ZNF668 Gene (Protein Coding)

Zinc Finger Protein 668

GC16M031072
GIFtS:
37

Aliases for ZNF668 Gene

Aliases for ZNF668 Gene

  • Zinc Finger Protein 668 2 3 4 5

External Ids for ZNF668 Gene

Previous GeneCards Identifiers for ZNF668 Gene

  • GC16M030980
  • GC16M028633

Summaries for ZNF668 Gene

GeneCards Summary for ZNF668 Gene

ZNF668 (Zinc Finger Protein 668) is a Protein Coding gene. Diseases associated with ZNF668 include Nodular Malignant Melanoma. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity. An important paralog of this gene is ZNF850.

UniProtKB/Swiss-Prot Summary for ZNF668 Gene

Additional gene information for ZNF668 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF668 Gene

Genomics for ZNF668 Gene

GeneHancer (GH) Regulatory Elements for ZNF668 Gene

Promoters and enhancers for ZNF668 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF668 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF668

Top Transcription factor binding sites by QIAGEN in the ZNF668 gene promoter:
  • AP-4
  • AREB6
  • c-Myc
  • Egr-2
  • GATA-2
  • Max
  • Pax-5
  • Pbx1a
  • SEF-1 (1)
  • Sp1

Genomic Locations for ZNF668 Gene

Genomic Locations for ZNF668 Gene
chr16:31,060,843-31,074,320
(GRCh38/hg38)
Size:
13,478 bases
Orientation:
Minus strand
chr16:31,072,164-31,085,641
(GRCh37/hg19)
Size:
13,478 bases
Orientation:
Minus strand

Genomic View for ZNF668 Gene

Genes around ZNF668 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF668 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF668 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ZNF668 Gene

Proteins for ZNF668 Gene

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  • Protein details for ZNF668 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96K58-ZN668_HUMAN
    Recommended name:
    Zinc finger protein 668
    Protein Accession:
    Q96K58
    Secondary Accessions:
    • C9JHH8
    • F5H7E7
    • Q59EV1
    • Q8N669
    • Q9H8L4

    Protein attributes for ZNF668 Gene

    Size:
    619 amino acids
    Molecular mass:
    67890 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB14602.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAD92947.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF668 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF668 Gene

Protein Expression for ZNF668 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for ZNF668 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF668 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF668 Gene

Domains & Families for ZNF668 Gene

Gene Families for ZNF668 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF668 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF668 Gene

GenScript: Design optimal peptide antigens:
  • ZNF668 protein (Q4G0L6_HUMAN)
  • Zinc finger protein 668 (ZN668_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96K58

UniProtKB/Swiss-Prot:

ZN668_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF668: view

Function for ZNF668 Gene

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  1. Animal Model
  2. CRISPR
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Molecular function for ZNF668 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF668 Gene

Gene Ontology (GO) - Molecular Function for ZNF668 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA --
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific IEA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IBA 21873635
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF668: view
genes like me logo Genes that share phenotypes with ZNF668: view

Animal Model Products

CRISPR Products

miRNA for ZNF668 Gene

miRTarBase miRNAs that target ZNF668

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF668 Gene

Localization for ZNF668 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF668 Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF668 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF668 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with ZNF668: view

Pathways & Interactions for ZNF668 Gene

PathCards logo

SuperPathways for ZNF668 Gene

SuperPathway Contained pathways
1 Gene Expression
Gene Expression
.48
Generic Transcription Pathway
.48
genes like me logo Genes that share pathways with ZNF668: view

Pathways by source for ZNF668 Gene

2 Reactome pathways for ZNF668 Gene

Gene Ontology (GO) - Biological Process for ZNF668 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF668: view

No data available for SIGNOR curated interactions for ZNF668 Gene

Drugs & Compounds for ZNF668 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for ZNF668 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for ZNF668 Gene

4 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF668 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6
SP1:
SP2: - - -
SP3: -
SP4: - -

Relevant External Links for ZNF668 Gene

GeneLoc Exon Structure for
ZNF668

Expression for ZNF668 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF668 Gene

mRNA expression in normal human tissues for ZNF668 Gene
mRNA expression by GTEx for ZNF668 GenemRNA expression by BioGPS for ZNF668 Gene

