Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZNF66 Gene

Aliases for ZNF66 Gene

  • Zinc Finger Protein 66 2 3 5
  • ZNF66P 3 4
  • Zinc Finger Protein 66, Pseudogene 2
  • Zinc Finger Protein 66 Pseudogene 4
  • Putative Zinc Finger Protein 66 3

External Ids for ZNF66 Gene

Previous HGNC Symbols for ZNF66 Gene

  • ZNF66P

Previous GeneCards Identifiers for ZNF66 Gene

  • GC19U990108
  • GC19M020521
  • GC19P020751
  • GC19P020944

Summaries for ZNF66 Gene

GeneCards Summary for ZNF66 Gene

ZNF66 (Zinc Finger Protein 66) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF93.

UniProtKB/Swiss-Prot for ZNF66 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF66 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF66 Gene

Genomics for ZNF66 Gene

GeneHancer (GH) Regulatory Elements for ZNF66 Gene

Promoters and enhancers for ZNF66 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I020775 Promoter/Enhancer 1.4 Ensembl ENCODE 568.2 +0.2 248 1.8 PKNOX1 RB1 ARID4B KLF17 ZNF76 SIN3A KLF5 ZNF48 YY1 ZNF335 ZNF66 GC19M022334 ZNF100 ENSG00000267481 ZNF90 ZNF506 LOC641367 ZNF56 ZNF486 ZNF85
GH19I021019 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 14.6 +246.0 246006 4.6 HDGF PKNOX1 ATF1 SMAD1 ARID4B SIN3A DMAP1 YY1 POLR2B ZNF207 ZNF430 ZNF100 LOC641367 ZNF714 ZNF90 BNIP3P26 RPL7AP10 ZNF66 ZNF431 ZNF486
GH19I020922 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 15.5 +147.3 147258 2.1 PKNOX1 RB1 ARID4B SIN3A ZNF48 ZBTB40 YY1 ZNF335 SCRT2 ZNF207 ZNF85 ZNF100 ZNF66 ZNF90 RPL7AP10 ZNF431 LOC641367 ZNF43 ZNF486 ENSG00000268416
GH19I019899 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 11.9 -875.1 -875112 3 PKNOX1 ATF1 FOXA2 SIN3A ZNF2 YY1 GTF3C2 TCF12 POLR2B ZNF766 ZNF93 ATP13A1 ZNF90 ZNF506 NR2C2AP ENSG00000267481 TMEM161A ZNF66 MAU2 ZNF101
GH19I021328 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 10.5 +552.9 552899 2 HDGF PKNOX1 ATF1 SMAD1 ARID4B SIN3A DMAP1 ZNF48 YY1 POLR2B ZNF708 LOC105372321 ZNF100 ZNF43 ZNF66 ENSG00000213976 GC19P021323
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF66 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ZNF66 Gene

Genomic Locations for ZNF66 Gene
61,207 bases
Plus strand

Genomic View for ZNF66 Gene

Genes around ZNF66 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF66 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF66 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF66 Gene

Proteins for ZNF66 Gene

  • Protein details for ZNF66 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative zinc finger protein 66
    Protein Accession:
    Secondary Accessions:
    • I3L4P5
    • Q15939

    Protein attributes for ZNF66 Gene

    573 amino acids
    Molecular mass:
    65874 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF66 Gene

Post-translational modifications for ZNF66 Gene

No Post-translational modifications

Other Protein References for ZNF66 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF66 Gene

Domains & Families for ZNF66 Gene

Gene Families for ZNF66 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transcription factors

Protein Domains for ZNF66 Gene

Suggested Antigen Peptide Sequences for ZNF66 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF66: view

Function for ZNF66 Gene

Molecular function for ZNF66 Gene

GENATLAS Biochemistry:
zinc finger protein 66 (C2H2 type,Kruppel-like)
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF66 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF66: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF66 Gene

Localization for ZNF66 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF66 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF66 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF66 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ZNF66: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF66 Gene

Pathways & Interactions for ZNF66 Gene

SuperPathways for ZNF66 Gene

No Data Available

Interacting Proteins for ZNF66 Gene

Gene Ontology (GO) - Biological Process for ZNF66 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF66: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF66 Gene

Drugs & Compounds for ZNF66 Gene

No Compound Related Data Available

Transcripts for ZNF66 Gene

mRNA/cDNA for ZNF66 Gene

(2) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF66 Gene

No ASD Table

Relevant External Links for ZNF66 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF66 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF66 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF66 Gene

This gene is overexpressed in Ovary (x4.0).

Protein differential expression in normal tissues from HIPED for ZNF66 Gene

This gene is overexpressed in Plasma (39.0), Monocytes (16.8), and Tlymphocyte (12.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF66 Gene

Protein tissue co-expression partners for ZNF66 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF66 Gene:


Evidence on tissue expression from TISSUES for ZNF66 Gene

  • Stomach(2.7)
genes like me logo Genes that share expression patterns with ZNF66: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF66 Gene

Orthologs for ZNF66 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF66 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF66 34
  • 93 (a)
(Bos Taurus)
Mammalia -- 34
  • 55 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 50 (a)
-- 34
  • 41 (a)
(Canis familiaris)
Mammalia -- 34
  • 39 (a)
(Mus musculus)
Mammalia Zfp386 34
  • 36 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 55 (a)
-- 34
  • 44 (a)
-- 34
  • 40 (a)
-- 34
  • 35 (a)
-- 34
  • 33 (a)
-- 34
  • 33 (a)
-- 34
  • 33 (a)
-- 34
  • 30 (a)
Species where no ortholog for ZNF66 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF66 Gene

Gene Tree for ZNF66 (if available)
Gene Tree for ZNF66 (if available)

Paralogs for ZNF66 Gene

(611) SIMAP similar genes for ZNF66 Gene using alignment to 5 proteins: Pseudogenes for ZNF66 Gene

genes like me logo Genes that share paralogs with ZNF66: view

Variants for ZNF66 Gene

Variation tolerance for ZNF66 Gene

Gene Damage Index Score: 16.80; 97.91% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF66 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for ZNF66 Gene

Disorders for ZNF66 Gene

Additional Disease Information for ZNF66

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ZNF66 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF66 Gene

Publications for ZNF66 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes. (PMID: 1505991) Lichter P … Ward DC (Genomics 1992) 2 3 58
  3. Characterization and mapping of human genes encoding zinc finger proteins. (PMID: 1946370) Bray P … Dawid IB (Proceedings of the National Academy of Sciences of the United States of America 1991) 3 4 58
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 4 58

Products for ZNF66 Gene

Sources for ZNF66 Gene

Loading form....