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Aliases for ZNF648 Gene
External Ids for ZNF648 Gene
- HGNC: 18190
- Entrez Gene: 127665
- Ensembl: ENSG00000179930
- UniProtKB: Q5T619
Previous GeneCards Identifiers for ZNF648 Gene
- GC01M178755
- GC01M180290
- GC01M182023
- GC01M153255
Summaries for ZNF648 Gene
GeneCards Summary for ZNF648 Gene
ZNF648 (Zinc Finger Protein 648) is a Protein Coding gene. Diseases associated with ZNF648 include Glycogen Storage Disease Iv. An important paralog of this gene is ZNF721.
UniProtKB/Swiss-Prot Summary for ZNF648 Gene
-
May be involved in transcriptional regulation.
Additional gene information for ZNF648 Gene
- HGNC(18190)
- Entrez Gene(127665)
- Ensembl(ENSG00000179930)
- UniProtKB(Q5T619)
- Open Targets Platform(ENSG00000179930)
- Monarch Initiative
- Search for ZNF648 at DataMed
- Search for ZNF648 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF648 Gene
Genomics for ZNF648 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for ZNF648 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ZNF648 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF648
- Top Transcription factor binding sites by QIAGEN in the ZNF648 gene promoter:
-
- AhR
- AP-4
- Arnt
- ATF6
- Lmo2
- NF-1
- NF-1/L
- Nkx2-2
- Nkx2-5
- YY1
Genomic Locations for ZNF648 Gene
Genomic Locations for ZNF648 Gene
- chr1:182,053,740-182,081,725
- (GRCh38/hg38)
- Size:
- 27,986 bases
- Orientation:
- Minus strand
- chr1:182,023,705-182,030,847
- (GRCh37/hg19)
- Size:
- 7,143 bases
- Orientation:
- Minus strand
Genomic View for ZNF648 Gene
Genes around ZNF648 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q25.3 by HGNC
- 1q25.3 by Entrez Gene
- 1q25.3 by Ensembl
ZNF648 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ZNF648 Gene
Proteins for ZNF648 Gene
-
Protein details for ZNF648 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q5T619-ZN648_HUMAN
- Recommended name:
- Zinc finger protein 648
- Protein Accession:
- Q5T619
- B2RP16
Protein attributes for ZNF648 Gene
- Size:
- 568 amino acids
- Molecular mass:
- 62341 Da
- Quaternary structure:
- No Data Available
Protein Expression for ZNF648 Gene
Post-translational modifications for ZNF648 Gene
Other Protein References for ZNF648 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for ZNF648
- Novus Biologicals Antibodies for ZNF648
- Invitrogen Antibodies for ZNF648 (AFLGC-ZNF648)
Protein Products
-
OriGene Purified Proteins for ZNF648
- Search Origene for MassSpec and Protein Over-expression Lysates for ZNF648
- Origene Custom Protein Services for ZNF648
- Novus Biologicals proteins for ZNF648
No data available for DME Specific Peptides for ZNF648 Gene
Domains & Families for ZNF648 Gene
Gene Families for ZNF648 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transcription factors
Protein Domains for ZNF648 Gene
- InterPro:
- Blocks:
-
- C2H2-type zinc finger signature
- ProtoNet:
Suggested Antigen Peptide Sequences for ZNF648 Gene
- GenScript: Design optimal peptide antigens:
-
- Zinc finger protein 648 (ZN648_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q5T619- Family:
-
- Belongs to the krueppel C2H2-type zinc-finger protein family.
Function for ZNF648 Gene
Molecular function for ZNF648 Gene
- UniProtKB/Swiss-Prot Function:
- May be involved in transcriptional regulation.
Phenotypes From GWAS Catalog for ZNF648 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0003677 | DNA binding | IBA | 21873635 |
| GO:0003700 | DNA-binding transcription factor activity | IBA | 21873635 |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for ZNF648 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ZNF648 - Select products 50% OFF >
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-
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-
Santa Cruz Biotechnology (SCBT) CRISPR for ZNF648
miRNA for ZNF648 Gene
- miRTarBase miRNAs that target ZNF648
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ZNF648
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Clone Products
- Applied Biological Materials (abm): Clones for ZNF648 - Select products 50% OFF >
- * ZNF648 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for ZNF648
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ZNF648
Cell Line Products
-
Horizon Cell Lines for ZNF648
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF648 Gene
Localization for ZNF648 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ZNF648 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 4 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IBA | 21873635 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF648 Gene
Pathways & Interactions for ZNF648 Gene
Interacting Proteins for ZNF648 Gene
Selected Interacting proteins:
Q5T619-ZN648_HUMAN
ENSP00000344129
for ZNF648 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for ZNF648
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006355 | regulation of transcription, DNA-templated | IBA | 21873635 |
No data available for Pathways by source and SIGNOR curated interactions for ZNF648 Gene
Transcripts for ZNF648 Gene
mRNA/cDNA for ZNF648 Gene
- 1 REFSEQ mRNAs :
- 3 NCBI additional mRNA sequence :
- 2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000339948 3649 nts (view in UCSC)
- ENST00000673963 1152 nts
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ZNF648 - Select products 50% OFF >
- * ZNF648 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for ZNF648
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ZNF648
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZNF648
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ZNF648
- Browse OriGene Inhibitory RNA Products For ZNF648
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF648
Clone Products
- Applied Biological Materials (abm): Clones for ZNF648 - Select products 50% OFF >
- * ZNF648 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for ZNF648
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ZNF648
Relevant External Links for ZNF648 Gene
- GeneLoc Exon Structure for
- ZNF648
Expression for ZNF648 Gene
mRNA differential expression in normal tissues according to GTEx for ZNF648 Gene
This gene is overexpressed in Testis (x10.7), Liver (x4.6), Pituitary (x4.1), and Ovary (x4.1).
