Aliases for ZNF676 Gene

Aliases for ZNF676 Gene

  • Zinc Finger Protein 676 2 3 4 5
  • ZNF676 5

External Ids for ZNF676 Gene

Previous GeneCards Identifiers for ZNF676 Gene

  • GC19M022155
  • GC19M022361
  • GC19M021899
  • GC19M022178

Summaries for ZNF676 Gene

GeneCards Summary for ZNF676 Gene

ZNF676 (Zinc Finger Protein 676) is a Protein Coding gene. Diseases associated with ZNF676 include Acth-Secreting Pituitary Adenoma and Spermatogenic Failure, Y-Linked, 2. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF728.

UniProtKB/Swiss-Prot Summary for ZNF676 Gene

Additional gene information for ZNF676 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF676 Gene

Genomics for ZNF676 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF676 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J022214 Promoter 0.3 Ensembl 620.6 +0.3 300 1 ZNF676 ENSG00000282732 BNIP3P30 lnc-ZNF729-5 ZNF257
GH19J022010 Promoter 0.9 EPDnew Ensembl 6 +205.6 205600 2 PKNOX1 PRDM10 GABPB1 ZNF208 ZNF257 BNIP3P29 ZNF676 BNIP3P28 lnc-ZNF257-2 ZNF43
GH19J021699 Enhancer 0.7 FANTOM5 ENCODE 1.3 +516.4 516402 0.3 RFX1 USF1 YY1 SIN3A MNT USF2 POU5F1 EGR1 RF02002-019 piR-35674-253 ZNF100 ZNF208 ZNF676 piR-50308-315 lnc-ZNF429-2 ZNF429
GH19J022429 Enhancer 0.2 FANTOM5 1.3 -211.8 -211802 0.3 ZNF208 ZNF98 ZNF257 ZNF492 ZNF676 ENSG00000269796 piR-48209-340 lnc-ZNF492-2 NONHSAG045689.2-002 ZNF729
GH19J022051 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE CraniofacialAtlas 0.1 +163.1 163100 2.2 PKNOX1 PBX2 GTF2F1 MGA ZFX SP2 POLR2A TAF9B EP400 SIN3A ZNF257 ENSG00000269504 BNIP3P29 ZNF208 piR-43105-335 ZNF676
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF676 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF676

Top Transcription factor binding sites by QIAGEN in the ZNF676 gene promoter:
  • HOXA9
  • HOXA9B
  • Meis-1
  • Meis-1b
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4
  • p53

Genomic Locations for ZNF676 Gene

Genomic Locations for ZNF676 Gene
chr19:22,179,089-22,215,801
(GRCh38/hg38)
Size:
36,713 bases
Orientation:
Minus strand
chr19:22,361,893-22,379,753
(GRCh37/hg19)
Size:
17,861 bases
Orientation:
Minus strand

Genomic View for ZNF676 Gene

Genes around ZNF676 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF676 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF676 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF676 Gene

Proteins for ZNF676 Gene

  • Protein details for ZNF676 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N7Q3-ZN676_HUMAN
    Recommended name:
    Zinc finger protein 676
    Protein Accession:
    Q8N7Q3
    Secondary Accessions:
    • A8MVX5

    Protein attributes for ZNF676 Gene

    Size:
    588 amino acids
    Molecular mass:
    67624 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF676 Gene

Post-translational modifications for ZNF676 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF676 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF676 Gene

Domains & Families for ZNF676 Gene

Gene Families for ZNF676 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF676 Gene

InterPro:
Blocks:
  • C2H2-type zinc finger signature
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF676 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 676 (ZN676_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8N7Q3

UniProtKB/Swiss-Prot:

ZN676_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF676: view

Function for ZNF676 Gene

Molecular function for ZNF676 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF676 Gene

Gene Ontology (GO) - Molecular Function for ZNF676 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA 21873635
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF676: view
genes like me logo Genes that share phenotypes with ZNF676: view

Animal Model Products

CRISPR Products

miRNA for ZNF676 Gene

miRTarBase miRNAs that target ZNF676

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF676

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF676 Gene

Localization for ZNF676 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF676 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF676 gene
Compartment Confidence
nucleus 4
plasma membrane 1
extracellular 1
peroxisome 0

Gene Ontology (GO) - Cellular Components for ZNF676 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IBA 21873635
genes like me logo Genes that share ontologies with ZNF676: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF676 Gene

Pathways & Interactions for ZNF676 Gene

genes like me logo Genes that share pathways with ZNF676: view

Pathways by source for ZNF676 Gene

2 Reactome pathways for ZNF676 Gene
1 KEGG pathway for ZNF676 Gene

Interacting Proteins for ZNF676 Gene

Gene Ontology (GO) - Biological Process for ZNF676 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA,IBA 21873635
genes like me logo Genes that share ontologies with ZNF676: view

No data available for SIGNOR curated interactions for ZNF676 Gene

Drugs & Compounds for ZNF676 Gene

No Compound Related Data Available

Transcripts for ZNF676 Gene

mRNA/cDNA for ZNF676 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF676

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF676 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15
SP1:
SP2:
SP3:
SP4: - -
SP5:
SP6: -
SP7: - - -
SP8: -
SP9: -

Relevant External Links for ZNF676 Gene

GeneLoc Exon Structure for
ZNF676

Expression for ZNF676 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF676 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF676 Gene

This gene is overexpressed in Thyroid (x4.4) and Testis (x4.3).

