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ZNF668 (Zinc Finger Protein 668) is a Protein Coding gene. Diseases associated with ZNF668 include Nodular Malignant Melanoma. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity. An important paralog of this gene is ZNF850.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IEA | -- |
GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific | IEA | -- |
GO:0003676 | nucleic acid binding | IEA | -- |
GO:0003677 | DNA binding | IBA | -- |
GO:0003700 | DNA-binding transcription factor activity | IBA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IBA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Gene Expression |
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GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000122 | negative regulation of transcription by RNA polymerase II | IEA | -- |
ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | ^ | 6 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||||||||||
SP2: | - | - | - | ||||||||||||||
SP3: | - | ||||||||||||||||
SP4: | - | - |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ZNF668 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | ZNF668 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | ZNF668 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Zfp668 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Zfp668 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | ZNF668 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | ZNF668 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | ZNF668 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | znf668 30 |
|
||
MGC76080 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.1627 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | znf668 30 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | CG17612 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 16 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
777008 | Benign: not provided | 31,063,914(-) | C/T | SYNONYMOUS_VARIANT | |
786291 | Benign: not provided | 31,061,069(-) | C/T | SYNONYMOUS_VARIANT | |
rs1429688220 | A breast cancer sample | p.Ala66Thr | |||
rs148738674 | A breast cancer sample | p.Arg556Gln | |||
rs1555498115 | Uncertain Significance: not provided | 31,061,919(-) | T/C | MISSENSE_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
nodular malignant melanoma |
|
|