Aliases for ZNF681 Gene

Aliases for ZNF681 Gene

  • Zinc Finger Protein 681 2 3 4 5
  • Hypothetical Protein FLJ31526 2

External Ids for ZNF681 Gene

Previous GeneCards Identifiers for ZNF681 Gene

  • GC19M023719
  • GC19M023921
  • GC19M023470
  • GC19M023741
  • GC19M023742
  • GC19M023751
  • GC19M023752
  • GC19M023753
  • GC19M023743
  • GC19M023744
  • GC19M023745
  • GC19M023746
  • GC19M023747
  • GC19M023748
  • GC19M023749
  • GC19M023750

Summaries for ZNF681 Gene

GeneCards Summary for ZNF681 Gene

ZNF681 (Zinc Finger Protein 681) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZNF43.

UniProtKB/Swiss-Prot Summary for ZNF681 Gene

Additional gene information for ZNF681 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF681 Gene

Genomics for ZNF681 Gene

GeneHancer (GH) Regulatory Elements for ZNF681 Gene

Promoters and enhancers for ZNF681 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J023757 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 500.7 +0.6 616 2.5 NRF1 SP1 GTF2E2 ZFX ZNF10 CHD1 MYC POLR2A NFRKB TAF9B ZNF681 ENSG00000233836 HE856079
GH19J023798 Promoter/Enhancer 0.7 Ensembl ENCODE 12.1 -41.1 -41070 2.4 POLR2A SMARCA4 SPI1 BNIP3P39 lnc-ZNF681-3 ENSG00000233836 ZNF681 ENSG00000268362 ENSG00000269397 ZNF726 ZNF675 ZNF91 piR-61223-009
GH19J023724 Enhancer 0.3 ENCODE 12.7 +34.3 34308 0.8 MAX IKZF1 piR-48049-039 ENSG00000233836 ZNF675 ZNF681 VN1R94P
GH19J023795 Enhancer 0.3 Ensembl 12.1 -36.9 -36910 0.8 SPI1 ENSG00000233836 ZNF681 ENSG00000268362 lnc-ZNF681-3 lnc-ZNF726-4 RPSAP58 lnc-ZNF726-5
GH19J023672 Enhancer 0.2 FANTOM5 12 +86.2 86150 0.2 ZNF681 ENSG00000233836 piR-30449-075 ZNF675
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF681 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF681

Top Transcription factor binding sites by QIAGEN in the ZNF681 gene promoter:
  • AREB6
  • CBF(2)
  • CBF-A
  • CBF-B
  • CP1A
  • NF-Y
  • NF-YA
  • NF-YB

Genomic Locations for ZNF681 Gene

Genomic Locations for ZNF681 Gene
19,697 bases
Minus strand
19,697 bases
Minus strand

Genomic View for ZNF681 Gene

Genes around ZNF681 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF681 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF681 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF681 Gene

Proteins for ZNF681 Gene

  • Protein details for ZNF681 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 681
    Protein Accession:
    Secondary Accessions:
    • B3KVF7

    Protein attributes for ZNF681 Gene

    645 amino acids
    Molecular mass:
    75059 Da
    Quaternary structure:
    No Data Available
    • Sequence=BC062216; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF681 Gene


neXtProt entry for ZNF681 Gene

Post-translational modifications for ZNF681 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF681 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF681 Gene

Domains & Families for ZNF681 Gene

Gene Families for ZNF681 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF681 Gene

  • C2H2-type zinc finger signature

Suggested Antigen Peptide Sequences for ZNF681 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 681, isoform CRA_c (B9EGB3_HUMAN)
  • Zinc finger protein 681 (ZN681_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF681: view

Function for ZNF681 Gene

Molecular function for ZNF681 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF681 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF681: view
genes like me logo Genes that share phenotypes with ZNF681: view

miRNA for ZNF681 Gene

miRTarBase miRNAs that target ZNF681

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF681 Gene

Localization for ZNF681 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF681 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF681 gene
Compartment Confidence
nucleus 4
golgi apparatus 1
mitochondrion 0

Gene Ontology (GO) - Cellular Components for ZNF681 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF681: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF681 Gene

