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Aliases for ZNF653 Gene

Aliases for ZNF653 Gene

  • Zinc Finger Protein 653 2 3 5
  • 67 KDa Zinc Finger Protein 3 4
  • Zinc Finger Protein Zip67 3 4
  • ZIP67 3 4
  • E430039K05Rik 3

External Ids for ZNF653 Gene

Previous GeneCards Identifiers for ZNF653 Gene

  • GC19M011457
  • GC19M011594
  • GC19M011168

Summaries for ZNF653 Gene

GeneCards Summary for ZNF653 Gene

ZNF653 (Zinc Finger Protein 653) is a Protein Coding gene. An important paralog of this gene is ENSG00000267477.

UniProtKB/Swiss-Prot for ZNF653 Gene

  • Transcriptional repressor. May repress NR5A1, PPARG, NR1H3, NR4A2, ESR1 and NR3C1 transcriptional activity.

Additional gene information for ZNF653 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF653 Gene

Genomics for ZNF653 Gene

GeneHancer (GH) Regulatory Elements for ZNF653 Gene

Promoters and enhancers for ZNF653 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I011504 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.2 180 2.6 HDGF ARID4B SIN3A ZNF2 ZBTB7B YY1 SLC30A9 POLR2B E2F8 ZNF143 ZNF653 ENSG00000267477 ECSIT
GH19I011373 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 2 +129.6 129603 6.2 HDGF PKNOX1 SMAD1 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ENSG00000267277 PIR61774 SWSAP1 ILF3 KRI1 ZNF627 ZNF136 ZNF442 ZNF844 ZNF44
GH19I011478 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE 2.3 +24.3 24297 5.4 HDGF PKNOX1 CLOCK SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 ELAVL3 ILF3 KRI1 ZNF627 ZNF136 TIMM29 ZNF44 ZNF441 ENSG00000242615 ZNF700
GH19I011530 Enhancer 1.4 FANTOM5 Ensembl ENCODE 1.8 -24.6 -24578 0.6 PKNOX1 MLX ARID4B SIN3A ZNF48 ETS1 SLC30A9 FOS RXRA NFYC ECSIT ZNF439 CCDC151 ELAVL3 ZNF491 ZNF653 ZNF441 GC19P011537
GH19I011489 Enhancer 1.1 FANTOM5 ENCODE 0.4 +15.3 15258 1.9 ELF3 FOXA2 ARID4B YY1 SLC30A9 ZNF143 FOS CREM THAP11 SP3 GC19M011484 ZNF491 ZNF441 ELAVL3 ENSG00000267477 ZNF653
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF653 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF653 gene promoter:

Genomic Locations for ZNF653 Gene

Genomic Locations for ZNF653 Gene
22,497 bases
Minus strand

Genomic View for ZNF653 Gene

Genes around ZNF653 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF653 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF653 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF653 Gene

Proteins for ZNF653 Gene

  • Protein details for ZNF653 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 653
    Protein Accession:
    Secondary Accessions:
    • Q96AS7

    Protein attributes for ZNF653 Gene

    615 amino acids
    Molecular mass:
    67235 Da
    Quaternary structure:
    • Interacts with NR5A1.

neXtProt entry for ZNF653 Gene

Post-translational modifications for ZNF653 Gene

No Post-translational modifications

Other Protein References for ZNF653 Gene

No data available for DME Specific Peptides for ZNF653 Gene

Domains & Families for ZNF653 Gene

Gene Families for ZNF653 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF653 Gene

Suggested Antigen Peptide Sequences for ZNF653 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF653: view

Function for ZNF653 Gene

Molecular function for ZNF653 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor. May repress NR5A1, PPARG, NR1H3, NR4A2, ESR1 and NR3C1 transcriptional activity.

