This gene encodes a zinc finger protein with an N-terminal Kruppel-associated box-containing (KRAB) domain and 11 Kruppel-type C2H2 zinc finger domains. Like other zinc finger proteins, this gene may function as a transcription factor. This gene resides on an area of chromosome X that has been implicated in nonsyndromic X-linked cognitive disabilities. Alternative splicing resu... See more...

Aliases for ZNF674 Gene

Aliases for ZNF674 Gene

  • Zinc Finger Protein 674 2 3 4 5
  • ZNF673B 2 3
  • Zinc Finger Family Member 674 3
  • ZNF674 5
  • MRX92 3

External Ids for ZNF674 Gene

Previous HGNC Symbols for ZNF674 Gene

  • MRX92

Previous GeneCards Identifiers for ZNF674 Gene

  • GC00U921661
  • GC0XM046243
  • GC0XM046358
  • GC0XM044070

Summaries for ZNF674 Gene

Entrez Gene Summary for ZNF674 Gene

  • This gene encodes a zinc finger protein with an N-terminal Kruppel-associated box-containing (KRAB) domain and 11 Kruppel-type C2H2 zinc finger domains. Like other zinc finger proteins, this gene may function as a transcription factor. This gene resides on an area of chromosome X that has been implicated in nonsyndromic X-linked cognitive disabilities. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2017]

GeneCards Summary for ZNF674 Gene

ZNF674 (Zinc Finger Protein 674) is a Protein Coding gene. Diseases associated with ZNF674 include Syndromic X-Linked Intellectual Disability and Autosomal Dominant Non-Syndromic Intellectual Disability 5. Among its related pathways are Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZFP90.

UniProtKB/Swiss-Prot Summary for ZNF674 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF674 Gene

Genomics for ZNF674 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF674 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF674 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF674

Top Transcription factor binding sites by QIAGEN in the ZNF674 gene promoter:
  • ARP-1
  • E47
  • ITF-2
  • RFX1
  • Tal-1
  • Tal-1beta
  • ZID

Genomic Locations for ZNF674 Gene

Genomic Locations for ZNF674 Gene
chrX:46,497,725-46,545,466
(GRCh38/hg38)
Size:
47,742 bases
Orientation:
Minus strand
chrX:46,357,160-46,404,892
(GRCh37/hg19)
Size:
47,733 bases
Orientation:
Minus strand

Genomic View for ZNF674 Gene

Genes around ZNF674 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF674 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF674 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF674 Gene

Proteins for ZNF674 Gene

  • Protein details for ZNF674 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2M3X9-ZN674_HUMAN
    Recommended name:
    Zinc finger protein 674
    Protein Accession:
    Q2M3X9
    Secondary Accessions:
    • B4DHE2
    • E9PHQ4

    Protein attributes for ZNF674 Gene

    Size:
    581 amino acids
    Molecular mass:
    67199 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF674 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF674 Gene

Post-translational modifications for ZNF674 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF674 Gene

Domains & Families for ZNF674 Gene

Gene Families for ZNF674 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF674 Gene

InterPro:
Blocks:
  • KRAB box
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF674 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 674 (ZN674_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q2M3X9

UniProtKB/Swiss-Prot:

ZN674_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF674: view

Function for ZNF674 Gene

Molecular function for ZNF674 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF674 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IBA 21873635
GO:0043565 sequence-specific DNA binding IBA 21873635
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF674: view

Phenotypes for ZNF674 Gene

genes like me logo Genes that share phenotypes with ZNF674: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF674

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF674 Gene

Localization for ZNF674 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF674 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF674 gene
Compartment Confidence
nucleus 4
cytosol 2
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF674 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF674: view

Pathways & Interactions for ZNF674 Gene

PathCards logo

SuperPathways for ZNF674 Gene

genes like me logo Genes that share pathways with ZNF674: view

Pathways by source for ZNF674 Gene

1 KEGG pathway for ZNF674 Gene

Interacting Proteins for ZNF674 Gene

Gene Ontology (GO) - Biological Process for ZNF674 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF674: view

No data available for SIGNOR curated interactions for ZNF674 Gene

Drugs & Compounds for ZNF674 Gene

No Compound Related Data Available

Transcripts for ZNF674 Gene

mRNA/cDNA for ZNF674 Gene

3 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF674

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF674 Gene

No ASD Table

Relevant External Links for ZNF674 Gene

GeneLoc Exon Structure for
ZNF674

Expression for ZNF674 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF674 Gene

Protein differential expression in normal tissues from HIPED for ZNF674 Gene

This gene is overexpressed in Gallbladder (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF674 Gene



Protein tissue co-expression partners for ZNF674 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF674

SOURCE GeneReport for Unigene cluster for ZNF674 Gene:

Hs.636105

mRNA Expression by UniProt/SwissProt for ZNF674 Gene:

Q2M3X9-ZN674_HUMAN
Tissue specificity: Expressed in testis.

