ZNF688 Gene (Protein Coding)

Zinc Finger Protein 688

GC16M030569
GIFtS:
32
See more...

Aliases for ZNF688 Gene

Aliases for ZNF688 Gene

  • Zinc Finger Protein 688 2 3 4 5
  • ZNF688 5

External Ids for ZNF688 Gene

Previous GeneCards Identifiers for ZNF688 Gene

  • GC16M030489
  • GC16M030009
  • GC16M030581
  • GC16M028144

Summaries for ZNF688 Gene

GeneCards Summary for ZNF688 Gene

ZNF688 (Zinc Finger Protein 688) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF785.

UniProtKB/Swiss-Prot Summary for ZNF688 Gene

Additional gene information for ZNF688 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF688 Gene

Genomics for ZNF688 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for ZNF688 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF688 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF688

Top Transcription factor binding sites by QIAGEN in the ZNF688 gene promoter:
  • deltaCREB
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • STAT1
  • STAT1alpha
  • STAT1beta

Genomic Locations for ZNF688 Gene

Latest Assembly
chr16:30,569,672-30,572,734
(GRCh38/hg38)
Size:
3,063 bases
Orientation:
Minus strand

Previous Assembly
chr16:30,581,047-30,583,728
(GRCh37/hg19 by Entrez Gene)
Size:
2,682 bases
Orientation:
Minus strand

chr16:30,580,667-30,584,055
(GRCh37/hg19 by Ensembl)
Size:
3,389 bases
Orientation:
Minus strand

Genomic View for ZNF688 Gene

Genes around ZNF688 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF688 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF688 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ZNF688 Gene

Proteins for ZNF688 Gene

Products:

  1. Antibodies for research
  2. Protein products for research
  3. Assay products for research

  • Protein details for ZNF688 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0C7X2-ZN688_HUMAN
    Recommended name:
    Zinc finger protein 688
    Protein Accession:
    P0C7X2
    Secondary Accessions:
    • A8MV39
    • B3KV51
    • O75701
    • Q8IW91
    • Q8WV14
    • Q96MN0

    Protein attributes for ZNF688 Gene

    Size:
    276 amino acids
    Molecular mass:
    30575 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC31673.1; Type=Erroneous gene model prediction; Note=The predicted gene has been split into 2 genes: ZNF688 and ZNF785.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF688 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF688 Gene

Protein Expression for ZNF688 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for ZNF688 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF688 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF688 Gene

Domains & Families for ZNF688 Gene

Gene Families for ZNF688 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZNF688 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF688 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 688, isoform CRA_a (A8MV39_HUMAN)
  • Zinc finger protein 688 (ZN688_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P0C7X2

UniProtKB/Swiss-Prot:

ZN688_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF688: view

Function for ZNF688 Gene

Products:

  1. Animal Models for research
  2. CRISPR products for research
  3. miRNA products for research
  4. Inhibitory RNAs for research
  5. Clone products for research
  6. Cell Lines for research

Molecular function for ZNF688 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF688 Gene

Gene Ontology (GO) - Molecular Function for ZNF688 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA 21873635
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific IBA 21873635
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific IBA 21873635
GO:0003674 molecular_function ND --
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with ZNF688: view
genes like me logo Genes that share phenotypes with ZNF688: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF688

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF688 Gene

Localization for ZNF688 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF688 Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF688 gene
Compartment Confidence
nucleus 4
plasma membrane 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (2)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF688 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin IBA --
GO:0005575 cellular_component ND --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF688: view

Pathways & Interactions for ZNF688 Gene

genes like me logo Genes that share pathways with ZNF688: view

Pathways by source for ZNF688 Gene

2 Reactome pathways for ZNF688 Gene
1 KEGG pathway for ZNF688 Gene

Gene Ontology (GO) - Biological Process for ZNF688 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IBA 21873635
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IBA 21873635
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with ZNF688: view

No data available for SIGNOR curated interactions for ZNF688 Gene

Drugs & Compounds for ZNF688 Gene

Products:

  1. Drug products for research
No Compound Related Data Available

Transcripts for ZNF688 Gene

Products:

  1. CRISPR products for research
  2. miRNA products for research
  3. Inhibitory RNAs for research
  4. Clone products for research

mRNA/cDNA for ZNF688 Gene

2 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF688

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF688 Gene

No ASD Table

Relevant External Links for ZNF688 Gene

GeneLoc Exon Structure for
ZNF688

Expression for ZNF688 Gene

Products:

  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF688 Gene

mRNA expression in normal human tissues for ZNF688 Gene
mRNA expression by GTEx for ZNF688 GenemRNA expression by BioGPS for ZNF688 Gene

Protein differential expression in normal tissues from HIPED for ZNF688 Gene

This gene is overexpressed in Blymphocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF688 Gene



Protein tissue co-expression partners for ZNF688 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF688

SOURCE GeneReport for Unigene cluster for ZNF688 Gene:

Hs.301463

Evidence on tissue expression from TISSUES for ZNF688 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with ZNF688: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF688 Gene

Orthologs for ZNF688 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF688 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia ZNF688 30 31
  • 99.76 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia ZNF688 30 31
  • 87.18 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia ZNF688 30 31
  • 86.55 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Zfp688 30 17 31
  • 79.82 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia LOC102554302 30
  • 79.31 (n)
Oppossum
(Monodelphis domestica)
 Mammalia -- 31
  • 29 (a)
 OneToMany
Species where no ortholog for ZNF688 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF688 Gene

ENSEMBL:
Gene Tree for ZNF688 (if available)
TreeFam:
Gene Tree for ZNF688 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF688: view image

Paralogs for ZNF688 Gene

Paralogs for ZNF688 Gene

(224) SIMAP similar genes for ZNF688 Gene using alignment to 6 proteins:

  • ZN688_HUMAN
  • H3BPA7_HUMAN
  • H3BR26_HUMAN
  • H3BR45_HUMAN
  • H3BTK8_HUMAN
  • L0R5I2_HUMAN
genes like me logo Genes that share paralogs with ZNF688: view

Variants for ZNF688 Gene

Products:

  1. SNP Genotyping and Copy Number Assays for research

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF688 Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
rs33997546 - p.Ser131Ile

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for ZNF688 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Variation tolerance for ZNF688 Gene

Residual Variation Intolerance Score: 35.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.94; 19.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF688 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF688

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZNF688 Gene

Disorders for ZNF688 Gene

Additional Disease Information for ZNF688

Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for ZNF688 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF688 Gene

Publications for ZNF688 Gene

  1. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PMID: 10493829) Loftus BJ … Adams MD (Genomics 1999) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. (PMID: 26871637) Yang X … Vidal M (Cell 2016) 3

ExternalLinks

View latest publications for ZNF688 gene in Mastermind

Products for ZNF688 Gene

Sources for ZNF688 Gene