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Aliases for ZNF682 Gene

Aliases for ZNF682 Gene

  • Zinc Finger Protein 682 2 3 5
  • BC39498_3 3

External Ids for ZNF682 Gene

Previous GeneCards Identifiers for ZNF682 Gene

  • GC19M019978
  • GC19M020115
  • GC19M019677
  • GC19M020696
  • GC19M020952
  • GC19M020180
  • GC19M020383
  • GC19M021101
  • GC19M021326
  • GC19M021506
  • GC19M021691
  • GC19M021887

Summaries for ZNF682 Gene

GeneCards Summary for ZNF682 Gene

ZNF682 (Zinc Finger Protein 682) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF92.

UniProtKB/Swiss-Prot for ZNF682 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF682 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF682 Gene

Genomics for ZNF682 Gene

GeneHancer (GH) Regulatory Elements for ZNF682 Gene

Promoters and enhancers for ZNF682 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I020038 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 580.7 +0.3 323 1.9 PKNOX1 ARID4B KLF17 SIN3A ZBTB40 YY1 ZNF335 SCRT2 FOS THAP11 ZNF682 LINC00663 LOC101928960
GH19I020036 Promoter 0.5 EPDnew 550.8 +2.7 2667 0.1 ZNF682 LOC101928960
GH19I020037 Enhancer 0.2 Ensembl 550.8 +1.5 1525 0.4 ZNF682 LOC101928960
GH19I020051 Enhancer 1.4 FANTOM5 Ensembl ENCODE 30.5 -12.8 -12811 1.9 ATF1 SIN3A DMAP1 YY1 ETS1 ZNF143 ATF7 SP3 RXRA REST LOC105372309 ZNF682 ZNF253 ZNF506 GC19M022339
GH19I020077 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 11.7 -41.2 -41188 6.8 TFAP4 MXI1 PKNOX1 USF1 SAP130 ARID4B MAX ZSCAN9 YY1 GATAD1 LOC100419301 ZNF90 ZNF682 BNIP3P15 CILP2 MEF2B ZNF506 BNIP3P14
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF682 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF682 gene promoter:

Genomic Locations for ZNF682 Gene

Genomic Locations for ZNF682 Gene
42,469 bases
Minus strand

Genomic View for ZNF682 Gene

Genes around ZNF682 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF682 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF682 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF682 Gene

Proteins for ZNF682 Gene

  • Protein details for ZNF682 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 682
    Protein Accession:
    Secondary Accessions:
    • B3KU64
    • E9PFJ5
    • Q96JV9

    Protein attributes for ZNF682 Gene

    498 amino acids
    Molecular mass:
    58361 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB55408.1; Type=Frameshift; Positions=441; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF682 Gene


neXtProt entry for ZNF682 Gene

Post-translational modifications for ZNF682 Gene

No Post-translational modifications

No data available for DME Specific Peptides for ZNF682 Gene

Domains & Families for ZNF682 Gene

Gene Families for ZNF682 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF682 Gene

Suggested Antigen Peptide Sequences for ZNF682 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF682: view

Function for ZNF682 Gene

Molecular function for ZNF682 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF682 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF682: view

Phenotypes for ZNF682 Gene

genes like me logo Genes that share phenotypes with ZNF682: view

miRNA for ZNF682 Gene

miRTarBase miRNAs that target ZNF682

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF682 Gene

Localization for ZNF682 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF682 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF682 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF682 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF682: view

Pathways & Interactions for ZNF682 Gene

SuperPathways for ZNF682 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF682: view

Pathways by source for ZNF682 Gene

2 Reactome pathways for ZNF682 Gene

Interacting Proteins for ZNF682 Gene

Gene Ontology (GO) - Biological Process for ZNF682 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF682: view

No data available for SIGNOR curated interactions for ZNF682 Gene

Drugs & Compounds for ZNF682 Gene

No Compound Related Data Available

Transcripts for ZNF682 Gene

Unigene Clusters for ZNF682 Gene

Zinc finger protein 682:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF682 Gene

No ASD Table

Relevant External Links for ZNF682 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF682 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF682 Gene

Protein differential expression in normal tissues from HIPED for ZNF682 Gene

This gene is overexpressed in Plasma (67.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF682 Gene

Protein tissue co-expression partners for ZNF682 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF682 Gene:


SOURCE GeneReport for Unigene cluster for ZNF682 Gene:


Evidence on tissue expression from TISSUES for ZNF682 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ZNF682: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF682 Gene

Orthologs for ZNF682 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF682 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF682 33 34
  • 99.46 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 51 (a)
-- 34
  • 36 (a)
(Bos Taurus)
Mammalia -- 34
  • 49 (a)
(Mus musculus)
Mammalia Zfp708 34
  • 42 (a)
(Canis familiaris)
Mammalia -- 34
  • 35 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 47 (a)
-- 34
  • 36 (a)
-- 34
  • 35 (a)
-- 34
  • 31 (a)
-- 34
  • 28 (a)
-- 34
  • 28 (a)
-- 34
  • 28 (a)
-- 34
  • 26 (a)
Species where no ortholog for ZNF682 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF682 Gene

Gene Tree for ZNF682 (if available)
Gene Tree for ZNF682 (if available)

Paralogs for ZNF682 Gene

(526) SIMAP similar genes for ZNF682 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with ZNF682: view

Variants for ZNF682 Gene

Sequence variations from dbSNP and Humsavar for ZNF682 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000048855 -- 20,004,523(-) T/C 3_prime_UTR_variant
rs1000113674 -- 20,004,336(-) C/T downstream_transcript_variant
rs1000115836 -- 20,017,617(-) TTT/TT intron_variant
rs1000145777 -- 20,008,136(-) T/C intron_variant
rs1000308928 -- 20,040,742(-) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF682 Gene

Variant ID Type Subtype PubMed ID
nsv1061846 CNV loss 25217958
esv3643864 CNV loss 21293372
esv2718300 CNV deletion 23290073
esv2718298 CNV deletion 23290073
esv2718296 CNV deletion 23290073
dgv630e199 CNV deletion 23128226
dgv6303n54 CNV loss 21841781
dgv509e201 CNV deletion 23290073
dgv3457n100 CNV gain 25217958
dgv3456n100 CNV gain 25217958
dgv1026e212 CNV loss 25503493
nsv578803 CNV gain 21841781
nsv578800 CNV gain 21841781
nsv519535 CNV gain 19592680
nsv458376 CNV gain 19166990
nsv1066970 CNV gain 25217958
nsv1066045 CNV loss 25217958

Variation tolerance for ZNF682 Gene

Residual Variation Intolerance Score: 61.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.92; 87.17% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF682 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF682 Gene

Disorders for ZNF682 Gene

Additional Disease Information for ZNF682

No disorders were found for ZNF682 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF682 Gene

Publications for ZNF682 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4 58
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for ZNF682 Gene

Sources for ZNF682 Gene

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