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Aliases for ZNF677 Gene

Aliases for ZNF677 Gene

  • Zinc Finger Protein 677 2 3 5
  • Hypothetical Protein MGC48625 2

External Ids for ZNF677 Gene

Previous GeneCards Identifiers for ZNF677 Gene

  • GC19M058431
  • GC19M053731
  • GC19M050059

Summaries for ZNF677 Gene

GeneCards Summary for ZNF677 Gene

ZNF677 (Zinc Finger Protein 677) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA binding transcription factor activity. An important paralog of this gene is ZNF888.

UniProtKB/Swiss-Prot for ZNF677 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF677 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF677 Gene

Genomics for ZNF677 Gene

GeneHancer (GH) Regulatory Elements for ZNF677 Gene

Promoters and enhancers for ZNF677 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I053254 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 565.5 0.0 -2 1.8 MXI1 BACH1 SIN3A ZBTB40 YY1 ETS1 HIC1 ZNF335 POLR2A ZSCAN29 ZNF677 VN1R2
GH19I054199 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 21.3 -950.8 -950812 12.1 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 RPS9 PRPF31 LENG8 LENG8-AS1 CNOT3 ZNF525 ZNF845 ENSG00000235681 LILRB5 ZNF765
GH19I054186 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 19.4 -934.7 -934724 6.8 HDGF PKNOX1 CLOCK FOXA2 SMAD1 ARNT ARID4B NEUROD1 SIN3A DMAP1 TSEN34 MBOAT7 PRPF31 ZNF845 ZNF665 ENSG00000269001 ZNF677 LENG8 CNOT3 ENSG00000269288
GH19I053517 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 18.1 -264.7 -264716 4.8 PKNOX1 SMAD1 ARNT ARID4B SIN3A YY1 ZNF766 E2F8 ZNF143 KLF13 ZNF331 ZNF137P LENG8 ZNF525 LENG8-AS1 PRPF31 CNOT3 ZNF160 ZNF701 ZNF83
GH19I052526 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 11.2 +727.2 727183 2.4 HDGF ATF1 ARID4B SIN3A YBX1 GLI4 ZNF48 POLR2B CBX5 ZNF416 ZNF808 ZNF611 ZNF613 ZNF137P ZNF701 ENSG00000268970 ENSG00000269001 TPM3P9 ZNF665 ZNF525
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF677 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF677 gene promoter:

Genomic Locations for ZNF677 Gene

Genomic Locations for ZNF677 Gene
19,518 bases
Minus strand

Genomic View for ZNF677 Gene

Genes around ZNF677 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF677 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF677 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF677 Gene

Proteins for ZNF677 Gene

  • Protein details for ZNF677 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 677
    Protein Accession:

    Protein attributes for ZNF677 Gene

    584 amino acids
    Molecular mass:
    67996 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF677 Gene

Post-translational modifications for ZNF677 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF677 Gene

Domains & Families for ZNF677 Gene

Gene Families for ZNF677 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF677 Gene

Suggested Antigen Peptide Sequences for ZNF677 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF677: view

Function for ZNF677 Gene

Molecular function for ZNF677 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF677 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF677: view
genes like me logo Genes that share phenotypes with ZNF677: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF677 Gene

Localization for ZNF677 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF677 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF677 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF677 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF677: view

Pathways & Interactions for ZNF677 Gene

SuperPathways for ZNF677 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF677: view

Pathways by source for ZNF677 Gene

2 Reactome pathways for ZNF677 Gene

Interacting Proteins for ZNF677 Gene

Gene Ontology (GO) - Biological Process for ZNF677 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF677: view

No data available for SIGNOR curated interactions for ZNF677 Gene

Drugs & Compounds for ZNF677 Gene

No Compound Related Data Available

Transcripts for ZNF677 Gene

Unigene Clusters for ZNF677 Gene

Zinc finger protein 677:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF677 Gene

No ASD Table

Relevant External Links for ZNF677 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF677 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF677 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF677 Gene

This gene is overexpressed in Testis (x5.0).

NURSA nuclear receptor signaling pathways regulating expression of ZNF677 Gene:


SOURCE GeneReport for Unigene cluster for ZNF677 Gene:

genes like me logo Genes that share expression patterns with ZNF677: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF677 Gene

Orthologs for ZNF677 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF677 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF677 33 34
  • 98.97 (n)
(Bos Taurus)
Mammalia ZNF677 33 34
  • 74.81 (n)
(Canis familiaris)
Mammalia ZNF677 34
  • 62 (a)
Species where no ortholog for ZNF677 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF677 Gene

Gene Tree for ZNF677 (if available)
Gene Tree for ZNF677 (if available)

Paralogs for ZNF677 Gene

(466) SIMAP similar genes for ZNF677 Gene using alignment to 7 proteins: Pseudogenes for ZNF677 Gene

genes like me logo Genes that share paralogs with ZNF677: view

Variants for ZNF677 Gene

Sequence variations from dbSNP and Humsavar for ZNF677 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000062047 -- 53,246,575(-) C/A intron_variant
rs1000125975 -- 53,242,432(-) G/A intron_variant
rs1000263130 -- 53,242,431(-) A/T intron_variant
rs1000367625 -- 53,247,739(-) G/C intron_variant
rs1000753206 -- 53,236,530(-) T/G 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF677 Gene

Variant ID Type Subtype PubMed ID
dgv3645n100 CNV gain 25217958
esv2718787 CNV deletion 23290073
esv2718812 CNV deletion 23290073
esv3644741 CNV gain 21293372
nsv1055236 CNV gain 25217958
nsv1064604 CNV loss 25217958
nsv1078889 OTHER inversion 25765185
nsv1141887 OTHER inversion 24896259
nsv580079 CNV loss 21841781

Variation tolerance for ZNF677 Gene

Residual Variation Intolerance Score: 33.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.66; 45.74% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF677 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF677 Gene

Disorders for ZNF677 Gene

Additional Disease Information for ZNF677

No disorders were found for ZNF677 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF677 Gene

Publications for ZNF677 Gene

  1. DNA methylation transcriptionally regulates the putative tumor cell growth suppressor ZNF677 in non-small cell lung cancers. (PMID: 25504438) Heller G … Zöchbauer-Müller S (Oncotarget 2015) 2 3 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J … Yang X (Molecular systems biology 2011) 3 58
  4. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L … Andersson-Svahn H (Molecular & cellular proteomics : MCP 2008) 3 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for ZNF677 Gene

Sources for ZNF677 Gene

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