Evidence on tissue expression from TISSUES for ZNF674 Gene

  • Nervous system(4.3)

Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF674 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • digestive
  • integumentary
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
  • urinary
Regions:
Head and neck:
  • brain
  • cerebellum
  • cheek
  • chin
  • cranial nerve
  • ear
  • eye
  • eyelid
  • face
  • forehead
  • head
  • jaw
  • lip
  • mandible
  • maxilla
  • mouth
  • nose
  • outer ear
  • salivary gland
  • skull
  • tooth
Thorax:
  • lung
  • rib
  • rib cage
Pelvis:
  • pelvis
  • testicle
  • urinary bladder
Limb:
  • ankle
  • digit
  • elbow
  • finger
  • foot
  • hand
  • hip
  • knee
  • lower limb
  • shoulder
  • toe
  • upper limb
  • wrist
General:
  • hair
  • peripheral nerve
  • peripheral nervous system
  • skin
  • spinal column
  • vertebrae
genes like me logo Genes that share expression patterns with ZNF674: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ZNF674 Gene

Orthologs for ZNF674 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF674 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF674 30 31
  • 99.36 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ZNF674 30 31
  • 87.94 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia LOC491850 30
  • 86.32 (n)
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 50 (a)
ManyToMany
-- 31
  • 47 (a)
ManyToMany
-- 31
  • 45 (a)
ManyToMany
-- 31
  • 44 (a)
ManyToMany
-- 31
  • 43 (a)
ManyToMany
-- 31
  • 43 (a)
ManyToMany
-- 31
  • 43 (a)
ManyToMany
-- 31
  • 42 (a)
ManyToMany
-- 31
  • 41 (a)
ManyToMany
-- 31
  • 38 (a)
ManyToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 39 (a)
OneToMany
Species where no ortholog for ZNF674 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF674 Gene

ENSEMBL:
Gene Tree for ZNF674 (if available)
TreeFam:
Gene Tree for ZNF674 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF674: view image

Paralogs for ZNF674 Gene

(490) SIMAP similar genes for ZNF674 Gene using alignment to 2 proteins:

  • ZN674_HUMAN
  • E5RHV3_HUMAN

Pseudogenes.org Pseudogenes for ZNF674 Gene

genes like me logo Genes that share paralogs with ZNF674: view

Variants for ZNF674 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF674 Gene

SNP ID Clinical significance and condition Chr 0X pos Variation AA Info Type
rs10156987 Benign: Non-syndromic X-linked intellectual disability 46,499,154(-) A/C THREE_PRIME_UTR_VARIANT
rs1057515887 Uncertain Significance: Non-syndromic X-linked intellectual disability 46,498,281(-) T/C THREE_PRIME_UTR_VARIANT
rs1057515889 Uncertain Significance: Non-syndromic X-linked intellectual disability 46,544,572(-) T/C FIVE_PRIME_UTR_VARIANT
rs121918362 Uncertain Significance: not provided 46,501,237(-) C/A NONSENSE
rs12687128 Benign: Non-syndromic X-linked intellectual disability 46,499,376(-) T/C THREE_PRIME_UTR_VARIANT

Additional dbSNP identifiers (rs#s) for ZNF674 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF674 Gene

Variant ID Type Subtype PubMed ID
esv3576853 CNV gain 25503493

Variation tolerance for ZNF674 Gene

Residual Variation Intolerance Score: 96.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.45; 28.33% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF674 Gene

Human Gene Mutation Database (HGMD)
ZNF674
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF674

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF674 Gene

Disorders for ZNF674 Gene

MalaCards: The human disease database

(11) MalaCards diseases for ZNF674 Gene - From: DISEASES and GeneCards

- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with ZNF674: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF674 Gene

Publications for ZNF674 Gene

  1. ZNF674: a new kruppel-associated box-containing zinc-finger gene involved in nonsyndromic X-linked mental retardation. (PMID: 16385466) Lugtenberg D … van Bokhoven H (American journal of human genetics 2006) 2 3 4
  2. XLID-causing mutations and associated genes challenged in light of data from large-scale human exome sequencing. (PMID: 23871722) Piton A … Mandel JL (American journal of human genetics 2013) 4
  3. Intellectual disability associated with retinal dystrophy in the Xp11.3 deletion syndrome: ZNF674 on trial. Guilty or innocent? (PMID: 22126752) Delphin N … Rozet JM (European journal of human genetics : EJHG 2012) 3
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3

Products for ZNF674 Gene

Sources for ZNF674 Gene