This gene is overexpressed in Serum (34.8) and Peripheral blood mononuclear cells (33.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF648 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF648
SOURCE GeneReport for Unigene cluster for ZNF648 Gene:
Hs.684328Primer Products
-
OriGene qPCR primer pairs for ZNF648
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF648 Gene
Orthologs for ZNF648 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | ZNF648 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | ZNF648 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | ZNF648 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Zfp648 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Zfp648 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | znf648 31 |
|
OneToOne |
- Species where no ortholog for ZNF648 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for ZNF648 Gene
- ENSEMBL:
- Gene Tree for ZNF648 (if available)
- TreeFam:
- Gene Tree for ZNF648 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ZNF648: view image
Paralogs for ZNF648 Gene
(409) SIMAP similar genes for ZNF648 Gene using alignment to 1 proteins:
- ZN648_HUMAN
- ZNF
- ZNF773
- HZF36
- ZFP3
- ZNF34
- DKFZp686N14223
- ZNF3
- ZNF519
- ZNF16
- ZNF146
- ZFP1
- DKFZp547L155
- ZNF345
- ZNF232
- ZNF135
- ZNF814
- ZNF771
- ZNF677
- ZNF595
- ZNF461
- ZNF397
- ZNF358
- ZNF211
- ZNF19
- ZNF420
- ZNF383
- ZNF323
- ZNF287
- ZNF189
- ZSCAN22
- ZNF852
- ZNF813
- ZNF780B
- ZNF708
- ZNF678
- ZNF675
- ZNF662
- ZNF546
- ZNF483
- ZNF480
- ZNF418
- ZNF417
- ZKSCAN7
- ZFS-1
- HZF30
- DKFZp434G1930
- ZNF599
- ZNF587
- ZNF582
- ZNF286A
- ZNF844
- ZNF671
- ZNF99
- ZNF93
- ZNF883
- ZNF879
- ZNF808
- ZNF782
- ZNF776
- ZNF728
- ZNF724P
- ZNF718
- ZNF624
- ZNF578
- ZNF550
- ZNF429
- ZNF350
- ZNF347
- ZNF286B
- ZNF271
- ZNF227
- ZNF14
- ZFP92
- ZFP28
- DKFZp686K03205
- DKFZp686H20223
- DKFZp686B16128
- DKFZp571N1833
- ZNF585B
- ZNF570
- ZNF566
- ZNF501
- ZNF45
- ZNF37A
- ZNF23
- ZKSCAN8
- ZKSCAN3
- ZNF729
- ZNF28
- ZNF510
- ZNF419
- ZNF324
- ZNF702P
- ZNF70
- ZNF682
- ZNF83
- ZNF829
- ZNF701
- ZNF665
- ZNF660
- ZNF619
- ZNF611
- ZNF607
- ZNF585A
- ZNF568
- ZNF534
- ZNF529
- ZNF491
- ZNF43
- ZNF404
- ZNF354C
- ZNF331
- ZNF268
- ZNF267
- ZNF256
- ZNF251
- ZNF250
- ZNF226
- ZNF214
- ZNF154
- ZNF140
- HKR1
- DKFZp686L0787
- ZNF571
- ZNF565
- ZNF471
- ZNF416
- ZNF300
- ZNF283
- ZNF180
- ZNF567
- ZNF557
- ZNF551
- ZNF92
- ZNF75A
- ZNF709
- ZNF664
- ZNF98
- ZNF891
- ZNF878
- ZNF860
- ZNF81
- ZNF765
- ZNF761
- ZNF730
- ZNF727
- ZNF720
- ZNF676
- ZNF616
- ZNF613
- ZNF573
- ZNF569
- ZNF549
- ZNF543
- ZNF492
- ZNF35
- ZNF343
- ZNF320
- ZNF304
- ZNF30
- ZNF266
- ZNF260
- ZNF239
- ZNF160
- ZNF12
- ZIK1
- Nbla00121
- HZF41
- DKFZp762K012
- DKFZp686G16228
- ZNF558
- ZNF527
- ZNF436
- ZNF234
- ZNF157
- KIAA1829
- ZNF888
- ZNF880
- ZNF845
- ZNF841
- ZNF836
- ZNF816
- ZNF799
- ZNF778
- ZNF736
- ZNF732
- ZNF700
- ZNF681
- ZNF658B
- ZNF658
- ZNF643
- ZNF626
- ZNF600
- ZNF596
- ZNF586
- ZNF554
- ZNF547
- ZNF525
- ZNF486
- ZNF485
- ZNF391
- ZNF273
- ZNF254
- ZNF253
- ZNF235
- ZNF182
- ZIM3
- ZFP69B
- ZFP69
- DKFZp666M039
- ZNF514
- ZNF426
- ZNF33B
- ZNF32
- ZNF175
- ZNF137P
- DKFZp434G1621
- ZNF717
- ZNF587B
- PRDM9
- ZNF793
- ZNF846
- ZNF840
- ZNF766
- ZNF716