Protein differential expression in normal tissues from HIPED for ZNF668 Gene

This gene is overexpressed in Monocytes (28.0), Neutrophil (14.6), Blymphocyte (10.7), and Tlymphocyte (10.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF668 Gene



Protein tissue co-expression partners for ZNF668 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF668

SOURCE GeneReport for Unigene cluster for ZNF668 Gene:

Hs.102928

Evidence on tissue expression from TISSUES for ZNF668 Gene

  • Nervous system(4.8)
  • Skin(4.2)
genes like me logo Genes that share expression patterns with ZNF668: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF668 Gene

Orthologs for ZNF668 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF668 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia ZNF668 31 30
  • 99.63 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia ZNF668 31 30
  • 89.07 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia ZNF668 31 30
  • 88.26 (n)
 OneToOne
mouse
(Mus musculus)
 Mammalia Zfp668 17 31 30
  • 83.68 (n)
rat
(Rattus norvegicus)
 Mammalia Zfp668 30
  • 83.25 (n)
oppossum
(Monodelphis domestica)
 Mammalia ZNF668 31
  • 78 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves ZNF668 31
  • 35 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia ZNF668 31
  • 62 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia znf668 30
  • 67.83 (n)
MGC76080 30
African clawed frog
(Xenopus laevis)
 Amphibia Xl.1627 30
zebrafish
(Danio rerio)
 Actinopterygii znf668 31 30
  • 56.63 (n)
 OneToOne
fruit fly
(Drosophila melanogaster)
 Insecta CG17612 31
  • 11 (a)
 OneToOne
Species where no ortholog for ZNF668 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF668 Gene

ENSEMBL:
Gene Tree for ZNF668 (if available)
TreeFam:
Gene Tree for ZNF668 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF668: view image

Paralogs for ZNF668 Gene

Paralogs for ZNF668 Gene

(448) SIMAP similar genes for ZNF668 Gene using alignment to 5 proteins:

  • ZN668_HUMAN
  • C9J092_HUMAN
  • C9JCJ0_HUMAN
  • C9JG35_HUMAN
  • Q4G0L6_HUMAN

Pseudogenes.org Pseudogenes for ZNF668 Gene

genes like me logo Genes that share paralogs with ZNF668: view

Variants for ZNF668 Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF668 Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
777008 Benign: not provided 31,063,914(-) C/T SYNONYMOUS_VARIANT
786291 Benign: not provided 31,061,069(-) C/T SYNONYMOUS_VARIANT
rs1429688220 A breast cancer sample p.Ala66Thr
rs148738674 A breast cancer sample p.Arg556Gln
rs1555498115 Uncertain Significance: not provided 31,061,919(-) T/C MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for ZNF668 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF668 Gene

Variant ID Type Subtype PubMed ID
esv3638391 CNV loss 21293372
nsv457483 CNV loss 19166990
nsv571820 CNV loss 21841781
nsv833193 CNV gain+loss 17160897

Variation tolerance for ZNF668 Gene

Residual Variation Intolerance Score: 7.33% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.91; 59.39% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF668 Gene

Human Gene Mutation Database (HGMD)
ZNF668
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF668

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF668 Gene

Disorders for ZNF668 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF668 Gene - From: DISEASES

Disorder Aliases PubMed IDs
nodular malignant melanoma
  • nodular melanoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF668

ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ZNF668: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF668 Gene

Publications for ZNF668 Gene

  1. Zinc finger protein 668 interacts with Tip60 to promote H2AX acetylation after DNA damage. (PMID: 23777805) Hu R … Lin SY (Cell cycle (Georgetown, Tex.) 2013) 2 3 54
  2. ZNF668 functions as a tumor suppressor by regulating p53 stability and function in breast cancer. (PMID: 21852383) Hu R … Lin SY (Cancer research 2011) 2 3 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  5. Insights into the ubiquitin-proteasome system of human embryonic stem cells. (PMID: 29511261) Saez I … Vilchez D (Scientific reports 2018) 3 54

ExternalLinks

View latest publications for ZNF668 gene in Mastermind

Products for ZNF668 Gene

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Sources for ZNF668 Gene