Aliases for ZNF66 Gene

Aliases for ZNF66 Gene

  • Zinc Finger Protein 66 2 3 5
  • Putative Zinc Finger Protein 66 3 4
  • ZNF66P 3 4
  • Zinc Finger Protein 66, Pseudogene 2
  • Zinc Finger Protein 66 Pseudogene 4
  • FLJ16537 2
  • ZNF66 5

External Ids for ZNF66 Gene

Previous HGNC Symbols for ZNF66 Gene

  • ZNF66P

Previous GeneCards Identifiers for ZNF66 Gene

  • GC19U990108
  • GC19M020521
  • GC19P020751
  • GC19P020944

Summaries for ZNF66 Gene

GeneCards Summary for ZNF66 Gene

ZNF66 (Zinc Finger Protein 66) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF737.

UniProtKB/Swiss-Prot Summary for ZNF66 Gene

Additional gene information for ZNF66 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF66 Gene

Genomics for ZNF66 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF66 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF66 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF66

Genomic Locations for ZNF66 Gene

Genomic Locations for ZNF66 Gene
chr19:20,776,304-20,809,995
(GRCh38/hg38)
Size:
33,692 bases
Orientation:
Plus strand
chr19:20,959,076-21,020,282
(GRCh37/hg19)
Size:
61,207 bases
Orientation:
Plus strand

Genomic View for ZNF66 Gene

Genes around ZNF66 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF66 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF66 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF66 Gene

Proteins for ZNF66 Gene

  • Protein details for ZNF66 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZN08-ZNF66_HUMAN
    Recommended name:
    Putative zinc finger protein 66
    Protein Accession:
    Q6ZN08
    Secondary Accessions:
    • I3L4P5
    • Q15939

    Protein attributes for ZNF66 Gene

    Size:
    573 amino acids
    Molecular mass:
    65874 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF66 Gene

Post-translational modifications for ZNF66 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF66 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF66 Gene

Domains & Families for ZNF66 Gene

Gene Families for ZNF66 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transcription factors

Protein Domains for ZNF66 Gene

InterPro:
Blocks:
  • C2H2-type zinc finger signature
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF66 Gene

GenScript: Design optimal peptide antigens:
  • ZNF66 protein (Q4G0J2_HUMAN)
  • Zinc finger protein 66 pseudogene (ZNF66_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6ZN08

UniProtKB/Swiss-Prot:

ZNF66_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF66: view

Function for ZNF66 Gene

Molecular function for ZNF66 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
GENATLAS Biochemistry:
zinc finger protein 66 (C2H2 type,Kruppel-like)

Phenotypes From GWAS Catalog for ZNF66 Gene

Gene Ontology (GO) - Molecular Function for ZNF66 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA 21873635
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF66: view

Phenotypes for ZNF66 Gene

genes like me logo Genes that share phenotypes with ZNF66: view

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF66 Gene

Localization for ZNF66 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF66 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF66 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF66 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ZNF66: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF66 Gene

Pathways & Interactions for ZNF66 Gene

PathCards logo

SuperPathways for ZNF66 Gene

No Data Available

Interacting Proteins for ZNF66 Gene

Gene Ontology (GO) - Biological Process for ZNF66 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA,IBA 21873635
genes like me logo Genes that share ontologies with ZNF66: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF66 Gene

Drugs & Compounds for ZNF66 Gene

No Compound Related Data Available

Transcripts for ZNF66 Gene

mRNA/cDNA for ZNF66 Gene

2 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF66 Gene

No ASD Table

Relevant External Links for ZNF66 Gene

GeneLoc Exon Structure for
ZNF66

Expression for ZNF66 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF66 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF66 Gene

This gene is overexpressed in Ovary (x4.0).

Protein differential expression in normal tissues from HIPED for ZNF66 Gene

This gene is overexpressed in Plasma (39.0), Monocytes (16.8), and Tlymphocyte (12.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF66 Gene



Protein tissue co-expression partners for ZNF66 Gene

Evidence on tissue expression from TISSUES for ZNF66 Gene

  • Stomach(2.7)
genes like me logo Genes that share expression patterns with ZNF66: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF66 Gene

Orthologs for ZNF66 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF66 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF66 31
  • 93 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia -- 31
  • 55 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 50 (a)
ManyToMany
-- 31
  • 41 (a)
ManyToMany
Dog
(Canis familiaris)
Mammalia -- 31
  • 39 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Zfp386 31
  • 36 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 55 (a)
ManyToMany
-- 31
  • 44 (a)
ManyToMany
-- 31
  • 40 (a)
ManyToMany
-- 31
  • 35 (a)
ManyToMany
-- 31
  • 33 (a)
ManyToMany
-- 31
  • 33 (a)
ManyToMany
-- 31
  • 33 (a)
ManyToMany
-- 31
  • 30 (a)
ManyToMany
Species where no ortholog for ZNF66 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF66 Gene

ENSEMBL:
Gene Tree for ZNF66 (if available)
TreeFam:
Gene Tree for ZNF66 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF66: view image

Paralogs for ZNF66 Gene

(611) SIMAP similar genes for ZNF66 Gene using alignment to 5 proteins:

  • ZNF66_HUMAN
  • I3L137_HUMAN
  • I3L2D0_HUMAN
  • M0QY27_HUMAN
  • Q4G0J2_HUMAN

Pseudogenes.org Pseudogenes for ZNF66 Gene

genes like me logo Genes that share paralogs with ZNF66: view

Variants for ZNF66 Gene

Additional dbSNP identifiers (rs#s) for ZNF66 Gene

Variation tolerance for ZNF66 Gene

Gene Damage Index Score: 16.80; 97.91% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF66 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF66

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Structural Variations from Database of Genomic Variants (DGV) for ZNF66 Gene

Disorders for ZNF66 Gene

Additional Disease Information for ZNF66

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for ZNF66 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF66 Gene

Publications for ZNF66 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  2. Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes. (PMID: 1505991) Lichter P … Ward DC (Genomics 1992) 2 3
  3. Characterization and mapping of human genes encoding zinc finger proteins. (PMID: 1946370) Bray P … Dawid IB (Proceedings of the National Academy of Sciences of the United States of America 1991) 3 4
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3

Products for ZNF66 Gene

Sources for ZNF66 Gene