Aliases for ZNF652 Gene

Aliases for ZNF652 Gene

  • Zinc Finger Protein 652 2 3 4 5
  • KIAA0924 2 4
  • ZNF652 5

External Ids for ZNF652 Gene

Previous GeneCards Identifiers for ZNF652 Gene

  • GC17M044728
  • GC17M047366
  • GC17M042731

Summaries for ZNF652 Gene

GeneCards Summary for ZNF652 Gene

ZNF652 (Zinc Finger Protein 652) is a Protein Coding gene. Diseases associated with ZNF652 include Vulvar Dystrophy and Vulva Cancer. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZBTB47.

UniProtKB/Swiss-Prot Summary for ZNF652 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF652 Gene

Genomics for ZNF652 Gene

GeneHancer (GH) Regulatory Elements Pubs

GeneHancers around ZNF652 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF652

Top Transcription factor binding sites by QIAGEN in the ZNF652 gene promoter:
  • AhR
  • E47
  • E4BP4
  • Egr-4
  • GATA-6
  • HOXA9

Genomic Locations for ZNF652 Gene

Latest Assembly
73,268 bases
Minus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
73,268 bases
Minus strand

(GRCh37/hg19 by Ensembl)
73,268 bases
Minus strand

Genomic View for ZNF652 Gene

Genes around ZNF652 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF652 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF652 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF652 Gene

Proteins for ZNF652 Gene

  • Protein details for ZNF652 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 652
    Protein Accession:
    Secondary Accessions:
    • A4QPD9
    • Q5H9Q0

    Protein attributes for ZNF652 Gene

    606 amino acids
    Molecular mass:
    69744 Da
    Quaternary structure:
    • Interacts with CBFA2T3.
    • Sequence=BAA76768.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF652 Gene

Post-translational modifications for ZNF652 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF652 Gene

Domains & Families for ZNF652 Gene

Gene Families for ZNF652 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF652 Gene

  • C2H2-type zinc finger signature

Suggested Antigen Peptide Sequences for ZNF652 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 652, isoform CRA_b (D6RF85_HUMAN)
  • Zinc finger protein 652 (ZN652_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF652: view

Function for ZNF652 Gene

Molecular function for ZNF652 Gene

UniProtKB/Swiss-Prot Function:
Functions as a transcriptional repressor.

Phenotypes From GWAS Catalog for ZNF652 Gene

Gene Ontology (GO) - Molecular Function for ZNF652 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA 21873635
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific IBA 21873635
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 16966434
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF652: view

Phenotypes for ZNF652 Gene

genes like me logo Genes that share phenotypes with ZNF652: view

miRNA for ZNF652 Gene

miRTarBase miRNAs that target ZNF652

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF652

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF652 Gene

Localization for ZNF652 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF652 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF652 gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF652 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with ZNF652: view

Pathways & Interactions for ZNF652 Gene

PathCards logo

SuperPathways for ZNF652 Gene

No Data Available

SIGNOR curated interactions for ZNF652 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for ZNF652 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription by RNA polymerase II IBA 21873635
genes like me logo Genes that share ontologies with ZNF652: view

No data available for Pathways by source for ZNF652 Gene

Drugs & Compounds for ZNF652 Gene

No Compound Related Data Available

Transcripts for ZNF652 Gene

mRNA/cDNA for ZNF652 Gene

14 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF652

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF652 Gene

No ASD Table

Relevant External Links for ZNF652 Gene

GeneLoc Exon Structure for

Expression for ZNF652 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF652 Gene

Protein differential expression in normal tissues from HIPED for ZNF652 Gene

This gene is overexpressed in Plasma (32.7), Peripheral blood mononuclear cells (16.3), CD8 Tcells (9.0), and NK cells (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF652 Gene

Protein tissue co-expression partners for ZNF652 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF652

SOURCE GeneReport for Unigene cluster for ZNF652 Gene:


mRNA Expression by UniProt/SwissProt for ZNF652 Gene:

Tissue specificity: Widely expressed with higher expression in breast, prostate, vulva and pancreas.

Evidence on tissue expression from TISSUES for ZNF652 Gene

  • Nervous system(4.7)
  • Liver(4.3)
genes like me logo Genes that share expression patterns with ZNF652: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF652 Gene

Orthologs for ZNF652 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF652 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF652 29 30
  • 99.78 (n)
(Monodelphis domestica)
Mammalia ZNF652 30
  • 96 (a)
(Bos Taurus)
Mammalia ZNF652 29 30
  • 94.44 (n)
(Canis familiaris)
Mammalia ZNF652 29 30
  • 94.22 (n)
(Rattus norvegicus)
Mammalia Zfp652 29
  • 89.04 (n)
(Mus musculus)
Mammalia Zfp652 29 16 30
  • 88.21 (n)
(Ornithorhynchus anatinus)
Mammalia ZNF652 30
  • 81 (a)
(Gallus gallus)
Aves ZNF652 29 30
  • 85.75 (n)
(Anolis carolinensis)
Reptilia ZNF652 30
  • 82 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia Str.14592 29
(Danio rerio)
Actinopterygii znf652 29 30
  • 62.76 (n)
Species where no ortholog for ZNF652 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ZNF652 Gene

Gene Tree for ZNF652 (if available)
Gene Tree for ZNF652 (if available)
Evolutionary constrained regions (ECRs) for ZNF652: view image
Alliance of Genome Resources:
Additional Orthologs for ZNF652

Paralogs for ZNF652 Gene

Paralogs for ZNF652 Gene Pseudogenes for ZNF652 Gene

genes like me logo Genes that share paralogs with ZNF652: view

Variants for ZNF652 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for ZNF652 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for ZNF652 Gene

Variant ID Type Subtype PubMed ID
esv3307703 CNV mobile element insertion 20981092
esv3326018 CNV insertion 20981092
esv3640739 CNV loss 21293372
nsv1112712 CNV deletion 24896259
nsv1118765 CNV deletion 24896259
nsv1138553 CNV deletion 24896259
nsv2075 CNV deletion 18451855
nsv526307 CNV gain 19592680

Variation tolerance for ZNF652 Gene

Residual Variation Intolerance Score: 17.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.01; 49.94% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF652 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF652 Gene

Disorders for ZNF652 Gene

MalaCards: The human disease database

(3) MalaCards diseases for ZNF652 Gene - From: COP

Disorder Aliases PubMed IDs
vulvar dystrophy
  • dystrophy of vulva
vulva cancer
  • ca vulva
vulva squamous cell carcinoma
  • squamous cell carcinoma of vulva
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF652

Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with ZNF652: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF652 Gene

Publications for ZNF652 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 2 3 4
  2. Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. (PMID: 21909110) Wain LV … van Duijn CM (Nature genetics 2011) 3 40
  3. Genome-wide association study of prostate cancer in men of African ancestry identifies a susceptibility locus at 17q21. (PMID: 21602798) Haiman CA … Henderson BE (Nature genetics 2011) 3 40
  4. Confirmation of top polymorphisms in hypertension genome wide association study among Han Chinese. (PMID: 20542020) Niu W … Zhu D (Clinica chimica acta; international journal of clinical chemistry 2010) 3 40
  5. Recapitulation of two genomewide association studies on blood pressure and essential hypertension in the Korean population. (PMID: 20414254) Hong KW … Oh B (Journal of human genetics 2010) 3 40

Products for ZNF652 Gene

Sources for ZNF652 Gene