Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZNF680 Gene

Aliases for ZNF680 Gene

  • Zinc Finger Protein 680 2 3 3 5
  • Hypothetical Protein FLJ90430 2

External Ids for ZNF680 Gene

Previous GeneCards Identifiers for ZNF680 Gene

  • GC07M063427
  • GC07M063617
  • GC07M063980
  • GC07M060361

Summaries for ZNF680 Gene

GeneCards Summary for ZNF680 Gene

ZNF680 (Zinc Finger Protein 680) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF92.

UniProtKB/Swiss-Prot for ZNF680 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF680 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF680 Gene

Genomics for ZNF680 Gene

GeneHancer (GH) Regulatory Elements for ZNF680 Gene

Promoters and enhancers for ZNF680 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J064562 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.7 +0.2 226 1.8 PKNOX1 ATF1 ARID4B SIN3A DMAP1 ZNF2 ZNF48 YY1 ETS1 POLR2B ZNF680 ZNF107 CCT6P3 GTF2IP14 ZNF736 GABPAP ZNF117 LOC644387 BNIP3P42
GH07J064561 Enhancer 0.2 Ensembl 650.7 +1.8 1826 0.2 ZNF680 ZNF107 BNIP3P42
GH07J064305 Promoter/Enhancer 1.6 FANTOM5 Ensembl ENCODE 9 +255.9 255896 2.6 HDGF ATF1 ZNF2 IRF4 YY1 ETS1 ZNF143 ATF7 RUNX3 SP3 GC07P064309 LOC105375322 PIR31902 ZNF736 GUSBP6 ZNF680 YWHAEP1 ZNF680P1 TRIM60P18 SEPHS1P1
GH07J064995 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 4.3 -438.8 -438758 11.8 MLX DMAP1 YY1 E2F8 ZNF143 SP3 NFYC MEF2D SSRP1 RCOR2 ZNF117 CCT6P3 GTF2IP14 ERV3-1 INTS4P1 CCT6P1 ZNF736 VKORC1L1 ENSG00000227113 GUSB
GH07J064894 Enhancer 0.8 dbSUPER 4.2 -328.9 -328892 0.2 HDAC1 PKNOX1 RB1 ARNT CHAMP1 NCOA2 TCF12 ZNF766 CEBPB NCOA1 LOC441239 EEF1DP4 ZNF680 ZNF273 VN1R42P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF680 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF680 gene promoter:
  • GR-alpha
  • GR
  • GATA-3
  • Pax-2
  • Pax-2a
  • RFX1
  • NF-1
  • MyoD
  • AML1a
  • E47

Genomic Locations for ZNF680 Gene

Genomic Locations for ZNF680 Gene
61,838 bases
Minus strand
43,251 bases
Minus strand

Genomic View for ZNF680 Gene

Genes around ZNF680 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF680 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF680 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF680 Gene

Proteins for ZNF680 Gene

  • Protein details for ZNF680 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 680
    Protein Accession:
    Secondary Accessions:
    • B3KVJ4
    • Q6ZNF3
    • Q8NC79

    Protein attributes for ZNF680 Gene

    530 amino acids
    Molecular mass:
    61798 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC11286.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF680 Gene


neXtProt entry for ZNF680 Gene

Post-translational modifications for ZNF680 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF680 Gene

Domains & Families for ZNF680 Gene

Gene Families for ZNF680 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF680 Gene

Suggested Antigen Peptide Sequences for ZNF680 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF680: view

Function for ZNF680 Gene

Molecular function for ZNF680 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF680 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF680: view
genes like me logo Genes that share phenotypes with ZNF680: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF680 Gene

Localization for ZNF680 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF680 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF680 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF680 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF680: view

Pathways & Interactions for ZNF680 Gene

SuperPathways for ZNF680 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF680: view

Pathways by source for ZNF680 Gene

2 Reactome pathways for ZNF680 Gene

Interacting Proteins for ZNF680 Gene

Gene Ontology (GO) - Biological Process for ZNF680 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF680: view

No data available for SIGNOR curated interactions for ZNF680 Gene

Drugs & Compounds for ZNF680 Gene

No Compound Related Data Available

Transcripts for ZNF680 Gene

Unigene Clusters for ZNF680 Gene

Zinc finger protein 680:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF680 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c · 9d · 9e
SP1: - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - - - - - - -
SP5: - - - - - - -
SP6: - - - - - - - -
SP7: - - -

Relevant External Links for ZNF680 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF680 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF680 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF680 Gene:


SOURCE GeneReport for Unigene cluster for ZNF680 Gene:


Evidence on tissue expression from TISSUES for ZNF680 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ZNF680: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF680 Gene

Orthologs for ZNF680 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF680 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF680 34 33
  • 99.43 (n)
(Mus musculus)
Mammalia Zfp953 34
  • 52 (a)
(Bos Taurus)
Mammalia -- 34
  • 52 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 48 (a)
-- 34
  • 35 (a)
(Canis familiaris)
Mammalia -- 34
  • 38 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 48 (a)
-- 34
  • 38 (a)
-- 34
  • 35 (a)
-- 34
  • 31 (a)
-- 34
  • 29 (a)
-- 34
  • 29 (a)
-- 34
  • 28 (a)
-- 34
  • 28 (a)
Species where no ortholog for ZNF680 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF680 Gene

Gene Tree for ZNF680 (if available)
Gene Tree for ZNF680 (if available)
Evolutionary constrained regions (ECRs) for ZNF680: view image

Paralogs for ZNF680 Gene

(491) SIMAP similar genes for ZNF680 Gene using alignment to 1 proteins:

  • ZN680_HUMAN Pseudogenes for ZNF680 Gene

genes like me logo Genes that share paralogs with ZNF680: view

Variants for ZNF680 Gene

Sequence variations from dbSNP and Humsavar for ZNF680 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000003437 -- 64,534,038(-) G/A/C intron_variant
rs1000051732 -- 64,564,538(-) G/C upstream_transcript_variant
rs1000126260 -- 64,500,093(-) C/G downstream_transcript_variant
rs1000133875 -- 64,511,670(-) T/A genic_downstream_transcript_variant, intron_variant
rs1000164570 -- 64,558,828(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF680 Gene

Variant ID Type Subtype PubMed ID
dgv1099e201 CNV deletion 23290073
dgv241n111 CNV duplication 26073780
esv2422405 CNV duplication 17116639
esv2764000 CNV gain+loss 21179565
esv3891131 CNV gain+loss 25118596
nsv1018445 CNV gain 25217958
nsv464518 CNV gain 19166990
nsv607312 CNV gain 21841781
nsv970855 CNV duplication 23825009

Variation tolerance for ZNF680 Gene

Residual Variation Intolerance Score: 47% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.53; 55.60% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF680 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF680 Gene

Disorders for ZNF680 Gene

Additional Disease Information for ZNF680

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ZNF680 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF680 Gene

Publications for ZNF680 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58

Products for ZNF680 Gene

Sources for ZNF680 Gene

Loading form....