- ZNF680
- ZNF679
- ZNF615
- ZNF614
- ZNF606
- ZNF577
- ZNF548
- ZNF506
- ZNF493
- ZNF490
- ZNF454
- ZNF430
- ZNF333
- ZNF324B
- ZNF224
- ZFP90
- DKFZp686C13142
- ZNF442
- ZNF257
- ZNF25
- ZFP14
- PRMD9
- ZNF10
- ZNF90
- ZNF85
- ZNF791
- ZNF774
- ZNF77
- ZNF737
- ZNF726
- ZNF7
- ZNF699
- ZNF667
- ZNF605
- ZNF555
- ZNF441
- ZNF322
- ZNF316
- ZNF311
- ZNF26
- ZNF20
- ZNF195
- ZNF17
- ZNF132
- ZNF117
- ZNF107
- ZF6
- HZF14
- GZF1
- GD
- DKFZp686O111
- ZNF627
- ZNF563
- ZNF544
- ZNF540
- ZNF502
- ZNF432
- ZNF382
- ZNF141
- ZNF823
- ZNF44
- ZNF696
- ZNF850
- ZNF780A
- ZNF695
- ZNF69
- ZNF57
- ZNF528
- ZNF479
- ZNF468
- ZNF439
- ZNF433
- ZNF425
- ZNF337
- ZNF222
- ZNF181
- ZNF112
- ZFP112
- LOC126295
- DKFZp686D2168
- ZNF625
- ZNF589
- ZNF580
- ZNF136
- ZFP82
- ZFP37
- ZFP30
- ZNF572
- ZNF285A
- ZFP62
- ZFP2
- ZSCAN12
- ZNF80
- ZNF697
- ZNF805
- ZNF735
- ZNF630
- ZNF584
- ZNF440
- ZNF415
- ZNF285
- ZNF225
- ZNF223
- ZNF124
- ZNF561
- ZNF594
- ZNF2
- ZNF713
- ZNF670
- ZNF669
- ZSCAN20
- ZSCAN2
- ZNF835
- ZNF790
- ZNF714
- ZNF66
- ZNF623
- ZNF517
- ZNF497
- ZNF484
- ZNF460
- ZNF431
- ZNF355P
- ZNF33A
- ZNF319
- ZNF275
- ZNF581
- ZNF559
- ZNF233
- CTCFL
- ZNF133
- ZNF792
- ZSCAN21
- ZNF71
- ZNF79
- ZNF610
- ZNF473
- ZNF329
- ZNF177
- ZNF134
- ZNF121
- DKFZp686J1732
- ZNF74
- ZNF649
- ZNF749
- ZNF674
- ZNF530
- ZNF48
- ZNF470
- ZNF354A
- ZNF230
- ZNF155
- ZNF100
- ZNF564
- ZNF354B
- ZNF284
- ZNF101
- GLI4
- GFI1B
- ZNF689
- ZNF672
- ZNF84
- ZNF772
- ZNF721
- ZNF668
- ZNF629
- ZNF184
- ZFP95
- TIPUH1
- ZKSCAN4
- OSR2
- ZNF263
- ZNF264
- ZNF443
- ZNF248
- ZNF229
- ZBTB41
- ZNF786
- ZNF583
- ZNF398
- ZNF221
- ZNF169
- ZKSCAN5
- ZNF556
Variants for ZNF648 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF648 Gene
| SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs12564283 | - | p.Glu42Lys | |||
| rs12568050 | - | p.Asn111Lys |
Residual Variation Intolerance Score:
91.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.91;
67.70% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ZNF648 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ZNF648
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZNF648 Gene
Disorders for ZNF648 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| glycogen storage disease iv |
|
|
Search ZNF648 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ZNF648
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF648 Gene
Publications for ZNF648 Gene
- Biological, clinical and population relevance of 95 loci for blood lipids. (PMID: 20686565) Teslovich TM … Kathiresan S (Nature 2010) 3 41
- The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
- A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
- Genome-wide association study of peripheral neuropathy with D-drug-containing regimens in AIDS Clinical Trials Group protocol 384. (PMID: 24554482) Leger PD … Haas DW (Journal of neurovirology 2014) 3
- Discovery and refinement of loci associated with lipid levels. (PMID: 24097068) Willer CJ … Global Lipids Genetics Consortium (Nature genetics 2013) 3
ExternalLinks
Products for ZNF648 Gene
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Sources for ZNF648 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
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