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This locus represents naturally occurring read-through transcription between the neighboring zinc finger protein 670 (ZNF670) and zinc finger protein 695 (ZNF695) genes on chromosome 1. The read-through transcript is a candidate for nonsense-mediated mRNA decay (NMD), and is thus unlikely to produce a protein product. [provided by RefSeq, Feb 2011] See more...
Aliases for ZNF670-ZNF695 Gene
Subcategory (RNA class) for ZNF670-ZNF695 Gene
lncRNA
Quality Score for this RNA gene is
14
Aliases for ZNF670-ZNF695 Gene
External Ids for ZNF670-ZNF695 Gene
- HGNC: 49200
- Entrez Gene: 100533111
- Ensembl: ENSG00000135747
- UniProtKB: F2Z2N8
- UniProtKB: E7EVQ0
Previous GeneCards Identifiers for ZNF670-ZNF695 Gene
- GC01U903219
- GC01M247112
Summaries for ZNF670-ZNF695 Gene
-
This locus represents naturally occurring read-through transcription between the neighboring zinc finger protein 670 (ZNF670) and zinc finger protein 695 (ZNF695) genes on chromosome 1. The read-through transcript is a candidate for nonsense-mediated mRNA decay (NMD), and is thus unlikely to produce a protein product. [provided by RefSeq, Feb 2011]
GeneCards Summary for ZNF670-ZNF695 Gene
ZNF670-ZNF695 (ZNF670-ZNF695 Readthrough (NMD Candidate)) is an RNA Gene, and is affiliated with the lncRNA class. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF720.
Additional gene information for ZNF670-ZNF695 Gene
No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF670-ZNF695 Gene
Genomics for ZNF670-ZNF695 Gene
GeneHancer (GH) Regulatory Elements for ZNF670-ZNF695 Gene
Promoters and enhancers for ZNF670-ZNF695 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ZNF670-ZNF695 on UCSC Golden Path with GeneCards custom track
Genomic Locations for ZNF670-ZNF695 Gene
Genomic Locations for ZNF670-ZNF695 Gene
- chr1:246,945,547-247,078,813
- (GRCh38/hg38)
- Size:
- 133,267 bases
- Orientation:
- Minus strand
- chr1:247,108,849-247,242,115
- (GRCh37/hg19)
- Size:
- 133,267 bases
- Orientation:
- Minus strand
Genomic View for ZNF670-ZNF695 Gene
Genes around ZNF670-ZNF695 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q44 by HGNC
- 1q44 by Entrez Gene
- 1q44 by Ensembl
ZNF670-ZNF695 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ZNF670-ZNF695 Gene
Proteins for ZNF670-ZNF695 Gene
-
Protein details for ZNF670-ZNF695 Gene (UniProtKB/TrEMBL)
- Protein Symbol:
- F2Z2N8-F2Z2N8_HUMAN
- Recommended name:
- ZNF670-ZNF695 readthrough (NMD candidate)
- Protein Accession:
- F2Z2N8
Protein attributes for ZNF670-ZNF695 Gene
- Size:
- 137 amino acids
- Molecular mass:
- 16018 Da
- Quaternary structure:
- No Data Available
-
Protein details for ZNF670-ZNF695 Gene (UniProtKB/TrEMBL)
- Protein Symbol:
- E7EVQ0-E7EVQ0_HUMAN
- Recommended name:
- ZNF670-ZNF695 readthrough (NMD candidate)
- Protein Accession:
- E7EVQ0
Protein attributes for ZNF670-ZNF695 Gene
- Size:
- 118 amino acids
- Molecular mass:
- 13151 Da
- Quaternary structure:
- No Data Available
Protein Expression for ZNF670-ZNF695 Gene
Post-translational modifications for ZNF670-ZNF695 Gene
No Post-translational modifications
Other Protein References for ZNF670-ZNF695 Gene
- ENSEMBL proteins:
Antibody Products
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for ZNF670-ZNF695
- Origene Custom Protein Services for ZNF670-ZNF695
No data available for DME Specific Peptides for ZNF670-ZNF695 Gene
