This gene encodes a protein that contains multiple C2H2 zinc finger domains, and is located in a cluster of zinc-finger encoding genes on chromosome 3. Naturally-occurring readthrough transcription is observed between this gene and the downstream zinc finger protein 197 gene and is represented by GeneID:110354863. [provided by RefSeq, May 2017] See more...

Aliases for ZNF660 Gene

Aliases for ZNF660 Gene

  • Zinc Finger Protein 660 2 3 4 5

External Ids for ZNF660 Gene

Previous GeneCards Identifiers for ZNF660 Gene

  • GC03P044602
  • GC03P044619
  • GC03P044600
  • GC03P044686
  • GC03P045147
  • GC03P045180
  • GC03P045214
  • GC03P044810
  • GC03P044848
  • GC03P044917
  • GC03P044953
  • GC03P044996
  • GC03P045035
  • GC03P045074
  • GC03P045110

Summaries for ZNF660 Gene

Entrez Gene Summary for ZNF660 Gene

  • This gene encodes a protein that contains multiple C2H2 zinc finger domains, and is located in a cluster of zinc-finger encoding genes on chromosome 3. Naturally-occurring readthrough transcription is observed between this gene and the downstream zinc finger protein 197 gene and is represented by GeneID:110354863. [provided by RefSeq, May 2017]

GeneCards Summary for ZNF660 Gene

ZNF660 (Zinc Finger Protein 660) is a Protein Coding gene. Among its related pathways are Gene Expression. An important paralog of this gene is ZNF79.

UniProtKB/Swiss-Prot Summary for ZNF660 Gene

Additional gene information for ZNF660 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF660 Gene

Genomics for ZNF660 Gene

GeneHancer (GH) Regulatory Elements for ZNF660 Gene

Promoters and enhancers for ZNF660 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF660 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF660

Top Transcription factor binding sites by QIAGEN in the ZNF660 gene promoter:
  • AML1a
  • AP-1
  • Arnt
  • HSF2
  • Ik-1
  • MIF-1
  • Nkx2-5
  • Pax-3
  • PPAR-alpha

Genomic Locations for ZNF660 Gene

Genomic Locations for ZNF660 Gene
chr3:44,578,223-44,599,699
(GRCh38/hg38)
Size:
21,477 bases
Orientation:
Plus strand
chr3:44,619,715-44,641,186
(GRCh37/hg19)
Size:
21,472 bases
Orientation:
Plus strand

Genomic View for ZNF660 Gene

Genes around ZNF660 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF660 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF660 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF660 Gene

Proteins for ZNF660 Gene

  • Protein details for ZNF660 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6AZW8-ZN660_HUMAN
    Recommended name:
    Zinc finger protein 660
    Protein Accession:
    Q6AZW8
    Secondary Accessions:
    • Q7Z331
    • Q8N9M8

    Protein attributes for ZNF660 Gene

    Size:
    331 amino acids
    Molecular mass:
    38270 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF660 Gene

Post-translational modifications for ZNF660 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF660 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF660 Gene

Domains & Families for ZNF660 Gene

Gene Families for ZNF660 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF660 Gene

Suggested Antigen Peptide Sequences for ZNF660 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 660 (ZN660_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6AZW8

UniProtKB/Swiss-Prot:

ZN660_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF660: view

Function for ZNF660 Gene

Molecular function for ZNF660 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF660 Gene

Gene Ontology (GO) - Molecular Function for ZNF660 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF660: view
genes like me logo Genes that share phenotypes with ZNF660: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF660 Gene

Localization for ZNF660 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF660 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF660 gene
Compartment Confidence
nucleus 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (1)
  • Nucleoli fibrillar center (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF660 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF660: view

Pathways & Interactions for ZNF660 Gene

PathCards logo

SuperPathways for ZNF660 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF660: view

Pathways by source for ZNF660 Gene

2 Reactome pathways for ZNF660 Gene

Interacting Proteins for ZNF660 Gene

;

Gene Ontology (GO) - Biological Process for ZNF660 Gene

None

No data available for SIGNOR curated interactions for ZNF660 Gene

Drugs & Compounds for ZNF660 Gene

No Compound Related Data Available

Transcripts for ZNF660 Gene

mRNA/cDNA for ZNF660 Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF660 Gene

No ASD Table

Relevant External Links for ZNF660 Gene

GeneLoc Exon Structure for
ZNF660

Expression for ZNF660 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF660 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF660

SOURCE GeneReport for Unigene cluster for ZNF660 Gene:

Hs.733134

Evidence on tissue expression from TISSUES for ZNF660 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ZNF660: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF660 Gene

Orthologs for ZNF660 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF660 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF660 31 30
  • 99.7 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF660 30
  • 92.35 (n)
-- 31
  • 42 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia LOC102639251 30
  • 85.35 (n)
Zscan26 31
  • 36 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia LOC102551231 30
  • 81.82 (n)
cow
(Bos Taurus)
Mammalia -- 31
  • 26 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii BX890548.2 31
  • 39 (a)
ManyToMany
BX005448.1 31
  • 38 (a)
ManyToMany
gb:am422109 31
  • 38 (a)
ManyToMany
zgc:174700 31
  • 38 (a)
ManyToMany
si:dkey-56m15.3 31
  • 37 (a)
ManyToMany
BX004879.1 31
  • 37 (a)
ManyToMany
si:ch211-283l16.1 31
  • 37 (a)
ManyToMany
CABZ01008480.1 31
  • 36 (a)
ManyToMany
si:dkey-22h13.2 31
  • 36 (a)
ManyToMany
CT573263.3 31
  • 36 (a)
ManyToMany
si:dkey-237m9.1 31
  • 35 (a)
ManyToMany
CR293532.1 31
  • 35 (a)
ManyToMany
si:dkey-54j5.2 31
  • 35 (a)
ManyToMany
si:ch211-226o13.2 31
  • 35 (a)
ManyToMany
zgc:174694 31
  • 34 (a)
ManyToMany
zgc:173714 31
  • 34 (a)
ManyToMany
si:dkey-16b10.2 31
  • 32 (a)
ManyToMany
BX005448.2 31
  • 29 (a)
ManyToMany
Species where no ortholog for ZNF660 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF660 Gene

ENSEMBL:
Gene Tree for ZNF660 (if available)
TreeFam:
Gene Tree for ZNF660 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF660: view image

Paralogs for ZNF660 Gene

(535) SIMAP similar genes for ZNF660 Gene using alignment to 3 proteins:

  • ZN660_HUMAN
  • C9J3D4_HUMAN
  • C9J3N9_HUMAN
genes like me logo Genes that share paralogs with ZNF660: view

Variants for ZNF660 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF660 Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
rs587776368 Not Provided: not provided 44,594,914(+) C/T MISSENSE_VARIANT,INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for ZNF660 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF660 Gene

Variant ID Type Subtype PubMed ID
nsv3790 CNV insertion 18451855

Variation tolerance for ZNF660 Gene

Residual Variation Intolerance Score: 58.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.15; 23.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF660 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF660

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF660 Gene

Disorders for ZNF660 Gene

Additional Disease Information for ZNF660

No disorders were found for ZNF660 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF660 Gene

Publications for ZNF660 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  3. Biomarker potential of ST6GALNAC3 and ZNF660 promoter hypermethylation in prostate cancer tissue and liquid biopsies. (PMID: 29465788) Haldrup C … Sørensen KD (Molecular oncology 2018) 3 54
  4. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PMID: 21406692) Rigbolt KT … Blagoev B (Science signaling 2011) 4 54
  5. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 54

Products for ZNF660 Gene

Sources for ZNF660 Gene