPCR primer pairs and template standards for ZNF688
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF688 Gene
Orthologs for ZNF688 Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | ZNF688 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | ZNF688 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | ZNF688 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Zfp688 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | LOC102554302 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany |
- Species where no ortholog for ZNF688 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for ZNF688 Gene
- ENSEMBL:
- Gene Tree for ZNF688 (if available)
- TreeFam:
- Gene Tree for ZNF688 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ZNF688: view image
Paralogs for ZNF688 Gene
Paralogs for ZNF688 Gene
- ZNF785 5
- ZNF764 5
- ZNF689 5
- ENSG00000261459 5
- ZNF747 5
- ZNF845 5
- ZNF160 5
- ZNF347 5
- ZNF107 5
- ZNF91 5
- ZNF184 5
- ZNF569 5
- ZNF208 5
- ZNF729 5
- ZNF665 5
- ZNF420 5
- ZNF84 5
- ZNF99 5
- ZNF181 5
- ZNF473 5
- ZNF142 5
- ZNF594 5
- ZNF302 5
- ZBTB48 5
- ZNF574 5
- ZNF771 5
- ZNF526 5
- CTCF 5
- ENSG00000269237 5
- ZNF275 5
- ZBTB24 5
- CTCFL 5
- ZNF48 5
- ZFP92 5
- ZNF497 5
- ZNF827 5
- ZNF282 5
- ZBTB34 5
- ZBTB37 5
(224) SIMAP similar genes for ZNF688 Gene using alignment to 6 proteins:
- ZN688_HUMAN
- H3BPA7_HUMAN
- H3BR26_HUMAN
- H3BR45_HUMAN
- H3BTK8_HUMAN
- L0R5I2_HUMAN
- ZNF619
- ZNF627
- ZNF707
- ZNF823
- ZNF75A
- ZNF616
- ZNF433
- ZNF785
- ZNF571
- ZNF3
- ZNF383
- ZNF320
- ZNF780A
- ZNF761
- ZNF519
- ZNF649
- ZNF347
- ZNF780B
- ZNF565
- ZNF124
- ZNF525
- ZNF331
- ZNF625
- ZNF721
- ZNF670
- ZNF669
- ZNF595
- ZNF562
- ZNF554
- ZFP14
- ZNF630
- ZNF101
- ZIK1
- ZNF83
- ZNF561
- ZNF607
- ZNF28
- ZNF747
- ZNF577
- ZNF766
- ZNF205
- ZNF549
- ZNF283
- ZNF17
- ZNF540
- ZNF230
- ZNF569
- ZNF140
- ZNF718
- ZNF556
- ZNF23
- ZNF141
- ZNF789
- ZNF133
- ZNF19
- ZNF841
- ZNF791
- ZNF529
- ZFP1
- ZNF613
- ZNF551
- ZNF547
- ZFS-6
- ZNF420
- ZNF695
- ZNF267
- ZNF470
- ZNF300
- ZNF250
- kr-znf3
- ZNF778
- ZNF234
- ZKSCAN5
- ZNF415
- LOC101928664
- ZNF350
- ZNF793
- ZNF426
- ZNF33B
- ZNF78L1
- ZNF788
- ZNF709
- ZNF700
- ZNF229
- ZNF682
- ZNF610
- ZNF559
- ZNF429
- ZNF208
- KRBOX1
- ZNF548
- ZNF717
- ZNF302
- ZNF
- ZNF880
- ZNF677
- ZNF274
- ZNF814
- ZNF624
- ZNF836
- ZNF705A
- ZNF850
- ZNF582
- HKR1
- ZNF621
- ZNF614
- ZNF517
- ZFS-5
- ZNF195
- ZNF226
- ZNF615
- ZNF790
- ZNF514
- ZNF528
- ZNF596
- ZNF776
- ZNF846
- ZNF317
- ZNF286A
- ZNF486
- ZNF300P1
- ZNF7
- ZNF675
- ZNF461
- ZNF181
- ZNF527
- ZNF227
- ZNF418
- ZNF138
- ZNF85
- ZNF324B
- ZNF84
- ZNF720
- ZNF91
- ZNF844
- ZNF816
- ZNF737
- ZNF471
- ZNF221
- ZNF155
- ZNF546
- ZNF510
- ZNF485
- ZNF443
- ZNF177
- ZNF169
- ZFP90
- ZNF724P
- ZFP30
- ZNF66
- ZNF273
- ZNF257
- POM121C
- MGC12518
- ZNF224
- ZNF773
- ZNF763
- ZNF599
- ZNF233
- ZNF112
- ZNF620
- ZNF585B
- ZNF354A
- ZNF33A
- ZNF93
- ZNF684
- ZNF432
- ZNF570
- ZNF223
- ZNF506
- ZNF135
- ZNF12
- ZNF667
- ZNF419
- ZNF268
- ZNF726
- ZNF611
- ZNF879
- ZNF584
- ZNF583
- ZNF431
- FIK
- ZNF264
- ZNF81
- ZFP28
- ZNF10
- ZNF430
- ZNF225
- ZNF222
- ZNF251
- HZF16
- ZNF738
- ZNF98
- ZNF43
- ZNF586
- ZNF248
- ZNF235
- ZNF516
- ZNF354B
- ZNF219
- DKFZp434J0650
- ZNF674
- ZNF552
- KRBOX4
- ZNF90
- ZNF573
- ZNF672
- ZNF254
- FLJ00301
- ZNF175
- ZNF585A
- ZFS-2
- ZNF808
- ZNF114
- ZNF550
- ZNF544
- ZNF410
- ZNF655
- ZNF493
- TIPUH1
- ZNF575
- ZNF480
- ZNF345
- A-328A3.4
Variants for ZNF688 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF688 Gene
| SNP ID | Clinical significance and condition | Chr 16 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs33997546 | - | p.Ser131Ile |
Residual Variation Intolerance Score:
35.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.94;
19.42% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ZNF688 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ZNF688
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZNF688 Gene
Disorders for ZNF688 Gene
Additional Disease Information for ZNF688
No disorders were found for ZNF688 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF688 Gene
Publications for ZNF688 Gene
- Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PMID: 10493829) Loftus BJ … Adams MD (Genomics 1999) 2 3 4
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
- A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
- Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. (PMID: 26871637) Yang X … Vidal M (Cell 2016) 3
ExternalLinks
Products for ZNF688 Gene
- Custom Antibody Services
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- Browse OriGene Inhibitory RNA Products For ZNF688
- OriGene qPCR primer pairs for ZNF688
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- antibodies-online: Show 32 available ZNF688 Antibodies ranked by validation data
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- antibodies-online: Show 2 available ZNF688 Proteins ranked by validation data
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- Quality Products:
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- Boster Bio Antibodies for ZNF688
- Browse Boster Bio ELISA Kits
Sources for ZNF688 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
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