Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZNF669 Gene

Aliases for ZNF669 Gene

  • Zinc Finger Protein 669 2 3 5

External Ids for ZNF669 Gene

Previous GeneCards Identifiers for ZNF669 Gene

  • GC01M243590
  • GC01M245327
  • GC01M247261
  • GC01M217657

Summaries for ZNF669 Gene

GeneCards Summary for ZNF669 Gene

ZNF669 (Zinc Finger Protein 669) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF670.

UniProtKB/Swiss-Prot for ZNF669 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF669 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF669 Gene

Genomics for ZNF669 Gene

GeneHancer (GH) Regulatory Elements for ZNF669 Gene

Promoters and enhancers for ZNF669 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I247103 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 591.6 +0.2 202 2.4 HDGF PKNOX1 ARID4B SIN3A DMAP1 YY1 POLR2B ZNF766 CBX5 E2F8 ZNF669 AHCTF1 ZNF670-ZNF695 ZNF124 ZNF496 ENSG00000228982
GH01I247077 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 70.8 +25.7 25671 3 PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 ZBTB7B IRF4 YY1 POLR2B ZNF670-ZNF695 ZNF670 ZNF669 AHCTF1 ENSG00000227671 ZNF124 ZNF496 ZNF695 LOC100420880
GH01I247006 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 46.1 +96.7 96657 1.9 PKNOX1 SMAD1 ATF1 ARID4B SIN3A DMAP1 ZNF48 POLR2B FOS ATF7 ZNF695 ZNF669 AHCTF1 ZNF670-ZNF695 ENSG00000227671 ZNF124 ZNF496
GH01I246564 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 29.5 +534.9 534914 9.4 HDGF PKNOX1 FOXA2 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 YY1 CNST TFB2M ZNF670-ZNF695 ZNF669 AHCTF1 ZNF496 ZNF124 SMYD3 LINC01341 ENSG00000225300
GH01I247330 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 30 -227.6 -227551 3.4 HDGF PKNOX1 ATF1 MLX ARID4B SIN3A DMAP1 ZNF48 YY1 ETS1 ZNF496 ZNF669 AHCTF1 ZNF670-ZNF695 ENSG00000227671 ZNF124 ENSG00000259865 ENSG00000202079
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF669 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF669 gene promoter:

Genomic Locations for ZNF669 Gene

Genomic Locations for ZNF669 Gene
4,439 bases
Minus strand

Genomic View for ZNF669 Gene

Genes around ZNF669 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF669 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF669 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF669 Gene

Proteins for ZNF669 Gene

  • Protein details for ZNF669 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 669
    Protein Accession:
    Secondary Accessions:
    • B3KP94
    • Q5VT39
    • Q9H9Q6

    Protein attributes for ZNF669 Gene

    464 amino acids
    Molecular mass:
    52597 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF669 Gene


neXtProt entry for ZNF669 Gene

Post-translational modifications for ZNF669 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF669 Gene

No data available for DME Specific Peptides for ZNF669 Gene

Domains & Families for ZNF669 Gene

Gene Families for ZNF669 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF669 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF669: view

Function for ZNF669 Gene

Molecular function for ZNF669 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF669 Gene

Gene Ontology (GO) - Molecular Function for ZNF669 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF669: view
genes like me logo Genes that share phenotypes with ZNF669: view

miRNA for ZNF669 Gene

miRTarBase miRNAs that target ZNF669
Targeted motifs for ZNF669 Gene
HOMER Transcription Factor Regulatory Elements motif ZNF669
  • Consensus sequence: GARTGGTCATCGCCC Submotif: canonical Cell Type: HEK293 GEO ID: GSE58341

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models and Transcription Factor Targets for ZNF669 Gene

Localization for ZNF669 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF669 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF669 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF669 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF669: view

Pathways & Interactions for ZNF669 Gene

SuperPathways for ZNF669 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF669: view

Pathways by source for ZNF669 Gene

2 Reactome pathways for ZNF669 Gene

Interacting Proteins for ZNF669 Gene

Gene Ontology (GO) - Biological Process for ZNF669 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF669: view

No data available for SIGNOR curated interactions for ZNF669 Gene

Drugs & Compounds for ZNF669 Gene

No Compound Related Data Available

Transcripts for ZNF669 Gene

Unigene Clusters for ZNF669 Gene

Zinc finger protein 669:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF669 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d · 4e
SP1: -
SP3: -
SP4: -
SP5: - -

Relevant External Links for ZNF669 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF669 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF669 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF669 Gene

Protein tissue co-expression partners for ZNF669 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF669 Gene:


SOURCE GeneReport for Unigene cluster for ZNF669 Gene:


Evidence on tissue expression from TISSUES for ZNF669 Gene

  • Liver(4.1)
genes like me logo Genes that share expression patterns with ZNF669: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF669 Gene

Orthologs for ZNF669 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF669 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF669 33
  • 98.94 (n)
(Mus musculus)
Mammalia Zfp963 33 16 34
  • 66.01 (n)
Zfp964 34
  • 36 (a)
Zfp866 34
  • 35 (a)
Zfp868 34
  • 35 (a)
Zfp869 34
  • 32 (a)
(Bos Taurus)
Mammalia -- 34
  • 44 (a)
Species where no ortholog for ZNF669 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF669 Gene

Gene Tree for ZNF669 (if available)
Gene Tree for ZNF669 (if available)

Paralogs for ZNF669 Gene

(469) SIMAP similar genes for ZNF669 Gene using alignment to 5 proteins: Pseudogenes for ZNF669 Gene

genes like me logo Genes that share paralogs with ZNF669: view

Variants for ZNF669 Gene

Sequence variations from dbSNP and Humsavar for ZNF669 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000921480 -- 247,104,544(-) C/A/T upstream_transcript_variant
rs1001066025 -- 247,105,581(-) G/A upstream_transcript_variant
rs1001920160 -- 247,105,784(-) T/C upstream_transcript_variant
rs1001975491 -- 247,105,570(-) T/A upstream_transcript_variant
rs1002067517 -- 247,100,264(-) G/A 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF669 Gene

Variant ID Type Subtype PubMed ID
esv33129 CNV gain+loss 17666407
esv3589499 CNV loss 21293372
esv3589503 CNV loss 21293372
esv3589507 CNV loss 21293372
esv3891392 CNV loss 25118596
nsv1014012 CNV loss 25217958
nsv509779 CNV insertion 20534489
nsv549547 CNV loss 21841781
nsv999879 CNV gain 25217958

Variation tolerance for ZNF669 Gene

Residual Variation Intolerance Score: 97.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.03; 80.18% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF669 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF669 Gene

Disorders for ZNF669 Gene

Additional Disease Information for ZNF669

No disorders were found for ZNF669 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF669 Gene

Publications for ZNF669 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for ZNF669 Gene

Sources for ZNF669 Gene

Loading form....