Free for academic non-profit institutions. Other users need a Commercial license
ZNF646 (Zinc Finger Protein 646) is a Protein Coding gene. Diseases associated with ZNF646 include Spastic Paraplegia 62, Autosomal Recessive and Ataxia, Sensory, 1, Autosomal Dominant. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF287.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003676 | nucleic acid binding | IEA | -- |
GO:0003677 | DNA binding | IBA | 21873635 |
GO:0003700 | DNA-binding transcription factor activity | IBA | 21873635 |
GO:0005515 | protein binding | IPI | 16189514 |
GO:0046872 | metal ion binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006355 | regulation of transcription, DNA-templated | IBA | 21873635 |
ExUns: | 1a | · | 1b | ^ | 2a | · | 2b |
---|---|---|---|---|---|---|---|
SP1: | - | ||||||
SP2: |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ZNF646 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | ZNF646 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | ZNF646 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Zfp646 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Zfp646 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | ZNF646 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | ZNF646 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | ZNF646 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC101732255 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | znf646p 31 |
|
OneToMany | |
ZNF646 (2 of 2) 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 16 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
VAR_035594 | A breast cancer sample | p.Asn1337Ile | |||
rs17641067 | - | p.Ile774Met | |||
rs28407985 | - | p.Ala98Val | |||
rs34259949 | - | p.Thr1788Met | |||
rs35376811 | - | p.Arg1249Trp |
Disorder | Aliases | PubMed IDs |
---|---|---|
spastic paraplegia 62, autosomal recessive |
|
|
ataxia, sensory, 1, autosomal dominant |
|
|
gillespie syndrome |
|
|
pseudobulbar palsy |
|
|