ZNF655 Gene (Protein Coding)

Zinc Finger Protein 655

GC07P099559
GIFtS:
36
This gene encodes a zinc finger protein. The zinc finger proteins are involved in DNA binding and protein-protein interactions. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008] See more...

Aliases for ZNF655 Gene

Aliases for ZNF655 Gene

  • Zinc Finger Protein 655 2 3 4 5
  • VIK 2 3 4
  • VIK-1 2 3
  • Vav-1 Interacting Kruppel-Like Protein 3
  • Vav-Interacting Krueppel-Like Protein 4
  • ZNF655 5

External Ids for ZNF655 Gene

Previous GeneCards Identifiers for ZNF655 Gene

  • GC07P098801
  • GC07P098993
  • GC07P099156
  • GC07P093793

Summaries for ZNF655 Gene

Entrez Gene Summary for ZNF655 Gene

  • This gene encodes a zinc finger protein. The zinc finger proteins are involved in DNA binding and protein-protein interactions. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZNF655 Gene

ZNF655 (Zinc Finger Protein 655) is a Protein Coding gene. Diseases associated with ZNF655 include Facial Neuralgia. Among its related pathways are Retinoblastoma (RB) in Cancer and Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZNF7.

UniProtKB/Swiss-Prot Summary for ZNF655 Gene

Gene Wiki entry for ZNF655 Gene

Additional gene information for ZNF655 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF655 Gene

Genomics for ZNF655 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for ZNF655 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH07J099557 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 650.5 +2.6 2556 7.9 HNRNPL CREB1 GATAD2A PRDM10 REST ZNF629 LEF1 IKZF1 KDM1A ZNF692 ZNF655 FAM200A ZSCAN25 ZNF3 TRIM4 PTCD1 ZNF394 RNF14P3 TRRAP PPP1R35
GH07J099574 Promoter 0.3 EPDnew 600.4 +16.1 16115 0.1 lnc-FAM200A-1 ZNF655 TMEM225B ENSG00000272647 ZSCAN25
GH07J100427 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 70.9 +874.6 874587 11.2 ZNF221 BRCA1 RNF2 ARHGAP35 SP1 HNRNPL CREB1 GATAD2A PRDM10 ZNF629 PPP1R35 MEPCE ZCWPW1 piR-33055 ZSCAN25 SRRT TRIM4 GIGYF1 ZNF3 ZNF655
GH07J100475 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 67.7 +919.4 919369 4.5 ZNF221 ARHGAP35 SP1 GATAD2A CTCF HNRNPL PRDM10 ZNF629 LEF1 IKZF1 TSC22D4 SRRT ZSCAN25 GIGYF1 TRIM4 ZNF655 ZNF3 PILRA AP4M1 ENSG00000242798
GH07J100148 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 50.4 +590.9 590910 2.7 ZNF221 SP1 HNRNPL CREB1 GATAD2A ZBTB33 PRDM10 ZNF629 TFE3 NFKBIZ HSALNG0059969 LAMTOR4 ZSCAN25 TRIM4 ZNF3 AP4M1 ZNF655 PTCD1 GIGYF1 SRRT
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF655 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF655

Top Transcription factor binding sites by QIAGEN in the ZNF655 gene promoter:
  • AML1a
  • IRF-1
  • Nkx2-5
  • Nkx6-1

Genomic Locations for ZNF655 Gene

Genomic Locations for ZNF655 Gene
chr7:99,558,406-99,576,453
(GRCh38/hg38)
Size:
18,048 bases
Orientation:
Plus strand
chr7:99,156,029-99,174,076
(GRCh37/hg19)
Size:
18,048 bases
Orientation:
Plus strand

Genomic View for ZNF655 Gene

Genes around ZNF655 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF655 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF655 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ZNF655 Gene

Proteins for ZNF655 Gene

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  • Protein details for ZNF655 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N720-ZN655_HUMAN
    Recommended name:
    Zinc finger protein 655
    Protein Accession:
    Q8N720
    Secondary Accessions:
    • A4D291
    • A6NGD3
    • B4E3M4
    • B7Z9Q9
    • D6W5T4
    • Q8IV00
    • Q8TA89
    • Q96EZ3
    • Q9BQ85

    Protein attributes for ZNF655 Gene

    Size:
    491 amino acids
    Molecular mass:
    57407 Da
    Quaternary structure:
    • Interacts with VAV1 and CDK4.

    Alternative splice isoforms for ZNF655 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF655 Gene

Protein Expression for ZNF655 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for ZNF655 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF655 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF655 Gene

Domains & Families for ZNF655 Gene

Gene Families for ZNF655 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF655 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF655 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 655, isoform CRA_a (D6W5T3_HUMAN)
  • cDNA FLJ46177 fis, clone TESTI4003796, highly similar to Zinc finger protein 655 (Q68DU4_HUMAN)
  • Vav-interacting Krueppel-like protein (ZN655_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8N720

UniProtKB/Swiss-Prot:

ZN655_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF655: view

Function for ZNF655 Gene

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  2. CRISPR
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  6. Cell Line

Molecular function for ZNF655 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF655 Gene

Gene Ontology (GO) - Molecular Function for ZNF655 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 15558030
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF655: view
genes like me logo Genes that share phenotypes with ZNF655: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF655

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF655 Gene

Localization for ZNF655 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF655 Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF655 gene
Compartment Confidence
nucleus 5
plasma membrane 3
cytosol 2
extracellular 1
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF655 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 15558030
GO:0005730 nucleolus IDA 15558030
GO:0005737 cytoplasm IDA 15558030
genes like me logo Genes that share ontologies with ZNF655: view