Domains & Families for ZNF670-ZNF695 Gene
Protein Domains for ZNF670-ZNF695 Gene
- InterPro:
- ProtoNet:
No data available for Gene Families , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ZNF670-ZNF695 Gene
Function for ZNF670-ZNF695 Gene
Phenotypes From GWAS Catalog for ZNF670-ZNF695 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
miRNA Products
Inhibitory RNA Products
Clone Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF670-ZNF695 Gene
Localization for ZNF670-ZNF695 Gene
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for ZNF670-ZNF695 Gene
Pathways & Interactions for ZNF670-ZNF695 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for ZNF670-ZNF695 Gene
Transcripts for ZNF670-ZNF695 Gene
mRNA/cDNA for ZNF670-ZNF695 Gene
- (1) REFSEQ mRNAs :
- (2) Additional mRNA sequences :
- (2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000465049 1042 bps (ENST00000465049.6)
- ENST00000474541 2751 bps (ENST00000474541.1)
- (1) NONCODE transcripts :
- (4) RNACentral transcripts :
- (1) LncBook transcripts :
- (2) LNCipedia transcripts :
CRISPR Products
- Browse CRISPR knockouts for ZNF670-ZNF695
miRNA Products
Inhibitory RNA Products
Clone Products
Relevant External Links for ZNF670-ZNF695 Gene
- GeneLoc Exon Structure for
- ZNF670-ZNF695
- ECgene alternative splicing isoforms for
- ZNF670-ZNF695
Expression for ZNF670-ZNF695 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from MaxQB and MOPED for ZNF670-ZNF695 Gene
Primer Products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF670-ZNF695 Gene
Orthologs for ZNF670-ZNF695 Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ZNF670 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | -- 33 |
|
ManyToMany | |
| mouse (Mus musculus) |
Mammalia | Zfp963 33 |
|
ManyToMany | |
| Zfp964 33 |
|
ManyToMany | |||
| Zfp866 33 |
|
ManyToMany | |||
| Zfp868 33 |
|
ManyToMany | |||
| Zfp869 33 |
|
ManyToMany |
- Species where no ortholog for ZNF670-ZNF695 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for ZNF670-ZNF695 Gene
Variants for ZNF670-ZNF695 Gene
| SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000020620 | -- | 246,992,688(-) | T/A | intron_variant | |
| rs1000024522 | -- | 247,036,897(-) | C/A | intron_variant | |
| rs1000025141 | -- | 247,073,649(-) | A/T | intron_variant | |
| rs1000027617 | -- | 246,974,943(-) | C/G | intron_variant | |
| rs1000083209 | -- | 247,041,219(-) | G/T | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2487818 | CNV | deletion | 19546169 |
| esv2668869 | CNV | deletion | 23128226 |
| esv2672680 | CNV | deletion | 23128226 |
| esv2673254 | CNV | deletion | 23128226 |
| esv29446 | CNV | loss | 19812545 |
| esv33129 | CNV | gain+loss | 17666407 |
| esv3589499 | CNV | loss | 21293372 |
| esv3589500 | CNV | loss | 21293372 |
| esv3589501 | CNV | loss | 21293372 |
| esv3589502 | CNV | loss | 21293372 |
| esv3589503 | CNV | loss | 21293372 |
| esv3589504 | CNV | loss | 21293372 |
| esv3589505 | CNV | loss | 21293372 |
| esv3891381 | CNV | loss | 25118596 |
| nsv1014012 | CNV | loss | 25217958 |
| nsv1141906 | OTHER | inversion | 24896259 |
| nsv524007 | CNV | gain | 19592680 |
| nsv549546 | CNV | loss | 21841781 |
| nsv549547 | CNV | loss | 21841781 |
| nsv945436 | CNV | duplication | 23825009 |
| nsv999879 | CNV | gain | 25217958 |
Additional Variant Information for ZNF670-ZNF695 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ZNF670-ZNF695
