Aliases for ZNF649 Gene

Aliases for ZNF649 Gene

  • Zinc Finger Protein 649 2 3 4 5
  • FLJ12644 2
  • ZNF649 5

External Ids for ZNF649 Gene

Previous GeneCards Identifiers for ZNF649 Gene

  • GC19M057085
  • GC19M052392
  • GC19M048724

Summaries for ZNF649 Gene

GeneCards Summary for ZNF649 Gene

ZNF649 (Zinc Finger Protein 649) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF613.

UniProtKB/Swiss-Prot Summary for ZNF649 Gene

  • Transcriptional repressor. Regulator of transcriptional factor complexes and may suppress SRE and AP-1 transcription activities mediated by growth factor signaling pathways.

Gene Wiki entry for ZNF649 Gene

Additional gene information for ZNF649 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF649 Gene

Genomics for ZNF649 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF649 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF649 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF649

Top Transcription factor binding sites by QIAGEN in the ZNF649 gene promoter:
  • AP-1
  • ATF-2
  • c-Fos
  • c-Jun

Genomic Locations for ZNF649 Gene

Genomic Locations for ZNF649 Gene
chr19:51,889,235-51,905,040
(GRCh38/hg38)
Size:
15,806 bases
Orientation:
Minus strand
chr19:52,392,477-52,408,305
(GRCh37/hg19)
Size:
15,829 bases
Orientation:
Minus strand

Genomic View for ZNF649 Gene

Genes around ZNF649 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF649 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF649 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF649 Gene

Proteins for ZNF649 Gene

  • Protein details for ZNF649 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BS31-ZN649_HUMAN
    Recommended name:
    Zinc finger protein 649
    Protein Accession:
    Q9BS31
    Secondary Accessions:
    • A8MYJ5
    • B2RDC4
    • Q9H9N2

    Protein attributes for ZNF649 Gene

    Size:
    505 amino acids
    Molecular mass:
    57683 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF649 Gene

Post-translational modifications for ZNF649 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF649 Gene

No data available for DME Specific Peptides for ZNF649 Gene

Domains & Families for ZNF649 Gene

Gene Families for ZNF649 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF649 Gene

InterPro:
Blocks:
  • KRAB box
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF649 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 649 (ZN649_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BS31

UniProtKB/Swiss-Prot:

ZN649_HUMAN :
  • The KRAB domain is required for transcriptional repression.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Domain:
  • The KRAB domain is required for transcriptional repression.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF649: view

Function for ZNF649 Gene

Molecular function for ZNF649 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor. Regulator of transcriptional factor complexes and may suppress SRE and AP-1 transcription activities mediated by growth factor signaling pathways.

Phenotypes From GWAS Catalog for ZNF649 Gene

Gene Ontology (GO) - Molecular Function for ZNF649 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000976 transcription regulatory region sequence-specific DNA binding IBA 21873635
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IBA 21873635
GO:0005515 protein binding IPI 23455924
genes like me logo Genes that share ontologies with ZNF649: view
genes like me logo Genes that share phenotypes with ZNF649: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF649

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF649 Gene

Localization for ZNF649 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF649 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF649 gene
Compartment Confidence
nucleus 5
extracellular 4
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF649 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 23580065
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IBA 21873635
genes like me logo Genes that share ontologies with ZNF649: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF649 Gene

Pathways & Interactions for ZNF649 Gene

genes like me logo Genes that share pathways with ZNF649: view

Pathways by source for ZNF649 Gene

2 Reactome pathways for ZNF649 Gene
1 KEGG pathway for ZNF649 Gene

Gene Ontology (GO) - Biological Process for ZNF649 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IBA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0045944 positive regulation of transcription by RNA polymerase II IBA 21873635
genes like me logo Genes that share ontologies with ZNF649: view

