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Aliases for ZNF660 Gene

Aliases for ZNF660 Gene

  • Zinc Finger Protein 660 2 3 5

External Ids for ZNF660 Gene

Previous GeneCards Identifiers for ZNF660 Gene

  • GC03P044602
  • GC03P044619
  • GC03P044600
  • GC03P044686
  • GC03P044810
  • GC03P044848
  • GC03P044917
  • GC03P044953
  • GC03P044996

Summaries for ZNF660 Gene

Entrez Gene Summary for ZNF660 Gene

  • This gene encodes a protein that contains multiple C2H2 zinc finger domains, and is located in a cluster of zinc-finger encoding genes on chromosome 3. Naturally-occurring readthrough transcription is observed between this gene and the downstream zinc finger protein 197 gene and is represented by GeneID:110354863. [provided by RefSeq, May 2017]

GeneCards Summary for ZNF660 Gene

ZNF660 (Zinc Finger Protein 660) is a Protein Coding gene. Among its related pathways are Gene Expression. An important paralog of this gene is ZNF35.

UniProtKB/Swiss-Prot for ZNF660 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF660 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF660 Gene

Genomics for ZNF660 Gene

GeneHancer (GH) Regulatory Elements for ZNF660 Gene

Promoters and enhancers for ZNF660 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I044584 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 550.4 +6.8 6764 1.7 MXI1 FOXA2 SAP130 ARID4B SIN3A KLF5 ETS1 POLR2A VEZF1 ZNF207 ZNF197 ZNF660 ZNF197-AS1 ZKSCAN7 ZNF501 ZNF35 PIR39553 ENSG00000236869
GH03I044509 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 50.7 -67.5 -67524 2.6 HDGF ATF1 ARNT ARID4B SIN3A ZNF2 ZNF48 YY1 TCF12 POLR2B ZNF852 ZNF660 ZNF197 ZNF35 ZDHHC3 ZNF502 EI24P3
GH03I044337 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 44.4 -239.2 -239154 3.6 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 TCAIM LOC105377055 ZNF660 ZNF852 ZNF35 SNRK-AS1 ZNF445 ZNF197 ENSG00000271941 ZNF502
GH03I044438 Enhancer 1.5 Ensembl ENCODE dbSUPER 48.7 -138.0 -138036 3.5 HDGF PKNOX1 SMAD1 FOXA2 MLX ARNT ARID4B DMAP1 YY1 SLC30A9 LINC00694 ZNF660 ZNF197 ZNF852 ZNF502 ZNF445 ZNF35 GC03M044441
GH03I044233 Enhancer 1.2 Ensembl ENCODE 39.6 -342.3 -342321 5.6 ATF1 PKNOX1 ARNT BRCA1 TCF12 GATA2 E2F8 ARID2 ZNF143 ATF7 ZNF660 ZNF502 ZNF197 ZKSCAN7 ZNF445 ZNF852 RNU6-367P ZNF35 SNRK-AS1 MIR138-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF660 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF660 gene promoter:

Genomic Locations for ZNF660 Gene

Genomic Locations for ZNF660 Gene
chr3:44,578,223-44,599,699
(GRCh38/hg38)
Size:
21,477 bases
Orientation:
Plus strand
chr3:44,619,715-44,641,186
(GRCh37/hg19)

Genomic View for ZNF660 Gene

Genes around ZNF660 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF660 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF660 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF660 Gene

Proteins for ZNF660 Gene

  • Protein details for ZNF660 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6AZW8-ZN660_HUMAN
    Recommended name:
    Zinc finger protein 660
    Protein Accession:
    Q6AZW8
    Secondary Accessions:
    • Q7Z331
    • Q8N9M8

    Protein attributes for ZNF660 Gene

    Size:
    331 amino acids
    Molecular mass:
    38270 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF660 Gene

Post-translational modifications for ZNF660 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF660 Gene

No data available for DME Specific Peptides for ZNF660 Gene

Domains & Families for ZNF660 Gene

Gene Families for ZNF660 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF660 Gene

Suggested Antigen Peptide Sequences for ZNF660 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6AZW8

UniProtKB/Swiss-Prot:

ZN660_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF660: view

Function for ZNF660 Gene

Molecular function for ZNF660 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF660 Gene

