Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZNF667 Gene

Aliases for ZNF667 Gene

  • Zinc Finger Protein 667 2 3 5
  • Myocardial Ischemic Preconditioning Upregulated 1 Ortholog 3
  • MIPU1 3

External Ids for ZNF667 Gene

Previous GeneCards Identifiers for ZNF667 Gene

  • GC19M061644
  • GC19M056951
  • GC19M053259

Summaries for ZNF667 Gene

GeneCards Summary for ZNF667 Gene

ZNF667 (Zinc Finger Protein 667) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and transcription cofactor activity.

UniProtKB/Swiss-Prot for ZNF667 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF667 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF667 Gene

Genomics for ZNF667 Gene

GeneHancer (GH) Regulatory Elements for ZNF667 Gene

Promoters and enhancers for ZNF667 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I056476 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 564.2 +0.4 434 3.1 ATF1 ZNF76 SIN3A YY1 ETS1 ZNF335 GLIS2 ZNF143 KLF7 ZNF548 ZNF667-AS1 ZNF667 ZNF264 SSC5D U2AF2 ZNF543 ENSG00000267523 ZNF582-AS1 ZNF805 ZNF17
GH19I056594 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 49.9 -117.4 -117375 1.4 HDGF PKNOX1 ZNF133 ARID4B SIN3A FEZF1 YBX1 GLI4 ZNF48 YY1 ZNF71 U2AF2 ZNF17 ZNF543 ZNF549 ZNF264 ZNF773 ENSG00000269696 ZNF550 ZFP28
GH19I055503 Enhancer 1.2 Ensembl ENCODE 59.4 +974.1 974096 1.6 PKNOX1 CLOCK ARNT ARID4B SIN3A DMAP1 ZNF2 CBX5 ZNF213 E2F8 U2AF2 FIZ1 ZNF667 ZNF582 ZNF582-AS1 NAT14 ZNF667-AS1 ZNF542P ZNF580 ZNF583
GH19I056403 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 31.2 +73.9 73916 2 HDGF ARNT ARID4B SIN3A DMAP1 YY1 POLR2B ZNF766 ZNF416 ZNF207 ZNF583 ZNF582-AS1 ZNF582 ZFP28 ZNF470 ZNF471 FIZ1 ZNF460-AS1 ENSG00000269696 ZNF542P
GH19I055519 Enhancer 1.4 FANTOM5 Ensembl ENCODE 42.9 +957.9 957856 1 HDGF ATF1 ZNF493 ZNF133 YBX1 GLI4 ZNF416 ZNF548 FOS ATF7 U2AF2 ZNF471 FIZ1 ZNF582 ZNF581 ZNF580 SSC5D ENSG00000267523 NAT14 ZNF667
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF667 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF667 gene promoter:

Genomic Locations for ZNF667 Gene

Genomic Locations for ZNF667 Gene
chr19:56,438,512-56,478,065
(GRCh38/hg38)
Size:
39,554 bases
Orientation:
Minus strand
chr19:56,950,693-56,989,434
(GRCh37/hg19)

Genomic View for ZNF667 Gene

Genes around ZNF667 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF667 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF667 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF667 Gene

Proteins for ZNF667 Gene

  • Protein details for ZNF667 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5HYK9-ZN667_HUMAN
    Recommended name:
    Zinc finger protein 667
    Protein Accession:
    Q5HYK9
    Secondary Accessions:
    • B2RMS6
    • B9EK36
    • Q6B093
    • Q9H807

    Protein attributes for ZNF667 Gene

    Size:
    610 amino acids
    Molecular mass:
    70161 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH74898.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH74899.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF667 Gene

Post-translational modifications for ZNF667 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF667 Gene

Domains & Families for ZNF667 Gene

Gene Families for ZNF667 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF667 Gene

Suggested Antigen Peptide Sequences for ZNF667 Gene

Graphical View of Domain Structure for InterPro Entry

Q5HYK9

UniProtKB/Swiss-Prot:

ZN667_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF667: view

Function for ZNF667 Gene

Molecular function for ZNF667 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF667 Gene

Gene Ontology (GO) - Molecular Function for ZNF667 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF667: view

Phenotypes for ZNF667 Gene

genes like me logo Genes that share phenotypes with ZNF667: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF667 Gene

