Aliases for ZNF678 Gene

Aliases for ZNF678 Gene

  • Zinc Finger Protein 678 2 3 4 5
  • Hypothetical Protein MGC42493 2 3
  • MGC42493 2
  • ZNF678 5

External Ids for ZNF678 Gene

Previous GeneCards Identifiers for ZNF678 Gene

  • GC01P224141
  • GC01P225817
  • GC01P227751
  • GC01P198267

Summaries for ZNF678 Gene

GeneCards Summary for ZNF678 Gene

ZNF678 (Zinc Finger Protein 678) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF43.

UniProtKB/Swiss-Prot Summary for ZNF678 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF678 Gene

Genomics for ZNF678 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF678 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF678 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF678

Top Transcription factor binding sites by QIAGEN in the ZNF678 gene promoter:
  • AP-2rep
  • En-1
  • LCR-F1
  • RORalpha1
  • RORalpha2
  • ZIC2

Genomic Locations for ZNF678 Gene

Latest Assembly
116,127 bases
Plus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
116,114 bases
Plus strand

(GRCh37/hg19 by Ensembl)
113,901 bases
Plus strand

Genomic View for ZNF678 Gene

Genes around ZNF678 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF678 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF678 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF678 Gene

Proteins for ZNF678 Gene

  • Protein details for ZNF678 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 678
    Protein Accession:
    Secondary Accessions:
    • Q8IVQ9

    Protein attributes for ZNF678 Gene

    525 amino acids
    Molecular mass:
    61411 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF678 Gene

Post-translational modifications for ZNF678 Gene

  • Ubiquitination at Lys68
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNF678 Gene

No data available for DME Specific Peptides for ZNF678 Gene

Domains & Families for ZNF678 Gene

Gene Families for ZNF678 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF678 Gene

Suggested Antigen Peptide Sequences for ZNF678 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 678 (B1APK8_HUMAN)
  • Zinc finger protein 678 (ZN678_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF678: view

Function for ZNF678 Gene

Molecular function for ZNF678 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF678 Gene

Gene Ontology (GO) - Molecular Function for ZNF678 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA 21873635
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific IBA 21873635
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF678: view
genes like me logo Genes that share phenotypes with ZNF678: view

miRNA for ZNF678 Gene

miRTarBase miRNAs that target ZNF678

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF678

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF678 Gene

Localization for ZNF678 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF678 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF678 gene
Compartment Confidence
nucleus 4
cytosol 3
mitochondrion 2
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Mitochondria (2)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF678 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin IBA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF678: view

Pathways & Interactions for ZNF678 Gene

PathCards logo

SuperPathways for ZNF678 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF678: view

Pathways by source for ZNF678 Gene

2 Reactome pathways for ZNF678 Gene

Interacting Proteins for ZNF678 Gene

Gene Ontology (GO) - Biological Process for ZNF678 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IBA 21873635
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF678: view

No data available for SIGNOR curated interactions for ZNF678 Gene

Drugs & Compounds for ZNF678 Gene

No Compound Related Data Available

Transcripts for ZNF678 Gene

mRNA/cDNA for ZNF678 Gene

9 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF678

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF678 Gene

No ASD Table

Relevant External Links for ZNF678 Gene

GeneLoc Exon Structure for

Expression for ZNF678 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF678 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Colon (Gastrointestinal Tract)

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF678

SOURCE GeneReport for Unigene cluster for ZNF678 Gene:

genes like me logo Genes that share expression patterns with ZNF678: view

Primer products for research

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF678 Gene

Orthologs for ZNF678 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF678 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF678 30
  • 97 (a)
(Bos Taurus)
Mammalia LOC101904664 29
  • 72.58 (n)
(Monodelphis domestica)
Mammalia -- 30
  • 60 (a)
-- 30
  • 60 (a)
-- 30
  • 57 (a)
-- 30
  • 50 (a)
-- 30
  • 43 (a)
-- 30
  • 42 (a)
-- 30
  • 35 (a)
-- 30
  • 33 (a)
(Mus musculus)
Mammalia Zfp72 30
  • 56 (a)
(Canis familiaris)
Mammalia -- 30
  • 55 (a)
(Gallus gallus)
Aves -- 30
  • 46 (a)
Species where no ortholog for ZNF678 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF678 Gene

Gene Tree for ZNF678 (if available)
Gene Tree for ZNF678 (if available)
Evolutionary constrained regions (ECRs) for ZNF678: view image
Alliance of Genome Resources:
Additional Orthologs for ZNF678

Paralogs for ZNF678 Gene

Paralogs for ZNF678 Gene

(540) SIMAP similar genes for ZNF678 Gene using alignment to 4 proteins:

  • ZN678_HUMAN
  • V9GYU6_HUMAN Pseudogenes for ZNF678 Gene

genes like me logo Genes that share paralogs with ZNF678: view

Variants for ZNF678 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF678 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs12118505 -- p.Thr197Ile
rs17854209 -- p.Lys144Glu
rs61283390 -- p.Pro152Thr

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for ZNF678 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for ZNF678 Gene

Variant ID Type Subtype PubMed ID
esv2662269 CNV deletion 23128226
esv2668154 CNV deletion 23128226
esv2724195 CNV deletion 23290073
esv2724206 CNV deletion 23290073
esv3407161 CNV insertion 20981092
esv3547766 CNV deletion 23714750
esv3589036 CNV loss 21293372
esv3589037 CNV loss 21293372
esv3589038 CNV loss 21293372
nsv1007479 CNV gain 25217958
nsv475962 CNV novel sequence insertion 20440878
nsv945340 CNV duplication 23825009
nsv945341 CNV duplication 23825009
nsv945342 CNV duplication 23825009
nsv945343 CNV duplication 23825009

Variation tolerance for ZNF678 Gene

Gene Damage Index Score: 3.46; 54.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF678 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF678 Gene

Disorders for ZNF678 Gene

Additional Disease Information for ZNF678

Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for ZNF678 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF678 Gene

Publications for ZNF678 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 40
  2. The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature. (PMID: 20546612) Zhao J … Grant SF (BMC medical genetics 2010) 3 40
  3. Association of linear growth impairment in pediatric Crohn's disease and a known height locus: a pilot study. (PMID: 20846217) Lee JJ … Hirschhorn J (Annals of human genetics 2010) 3 40
  4. Genome-wide association analysis identifies 20 loci that influence adult height. (PMID: 18391952) Weedon MN … Frayling TM (Nature genetics 2008) 3 40
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4

Products for ZNF678 Gene

Sources for ZNF678 Gene