ZNF664 Gene (Protein Coding)

Zinc Finger Protein 664

GC12P123971
GIFtS:
36
See more...

Aliases for ZNF664 Gene

Aliases for ZNF664 Gene

  • Zinc Finger Protein 664 2 3 4 5
  • Zinc Finger Protein 176 2 3 4
  • ZFOC1 2 3 4
  • Zinc Finger Protein From Organ Of Corti 3 4
  • ZNF176 3 4
  • Zinc Finger, Organ Of Corti 1 2
  • Zinc Finger Organ Of Corti 1 3
  • DKFZp761B128 2
  • ZNF664 5

External Ids for ZNF664 Gene

Previous HGNC Symbols for ZNF664 Gene

  • ZNF176

Previous GeneCards Identifiers for ZNF664 Gene

  • GC12P122983
  • GC12P124457
  • GC12P121419

Summaries for ZNF664 Gene

GeneCards Summary for ZNF664 Gene

ZNF664 (Zinc Finger Protein 664) is a Protein Coding gene. Diseases associated with ZNF664 include Deafness, Autosomal Dominant 41 and Clubfoot. Among its related pathways are Gene Expression. An important paralog of this gene is ZFP62.

UniProtKB/Swiss-Prot Summary for ZNF664 Gene

Gene Wiki entry for ZNF664 Gene

Additional gene information for ZNF664 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF664 Gene

Genomics for ZNF664 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for ZNF664 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF664 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF664

Top Transcription factor binding sites by QIAGEN in the ZNF664 gene promoter:
  • Arnt
  • ATF
  • c-Ets-1
  • E47
  • E4BP4
  • Evi-1
  • Hand1
  • Pax-4a
  • Sox9
  • STAT5A

Genomic Locations for ZNF664 Gene

Latest Assembly
chr12:123,971,845-124,015,439
(GRCh38/hg38)
Size:
43,595 bases
Orientation:
Plus strand

Previous Assembly
chr12:124,457,762-124,499,974
(GRCh37/hg19 by Entrez Gene)
Size:
42,213 bases
Orientation:
Plus strand

chr12:124,456,392-124,499,986
(GRCh37/hg19 by Ensembl)
Size:
43,595 bases
Orientation:
Plus strand

Genomic View for ZNF664 Gene

Genes around ZNF664 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF664 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF664 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ZNF664 Gene

Proteins for ZNF664 Gene

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  1. Antibodies for research
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  3. Assay products for research

  • Protein details for ZNF664 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N3J9-ZN664_HUMAN
    Recommended name:
    Zinc finger protein 664
    Protein Accession:
    Q8N3J9
    Secondary Accessions:
    • B3KP97
    • Q15914
    • Q3ZCQ7

    Protein attributes for ZNF664 Gene

    Size:
    261 amino acids
    Molecular mass:
    30284 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF664 Gene

Protein Expression for ZNF664 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for ZNF664 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF664 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF664 Gene

Domains & Families for ZNF664 Gene

Gene Families for ZNF664 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF664 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF664 Gene

GenScript: Design optimal peptide antigens:
  • ZNF664 protein (Q0P6D9_HUMAN)
  • Zinc finger protein from organ of Corti (ZN664_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8N3J9

UniProtKB/Swiss-Prot:

ZN664_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF664: view

Function for ZNF664 Gene

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  1. Animal Models for research
  2. CRISPR products for research
  3. miRNA products for research
  4. Inhibitory RNAs for research
  5. Clone products for research
  6. Cell Lines for research

Molecular function for ZNF664 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF664 Gene

Gene Ontology (GO) - Molecular Function for ZNF664 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA 21873635
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific IBA 21873635
GO:0003674 molecular_function ND --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 32296183
genes like me logo Genes that share ontologies with ZNF664: view
genes like me logo Genes that share phenotypes with ZNF664: view

