Aliases for ZNF654 Gene

Aliases for ZNF654 Gene

  • Zinc Finger Protein 654 2 3 4 5
  • Melanoma-Associated Antigen 3 4
  • FLJ10997 2
  • FLJ21142 2
  • ZNF654 5

External Ids for ZNF654 Gene

Previous GeneCards Identifiers for ZNF654 Gene

  • GC03P088271
  • GC03P088188
  • GC03P088139

Summaries for ZNF654 Gene

GeneCards Summary for ZNF654 Gene

ZNF654 (Zinc Finger Protein 654) is a Protein Coding gene. An important paralog of this gene is ZNF292.

UniProtKB/Swiss-Prot Summary for ZNF654 Gene

Additional gene information for ZNF654 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF654 Gene

Genomics for ZNF654 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF654 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J088057 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 619.2 +0.6 639 5.5 SP1 CREB1 RFX1 POLR2A ZNF692 BACH1 FOS LARP7 GABPA PRDM1 CGGBP1 ZNF654 lnc-POU1F1-2 lnc-POU1F1-3
GH03J088139 Promoter 0.3 EPDnew 600.2 +79.9 79925 0.1 ZNF654 lnc-C3orf38-2 CGGBP1 NONHSAG035519.2
GH03J087791 Promoter/Enhancer 1.4 Ensembl ENCODE dbSUPER 37.8 -265.9 -265883 3 HNRNPL PRDM10 IKZF1 KDM1A PRDM1 MTA2 ZIC2 PATZ1 REST EZH2 HTR1F ENSG00000239572 CGGBP1 ZNF654 VGLL3
GH03J088148 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 9.5 +91.2 91204 4.8 HNRNPL CREB1 GATAD2A REST ZNF629 RFX1 SIX5 LEF1 IKZF1 NFKBIZ CGGBP1 C3orf38 ZNF654 lnc-C3orf38-1 CSNKA2IP
GH03J087795 Enhancer 1.3 Ensembl ENCODE dbSUPER 14 -261.9 -261923 4.2 LEF1 IKZF1 JUND DDX20 MTA2 PKNOX1 ZNF24 MTA1 BRD9 DPF2 ZNF654 HTR1F CGGBP1 ENSG00000239572 piR-51137-075
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF654 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF654

Top Transcription factor binding sites by QIAGEN in the ZNF654 gene promoter:
  • AML1a
  • CUTL1
  • FOXD3
  • HFH-1
  • Oct-B1
  • oct-B2
  • POU3F1

Genomic Locations for ZNF654 Gene

Genomic Locations for ZNF654 Gene
chr3:88,059,197-88,144,664
(GRCh38/hg38)
Size:
85,468 bases
Orientation:
Plus strand
chr3:88,188,254-88,193,815
(GRCh37/hg19)
Size:
5,562 bases
Orientation:
Plus strand

Genomic View for ZNF654 Gene

Genes around ZNF654 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF654 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF654 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF654 Gene

Proteins for ZNF654 Gene

  • Protein details for ZNF654 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZM8-ZN654_HUMAN
    Recommended name:
    Zinc finger protein 654
    Protein Accession:
    Q8IZM8
    Secondary Accessions:
    • Q9H791
    • Q9NV14

    Protein attributes for ZNF654 Gene

    Size:
    581 amino acids
    Molecular mass:
    65854 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAN40504.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=BAA91946.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAB15007.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

neXtProt entry for ZNF654 Gene

Post-translational modifications for ZNF654 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF654 Gene

Domains & Families for ZNF654 Gene

Gene Families for ZNF654 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF654 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF654 Gene

GenScript: Design optimal peptide antigens:
  • Melanoma-associated antigen (ZN654_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8IZM8

UniProtKB/Swiss-Prot:

ZN654_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF654: view

Function for ZNF654 Gene

Molecular function for ZNF654 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF654 Gene

Gene Ontology (GO) - Molecular Function for ZNF654 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IBA 21873635
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IBA 21873635
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF654: view
genes like me logo Genes that share phenotypes with ZNF654: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF654

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF654 Gene

Localization for ZNF654 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF654 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF654 gene
Compartment Confidence
nucleus 4
cytoskeleton 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytokinetic bridge (2)
  • Microtubules (2)
  • Mitotic spindle (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF654 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with ZNF654: view

Pathways & Interactions for ZNF654 Gene

PathCards logo

SuperPathways for ZNF654 Gene

No Data Available

Interacting Proteins for ZNF654 Gene

Gene Ontology (GO) - Biological Process for ZNF654 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription by RNA polymerase II IBA 21873635
GO:0045944 positive regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF654: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF654 Gene

Drugs & Compounds for ZNF654 Gene

No Compound Related Data Available

Transcripts for ZNF654 Gene

mRNA/cDNA for ZNF654 Gene

10 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF654

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF654 Gene

No ASD Table

Relevant External Links for ZNF654 Gene

GeneLoc Exon Structure for
ZNF654

Expression for ZNF654 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF654 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF654 Gene

This gene is overexpressed in Prostate (45.1) and CD8 Tcells (23.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF654 Gene



Protein tissue co-expression partners for ZNF654 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF654

SOURCE GeneReport for Unigene cluster for ZNF654 Gene:

Hs.591650
genes like me logo Genes that share expression patterns with ZNF654: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF654 Gene

Orthologs for ZNF654 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF654 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF654 31
  • 100 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia ZNF654 30
  • 93.57 (n)
Cow
(Bos Taurus)
Mammalia ZNF654 30
  • 92.47 (n)
Rat
(Rattus norvegicus)
Mammalia Zfp654 30
  • 87.89 (n)
Mouse
(Mus musculus)
Mammalia Zfp654 30 17 31
  • 87.84 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia ZNF654 31
  • 58 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 26 (a)
OneToMany
Chicken
(Gallus gallus)
Aves ZNF654 30
  • 68.44 (n)
-- 31
  • 24 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 21 (a)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia znf654 30
  • 56.02 (n)
Zebrafish
(Danio rerio)
Actinopterygii LOC100536880 30
  • 46.03 (n)
znf654 31
  • 4 (a)
OneToMany
Species where no ortholog for ZNF654 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ZNF654 Gene

ENSEMBL:
Gene Tree for ZNF654 (if available)
TreeFam:
Gene Tree for ZNF654 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF654: view image

Paralogs for ZNF654 Gene

Paralogs for ZNF654 Gene

(1) SIMAP similar genes for ZNF654 Gene using alignment to 1 proteins:

  • ZN654_HUMAN

Pseudogenes.org Pseudogenes for ZNF654 Gene

genes like me logo Genes that share paralogs with ZNF654: view

Variants for ZNF654 Gene

Additional dbSNP identifiers (rs#s) for ZNF654 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF654 Gene

Variant ID Type Subtype PubMed ID
esv3596913 CNV gain 21293372
esv3596914 CNV gain 21293372

Variation tolerance for ZNF654 Gene

Residual Variation Intolerance Score: 67.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.61; 56.48% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF654 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF654

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF654 Gene

Disorders for ZNF654 Gene

No disorders were found for ZNF654 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF654 Gene

Publications for ZNF654 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. (PMID: 25231870) Perry JR … Ong KK (Nature 2014) 3
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  4. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny DM … Gibbs RA (Nature 2006) 4

Products for ZNF654 Gene

  • Signalway ELISA kits for ZNF654
  • Signalway Proteins for ZNF654

Sources for ZNF654 Gene