Pathways & Interactions for ZNF681 Gene

PathCards logo

SuperPathways for ZNF681 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF681: view

Pathways by source for ZNF681 Gene

2 Reactome pathways for ZNF681 Gene

Interacting Proteins for ZNF681 Gene


Gene Ontology (GO) - Biological Process for ZNF681 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF681: view

No data available for SIGNOR curated interactions for ZNF681 Gene

Drugs & Compounds for ZNF681 Gene

No Compound Related Data Available

Transcripts for ZNF681 Gene

mRNA/cDNA for ZNF681 Gene

6 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF681 Gene

No ASD Table

Relevant External Links for ZNF681 Gene

GeneLoc Exon Structure for

Expression for ZNF681 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF681 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF681

SOURCE GeneReport for Unigene cluster for ZNF681 Gene:


Evidence on tissue expression from TISSUES for ZNF681 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with ZNF681: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF681 Gene

Orthologs for ZNF681 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF681 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF681 31 30
  • 99.12 (n)
(Bos Taurus)
Mammalia -- 31
  • 54 (a)
(Monodelphis domestica)
Mammalia -- 31
  • 51 (a)
-- 31
  • 42 (a)
(Mus musculus)
Mammalia Zfp874a 31
  • 49 (a)
(Canis familiaris)
Mammalia -- 31
  • 41 (a)
(Anolis carolinensis)
Reptilia -- 31
  • 53 (a)
-- 31
  • 44 (a)
-- 31
  • 40 (a)
-- 31
  • 36 (a)
-- 31
  • 34 (a)
-- 31
  • 33 (a)
-- 31
  • 33 (a)
-- 31
  • 30 (a)
Species where no ortholog for ZNF681 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF681 Gene

Gene Tree for ZNF681 (if available)
Gene Tree for ZNF681 (if available)
Evolutionary constrained regions (ECRs) for ZNF681: view image

Paralogs for ZNF681 Gene

Paralogs for ZNF681 Gene

(510) SIMAP similar genes for ZNF681 Gene using alignment to 4 proteins:

  • ZN681_HUMAN
  • E9PSC0_HUMAN Pseudogenes for ZNF681 Gene

genes like me logo Genes that share paralogs with ZNF681: view

Variants for ZNF681 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF681 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs1818989 - p.Leu295Ser
rs1818990 - p.Arg367Lys
rs1852433 - p.His548Gln
rs7248674 - p.Asp84His

Additional dbSNP identifiers (rs#s) for ZNF681 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF681 Gene

Variant ID Type Subtype PubMed ID
dgv1741n106 OTHER inversion 24896259
dgv3479n100 CNV loss 25217958
dgv3481n100 CNV gain 25217958
dgv3482n100 CNV loss 25217958
dgv6344n54 CNV loss 21841781
esv1418599 CNV insertion 17803354
esv2718381 CNV deletion 23290073
esv2751784 CNV gain 17911159
esv2758750 CNV gain+loss 17122850
esv3583313 CNV loss 25503493
esv3644015 CNV loss 21293372
esv3644017 CNV loss 21293372
esv3644018 CNV gain 21293372
esv3893187 CNV gain 25118596
nsv1057420 CNV gain 25217958
nsv1058651 CNV loss 25217958
nsv1078888 OTHER inversion 25765185
nsv1123240 CNV deletion 24896259
nsv1133258 CNV tandem duplication 24896259
nsv1153393 OTHER inversion 26484159
nsv458528 CNV loss 19166990
nsv524183 CNV gain 19592680
nsv579051 CNV loss 21841781
nsv960818 CNV duplication 23825009

Variation tolerance for ZNF681 Gene

Residual Variation Intolerance Score: 95.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.56; 88.94% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF681 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF681 Gene

Disorders for ZNF681 Gene

Additional Disease Information for ZNF681

No disorders were found for ZNF681 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF681 Gene

Publications for ZNF681 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  2. Image-based genome-wide siRNA screen identifies selective autophagy factors. (PMID: 22020285) Orvedahl A … Levine B (Nature 2011) 3 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 54
  4. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 4 54
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 54

Products for ZNF681 Gene

Sources for ZNF681 Gene