Aliases for ZNF677 Gene

Aliases for ZNF677 Gene

  • Zinc Finger Protein 677 2 3 4 5
  • Hypothetical Protein MGC48625 2 3
  • MGC48625 2
  • ZNF677 5

External Ids for ZNF677 Gene

Previous GeneCards Identifiers for ZNF677 Gene

  • GC19M058431
  • GC19M053731
  • GC19M050059

Summaries for ZNF677 Gene

GeneCards Summary for ZNF677 Gene

ZNF677 (Zinc Finger Protein 677) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZNF85.

UniProtKB/Swiss-Prot Summary for ZNF677 Gene

Additional gene information for ZNF677 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF677 Gene

Genomics for ZNF677 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF677 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF677 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF677

Top Transcription factor binding sites by QIAGEN in the ZNF677 gene promoter:
  • Pax-4a

Genomic Locations for ZNF677 Gene

Genomic Locations for ZNF677 Gene
chr19:53,235,381-53,254,903
(GRCh38/hg38)
Size:
19,523 bases
Orientation:
Minus strand
chr19:53,731,577-53,758,151
(GRCh37/hg19)
Size:
26,575 bases
Orientation:
Minus strand

Genomic View for ZNF677 Gene

Genes around ZNF677 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF677 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF677 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF677 Gene

Proteins for ZNF677 Gene

  • Protein details for ZNF677 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86XU0-ZN677_HUMAN
    Recommended name:
    Zinc finger protein 677
    Protein Accession:
    Q86XU0

    Protein attributes for ZNF677 Gene

    Size:
    584 amino acids
    Molecular mass:
    67996 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF677 Gene

Post-translational modifications for ZNF677 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF677 Gene

Domains & Families for ZNF677 Gene

Gene Families for ZNF677 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF677 Gene

InterPro:
Blocks:
  • KRAB box
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF677 Gene

GenScript: Design optimal peptide antigens:
  • ZNF677 protein (Q05C29_HUMAN)
  • Zinc finger protein 677 (ZN677_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q86XU0

UniProtKB/Swiss-Prot:

ZN677_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF677: view

Function for ZNF677 Gene

Molecular function for ZNF677 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF677 Gene

Gene Ontology (GO) - Molecular Function for ZNF677 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF677: view
genes like me logo Genes that share phenotypes with ZNF677: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF677

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF677 Gene

Localization for ZNF677 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF677 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF677 gene
Compartment Confidence
nucleus 4
cytosol 2
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF677 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF677: view

Pathways & Interactions for ZNF677 Gene

genes like me logo Genes that share pathways with ZNF677: view

Pathways by source for ZNF677 Gene

2 Reactome pathways for ZNF677 Gene
1 KEGG pathway for ZNF677 Gene

Interacting Proteins for ZNF677 Gene

Gene Ontology (GO) - Biological Process for ZNF677 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF677: view

No data available for SIGNOR curated interactions for ZNF677 Gene

Drugs & Compounds for ZNF677 Gene

No Compound Related Data Available

Transcripts for ZNF677 Gene

mRNA/cDNA for ZNF677 Gene

2 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF677

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF677 Gene

No ASD Table

Relevant External Links for ZNF677 Gene

GeneLoc Exon Structure for
ZNF677

Expression for ZNF677 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF677 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Spleen (Hematopoietic System)
  • Testis (Reproductive System)

mRNA differential expression in normal tissues according to GTEx for ZNF677 Gene

This gene is overexpressed in Testis (x5.0).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF677

SOURCE GeneReport for Unigene cluster for ZNF677 Gene:

Hs.20506
genes like me logo Genes that share expression patterns with ZNF677: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF677 Gene

Orthologs for ZNF677 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF677 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF677 30 31
  • 98.97 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ZNF677 30 31
  • 74.81 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZNF677 31
  • 62 (a)
OneToOne
Species where no ortholog for ZNF677 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF677 Gene

ENSEMBL:
Gene Tree for ZNF677 (if available)
TreeFam:
Gene Tree for ZNF677 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF677: view image

Paralogs for ZNF677 Gene

Paralogs for ZNF677 Gene

(466) SIMAP similar genes for ZNF677 Gene using alignment to 7 proteins:

  • ZN677_HUMAN
  • M0QYA4_HUMAN
  • M0R079_HUMAN
  • M0R0I7_HUMAN
  • M0R1V2_HUMAN
  • M0R297_HUMAN
  • Q05C29_HUMAN

Pseudogenes.org Pseudogenes for ZNF677 Gene

genes like me logo Genes that share paralogs with ZNF677: view

Variants for ZNF677 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF677 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs10425706 - p.Gly254Glu
rs11881131 - p.Asp56Asn

Additional dbSNP identifiers (rs#s) for ZNF677 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF677 Gene

Variant ID Type Subtype PubMed ID
dgv3645n100 CNV gain 25217958
esv2718787 CNV deletion 23290073
esv2718812 CNV deletion 23290073
esv3644741 CNV gain 21293372
nsv1055236 CNV gain 25217958
nsv1064604 CNV loss 25217958
nsv1078889 OTHER inversion 25765185
nsv1141887 OTHER inversion 24896259
nsv580079 CNV loss 21841781

Variation tolerance for ZNF677 Gene

Residual Variation Intolerance Score: 33.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.66; 45.74% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF677 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF677

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF677 Gene

Disorders for ZNF677 Gene

No disorders were found for ZNF677 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF677 Gene

Publications for ZNF677 Gene

  1. DNA methylation transcriptionally regulates the putative tumor cell growth suppressor ZNF677 in non-small cell lung cancers. (PMID: 25504438) Heller G … Zöchbauer-Müller S (Oncotarget 2015) 2 3
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. ZNF677 Suppresses Akt Phosphorylation and Tumorigenesis in Thyroid Cancer. (PMID: 29997231) Li Y … Hou P (Cancer research 2018) 3
  4. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J … Yang X (Molecular systems biology 2011) 3
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for ZNF677 Gene

Sources for ZNF677 Gene