Aliases for ZNF648 Gene

Aliases for ZNF648 Gene

  • Zinc Finger Protein 648 2 3 4 5
  • FLJ46813 2
  • ZNF648 5

External Ids for ZNF648 Gene

Previous GeneCards Identifiers for ZNF648 Gene

  • GC01M178755
  • GC01M180290
  • GC01M182023
  • GC01M153255

Summaries for ZNF648 Gene

GeneCards Summary for ZNF648 Gene

ZNF648 (Zinc Finger Protein 648) is a Protein Coding gene. Diseases associated with ZNF648 include Glycogen Storage Disease Iv. An important paralog of this gene is ZFP62.

UniProtKB/Swiss-Prot Summary for ZNF648 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF648 Gene

Genomics for ZNF648 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF648 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF648 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF648

Top Transcription factor binding sites by QIAGEN in the ZNF648 gene promoter:
  • AhR
  • AP-4
  • Arnt
  • ATF6
  • Lmo2
  • NF-1
  • NF-1/L
  • Nkx2-2
  • Nkx2-5
  • YY1

Genomic Locations for ZNF648 Gene

Latest Assembly
chr1:182,053,740-182,081,725
(GRCh38/hg38)
Size:
27,986 bases
Orientation:
Minus strand

Previous Assembly
chr1:182,023,705-182,030,847
(GRCh37/hg19 by Entrez Gene)
Size:
7,143 bases
Orientation:
Minus strand

chr1:182,023,705-182,030,847
(GRCh37/hg19 by Ensembl)
Size:
7,143 bases
Orientation:
Minus strand

Genomic View for ZNF648 Gene

Genes around ZNF648 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF648 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF648 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF648 Gene

Proteins for ZNF648 Gene

  • Protein details for ZNF648 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T619-ZN648_HUMAN
    Recommended name:
    Zinc finger protein 648
    Protein Accession:
    Q5T619
    Secondary Accessions:
    • B2RP16

    Protein attributes for ZNF648 Gene

    Size:
    568 amino acids
    Molecular mass:
    62341 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF648 Gene

Post-translational modifications for ZNF648 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF648 Gene

No data available for DME Specific Peptides for ZNF648 Gene

Domains & Families for ZNF648 Gene

Gene Families for ZNF648 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF648 Gene

InterPro:
Blocks:
  • C2H2-type zinc finger signature
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF648 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 648 (ZN648_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q5T619

UniProtKB/Swiss-Prot:

ZN648_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF648: view

Function for ZNF648 Gene

Molecular function for ZNF648 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF648 Gene

Gene Ontology (GO) - Molecular Function for ZNF648 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA 21873635
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific IBA 21873635
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 32296183
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF648: view
genes like me logo Genes that share phenotypes with ZNF648: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF648

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF648 Gene

Localization for ZNF648 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF648 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF648 gene
Compartment Confidence
nucleus 4
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ZNF648 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin IBA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF648: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF648 Gene

Pathways & Interactions for ZNF648 Gene

PathCards logo

SuperPathways for ZNF648 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF648 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IBA 21873635
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF648: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF648 Gene

Drugs & Compounds for ZNF648 Gene

No Compound Related Data Available

Transcripts for ZNF648 Gene

mRNA/cDNA for ZNF648 Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF648

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF648 Gene

No ASD Table

Relevant External Links for ZNF648 Gene

GeneLoc Exon Structure for
ZNF648

Expression for ZNF648 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF648 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF648 Gene

This gene is overexpressed in Testis (x10.7), Liver (x4.6), Pituitary (x4.1), and Ovary (x4.1).

Protein differential expression in normal tissues from HIPED for ZNF648 Gene

This gene is overexpressed in Serum (34.8) and Peripheral blood mononuclear cells (33.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF648 Gene



Protein tissue co-expression partners for ZNF648 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF648

SOURCE GeneReport for Unigene cluster for ZNF648 Gene:

Hs.684328
genes like me logo Genes that share expression patterns with ZNF648: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF648 Gene

Orthologs for ZNF648 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF648 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF648 30 31
  • 99.3 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZNF648 30 31
  • 84.07 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ZNF648 30 31
  • 83 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Zfp648 30 17 31
  • 77.76 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Zfp648 30
  • 76.19 (n)
Zebrafish
(Danio rerio)
Actinopterygii znf648 31
  • 38 (a)
OneToOne
Species where no ortholog for ZNF648 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ZNF648 Gene

ENSEMBL:
Gene Tree for ZNF648 (if available)
TreeFam:
Gene Tree for ZNF648 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF648: view image

Paralogs for ZNF648 Gene

Paralogs for ZNF648 Gene

(409) SIMAP similar genes for ZNF648 Gene using alignment to 1 proteins:

  • ZN648_HUMAN
genes like me logo Genes that share paralogs with ZNF648: view

Variants for ZNF648 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF648 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs12564283 - p.Glu42Lys
rs12568050 - p.Asn111Lys

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for ZNF648 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Variation tolerance for ZNF648 Gene

Residual Variation Intolerance Score: 91.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.91; 67.70% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF648 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF648

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZNF648 Gene

Disorders for ZNF648 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF648 Gene - From: COP

Disorder Aliases PubMed IDs
glycogen storage disease iv
  • gsd4
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF648

Genetic Association Database
(GAD)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with ZNF648: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF648 Gene

Publications for ZNF648 Gene

  1. Biological, clinical and population relevance of 95 loci for blood lipids. (PMID: 20686565) Teslovich TM … Kathiresan S (Nature 2010) 3 41
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. A Single Adaptable Cochaperone-Scaffold Complex Delivers Nascent Iron-Sulfur Clusters to Mammalian Respiratory Chain Complexes I-III. (PMID: 28380382) Maio N … Rouault TA (Cell metabolism 2017) 3
  5. Genome-wide association study of peripheral neuropathy with D-drug-containing regimens in AIDS Clinical Trials Group protocol 384. (PMID: 24554482) Leger PD … Haas DW (Journal of neurovirology 2014) 3

Products for ZNF648 Gene

Sources for ZNF648 Gene