Protein differential expression in normal tissues from HIPED for ZNF676 Gene

This gene is overexpressed in Tlymphocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF676 Gene



Protein tissue co-expression partners for ZNF676 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF676

SOURCE GeneReport for Unigene cluster for ZNF676 Gene:

Hs.55452
genes like me logo Genes that share expression patterns with ZNF676: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF676 Gene

Orthologs for ZNF676 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF676 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF676 31
  • 99 (a)
OneToOne
ZNF208 30
  • 95 (n)
Rat
(Rattus norvegicus)
Mammalia LOC501406 30
  • 72.38 (n)
Mouse
(Mus musculus)
Mammalia Zfp273 30 17
  • 72.22 (n)
Zfp493 31
  • 54 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia -- 31
  • 52 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 48 (a)
ManyToMany
-- 31
  • 42 (a)
ManyToMany
Dog
(Canis familiaris)
Mammalia -- 31
  • 38 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 54 (a)
ManyToMany
-- 31
  • 45 (a)
ManyToMany
-- 31
  • 39 (a)
ManyToMany
-- 31
  • 37 (a)
ManyToMany
-- 31
  • 35 (a)
ManyToMany
-- 31
  • 35 (a)
ManyToMany
-- 31
  • 33 (a)
ManyToMany
-- 31
  • 28 (a)
ManyToMany
Species where no ortholog for ZNF676 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF676 Gene

ENSEMBL:
Gene Tree for ZNF676 (if available)
TreeFam:
Gene Tree for ZNF676 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF676: view image

Paralogs for ZNF676 Gene

Paralogs for ZNF676 Gene

(504) SIMAP similar genes for ZNF676 Gene using alignment to 1 proteins:

  • ZN676_HUMAN
genes like me logo Genes that share paralogs with ZNF676: view

Variants for ZNF676 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF676 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs11671538 - p.Ser292Trp
rs12986319 - p.Glu96Lys
rs8104929 - p.Gly27Glu

Additional dbSNP identifiers (rs#s) for ZNF676 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF676 Gene

Variant ID Type Subtype PubMed ID
dgv139n111 CNV duplication 26073780
dgv3n43 CNV gain 19587683
dgv511e201 CNV deletion 23290073
dgv512e201 CNV deletion 23290073
dgv513e201 CNV deletion 23290073
dgv633e199 CNV deletion 23128226
esv1004381 CNV deletion 20482838
esv1536549 CNV insertion 17803354
esv2718335 CNV deletion 23290073
esv2758750 CNV gain+loss 17122850
esv34340 CNV loss 17911159
esv3893182 CNV gain 25118596
esv3893183 CNV gain 25118596
esv3893184 CNV gain 25118596
esv4924 OTHER complex 18987735
nsv1055550 CNV loss 25217958
nsv1061327 CNV gain 25217958
nsv1063115 CNV gain 25217958
nsv1112317 CNV deletion 24896259
nsv2440 CNV insertion 18451855
nsv436253 CNV deletion 17901297
nsv436853 CNV insertion 17901297
nsv436857 CNV insertion 17901297
nsv469671 CNV loss 16826518
nsv525240 CNV gain 19592680
nsv578974 CNV gain 21841781
nsv833786 CNV gain 17160897
nsv961197 CNV duplication 23825009

Variation tolerance for ZNF676 Gene

Residual Variation Intolerance Score: 94.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.32; 92.62% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF676 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF676

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF676 Gene

Disorders for ZNF676 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ZNF676 Gene - From: DISEASES

Disorder Aliases PubMed IDs
acth-secreting pituitary adenoma
  • pituitary-dependent cushing's disease
spermatogenic failure, y-linked, 2
  • spgfy2
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF676

genes like me logo Genes that share disorders with ZNF676: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF676 Gene

Publications for ZNF676 Gene

  1. Genome-wide association identifies OBFC1 as a locus involved in human leukocyte telomere biology. (PMID: 20421499) Levy D … Aviv A (Proceedings of the National Academy of Sciences of the United States of America 2010) 3 41
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. Transcriptome-wide association study revealed two novel genes associated with nonobstructive azoospermia in a Chinese population. (PMID: 29202958) Jiang T … Hu Z (Fertility and sterility 2017) 3
  4. Genome-wide meta-analysis points to CTC1 and ZNF676 as genes regulating telomere homeostasis in humans. (PMID: 23001564) Mangino M … Aviv A (Human molecular genetics 2012) 3
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for ZNF676 Gene

Sources for ZNF676 Gene