Aliases for ZNF679 Gene

Aliases for ZNF679 Gene

  • Zinc Finger Protein 679 2 3 4 5
  • Hypothetical Protein MGC42415 2 3
  • MGC42415 2
  • ZNF679 5

External Ids for ZNF679 Gene

Previous GeneCards Identifiers for ZNF679 Gene

  • GC07P063134
  • GC07P063346
  • GC07P063326
  • GC07P063688
  • GC07P063490
  • GC07P064030

Summaries for ZNF679 Gene

GeneCards Summary for ZNF679 Gene

ZNF679 (Zinc Finger Protein 679) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF716.

UniProtKB/Swiss-Prot Summary for ZNF679 Gene

Additional gene information for ZNF679 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF679 Gene

Genomics for ZNF679 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF679 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J064305 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE CraniofacialAtlas 0.2 +78.8 78757 2.6 SP1 PRDM10 ZNF692 POLR2A FOXA1 ZNF143 ZIC2 IKZF2 HDAC1 ZNF600 ENSG00000287699 LOC105375322 ZNF736 piR-30903 lnc-ZNF680-46 lnc-ZNF736-3 GUSBP6 ZNF680 YWHAEP1 ZNF680P1
GH07J064306 Enhancer 0.6 ENCODE 0.2 +76.8 76764 0.2 TCF12 IKZF2 TRIM22 DPF2 RELB BCL11A ELF1 NBN IKZF1 JUNB ENSG00000287699 TRIM60P18 LOC105375322 ZNF736 lnc-ZNF680-1 ZNF679
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF679 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF679

Genomic Locations for ZNF679 Gene

Genomic Locations for ZNF679 Gene
chr7:64,228,474-64,266,931
(GRCh38/hg38)
Size:
38,458 bases
Orientation:
Plus strand
chr7:63,688,852-63,727,309
(GRCh37/hg19)
Size:
38,458 bases
Orientation:
Plus strand

Genomic View for ZNF679 Gene

Genes around ZNF679 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF679 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF679 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF679 Gene

Proteins for ZNF679 Gene

  • Protein details for ZNF679 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYX0-ZN679_HUMAN
    Recommended name:
    Zinc finger protein 679
    Protein Accession:
    Q8IYX0

    Protein attributes for ZNF679 Gene

    Size:
    411 amino acids
    Molecular mass:
    47179 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF679 Gene

Post-translational modifications for ZNF679 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF679 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF679 Gene

Domains & Families for ZNF679 Gene

Gene Families for ZNF679 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF679 Gene

InterPro:
Blocks:
  • KRAB box
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF679 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 679 (ZN679_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8IYX0

UniProtKB/Swiss-Prot:

ZN679_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF679: view

Function for ZNF679 Gene

Molecular function for ZNF679 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF679 Gene

Gene Ontology (GO) - Molecular Function for ZNF679 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA 21873635
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 16189514
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF679: view
genes like me logo Genes that share phenotypes with ZNF679: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF679

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF679 Gene

Localization for ZNF679 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF679 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF679 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF679 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IBA 21873635
genes like me logo Genes that share ontologies with ZNF679: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF679 Gene

Pathways & Interactions for ZNF679 Gene

genes like me logo Genes that share pathways with ZNF679: view

Pathways by source for ZNF679 Gene

2 Reactome pathways for ZNF679 Gene
1 KEGG pathway for ZNF679 Gene

Gene Ontology (GO) - Biological Process for ZNF679 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA,IBA 21873635
genes like me logo Genes that share ontologies with ZNF679: view

No data available for SIGNOR curated interactions for ZNF679 Gene

Drugs & Compounds for ZNF679 Gene

No Compound Related Data Available

Transcripts for ZNF679 Gene

mRNA/cDNA for ZNF679 Gene

1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF679

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF679 Gene

No ASD Table

Relevant External Links for ZNF679 Gene

GeneLoc Exon Structure for
ZNF679

Expression for ZNF679 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF679 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF679 Gene

This gene is overexpressed in Testis (x53.0).

Protein differential expression in normal tissues from HIPED for ZNF679 Gene

This gene is overexpressed in Rectum (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF679 Gene



Protein tissue co-expression partners for ZNF679 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF679

SOURCE GeneReport for Unigene cluster for ZNF679 Gene:

Hs.520884
genes like me logo Genes that share expression patterns with ZNF679: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF679 Gene

Orthologs for ZNF679 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF679 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF679 30 31
  • 99.03 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Zfp493 31
  • 45 (a)
ManyToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 38 (a)
ManyToMany
-- 31
  • 27 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia -- 31
  • 38 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia -- 31
  • 29 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 36 (a)
ManyToMany
-- 31
  • 30 (a)
ManyToMany
-- 31
  • 27 (a)
ManyToMany
-- 31
  • 24 (a)
ManyToMany
-- 31
  • 23 (a)
ManyToMany
-- 31
  • 22 (a)
ManyToMany
-- 31
  • 22 (a)
ManyToMany
-- 31
  • 20 (a)
ManyToMany
Species where no ortholog for ZNF679 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF679 Gene

ENSEMBL:
Gene Tree for ZNF679 (if available)
TreeFam:
Gene Tree for ZNF679 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF679: view image

Paralogs for ZNF679 Gene

Paralogs for ZNF679 Gene

(488) SIMAP similar genes for ZNF679 Gene using alignment to 1 proteins:

  • ZN679_HUMAN

Pseudogenes.org Pseudogenes for ZNF679 Gene

genes like me logo Genes that share paralogs with ZNF679: view

Variants for ZNF679 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF679 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
rs12154540 - p.Glu69Gly
rs17139320 - p.His120Arg
rs1830035 - p.Tyr212His
rs1830036 - p.Cys223Ser

Additional dbSNP identifiers (rs#s) for ZNF679 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF679 Gene

Variant ID Type Subtype PubMed ID
dgv1099e201 CNV deletion 23290073
dgv11415n54 CNV loss 21841781
dgv1212e199 CNV deletion 23128226
dgv6434n100 CNV loss 25217958
esv2422405 CNV duplication 17116639
esv3541760 CNV deletion 23714750
esv3613412 CNV loss 21293372
esv3891131 CNV gain+loss 25118596
esv3891132 CNV gain 25118596
nsv1016596 CNV loss 25217958
nsv1016645 CNV gain+loss 25217958
nsv1018445 CNV gain 25217958
nsv1018858 CNV loss 25217958
nsv1019909 CNV gain 25217958
nsv1140796 CNV deletion 24896259
nsv522412 CNV loss 19592680
nsv607304 CNV gain 21841781
nsv607309 CNV loss 21841781
nsv981495 CNV duplication 23825009

Variation tolerance for ZNF679 Gene

Residual Variation Intolerance Score: 89% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.62; 89.07% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF679 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF679

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF679 Gene

Disorders for ZNF679 Gene

Additional Disease Information for ZNF679

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for ZNF679 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF679 Gene

Publications for ZNF679 Gene

  1. Genome-wide association of lipid-lowering response to statins in combined study populations. (PMID: 20339536) Barber MJ … Krauss RM (PloS one 2010) 3 41
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for ZNF679 Gene

Sources for ZNF679 Gene