Aliases for ZNF669 Gene

Aliases for ZNF669 Gene

  • Zinc Finger Protein 669 2 3 4 5
  • FLJ12606 2
  • ZNF669 5

External Ids for ZNF669 Gene

Previous GeneCards Identifiers for ZNF669 Gene

  • GC01M243590
  • GC01M245327
  • GC01M247261
  • GC01M217657

Summaries for ZNF669 Gene

GeneCards Summary for ZNF669 Gene

ZNF669 (Zinc Finger Protein 669) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF20.

UniProtKB/Swiss-Prot Summary for ZNF669 Gene

Additional gene information for ZNF669 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF669 Gene

Genomics for ZNF669 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF669 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF669 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF669

Top Transcription factor binding sites by QIAGEN in the ZNF669 gene promoter:
  • CBF(2)
  • E47
  • Meis-1
  • Meis-1a
  • Meis-1b
  • MZF-1
  • NF-Y
  • POU2F1
  • POU2F1a

Genomic Locations for ZNF669 Gene

Genomic Locations for ZNF669 Gene
chr1:247,099,962-247,104,372
(GRCh38/hg38)
Size:
4,411 bases
Orientation:
Minus strand
chr1:247,263,264-247,267,674
(GRCh37/hg19)
Size:
4,411 bases
Orientation:
Minus strand

Genomic View for ZNF669 Gene

Genes around ZNF669 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF669 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF669 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF669 Gene

Proteins for ZNF669 Gene

  • Protein details for ZNF669 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96BR6-ZN669_HUMAN
    Recommended name:
    Zinc finger protein 669
    Protein Accession:
    Q96BR6
    Secondary Accessions:
    • B3KP94
    • Q5VT39
    • Q9H9Q6

    Protein attributes for ZNF669 Gene

    Size:
    464 amino acids
    Molecular mass:
    52597 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF669 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF669 Gene

Post-translational modifications for ZNF669 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF669 Gene

No data available for DME Specific Peptides for ZNF669 Gene

Domains & Families for ZNF669 Gene

Gene Families for ZNF669 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF669 Gene

InterPro:
Blocks:
  • KRAB box
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF669 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ31458 fis, clone NT2NE2001181, highly similar to Zinc finger protein 669 (B3KP94_HUMAN)
  • Zinc finger protein 669 (Q5VT36_HUMAN)
  • Zinc finger protein 669 (Q5VT37_HUMAN)
  • Zinc finger protein 669 (ZN669_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96BR6

UniProtKB/Swiss-Prot:

ZN669_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF669: view

Function for ZNF669 Gene

Molecular function for ZNF669 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF669 Gene

Gene Ontology (GO) - Molecular Function for ZNF669 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IBA 21873635
GO:0043565 sequence-specific DNA binding IBA 21873635
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF669: view
genes like me logo Genes that share phenotypes with ZNF669: view

Animal Model Products

CRISPR Products

miRNA for ZNF669 Gene

miRTarBase miRNAs that target ZNF669
Targeted motifs for ZNF669 Gene
HOMER Transcription Factor Regulatory Elements motif ZNF669
  • Consensus sequence: GARTGGTCATCGCCC Submotif: canonical Cell Type: HEK293 GEO ID: GSE58341

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF669

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models and Transcription Factor Targets for ZNF669 Gene

Localization for ZNF669 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF669 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF669 gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for ZNF669 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with ZNF669: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF669 Gene

Pathways & Interactions for ZNF669 Gene

genes like me logo Genes that share pathways with ZNF669: view

Pathways by source for ZNF669 Gene

2 Reactome pathways for ZNF669 Gene
1 KEGG pathway for ZNF669 Gene

Gene Ontology (GO) - Biological Process for ZNF669 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF669: view

No data available for SIGNOR curated interactions for ZNF669 Gene

Drugs & Compounds for ZNF669 Gene

No Compound Related Data Available

Transcripts for ZNF669 Gene

mRNA/cDNA for ZNF669 Gene

2 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF669

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF669 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d · 4e
SP1: -
SP2:
SP3: -
SP4: -
SP5: - -

Relevant External Links for ZNF669 Gene

GeneLoc Exon Structure for
ZNF669

Expression for ZNF669 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF669 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF669 Gene



Protein tissue co-expression partners for ZNF669 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF669

SOURCE GeneReport for Unigene cluster for ZNF669 Gene:

Hs.163754

Evidence on tissue expression from TISSUES for ZNF669 Gene

  • Liver(4.1)
genes like me logo Genes that share expression patterns with ZNF669: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF669 Gene

Orthologs for ZNF669 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF669 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF669 30
  • 98.94 (n)
Mouse
(Mus musculus)
Mammalia Zfp963 30 17 31
  • 66.01 (n)
ManyToMany
Zfp964 31
  • 36 (a)
ManyToMany
Zfp868 31
  • 35 (a)
ManyToMany
Zfp866 31
  • 35 (a)
ManyToMany
Zfp869 31
  • 32 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia -- 31
  • 44 (a)
ManyToMany
Species where no ortholog for ZNF669 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF669 Gene

ENSEMBL:
Gene Tree for ZNF669 (if available)
TreeFam:
Gene Tree for ZNF669 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF669: view image

Paralogs for ZNF669 Gene

(469) SIMAP similar genes for ZNF669 Gene using alignment to 5 proteins:

  • ZN669_HUMAN
  • E2QRF4_HUMAN
  • E5RI66_HUMAN
  • Q5VT36_HUMAN
  • Q5VT37_HUMAN

Pseudogenes.org Pseudogenes for ZNF669 Gene

genes like me logo Genes that share paralogs with ZNF669: view

Variants for ZNF669 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF669 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs4925692 - p.Glu76Asp
rs7533935 - p.Gly460Ser

Additional dbSNP identifiers (rs#s) for ZNF669 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF669 Gene

Variant ID Type Subtype PubMed ID
esv33129 CNV gain+loss 17666407
esv3589499 CNV loss 21293372
esv3589503 CNV loss 21293372
esv3589507 CNV loss 21293372
esv3891392 CNV loss 25118596
nsv1014012 CNV loss 25217958
nsv509779 CNV insertion 20534489
nsv549547 CNV loss 21841781
nsv999879 CNV gain 25217958

Variation tolerance for ZNF669 Gene

Residual Variation Intolerance Score: 97.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.03; 80.18% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF669 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF669

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF669 Gene

Disorders for ZNF669 Gene

No disorders were found for ZNF669 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF669 Gene

Publications for ZNF669 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for ZNF669 Gene

Sources for ZNF669 Gene