Aliases for ZNF671 Gene

Aliases for ZNF671 Gene

  • Zinc Finger Protein 671 2 3 4 5
  • Hypothetical Protein FLJ23506 2
  • FLJ23506 2
  • ZNF671 5

External Ids for ZNF671 Gene

Previous GeneCards Identifiers for ZNF671 Gene

  • GC19M062923
  • GC19M058231
  • GC19M054543

Summaries for ZNF671 Gene

GeneCards Summary for ZNF671 Gene

ZNF671 (Zinc Finger Protein 671) is a Protein Coding gene. Diseases associated with ZNF671 include Endocervical Carcinoma and Endocervical Adenocarcinoma. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and transcription coregulator activity. An important paralog of this gene is ZNF667.

UniProtKB/Swiss-Prot Summary for ZNF671 Gene

Additional gene information for ZNF671 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF671 Gene

Genomics for ZNF671 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF671 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF671 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF671

Top Transcription factor binding sites by QIAGEN in the ZNF671 gene promoter:
  • AREB6

Genomic Locations for ZNF671 Gene

Genomic Locations for ZNF671 Gene
chr19:57,719,747-57,727,637
(GRCh38/hg38)
Size:
7,891 bases
Orientation:
Minus strand
chr19:58,231,119-58,238,995
(GRCh37/hg19)
Size:
7,877 bases
Orientation:
Minus strand

Genomic View for ZNF671 Gene

Genes around ZNF671 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF671 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF671 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF671 Gene

Proteins for ZNF671 Gene

  • Protein details for ZNF671 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TAW3-ZN671_HUMAN
    Recommended name:
    Zinc finger protein 671
    Protein Accession:
    Q8TAW3
    Secondary Accessions:
    • A6NF07
    • Q9H5E9

    Protein attributes for ZNF671 Gene

    Size:
    534 amino acids
    Molecular mass:
    60972 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH25728.1; Type=Frameshift; Evidence={ECO:0000305};

neXtProt entry for ZNF671 Gene

Post-translational modifications for ZNF671 Gene

  • Ubiquitination at Lys381
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNF671 Gene

No data available for DME Specific Peptides for ZNF671 Gene

Domains & Families for ZNF671 Gene

Gene Families for ZNF671 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF671 Gene

InterPro:
Blocks:
  • KRAB box
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF671 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 671 (ZN671_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8TAW3

UniProtKB/Swiss-Prot:

ZN671_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF671: view

Function for ZNF671 Gene

Molecular function for ZNF671 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF671 Gene

Gene Ontology (GO) - Molecular Function for ZNF671 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF671: view
genes like me logo Genes that share phenotypes with ZNF671: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF671

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF671 Gene

Localization for ZNF671 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF671 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF671 gene
Compartment Confidence
nucleus 5
cytosol 2
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF671 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF671: view

Pathways & Interactions for ZNF671 Gene

genes like me logo Genes that share pathways with ZNF671: view

Pathways by source for ZNF671 Gene

2 Reactome pathways for ZNF671 Gene
1 KEGG pathway for ZNF671 Gene

Gene Ontology (GO) - Biological Process for ZNF671 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF671: view

No data available for SIGNOR curated interactions for ZNF671 Gene

Drugs & Compounds for ZNF671 Gene

No Compound Related Data Available

Transcripts for ZNF671 Gene

mRNA/cDNA for ZNF671 Gene

3 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF671

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF671 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b
SP1: - -
SP2: - - -
SP3: - - - - -
SP4: - - - -
SP5: - -
SP6: -

Relevant External Links for ZNF671 Gene

GeneLoc Exon Structure for
ZNF671

Expression for ZNF671 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF671 Gene

Protein differential expression in normal tissues from HIPED for ZNF671 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF671 Gene



Protein tissue co-expression partners for ZNF671 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF671

SOURCE GeneReport for Unigene cluster for ZNF671 Gene:

Hs.180402

Evidence on tissue expression from TISSUES for ZNF671 Gene

  • Lung(4.3)
  • Nervous system(3.4)
genes like me logo Genes that share expression patterns with ZNF671: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF671 Gene

Orthologs for ZNF671 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF671 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF671 30 31
  • 99.5 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZNF671 30
  • 79.72 (n)
Species where no ortholog for ZNF671 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF671 Gene

ENSEMBL:
Gene Tree for ZNF671 (if available)
TreeFam:
Gene Tree for ZNF671 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF671: view image

Paralogs for ZNF671 Gene

Paralogs for ZNF671 Gene

(516) SIMAP similar genes for ZNF671 Gene using alignment to 4 proteins:

  • ZN671_HUMAN
  • C9J3V7_HUMAN
  • M0QX87_HUMAN
  • M0R091_HUMAN
genes like me logo Genes that share paralogs with ZNF671: view

Variants for ZNF671 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF671 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
769060 Benign: not provided 57,720,878(-) C/T MISSENSE_VARIANT
790766 Benign: not provided 57,720,895(-) A/G SYNONYMOUS_VARIANT
rs34419645 - p.Pro237Ser
rs3746207 - p.Ala149Val

Additional dbSNP identifiers (rs#s) for ZNF671 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF671 Gene

Variant ID Type Subtype PubMed ID
nsv1066059 CNV gain 25217958

Variation tolerance for ZNF671 Gene

Residual Variation Intolerance Score: 11% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.05; 68.74% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF671 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF671

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF671 Gene

Disorders for ZNF671 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ZNF671 Gene - From: DISEASES

Disorder Aliases PubMed IDs
endocervical carcinoma
  • carcinoma of endocervix
endocervical adenocarcinoma
  • endocervical carcinoma
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with ZNF671: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF671 Gene

Publications for ZNF671 Gene

  1. ZNF671 DNA methylation as a molecular predictor for the early recurrence of serous ovarian cancer. (PMID: 30633424) Mase S … Kondo Y (Cancer science 2019) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Quantitation of DNA methylation in Epstein-Barr virus-associated nasopharyngeal carcinoma by bisulfite amplicon sequencing. (PMID: 28716111) Zhao W … Takeuchi K (BMC cancer 2017) 3
  5. Epigenetic mediated zinc finger protein 671 downregulation promotes cell proliferation and tumorigenicity in nasopharyngeal carcinoma by inhibiting cell cycle arrest. (PMID: 29052525) Zhang J … Sun Y (Journal of experimental & clinical cancer research : CR 2017) 3

Products for ZNF671 Gene

Sources for ZNF671 Gene