Animal Models for ZNF664 Gene

MGI Knock Outs for ZNF664:
  • Zfp664 Zfp664<tm1b(EUCOMM)Wtsi>

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF664

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZNF664 Gene

Localization for ZNF664 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF664 Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF664 gene
Compartment Confidence
nucleus 5
plasma membrane 1
extracellular 1
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF664 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin IBA --
GO:0005634 nucleus IDA --
genes like me logo Genes that share ontologies with ZNF664: view

Pathways & Interactions for ZNF664 Gene

PathCards logo

SuperPathways for ZNF664 Gene

SuperPathway Contained pathways
1 Gene Expression
Gene Expression
.48
Generic Transcription Pathway
.48
genes like me logo Genes that share pathways with ZNF664: view

Pathways by source for ZNF664 Gene

2 Reactome pathways for ZNF664 Gene

Gene Ontology (GO) - Biological Process for ZNF664 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IBA 21873635
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with ZNF664: view

No data available for SIGNOR curated interactions for ZNF664 Gene

Drugs & Compounds for ZNF664 Gene

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  1. Drug products for research
No Compound Related Data Available

Transcripts for ZNF664 Gene

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  3. Inhibitory RNAs for research
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mRNA/cDNA for ZNF664 Gene

2 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
14 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF664

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF664 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d · 12e · 12f · 12g
SP1: - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - - -
SP4: - - - - - - - - -
SP5: - - - - - - -
SP6: - - - - - - - -
SP7: - - - - - - - -
SP8: - - - -
SP9: - - - - - - - - -
SP10: - - - - -
SP11:
SP12:

Relevant External Links for ZNF664 Gene

GeneLoc Exon Structure for
ZNF664

Expression for ZNF664 Gene

Products:

  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF664 Gene

mRNA expression in normal human tissues for ZNF664 Gene
mRNA expression by GTEx for ZNF664 GenemRNA expression by BioGPS for ZNF664 Gene

Protein differential expression in normal tissues from HIPED for ZNF664 Gene

This gene is overexpressed in Retina (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF664 Gene



Protein tissue co-expression partners for ZNF664 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF664

SOURCE GeneReport for Unigene cluster for ZNF664 Gene:

Hs.524828

Evidence on tissue expression from TISSUES for ZNF664 Gene

  • Nervous system(4.8)
  • Eye(4.2)
  • Heart(2.2)
  • Liver(2.2)
  • Lung(2.1)
  • Muscle(2)
genes like me logo Genes that share expression patterns with ZNF664: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF664 Gene