Gene Ontology (GO) - Molecular Function for ZNF660 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF660: view
genes like me logo Genes that share phenotypes with ZNF660: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF660 Gene

Localization for ZNF660 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF660 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF660 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (1)
  • Nucleoli fibrillar center (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF660 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF660: view

Pathways & Interactions for ZNF660 Gene

SuperPathways for ZNF660 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF660: view

Pathways by source for ZNF660 Gene

2 Reactome pathways for ZNF660 Gene

Interacting Proteins for ZNF660 Gene

Gene Ontology (GO) - Biological Process for ZNF660 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF660: view

No data available for SIGNOR curated interactions for ZNF660 Gene

Drugs & Compounds for ZNF660 Gene

No Compound Related Data Available

Transcripts for ZNF660 Gene

mRNA/cDNA for ZNF660 Gene

(4) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF660 Gene

Zinc finger protein 660:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF660 Gene

No ASD Table

Relevant External Links for ZNF660 Gene

GeneLoc Exon Structure for
ZNF660
ECgene alternative splicing isoforms for
ZNF660

Expression for ZNF660 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF660 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF660 Gene:

ZNF660

SOURCE GeneReport for Unigene cluster for ZNF660 Gene:

Hs.733134

Evidence on tissue expression from TISSUES for ZNF660 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ZNF660: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF660 Gene

Orthologs for ZNF660 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF660 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF660 33 34
  • 99.7 (n)
dog
(Canis familiaris)
Mammalia ZNF660 33
  • 92.35 (n)
-- 34
  • 42 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia LOC102639251 33
  • 85.35 (n)
Zscan26 34
  • 36 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia LOC102551231 33
  • 81.82 (n)
cow
(Bos Taurus)
Mammalia -- 34
  • 26 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii BX890548.2 34
  • 39 (a)
ManyToMany
BX005448.1 34
  • 38 (a)
ManyToMany
gb:am422109 34
  • 38 (a)
ManyToMany
zgc:174700 34
  • 38 (a)
ManyToMany
BX004879.1 34
  • 37 (a)
ManyToMany
si:ch211-283l16.1 34
  • 37 (a)
ManyToMany
si:dkey-56m15.3 34
  • 37 (a)
ManyToMany
CABZ01008480.1 34
  • 36 (a)
ManyToMany
CT573263.3 34
  • 36 (a)
ManyToMany
si:dkey-22h13.2 34
  • 36 (a)
ManyToMany
CR293532.1 34
  • 35 (a)
ManyToMany
si:ch211-226o13.2 34
  • 35 (a)
ManyToMany
si:dkey-237m9.1 34
  • 35 (a)
ManyToMany
si:dkey-54j5.2 34
  • 35 (a)
ManyToMany
zgc:173714 34
  • 34 (a)
ManyToMany
zgc:174694 34
  • 34 (a)
ManyToMany
si:dkey-16b10.2 34
  • 32 (a)
ManyToMany
BX005448.2 34
  • 29 (a)
ManyToMany
Species where no ortholog for ZNF660 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF660 Gene

ENSEMBL:
Gene Tree for ZNF660 (if available)
TreeFam:
Gene Tree for ZNF660 (if available)

Paralogs for ZNF660 Gene

Paralogs for ZNF660 Gene

(535) SIMAP similar genes for ZNF660 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZNF660: view

Variants for ZNF660 Gene

Sequence variations from dbSNP and Humsavar for ZNF660 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs587776368 not-provided, not provided 44,594,914(+) C/A/T coding_sequence_variant, missense_variant
rs1000001117 -- 44,593,654(+) G/C intron_variant
rs1000096946 -- 44,593,409(+) C/A intron_variant
rs1000144545 -- 44,587,720(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000231525 -- 44,586,555(+) A/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF660 Gene

Variant ID Type Subtype PubMed ID
nsv3790 CNV insertion 18451855

Variation tolerance for ZNF660 Gene

Residual Variation Intolerance Score: 58.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.15; 23.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF660 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF660

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF660 Gene

Disorders for ZNF660 Gene

Additional Disease Information for ZNF660

No disorders were found for ZNF660 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF660 Gene

Publications for ZNF660 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PMID: 21406692) Rigbolt KT … Blagoev B (Science signaling 2011) 4 58
  4. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for ZNF660 Gene

Sources for ZNF660 Gene

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