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for ZNF670-ZNF695 Gene
Disorders for ZNF670-ZNF695 Gene
Additional Disease Information for ZNF670-ZNF695
No disorders were found for ZNF670-ZNF695 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF670-ZNF695 Gene
Publications for ZNF670-ZNF695 Gene
- Genetic association with overall survival of taxane-treated lung cancer patients - a genome-wide association study in human lymphoblastoid cell lines followed by a clinical association study. (PMID: 23006423) Niu N … Wang L (BMC cancer 2012) 3 56
- Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T … Taylor TD (PloS one 2010) 3 56
- The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 13 56
Products for ZNF670-ZNF695 Gene
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Sources for ZNF670-ZNF695 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
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- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) CGAP SAGE
- (31) SOURCE
- (32) HomoloGene
- (33) PanEnsembl
- (34) euGenes
- (35) SGD
- (36) FlyBase
- (37) WormBase
- (38) Pseudogene
- (39) DGV
- (40) dbSNP
- (41) GenAtlas
- (42) HGMD
- (43) GAD
- (44) BGMUT
- (45) HuGE
- (46) Atlas
- (47) GenBank
- (48) H-invDB
- (49) HORDE
- (50) HUGE
- (51) IMGT
- (52) Leiden
- (53) miRBase
- (54) DME
- (55) OriGene
- (56) PubMed
- (57) R&D Systems
- (58) TGDB
- (59) Tocris
- (60) Abcam
- (61) Novus Biologicals
- (62) ProSpec
- (63) Sino Biological
- (64) GenScript
- (65) Qiagen
- (66) OCA
- (67) Proteopedia
- (68) MOPED
- (69) neXtProt
- (70) Reactome
- (71) GeneGo (Thomson Reuters)
- (72) DISEASES
- (73) SIMAP
- (74) GenomeRNAi
- (75) LifeMap
- (76) miRTarBase
- (77) MalaCards
- (78) Invitrogen
- (79) BitterDB
- (80) ESI-BIO
- (81) RefSeq
- (82) BioSystems
- (83) MaxQB
- (84) IUPHAR
- (85) BioGPS
- (86) Illumina
- (87) COMPARTMENTS
- (88) HOMER
- (89) PaxDb
- (90) ApexBio
- (91) Addgene
- (92) antibodies-online
- (93) CYP
- (94) NONCODE
- (95) TreeFam
- (96) PathCards
- (97) GeneReviews
- (98) GeneTex
- (99) Taconic Biosciences
- (100) GTEx
- (101) ProteomicsDB
- (102) SCBT
- (103) DGIdb
- (104) ClinicalTrials
- (105) RVIS
- (106) SIGNOR
- (107) diseasecard
- (108) NIH Rare Diseases
- (109) Orphanet
- (110) UMLS
- (111) GTR
- (112) Disease Ontology
- (113) Genetics Home Reference
- (114) MeSH
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- (136) TISSUES
- (137) Gene ORGANizer
- (138) abm
- (139) Human Protein Atlas
- (140) GWAS Catalog
- (141) Monarch Initiative
- (142) DataMed
- (143) HumanCyc
- (144) genomics-online
- (145) UCNEbase
- (146) EPDnew
- (147) Applied Biosystems
- (148) GlyConnect
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- (150) GeneCopoeia
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- (152) RNACentral
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- (154) LOVD
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- (156) DiseaseEnhancer
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- (161) CTD^2 Dashboard
- (162) CraniofacialAtlas
- (163) GeneImprint
- (164) Synthego
- (165) Bio Basic
- (166) ENA
- (167) GtRNAdb
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- (169) LncBook
- (170) LNCipedia
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- (178) GENCODE
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