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Aliases for ZNF684 Gene

Aliases for ZNF684 Gene

  • Zinc Finger Protein 684 2 3 5
  • Hypothetical Protein MGC27466 2

External Ids for ZNF684 Gene

Previous GeneCards Identifiers for ZNF684 Gene

  • GC01P040667
  • GC01P040769
  • GC01P040997
  • GC01P039115

Summaries for ZNF684 Gene

GeneCards Summary for ZNF684 Gene

ZNF684 (Zinc Finger Protein 684) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF793.

UniProtKB/Swiss-Prot for ZNF684 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF684 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF684 Gene

Genomics for ZNF684 Gene

GeneHancer (GH) Regulatory Elements for ZNF684 Gene

Promoters and enhancers for ZNF684 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I040530 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 +1.0 970 2.9 HDGF PKNOX1 SMAD1 MLX ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 ZNF684 EXO5 LOC105378672 PPIE ZFP69 NFYC PABPC4 RLF LOC101929516 TRIT1
GH01I040476 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 11.5 -53.6 -53637 1.4 PKNOX1 ARID4B SIN3A ZNF2 POLR2B E2F8 ZNF207 ZNF143 SP3 SP5 ZFP69 EXO5 PPIE PPIEL TRIT1 LOC105378672 ENSG00000227278 ENSG00000238186 ZNF684 RLF
GH01I040449 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.7 -80.6 -80565 2.5 HDGF PKNOX1 ARID4B SIN3A ZNF2 IRF4 YY1 POLR2B CBX5 ZNF207 ENSG00000284677 ZFP69B LOC105378672 ZFP69 EXO5 ENSG00000227278 ENSG00000238186 ZNF684 OXCT2 ENSG00000260920
GH01I040708 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 4.4 +180.1 180083 6.1 PKNOX1 SMAD1 FOXA2 ARNT ARID4B FEZF1 DMAP1 YY1 SLC30A9 POLR2B NFYC EXO5 RLF RIMS3 TRIT1 LOC105378674 NFYC-AS1 MIR30E MIR30C1 LOC105378672
GH01I040698 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 7.2 +168.4 168388 2 HDGF ATF1 ZBTB40 BATF IRF4 ZNF121 FOS ATF7 IKZF2 RUNX3 RIMS3 LOC105378674 MIR30E MIR30C1 NFYC ZNF684 KCNQ4 EXO5 CITED4 ZFP69
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF684 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF684 gene promoter:

Genomic Locations for ZNF684 Gene

Genomic Locations for ZNF684 Gene
17,015 bases
Plus strand

Genomic View for ZNF684 Gene

Genes around ZNF684 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF684 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF684 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF684 Gene

Proteins for ZNF684 Gene

  • Protein details for ZNF684 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 684
    Protein Accession:
    Secondary Accessions:
    • Q2NKY4

    Protein attributes for ZNF684 Gene

    378 amino acids
    Molecular mass:
    43945 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF684 Gene

Post-translational modifications for ZNF684 Gene

No Post-translational modifications

No data available for DME Specific Peptides for ZNF684 Gene

Domains & Families for ZNF684 Gene

Gene Families for ZNF684 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF684 Gene

Suggested Antigen Peptide Sequences for ZNF684 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF684: view

Function for ZNF684 Gene

Molecular function for ZNF684 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF684 Gene

Gene Ontology (GO) - Molecular Function for ZNF684 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF684: view
genes like me logo Genes that share phenotypes with ZNF684: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF684 Gene

Localization for ZNF684 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF684 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF684 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF684 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF684: view

Pathways & Interactions for ZNF684 Gene

SuperPathways for ZNF684 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF684: view

Pathways by source for ZNF684 Gene

2 Reactome pathways for ZNF684 Gene

Interacting Proteins for ZNF684 Gene

Gene Ontology (GO) - Biological Process for ZNF684 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF684: view

No data available for SIGNOR curated interactions for ZNF684 Gene

Drugs & Compounds for ZNF684 Gene

No Compound Related Data Available

Transcripts for ZNF684 Gene

Unigene Clusters for ZNF684 Gene

Zinc finger protein 684:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF684 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c
SP1: - - -
SP2: -
SP3: - -
SP4: - - - - -
SP5: - -

Relevant External Links for ZNF684 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF684 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF684 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF684 Gene

This gene is overexpressed in Liver (x4.6).

Protein differential expression in normal tissues from HIPED for ZNF684 Gene

This gene is overexpressed in Pancreatic juice (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF684 Gene

Protein tissue co-expression partners for ZNF684 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF684 Gene:


SOURCE GeneReport for Unigene cluster for ZNF684 Gene:


Evidence on tissue expression from TISSUES for ZNF684 Gene

  • Skin(4.1)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with ZNF684: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF684 Gene

Orthologs for ZNF684 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF684 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF684 33 34
  • 99.38 (n)
(Canis familiaris)
Mammalia ZNF684 33 34
  • 89.24 (n)
(Bos Taurus)
Mammalia ZNF684 34
  • 81 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 33 (a)
-- 34
  • 30 (a)
-- 34
  • 28 (a)
-- 34
  • 21 (a)
-- 34
  • 14 (a)
Species where no ortholog for ZNF684 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF684 Gene

Gene Tree for ZNF684 (if available)
Gene Tree for ZNF684 (if available)

Paralogs for ZNF684 Gene

Paralogs for ZNF684 Gene

(532) SIMAP similar genes for ZNF684 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZNF684: view

Variants for ZNF684 Gene

Sequence variations from dbSNP and Humsavar for ZNF684 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000007677 -- 40,529,434(+) G/A upstream_transcript_variant
rs1000058364 -- 40,541,462(+) C/T intron_variant
rs1000107341 -- 40,536,884(+) G/A/C genic_upstream_transcript_variant, intron_variant
rs1000165183 -- 40,543,824(+) A/G intron_variant
rs1000310434 -- 40,547,615(+) T/C 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF684 Gene

Variant ID Type Subtype PubMed ID
nsv546065 CNV loss 21841781
nsv546064 CNV gain 21841781
dgv243n54 CNV loss 21841781

Variation tolerance for ZNF684 Gene

Residual Variation Intolerance Score: 57.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.24; 40.35% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF684 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF684 Gene

Disorders for ZNF684 Gene

Additional Disease Information for ZNF684

No disorders were found for ZNF684 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF684 Gene

Publications for ZNF684 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Protein array based interactome analysis of amyloid-β indicates an inhibition of protein translation. (PMID: 21244100) Virok DP … Fülöp L (Journal of proteome research 2011) 3 58

Products for ZNF684 Gene

Sources for ZNF684 Gene

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