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Aliases for ZNF654 Gene

Aliases for ZNF654 Gene

  • Zinc Finger Protein 654 2 3 3 5
  • Melanoma-Associated Antigen 3 4

External Ids for ZNF654 Gene

Previous GeneCards Identifiers for ZNF654 Gene

  • GC03P088271
  • GC03P088188
  • GC03P088139

Summaries for ZNF654 Gene

GeneCards Summary for ZNF654 Gene

ZNF654 (Zinc Finger Protein 654) is a Protein Coding gene. Diseases associated with ZNF654 include Malignant Choroid Melanoma and Pigmented Basal Cell Carcinoma. An important paralog of this gene is ZNF292.

UniProtKB/Swiss-Prot for ZNF654 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF654 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF654 Gene

Genomics for ZNF654 Gene

GeneHancer (GH) Regulatory Elements for ZNF654 Gene

Promoters and enhancers for ZNF654 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J088057 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 669.2 -0.2 -187 4 HDGF PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZBTB7B YY1 POLR2B ZNF213 CGGBP1 ZNF654 C3orf38 GC03P088045
GH03J088139 Promoter 0.5 EPDnew 650.2 +79.8 79848 0.1 ZNF654 GC03P088128 C3orf38 CGGBP1 GC03P088045
GH03J087791 Enhancer 1.3 Ensembl ENCODE dbSUPER 52.2 -265.9 -265911 2.9 HDAC1 RB1 ZNF335 GLIS2 ZNF213 RBM34 EGR1 ZNF202 ZNF680 ZBTB11 HTR1F LOC105377198 CGGBP1 ZNF654 VGLL3
GH03J088148 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 27.9 +90.9 90880 3.6 HDGF PKNOX1 CLOCK SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 CGGBP1 C3orf38 ZNF654 GC03P088161 GC03P088045
GH03J088140 Enhancer 0.9 Ensembl ENCODE 8.7 +82.9 82898 2.8 PKNOX1 NR2F1 TRIM22 BMI1 MEF2B DPF2 BATF JUND PRDM6 TARDBP CGGBP1 ZNF654 C3orf38 GC03P088128 GC03P088045
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF654 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF654 gene promoter:
  • HFH-1
  • POU3F1
  • AML1a
  • FOXD3
  • CUTL1
  • oct-B2
  • Oct-B1

Genomic Locations for ZNF654 Gene

Genomic Locations for ZNF654 Gene
chr3:88,059,274-88,144,665
(GRCh38/hg38)
Size:
85,392 bases
Orientation:
Plus strand
chr3:88,188,254-88,193,815
(GRCh37/hg19)
Size:
5,562 bases
Orientation:
Plus strand

Genomic View for ZNF654 Gene

Genes around ZNF654 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF654 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF654 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF654 Gene

Proteins for ZNF654 Gene

  • Protein details for ZNF654 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZM8-ZN654_HUMAN
    Recommended name:
    Zinc finger protein 654
    Protein Accession:
    Q8IZM8
    Secondary Accessions:
    • Q9H791
    • Q9NV14

    Protein attributes for ZNF654 Gene

    Size:
    581 amino acids
    Molecular mass:
    65854 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAN40504.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAA91946.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB15007.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for ZNF654 Gene

Post-translational modifications for ZNF654 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF654 Gene

Domains & Families for ZNF654 Gene

Gene Families for ZNF654 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF654 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF654 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IZM8

UniProtKB/Swiss-Prot:

ZN654_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF654: view

Function for ZNF654 Gene

Molecular function for ZNF654 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF654 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF654: view
genes like me logo Genes that share phenotypes with ZNF654: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF654

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF654 Gene

Localization for ZNF654 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF654 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF654 gene
Compartment Confidence
nucleus 5
cytoskeleton 3
plasma membrane 1
extracellular 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Microtubules (3)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF654 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF654: view

Pathways & Interactions for ZNF654 Gene

SuperPathways for ZNF654 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF654 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF654: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF654 Gene

Drugs & Compounds for ZNF654 Gene

No Compound Related Data Available

Transcripts for ZNF654 Gene

mRNA/cDNA for ZNF654 Gene

Unigene Clusters for ZNF654 Gene

Zinc finger protein 654:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF654

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF654 Gene

No ASD Table

Relevant External Links for ZNF654 Gene

GeneLoc Exon Structure for
ZNF654
ECgene alternative splicing isoforms for
ZNF654

Expression for ZNF654 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF654 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF654 Gene

This gene is overexpressed in Prostate (45.1) and CD8 Tcells (23.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF654 Gene



Protein tissue co-expression partners for ZNF654 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF654 Gene:

ZNF654

SOURCE GeneReport for Unigene cluster for ZNF654 Gene:

Hs.591650

Evidence on tissue expression from TISSUES for ZNF654 Gene

  • Spleen(2.4)
  • Blood(2.3)
  • Lymph node(2.3)
  • Skin(2.1)
genes like me logo Genes that share expression patterns with ZNF654: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF654 Gene

Orthologs for ZNF654 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF654 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF654 34
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF654 33
  • 93.57 (n)
cow
(Bos Taurus)
Mammalia ZNF654 33
  • 92.47 (n)
rat
(Rattus norvegicus)
Mammalia Zfp654 33
  • 87.89 (n)
mouse
(Mus musculus)
Mammalia Zfp654 16 34 33
  • 87.84 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF654 34
  • 58 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 26 (a)
OneToMany
chicken
(Gallus gallus)
Aves ZNF654 33
  • 68.44 (n)
-- 34
  • 24 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 21 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia znf654 33
  • 56.02 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100536880 33
  • 46.03 (n)
znf654 34
  • 4 (a)
OneToMany
Species where no ortholog for ZNF654 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF654 Gene

ENSEMBL:
Gene Tree for ZNF654 (if available)
TreeFam:
Gene Tree for ZNF654 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF654: view image

Paralogs for ZNF654 Gene

Paralogs for ZNF654 Gene

(1) SIMAP similar genes for ZNF654 Gene using alignment to 1 proteins:

  • ZN654_HUMAN

Pseudogenes.org Pseudogenes for ZNF654 Gene

genes like me logo Genes that share paralogs with ZNF654: view

Variants for ZNF654 Gene

Sequence variations from dbSNP and Humsavar for ZNF654 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000021226 -- 88,072,811(+) A/C/G genic_upstream_transcript_variant, intron_variant
rs1000088188 -- 88,071,515(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000198310 -- 88,143,149(+) C/T 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000255636 -- 88,143,402(+) C/T 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000302459 -- 88,110,295(+) A/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF654 Gene

Variant ID Type Subtype PubMed ID
esv3596914 CNV gain 21293372
esv3596913 CNV gain 21293372

Variation tolerance for ZNF654 Gene

Residual Variation Intolerance Score: 67.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.61; 56.48% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF654 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF654

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF654 Gene

Disorders for ZNF654 Gene

MalaCards: The human disease database

(3) MalaCards diseases for ZNF654 Gene - From: DISEASES

Disorder Aliases PubMed IDs
malignant choroid melanoma
  • malignant melanoma of choroid
pigmented basal cell carcinoma
  • skin pigmented basal cell carcinoma
cell type cancer
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF654

genes like me logo Genes that share disorders with ZNF654: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF654 Gene

Publications for ZNF654 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. (PMID: 25231870) Perry JR … Ong KK (Nature 2014) 3 58
  3. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny DM … Gibbs RA (Nature 2006) 4 58

Products for ZNF654 Gene

Sources for ZNF654 Gene

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