Aliases for ZNF670 Gene

Aliases for ZNF670 Gene

  • Zinc Finger Protein 670 2 3 4 5

External Ids for ZNF670 Gene

Previous GeneCards Identifiers for ZNF670 Gene

  • GC01M243527
  • GC01M245266
  • GC01M247200
  • GC01M217593
  • GC01M247111
  • GC01M247114

Summaries for ZNF670 Gene

GeneCards Summary for ZNF670 Gene

ZNF670 (Zinc Finger Protein 670) is a Protein Coding gene. Diseases associated with ZNF670 include Vitreous Disease. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF627.

UniProtKB/Swiss-Prot Summary for ZNF670 Gene

Additional gene information for ZNF670 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF670 Gene

Genomics for ZNF670 Gene

GeneHancer (GH) Regulatory Elements for ZNF670 Gene

Promoters and enhancers for ZNF670 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J247077 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 500.7 +0.3 297 3.4 ZBTB40 ZNF217 EP300 CTCF SIN3A NRF1 TCF12 POLR2G SP1 GTF2E2 ZNF670-ZNF695 ZNF670 ZNF669 AHCTF1 ZNF496 ZNF695 ENSG00000215796 MG828730-009
GH01J247151 Enhancer 0.2 FANTOM5 3.8 -73.1 -73129 0.3 lnc-ZNF669-2-001 ZNF124 ZNF670 ZNF669 ZNF695 OR2G3 OR2G2 ZNF496 HQ292108 lnc-ZNF669-2-002
GH01J247132 Enhancer 0.2 FANTOM5 2.5 -53.9 -53930 0.4 RF00017-556 piR-56133-021 ZNF124 ZNF670 ZNF695 ZNF669 lnc-NLRP3-11 lnc-ZNF669-2-001 MG828730-009
GH01J247055 Enhancer 1 Ensembl ENCODE 0.4 +23.7 23678 1.5 TCF7 CTBP1 TEAD1 NFIC TRIM24 TBP SAP130 RBBP5 FOSL1 CREM ZNF670-ZNF695 ZNF496 ZNF669 ENSG00000215796 MG828730-009 ZNF670
GH01J247064 Enhancer 0.3 Ensembl 0.4 +14.0 14012 0.4 ETV5 ZNF669 ZNF670 ZNF670-ZNF695 ENSG00000215796 MG828730-009
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF670 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF670

Top Transcription factor binding sites by QIAGEN in the ZNF670 gene promoter:
  • AREB6
  • E47
  • ITF-2
  • Pax-5
  • RFX1
  • Tal-1beta
  • Zic1
  • ZIC2

Genomic Locations for ZNF670 Gene

Genomic Locations for ZNF670 Gene
chr1:247,034,637-247,078,813
(GRCh38/hg38)
Size:
44,177 bases
Orientation:
Minus strand
chr1:247,108,849-247,242,115
(GRCh37/hg19)
Size:
133,267 bases
Orientation:
Minus strand

Genomic View for ZNF670 Gene

Genes around ZNF670 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF670 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF670 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF670 Gene

Proteins for ZNF670 Gene

  • Protein details for ZNF670 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BS34-ZN670_HUMAN
    Recommended name:
    Zinc finger protein 670
    Protein Accession:
    Q9BS34

    Protein attributes for ZNF670 Gene

    Size:
    389 amino acids
    Molecular mass:
    44603 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF670 Gene

Post-translational modifications for ZNF670 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF670 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF670 Gene

Domains & Families for ZNF670 Gene

Gene Families for ZNF670 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF670 Gene

Blocks:
  • KRAB box
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF670 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 670 (ZN670_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BS34

UniProtKB/Swiss-Prot:

ZN670_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF670: view

Function for ZNF670 Gene

Molecular function for ZNF670 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF670 Gene

Gene Ontology (GO) - Molecular Function for ZNF670 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 19060904
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF670: view
genes like me logo Genes that share phenotypes with ZNF670: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF670 Gene

Localization for ZNF670 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF670 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF670 gene
Compartment Confidence
nucleus 4
cytosol 3
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF670 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF670: view

Pathways & Interactions for ZNF670 Gene

genes like me logo Genes that share pathways with ZNF670: view

Pathways by source for ZNF670 Gene

2 Reactome pathways for ZNF670 Gene
1 KEGG pathway for ZNF670 Gene

Gene Ontology (GO) - Biological Process for ZNF670 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF670: view

No data available for SIGNOR curated interactions for ZNF670 Gene

Drugs & Compounds for ZNF670 Gene

No Compound Related Data Available

Transcripts for ZNF670 Gene

mRNA/cDNA for ZNF670 Gene

2 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF670 Gene

No ASD Table

Relevant External Links for ZNF670 Gene

GeneLoc Exon Structure for
ZNF670

Expression for ZNF670 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF670 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF670 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF670

SOURCE GeneReport for Unigene cluster for ZNF670 Gene:

Hs.732305

Evidence on tissue expression from TISSUES for ZNF670 Gene

  • Gall bladder(4.1)
  • Nervous system(3.7)
genes like me logo Genes that share expression patterns with ZNF670: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF670 Gene

Orthologs for ZNF670 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for ZNF670 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF670 30
  • 99.83 (n)
Species where no ortholog for ZNF670 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF670 Gene

ENSEMBL:
Gene Tree for ZNF670 (if available)
TreeFam:
Gene Tree for ZNF670 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF670: view image

Paralogs for ZNF670 Gene

(503) SIMAP similar genes for ZNF670 Gene using alignment to 3 proteins:

  • ZN670_HUMAN
  • E7EVQ0_HUMAN
  • F2Z2N8_HUMAN
genes like me logo Genes that share paralogs with ZNF670: view

Variants for ZNF670 Gene

Additional dbSNP identifiers (rs#s) for ZNF670 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF670 Gene

Variant ID Type Subtype PubMed ID
esv2672680 CNV deletion 23128226
esv29446 CNV loss 19812545
esv33129 CNV gain+loss 17666407
esv3589499 CNV loss 21293372
esv3589503 CNV loss 21293372
esv3589504 CNV loss 21293372
esv3589505 CNV loss 21293372
nsv1014012 CNV loss 25217958
nsv549546 CNV loss 21841781
nsv549547 CNV loss 21841781
nsv999879 CNV gain 25217958

Variation tolerance for ZNF670 Gene

Residual Variation Intolerance Score: 26.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.78; 16.45% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF670 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF670

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF670 Gene

Disorders for ZNF670 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF670 Gene - From: DISEASES

Disorder Aliases PubMed IDs
vitreous disease
  • disorder of vitreous body
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF670

genes like me logo Genes that share disorders with ZNF670: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF670 Gene

Publications for ZNF670 Gene

No publications were found for ZNF670 Gene.

Products for ZNF670 Gene

Sources for ZNF670 Gene