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Aliases for ZNF645 Gene

Aliases for ZNF645 Gene

  • Zinc Finger Protein 645 2 3 4 5
  • RING-Type E3 Ubiquitin Transferase ZNF645 3 4
  • E3 Ubiquitin-Protein Ligase ZNF645 3
  • E3 Ubiquitin Ligase 3
  • EC 4
  • HAKAIL 3
  • CT138 3

External Ids for ZNF645 Gene

Previous GeneCards Identifiers for ZNF645 Gene

  • GC0XP022051
  • GC0XP020031

Summaries for ZNF645 Gene

Entrez Gene Summary for ZNF645 Gene

  • This gene encodes a member of the zinc finger domain-containing protein family. This family member contains both a RING-type and a C2H2-type of zinc finger domain, and it may function as an E3 ubiquitin-protein ligase. Protein localization suggests a role in human sperm production and quality control. [provided by RefSeq, Aug 2011]

GeneCards Summary for ZNF645 Gene

ZNF645 (Zinc Finger Protein 645) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include ligase activity. An important paralog of this gene is CBLL1.

UniProtKB/Swiss-Prot for ZNF645 Gene

  • E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. May operate on tyrosine-phosphorylated SRC substrates.

Additional gene information for ZNF645 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF645 Gene

Genomics for ZNF645 Gene

GeneHancer (GH) Regulatory Elements for ZNF645 Gene

Promoters and enhancers for ZNF645 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI022272 Promoter 0.5 EPDnew 550.8 +0.0 10 0.1 ZNF645 ENSG00000231846
GH0XI022313 Enhancer 0.5 ENCODE 0.3 +41.5 41513 2.2 POLR2A JUN BACH1 NFE2 REST EGR2 ZNF645 ENSG00000231846 PTCHD1-AS
GH0XI022364 Enhancer 0.5 ENCODE 0.2 +92.7 92669 1.3 JUND JUN CEBPB FOS EP300 ENSG00000231846 ZNF645 PTCHD1-AS
GH0XI022338 Enhancer 0.4 ENCODE 0.2 +65.9 65886 0.2 GATA3 SETDB1 TRIM28 ZNF645 ENSG00000231846 PTCHD1-AS
GH0XI022388 Enhancer 0.8 Ensembl ENCODE 0.1 +116.7 116725 2 SRF PKNOX1 JUN JUND CTBP1 FOS SETDB1 TCF7L2 ENSG00000231846 ZNF645 PTCHD1-AS
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF645 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF645 gene promoter:

Genomic Locations for ZNF645 Gene

Genomic Locations for ZNF645 Gene
1,549 bases
Plus strand

Genomic View for ZNF645 Gene

Genes around ZNF645 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF645 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF645 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF645 Gene

Proteins for ZNF645 Gene

  • Protein details for ZNF645 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    E3 ubiquitin-protein ligase ZNF645
    Protein Accession:
    Secondary Accessions:
    • A0AV29
    • A0AV31
    • E3SBK4
    • Q6DJY9

    Protein attributes for ZNF645 Gene

    425 amino acids
    Molecular mass:
    48785 Da
    Quaternary structure:
    • Homodimer.

neXtProt entry for ZNF645 Gene

Post-translational modifications for ZNF645 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF645 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF645 Gene

Domains & Families for ZNF645 Gene

Gene Families for ZNF645 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for ZNF645 Gene

Suggested Antigen Peptide Sequences for ZNF645 Gene

Graphical View of Domain Structure for InterPro Entry



  • The HYB domain forms a phosphotyrosine-binding pocket upon dimerization, and mediates as well the recognition of its flanking acidic amino acids.
  • The HYB domain forms a phosphotyrosine-binding pocket upon dimerization, and mediates as well the recognition of its flanking acidic amino acids.
genes like me logo Genes that share domains with ZNF645: view

Function for ZNF645 Gene

Molecular function for ZNF645 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
UniProtKB/Swiss-Prot Function:
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. May operate on tyrosine-phosphorylated SRC substrates.