Localization for ZNF667 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF667 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF667 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF667 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF667: view

Pathways & Interactions for ZNF667 Gene

SuperPathways for ZNF667 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF667: view

Pathways by source for ZNF667 Gene

2 Reactome pathways for ZNF667 Gene

Interacting Proteins for ZNF667 Gene

Gene Ontology (GO) - Biological Process for ZNF667 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF667: view

No data available for SIGNOR curated interactions for ZNF667 Gene

Drugs & Compounds for ZNF667 Gene

No Compound Related Data Available

Transcripts for ZNF667 Gene

Unigene Clusters for ZNF667 Gene

Zinc finger protein 667:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF667 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c · 11d
SP1: - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - - -
SP4: -
SP5: - - - - - - - - - -
SP6: - - - - - -
SP7: - - -
SP8: -
SP9: - - - -

Relevant External Links for ZNF667 Gene

GeneLoc Exon Structure for
ZNF667
ECgene alternative splicing isoforms for
ZNF667

Expression for ZNF667 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF667 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZNF667 Gene

This gene is overexpressed in Pituitary (x5.1).

Protein differential expression in normal tissues from HIPED for ZNF667 Gene

This gene is overexpressed in Urine (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF667 Gene



Protein tissue co-expression partners for ZNF667 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF667 Gene:

ZNF667

SOURCE GeneReport for Unigene cluster for ZNF667 Gene:

Hs.676605

Evidence on tissue expression from TISSUES for ZNF667 Gene

  • Lung(4.2)
  • Heart(2.1)
  • Muscle(2)
genes like me logo Genes that share expression patterns with ZNF667: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF667 Gene

Orthologs for ZNF667 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF667 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF667 33 34
  • 99.67 (n)
cow
(Bos Taurus)
Mammalia ZNF667 33 34
  • 88.42 (n)
dog
(Canis familiaris)
Mammalia ZNF667 33 34
  • 88.42 (n)
rat
(Rattus norvegicus)
Mammalia Zfp667 33
  • 80.8 (n)
mouse
(Mus musculus)
Mammalia Zfp667 33 16 34
  • 80.01 (n)
Species where no ortholog for ZNF667 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF667 Gene

ENSEMBL:
Gene Tree for ZNF667 (if available)
TreeFam:
Gene Tree for ZNF667 (if available)

Paralogs for ZNF667 Gene

(504) SIMAP similar genes for ZNF667 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with ZNF667: view

No data available for Paralogs for ZNF667 Gene

Variants for ZNF667 Gene

Sequence variations from dbSNP and Humsavar for ZNF667 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000034281 -- 56,477,642(-) A/C upstream_transcript_variant
rs1000115909 -- 56,446,837(-) C/T intron_variant
rs1000136988 -- 56,466,522(-) G/C intron_variant
rs1000188556 -- 56,474,402(-) C/G 5_prime_UTR_variant, intron_variant
rs1000254031 -- 56,472,527(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF667 Gene

Variant ID Type Subtype PubMed ID
dgv6591n54 CNV loss 21841781
esv1044797 CNV insertion 17803354
esv2719037 CNV deletion 23290073
esv2719038 CNV deletion 23290073
esv3304685 CNV mobile element insertion 20981092
esv3309659 CNV mobile element insertion 20981092
esv3324616 CNV insertion 20981092
esv3424509 CNV insertion 20981092
esv3440809 CNV insertion 20981092
nsv1055357 CNV gain 25217958

Variation tolerance for ZNF667 Gene

Residual Variation Intolerance Score: 66.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.97; 79.93% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF667 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF667

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF667 Gene

Disorders for ZNF667 Gene

Additional Disease Information for ZNF667

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ZNF667 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF667 Gene

Publications for ZNF667 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. ZNF667 Serves as a Putative Oncogene in Human Hepatocellular Carcinoma. (PMID: 28472789) Cheng K … Ye Q (Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017) 3 58
  5. Mipu1 protects H9c2 myogenic cells from hydrogen peroxide-induced apoptosis through inhibition of the expression of the death receptor Fas. (PMID: 25310648) Wang G … Xiao X (International journal of molecular sciences 2014) 3 58

Products for ZNF667 Gene

Sources for ZNF667 Gene

Content
Loading form....