Orthologs for ZNF664 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF664 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia ZNF664 30 31
  • 99.74 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia ZNF664 30 31
  • 95.15 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia ZNF664 30 31
  • 93.1 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia LOC100911699 30
  • 91.53 (n)
Mouse
(Mus musculus)
 Mammalia Zfp664 30 17 31
  • 90.93 (n)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia -- 31
  • 21 (a)
 OneToMany
Lizard
(Anolis carolinensis)
 Reptilia -- 31
  • 27 (a)
 OneToMany
Zebrafish
(Danio rerio)
 Actinopterygii BX649556.2 31
  • 54 (a)
 ManyToMany
CR388052.2 31
  • 44 (a)
 ManyToMany
si:ch211-178j18.2 31
  • 43 (a)
 ManyToMany
si:dkey-146c18.5 31
  • 41 (a)
 ManyToMany
si:ch211-231i17.4 31
  • 40 (a)
 ManyToMany
zgc:173619 31 31
  • 40 (a)
 ManyToMany
si:ch211-208f21.2 31
  • 40 (a)
 ManyToMany
si:dkey-3p4.8 31
  • 40 (a)
 ManyToMany
BX927193.1 31
  • 40 (a)
 ManyToMany
BX324003.4 31
  • 40 (a)
 ManyToMany
BX901892.1 31
  • 40 (a)
 ManyToMany
BX950868.2 31
  • 40 (a)
 ManyToMany
BX548067.3 31
  • 40 (a)
 ManyToMany
BX511066.4 31
  • 40 (a)
 ManyToMany
CR759907.4 31
  • 39 (a)
 ManyToMany
CABZ01001466.1 31
  • 39 (a)
 ManyToMany
zgc:173620 31
  • 39 (a)
 ManyToMany
BX276122.1 31
  • 39 (a)
 ManyToMany
si:ch211-209j12.3 31
  • 39 (a)
 ManyToMany
CABZ01028403.3 31
  • 39 (a)
 ManyToMany
BX537137.1 31
  • 39 (a)
 ManyToMany
si:dkey-7j22.4 31
  • 38 (a)
 ManyToMany
si:dkey-156j15.1 31
  • 38 (a)
 ManyToMany
si:dkey-28i19.1 31
  • 37 (a)
 ManyToMany
si:dkey-285e18.6 31
  • 37 (a)
 ManyToMany
BX842593.1 31
  • 37 (a)
 ManyToMany
CU138542.1 31
  • 33 (a)
 ManyToMany
CABZ01017733.1 31
  • 33 (a)
 ManyToMany
si:dkey-264f17.4 31
  • 31 (a)
 ManyToMany
si:ch211-79k12.2 31
  • 18 (a)
 ManyToMany
Fruit Fly
(Drosophila melanogaster)
 Insecta CG1832 31
  • 18 (a)
 OneToMany
Worm
(Caenorhabditis elegans)
 Secernentea eor-1 31
  • 8 (a)
 OneToMany
Species where no ortholog for ZNF664 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for ZNF664 Gene

ENSEMBL:
Gene Tree for ZNF664 (if available)
TreeFam:
Gene Tree for ZNF664 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF664: view image

Paralogs for ZNF664 Gene

Paralogs for ZNF664 Gene

(583) SIMAP similar genes for ZNF664 Gene using alignment to 2 proteins:

  • ZN664_HUMAN
  • Q0P6D9_HUMAN
genes like me logo Genes that share paralogs with ZNF664: view

Variants for ZNF664 Gene

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dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for ZNF664 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for ZNF664 Gene

Variant ID Type Subtype PubMed ID
dgv2934n54 CNV gain 21841781
esv22500 CNV loss 19812545
esv2746515 CNV deletion 23290073
esv3631000 CNV gain 21293372
nsv819172 CNV loss 19587683
nsv819689 CNV loss 19587683
nsv820508 CNV duplication 20802225
nsv826535 CNV gain 20364138
nsv975536 CNV duplication 23825009

Variation tolerance for ZNF664 Gene

Residual Variation Intolerance Score: 45.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.45; 64.13% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF664 Gene

Human Gene Mutation Database (HGMD)
ZNF664
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF664

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF664 Gene

Disorders for ZNF664 Gene

MalaCards: The human disease database

(6) MalaCards diseases for ZNF664 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
deafness, autosomal dominant 41
  • dfna41
clubfoot
  • congenital clubfoot
deafness, autosomal dominant 25
  • dfna25
saul-wilson syndrome
  • swils
myopia
  • near vision
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF664

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with ZNF664: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF664 Gene

Publications for ZNF664 Gene

  1. Exome sequencing identifies ZNF644 mutations in high myopia. (PMID: 21695231) Shi Y … Yang Z (PLoS genetics 2011) 2 3
  2. Biological, clinical and population relevance of 95 loci for blood lipids. (PMID: 20686565) Teslovich TM … Kathiresan S (Nature 2010) 3 41
  3. Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis. (PMID: 19936222) Chasman DI … Ridker PM (PLoS genetics 2009) 3 41
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  5. A novel zinc finger gene preferentially expressed in the retina and the organ of Corti localizes to human chromosome 12q24.3. (PMID: 8634327) Rivolta MN … Wilcox ER (Biochimica et biophysica acta 1996) 3 4

ExternalLinks

View latest publications for ZNF664 gene in Mastermind

Products for ZNF664 Gene

Sources for ZNF664 Gene