Phenotypes From GWAS Catalog for ZNF653 Gene

Gene Ontology (GO) - Molecular Function for ZNF653 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003714 transcription corepressor activity IDA 12920234
GO:0008134 transcription factor binding IPI 12920234
GO:0046872 metal ion binding IEA --
GO:0048019 receptor antagonist activity IDA 12920234
genes like me logo Genes that share ontologies with ZNF653: view
genes like me logo Genes that share phenotypes with ZNF653: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF653 Gene

Localization for ZNF653 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF653 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF653 gene
Compartment Confidence
nucleus 5
extracellular 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF653 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005576 extracellular region IEA --
GO:0005634 nucleus IC,IEA 12920234
genes like me logo Genes that share ontologies with ZNF653: view

Pathways & Interactions for ZNF653 Gene

SuperPathways for ZNF653 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF653 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:1900116 extracellular negative regulation of signal transduction IDA 12920234
GO:1903507 negative regulation of nucleic acid-templated transcription IDA 12920234
genes like me logo Genes that share ontologies with ZNF653: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF653 Gene

Drugs & Compounds for ZNF653 Gene

No Compound Related Data Available

Transcripts for ZNF653 Gene

Unigene Clusters for ZNF653 Gene

Zinc finger protein 653:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF653 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b
SP1: - - - - -
SP2: - - - - - - - - -
SP4: - -
SP5: -

Relevant External Links for ZNF653 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF653 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF653 Gene

Protein differential expression in normal tissues from HIPED for ZNF653 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF653 Gene

Protein tissue co-expression partners for ZNF653 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF653 Gene:


SOURCE GeneReport for Unigene cluster for ZNF653 Gene:


mRNA Expression by UniProt/SwissProt for ZNF653 Gene:

Tissue specificity: Highly expressed in testis, cerebellum, temporal lobe, hippocampus and the adrenal gland. Moderately expressed in spleen, uterus, thymus, pancreas, kidney, stomach and rectum.

Evidence on tissue expression from TISSUES for ZNF653 Gene

  • Nervous system(4.2)
  • Eye(4)
genes like me logo Genes that share expression patterns with ZNF653: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF653 Gene

Orthologs for ZNF653 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF653 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF653 33 34
  • 97.95 (n)
(Canis familiaris)
Mammalia ZNF653 33 34
  • 91.69 (n)
(Bos Taurus)
Mammalia ZNF653 33 34
  • 90.97 (n)
(Mus musculus)
Mammalia Zfp653 33 16 34
  • 87.73 (n)
(Rattus norvegicus)
Mammalia Zfp653 33
  • 87.08 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 70 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 74 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486237 33
  • 58.65 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15416 33
(Danio rerio)
Actinopterygii znf653 34
  • 52 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 17 (a)
Species where no ortholog for ZNF653 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF653 Gene

Gene Tree for ZNF653 (if available)
Gene Tree for ZNF653 (if available)

Paralogs for ZNF653 Gene

Variants for ZNF653 Gene

Sequence variations from dbSNP and Humsavar for ZNF653 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000018285 -- 11,494,860(-) G/A intron_variant
rs1000046368 -- 11,489,207(-) G/C intron_variant
rs1000294178 -- 11,505,625(-) CTTCTTC/CTTC coding_sequence_variant, inframe_deletion
rs1000329578 -- 11,499,956(-) T/C intron_variant
rs1000341825 -- 11,494,639(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF653 Gene

Variant ID Type Subtype PubMed ID
nsv519802 CNV loss 19592680

Variation tolerance for ZNF653 Gene

Residual Variation Intolerance Score: 24.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.31; 53.29% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF653 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF653 Gene

Disorders for ZNF653 Gene

Additional Disease Information for ZNF653

No disorders were found for ZNF653 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF653 Gene

Publications for ZNF653 Gene

  1. Cloning and characterization of a novel zinc finger protein that modulates the transcriptional activity of nuclear receptors. (PMID: 12920234) Borud B … Bakke M (Molecular endocrinology (Baltimore, Md.) 2003) 3 4 22 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  4. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo MF … Soares MB (Genome research 1996) 3 58
  5. A census of human transcription factors: function, expression and evolution. (PMID: 19274049) Vaquerizas JM … Luscombe NM (Nature reviews. Genetics 2009) 3

Products for ZNF653 Gene

Sources for ZNF653 Gene

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