No data available for SIGNOR curated interactions for ZNF649 Gene

Drugs & Compounds for ZNF649 Gene

No Compound Related Data Available

Transcripts for ZNF649 Gene

mRNA/cDNA for ZNF649 Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF649

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF649 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b
SP1: - - - - -
SP2: - - - - - -
SP3: - - -
SP4: - - - -
SP5: - - -
SP6:

Relevant External Links for ZNF649 Gene

GeneLoc Exon Structure for
ZNF649

Expression for ZNF649 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF649 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF649 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF649

SOURCE GeneReport for Unigene cluster for ZNF649 Gene:

Hs.148322

mRNA Expression by UniProt/SwissProt for ZNF649 Gene:

Q9BS31-ZN649_HUMAN
Tissue specificity: Highly expressed in heart, skeletal muscle, and brain. Lower expression in liver, lung, kidney, pancreas and placenta.

Evidence on tissue expression from TISSUES for ZNF649 Gene

  • Nervous system(4.4)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with ZNF649: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF649 Gene

Orthologs for ZNF649 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF649 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF649 30 31
  • 99.6 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 37 (a)
ManyToMany
-- 31
  • 36 (a)
ManyToMany
-- 31
  • 36 (a)
ManyToMany
-- 31
  • 36 (a)
ManyToMany
-- 31
  • 35 (a)
ManyToMany
-- 31
  • 35 (a)
ManyToMany
-- 31
  • 33 (a)
ManyToMany
-- 31
  • 32 (a)
ManyToMany
-- 31
  • 32 (a)
ManyToMany
-- 31
  • 31 (a)
ManyToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 31 (a)
OneToMany
Species where no ortholog for ZNF649 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF649 Gene

ENSEMBL:
Gene Tree for ZNF649 (if available)
TreeFam:
Gene Tree for ZNF649 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF649: view image

Paralogs for ZNF649 Gene

(529) SIMAP similar genes for ZNF649 Gene using alignment to 6 proteins:

  • ZN649_HUMAN
  • L8E957_HUMAN
  • M0QX90_HUMAN
  • M0QYA0_HUMAN
  • M0R098_HUMAN
  • M0R1B1_HUMAN
genes like me logo Genes that share paralogs with ZNF649: view

Variants for ZNF649 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF649 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs1433083 - p.Ala469Thr
rs6509593 - p.Gly352Asp

Additional dbSNP identifiers (rs#s) for ZNF649 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF649 Gene

Variant ID Type Subtype PubMed ID
dgv1067e212 CNV gain 25503493
dgv143e55 CNV gain 17911159
dgv3626n100 CNV gain 25217958
dgv425n27 CNV gain 19166990
dgv6523n54 CNV gain 21841781
esv2758767 CNV gain+loss 17122850
esv3644680 CNV gain 21293372
esv3644682 CNV gain 21293372
nsv1063362 CNV gain 25217958
nsv1140251 OTHER inversion 24896259
nsv580001 CNV gain 21841781
nsv580005 CNV loss 21841781
nsv978837 CNV duplication 23825009

Variation tolerance for ZNF649 Gene

Residual Variation Intolerance Score: 42.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.44; 42.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF649 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF649

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF649 Gene

Disorders for ZNF649 Gene

No disorders were found for ZNF649 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF649 Gene

Publications for ZNF649 Gene

  1. ZNF649, a novel Kruppel type zinc-finger protein, functions as a transcriptional suppressor. (PMID: 15950191) Yang H … Liu M (Biochemical and biophysical research communications 2005) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. RNF12 catalyzes BRF1 ubiquitination and regulates RNA polymerase III-dependent transcription. (PMID: 30413534) Wang F … Mei Y (The Journal of biological chemistry 2019) 3
  5. Genome-Wide Association Study Identifies African-Specific Susceptibility Loci in African Americans With Inflammatory Bowel Disease. (PMID: 27693347) Brant SR … Kugathasan S (Gastroenterology 2017) 3

Products for ZNF649 Gene

Sources for ZNF649 Gene