Aliases for ZNF665 Gene

Aliases for ZNF665 Gene

  • Zinc Finger Protein 665 2 3 4 5
  • ZFP160L 2 3 4
  • Zinc Finger Protein 160-Like 4
  • FLJ14345 2
  • ZNF665 5

External Ids for ZNF665 Gene

Previous GeneCards Identifiers for ZNF665 Gene

  • GC19M058358
  • GC19M053667
  • GC19M049990

Summaries for ZNF665 Gene

GeneCards Summary for ZNF665 Gene

ZNF665 (Zinc Finger Protein 665) is a Protein Coding gene. Diseases associated with ZNF665 include Fraser Syndrome 1 and Cri-Du-Chat Syndrome. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZNF160.

UniProtKB/Swiss-Prot Summary for ZNF665 Gene

Additional gene information for ZNF665 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF665 Gene

Genomics for ZNF665 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF665 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF665 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF665

Top Transcription factor binding sites by QIAGEN in the ZNF665 gene promoter:
  • ATF6
  • Ik-1

Genomic Locations for ZNF665 Gene

Genomic Locations for ZNF665 Gene
chr19:53,159,213-53,193,404
(GRCh38/hg38)
Size:
34,192 bases
Orientation:
Minus strand
chr19:53,662,466-53,696,639
(GRCh37/hg19)
Size:
34,174 bases
Orientation:
Minus strand

Genomic View for ZNF665 Gene

Genes around ZNF665 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF665 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF665 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF665 Gene

Proteins for ZNF665 Gene

  • Protein details for ZNF665 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H7R5-ZN665_HUMAN
    Recommended name:
    Zinc finger protein 665
    Protein Accession:
    Q9H7R5
    Secondary Accessions:
    • A8K5T8

    Protein attributes for ZNF665 Gene

    Size:
    678 amino acids
    Molecular mass:
    77640 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB14911.1; Type=Miscellaneous discrepancy; Note=Chimeric sequence.; Evidence={ECO:0000305};

neXtProt entry for ZNF665 Gene

Post-translational modifications for ZNF665 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF665 Gene

No data available for DME Specific Peptides for ZNF665 Gene

Domains & Families for ZNF665 Gene

Gene Families for ZNF665 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF665 Gene

InterPro:
Blocks:
  • C2H2-type zinc finger signature
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF665 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 160-like (ZN665_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9H7R5

UniProtKB/Swiss-Prot:

ZN665_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF665: view

Function for ZNF665 Gene

Molecular function for ZNF665 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF665 Gene

Gene Ontology (GO) - Molecular Function for ZNF665 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF665: view
genes like me logo Genes that share phenotypes with ZNF665: view

Animal Models for ZNF665 Gene

MGI Knock Outs for ZNF665:
  • Zfp160 Zfp160<tm1b(EUCOMM)Wtsi>

Animal Model Products

CRISPR Products

miRNA for ZNF665 Gene

miRTarBase miRNAs that target ZNF665

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF665

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZNF665 Gene

Localization for ZNF665 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF665 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF665 gene
Compartment Confidence
nucleus 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF665 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF665: view

Pathways & Interactions for ZNF665 Gene

genes like me logo Genes that share pathways with ZNF665: view

Pathways by source for ZNF665 Gene

2 Reactome pathways for ZNF665 Gene
1 KEGG pathway for ZNF665 Gene

Gene Ontology (GO) - Biological Process for ZNF665 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF665: view

No data available for SIGNOR curated interactions for ZNF665 Gene

Drugs & Compounds for ZNF665 Gene

No Compound Related Data Available

Transcripts for ZNF665 Gene

mRNA/cDNA for ZNF665 Gene

4 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF665

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF665 Gene

No ASD Table

Relevant External Links for ZNF665 Gene

GeneLoc Exon Structure for
ZNF665

Expression for ZNF665 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF665 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF665 Gene



Protein tissue co-expression partners for ZNF665 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF665

SOURCE GeneReport for Unigene cluster for ZNF665 Gene:

Hs.745230

Evidence on tissue expression from TISSUES for ZNF665 Gene

  • Thyroid gland(4.1)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with ZNF665: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF665 Gene

Orthologs for ZNF665 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF665 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF665 30 31
  • 98.92 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia LOC100365363 30
  • 72.65 (n)
Mouse
(Mus musculus)
Mammalia Zfp160 30 17 31
  • 71.47 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 52 (a)
ManyToMany
-- 31
  • 40 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia -- 31
  • 50 (a)
ManyToMany
Species where no ortholog for ZNF665 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF665 Gene

ENSEMBL:
Gene Tree for ZNF665 (if available)
TreeFam:
Gene Tree for ZNF665 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF665: view image

Paralogs for ZNF665 Gene

(538) SIMAP similar genes for ZNF665 Gene using alignment to 1 proteins:

  • ZN665_HUMAN

Pseudogenes.org Pseudogenes for ZNF665 Gene

genes like me logo Genes that share paralogs with ZNF665: view

Variants for ZNF665 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF665 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs12460170 - p.Val84Ala
rs4801958 - p.Val647Ile
rs4801959 - p.His157Arg

Additional dbSNP identifiers (rs#s) for ZNF665 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF665 Gene

Variant ID Type Subtype PubMed ID
dgv1812n106 CNV deletion 24896259
dgv3644n100 CNV gain 25217958
dgv430n27 CNV gain 19166990
esv1006343 CNV deletion 20482838
esv1301232 CNV deletion 17803354
esv2611703 CNV deletion 19546169
esv2718787 CNV deletion 23290073
esv2718812 CNV deletion 23290073
esv2718813 CNV deletion 23290073
esv2762999 CNV gain 21179565
esv3556584 CNV deletion 23714750
esv3574753 CNV gain 25503493
esv3644740 CNV gain 21293372
esv3644741 CNV gain 21293372
esv3644742 CNV gain 21293372
esv3644743 CNV loss 21293372
esv3893240 CNV loss 25118596
nsv1071945 CNV deletion 25765185
nsv1078889 OTHER inversion 25765185
nsv1141887 OTHER inversion 24896259
nsv1146588 CNV deletion 26484159
nsv435701 CNV deletion 17901297
nsv512592 CNV loss 21212237
nsv580077 CNV loss 21841781
nsv580078 CNV gain 21841781
nsv956581 CNV deletion 24416366
nsv960867 CNV duplication 23825009

Variation tolerance for ZNF665 Gene

Residual Variation Intolerance Score: 98.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.28; 40.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF665 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF665

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF665 Gene

Disorders for ZNF665 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ZNF665 Gene - From: DISEASES

Disorder Aliases PubMed IDs
fraser syndrome 1
  • frasrs1
cri-du-chat syndrome
  • cat cry syndrome
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with ZNF665: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF665 Gene

Publications for ZNF665 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. Genome-wide association study to identify genetic determinants of severe asthma. (PMID: 22561531) Wan YI … Hall IP (Thorax 2012) 3
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 4

Products for ZNF665 Gene

Sources for ZNF665 Gene