Pathways & Interactions for ZNF655 Gene

genes like me logo Genes that share pathways with ZNF655: view

Pathways by source for ZNF655 Gene

2 BioSystems pathways for ZNF655 Gene
2 Reactome pathways for ZNF655 Gene

Gene Ontology (GO) - Biological Process for ZNF655 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle IDA 15558030
genes like me logo Genes that share ontologies with ZNF655: view

No data available for SIGNOR curated interactions for ZNF655 Gene

Drugs & Compounds for ZNF655 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for ZNF655 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for ZNF655 Gene

13 REFSEQ mRNAs :
29 NCBI additional mRNA sequence :
25 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF655

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF655 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h · 1i ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e ·
SP1: - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - - - - - - - - - -
SP4: - - - - - - - - - - - - - - -
SP5: - - - - - - - - - - - - - - -
SP6: - - - - -
SP7: - - - - - - - - - - - -
SP8: - - - - - - -
SP9: - - - - - - - - - - - - - -
SP10: - - - - - - - - - - - - - - - -
SP11: - - - - - - -
SP12: - - - - - - - - - -
SP13: - - - - - - - - - - - - -
SP14: - - - - - - - - - - - -
SP15: - - - - - - - - - - -
SP16: - - - - - - - - - - - - - - - -
SP17: - - - - - - - - - - - - - - - -
SP18: - - - - - - - - - - - -
SP19: - -
SP20: - - - - - - -
SP21: - - - - - - -
SP22: - - - - -
SP23:
SP24: - - - - -

ExUns: 7f · 7g · 7h ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c · 11d · 11e · 11f · 11g · 11h
SP1:
SP2:
SP3: - - - -
SP4: - - - - -
SP5: - - - - -
SP6:
SP7: - - - - -
SP8:
SP9: - - - - -
SP10: - - - - -
SP11:
SP12:
SP13: - - - - -
SP14: - - - - -
SP15:
SP16: - - - - - -
SP17: - - -
SP18: - - - - - -
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:

Relevant External Links for ZNF655 Gene

GeneLoc Exon Structure for
ZNF655

Expression for ZNF655 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF655 Gene

mRNA expression in normal human tissues for ZNF655 Gene
mRNA expression by GTEx for ZNF655 Gene

Protein differential expression in normal tissues from HIPED for ZNF655 Gene

This gene is overexpressed in Adipocyte (54.1) and Placenta (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF655 Gene



Protein tissue co-expression partners for ZNF655 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF655

SOURCE GeneReport for Unigene cluster for ZNF655 Gene:

Hs.599798

Evidence on tissue expression from TISSUES for ZNF655 Gene

  • Nervous system(4.9)
  • Skin(4.5)
  • Intestine(4.4)
  • Pancreas(4.2)
  • Lung(2.5)
genes like me logo Genes that share expression patterns with ZNF655: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF655 Gene

Orthologs for ZNF655 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF655 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia ZNF655 31
  • 100 (a)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Zfp655 30 17 31
  • 85.71 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Zfp655 30
  • 85.64 (n)
Dog
(Canis familiaris)
 Mammalia ZNF655 31
  • 79 (a)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia -- 31
  • 24 (a)
 ManyToMany
Lizard
(Anolis carolinensis)
 Reptilia -- 31
  • 29 (a)
 OneToMany
Zebrafish
(Danio rerio)
 Actinopterygii BX927130.1 31
  • 24 (a)
 OneToMany
Species where no ortholog for ZNF655 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ZNF655 Gene

ENSEMBL:
Gene Tree for ZNF655 (if available)
TreeFam:
Gene Tree for ZNF655 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF655: view image

Paralogs for ZNF655 Gene

Paralogs for ZNF655 Gene

(427) SIMAP similar genes for ZNF655 Gene using alignment to 13 proteins:

  • ZN655_HUMAN
  • C9IYG2_HUMAN
  • C9J0V9_HUMAN
  • C9J9R2_HUMAN
  • C9JNK1_HUMAN
  • C9JS03_HUMAN
  • C9JUB9_HUMAN
  • D6W5T3_HUMAN
  • F8WCS2_HUMAN
  • F8WDU5_HUMAN
  • F8WE52_HUMAN
  • F8WEB1_HUMAN
  • Q68DU4_HUMAN

Pseudogenes.org Pseudogenes for ZNF655 Gene

genes like me logo Genes that share paralogs with ZNF655: view

Variants for ZNF655 Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF655 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
783501 Benign: not provided 99,573,504(+) T/G MISSENSE_VARIANT
rs17853754 - p.Glu52Asp

Additional dbSNP identifiers (rs#s) for ZNF655 Gene

Variation tolerance for ZNF655 Gene

Residual Variation Intolerance Score: 73.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.29; 53.11% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF655 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF655

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZNF655 Gene

Disorders for ZNF655 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF655 Gene - From: DISEASES

Disorder Aliases PubMed IDs
facial neuralgia
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF655

Genetic Association Database
(GAD)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with ZNF655: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF655 Gene

Publications for ZNF655 Gene

  1. Characterization of VIK-1: a new Vav-interacting Kruppel-like protein. (PMID: 15558030) Houlard M … Varin-Blank N (Oncogene 2005) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4
  5. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 4

ExternalLinks

View latest publications for ZNF655 gene in Mastermind

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