Enzyme Numbers (IUBMB) for ZNF645 Gene

Gene Ontology (GO) - Molecular Function for ZNF645 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0016740 transferase activity IEA --
GO:0046872 metal ion binding IEA --
GO:0061630 ubiquitin protein ligase activity IBA --
genes like me logo Genes that share ontologies with ZNF645: view
genes like me logo Genes that share phenotypes with ZNF645: view

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF645 Gene

Localization for ZNF645 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF645 Gene

Cytoplasm. Note=Localized over the postacrosomal perinuclear theca region and the entire length of sperm tail.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF645 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for ZNF645 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with ZNF645: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF645 Gene

Pathways & Interactions for ZNF645 Gene

genes like me logo Genes that share pathways with ZNF645: view

UniProtKB/Swiss-Prot Q8N7E2-ZN645_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for ZNF645 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0030155 regulation of cell adhesion IBA --
genes like me logo Genes that share ontologies with ZNF645: view

No data available for SIGNOR curated interactions for ZNF645 Gene

Drugs & Compounds for ZNF645 Gene

No Compound Related Data Available

Transcripts for ZNF645 Gene

mRNA/cDNA for ZNF645 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF645 Gene

Zinc finger protein 645:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF645 Gene

No ASD Table

Relevant External Links for ZNF645 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF645 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF645 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF645 Gene

This gene is overexpressed in Testis (x51.8).

NURSA nuclear receptor signaling pathways regulating expression of ZNF645 Gene:


SOURCE GeneReport for Unigene cluster for ZNF645 Gene:


mRNA Expression by UniProt/SwissProt for ZNF645 Gene:

Tissue specificity: Exclusively expressed in testis and sperm, including spermatocytes, round and elongated spermatids, and Leydig cells.
genes like me logo Genes that share expression patterns with ZNF645: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF645 Gene

Orthologs for ZNF645 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF645 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF645 33 34
  • 98.3 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 45 (a)
-- 34
  • 37 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 42 (a)
(Gallus gallus)
Aves CBLL1 34
  • 35 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 41 (a)
(Danio rerio)
Actinopterygii cbll1 34
  • 35 (a)
CU041386.1 34
  • 35 (a)
fruit fly
(Drosophila melanogaster)
Insecta Hakai 34
  • 16 (a)
Species where no ortholog for ZNF645 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF645 Gene

Gene Tree for ZNF645 (if available)
Gene Tree for ZNF645 (if available)

Paralogs for ZNF645 Gene

Paralogs for ZNF645 Gene

(1) SIMAP similar genes for ZNF645 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF645: view

Variants for ZNF645 Gene

Sequence variations from dbSNP and Humsavar for ZNF645 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1002283667 -- 22,274,957(+) C/T downstream_transcript_variant
rs1002708067 -- 22,274,530(+) A/T downstream_transcript_variant
rs1003159529 -- 22,271,485(+) G/A upstream_transcript_variant
rs1003619187 -- 22,272,203(+) C/T upstream_transcript_variant
rs1003703661 -- 22,273,356(+) G/A coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF645 Gene

Variant ID Type Subtype PubMed ID
nsv521384 CNV gain 19592680

Variation tolerance for ZNF645 Gene

Residual Variation Intolerance Score: 82.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.44; 64.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF645 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF645 Gene

Disorders for ZNF645 Gene

Additional Disease Information for ZNF645

No disorders were found for ZNF645 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF645 Gene

Publications for ZNF645 Gene

  1. Human RING finger protein ZNF645 is a novel testis-specific E3 ubiquitin ligase. (PMID: 20657603) Liu YQ … Zhang SZ (Asian journal of andrology 2010) 2 3 4 58
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for ZNF645 Gene

Sources for ZNF645 Gene

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